<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE12845_IGD_POS_BLOOD_VS_PRE_GC_TONSIL_BCELL_DN" SYSTEMATIC_NAME="M3188" HISTORICAL_NAMES="" PMID="19023113" AUTHORS="Longo NS,Lugar PL,Yavuz S,Zhang W,Krijger PH,Russ DE,Jima DD,Dave SS,Grammer AC,Lipsky PE" GEOID="GSE12845" EXACT_SOURCE="GSE12845_2021_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in comparison of IgD+ B cells from peripheral blood versus CD19 pre-germinal center tonsil B cell" DESCRIPTION_FULL="B cells from human tonsil and blood were sorted using flow cytometry. The human samples were processed immediately ex-vivo using markers for known B cell subsets." TAGS="" MEMBERS="ADA,ADAMDEC1,ADCK2,AIMP2,ALDH18A1,ANP32B,ANP32E,AP2S1,ARMCX3,ARPC2,ASPM,ATOX1,ATP6V1A,AURKB,BANF1,BCAR3,BID,BIRC2,BRCA2,C10orf137,C1orf27,C3orf37,C5orf13,CALML4,CAMK1,CASP3,CBX5,CCDC99,CCNB1,CCNB2,CCT5,CD69,CDC20,CDC45,CDC6,CDK4,CDKN3,CENPE,CLASP2,CLTA,CSK,CTNNAL1,CTSD,DCP2,DCTPP1,DDIT4,DDX21,DEPDC1,DHFR,DLGAP5,DNMT1,DPP3,DTL,DUSP2,EHD4,ENO2,ESPL1,EZH2,FABP5,FADS3,FAM120A,FANCI,FANCL,FEN1,FGFR1OP,FNDC3B,FOXM1,FUCA1,GINS2,GLRX5,GRB2,GRHPR,GSN,H2AFX,HIST1H2AM,HMGA1,HMGB1,HMGN2,HN1,HNRNPA2B1,HSPA5,HSPA8,IPO9,ITPR3,KANK1,KIF11,KIF15,KIF20A,KIF23,KIF4A,KLHL18,LANCL2,LGMN,LNPEP,LPIN1,LPXN,LRRK1,MAD2L1,MAFB,MAGED1,MANF,MAP3K8,MARCH6,MCM10,MCM7,MCTP2,MDC1,MELK,METAP2,MFAP1,MKI67,MME,MORF4L2,MRPL35,MTF2,MTHFD2,MYB,NANS,NCAPD2,NCAPG,NCAPG2,NCL,NFATC2IP,NME1,NT5DC2,ORC1,PAQR4,PBK,PDGFD,PGAM1,PHGDH,PKD2,PLA2G7,PLIN3,PLXNB2,POLD1,PPIA,PPIF,PRRC2C,PTGDS,PTTG1,RAB11FIP1,RACGAP1,RAD51AP1,RAD54L,RARRES1,RASA2,RBBP8,RER1,RFWD3,RFX7,RNASE1,RNF103,ROCK1,RPLP0,RUVBL1,SAC3D1,SCAF11,SEC14L1,SEPHS1,SEPT11,SF3B4,SFPQ,SH2B3,SHCBP1,SKA1,SLC1A4,SLC43A3,SMARCA4,SMC2,SMPDL3A,SNTB2,SPAG5,SPATS2,SPC25,SRP54,SRSF1,SUMO4,TACC3,TBC1D4,TERF2,TFDP1,TMEM48,TNS3,TRIP13,TRMT5,TSFM,TUBB2A,TUBG1,UBE2C,UBR5,USP14,VGLL4,VNN2,WSB1,XPNPEP1,YWHAE,ZCCHC11,ZNF160,ZNF331" MEMBERS_SYMBOLIZED="ADA,ADAMDEC1,ADCK2,AIMP2,ALDH18A1,ANP32B,ANP32E,AP2S1,ARMCX3,ARPC2,ASPM,ATOX1,ATP6V1A,AURKB,BANF1,BCAR3,BID,BIRC2,BRCA2,CALML4,CAMK1,CASP3,CBX5,CCNB1,CCNB2,CCT5,CD69,CDC20,CDC45,CDC6,CDK4,CDKN3,CENPE,CEP43,CLASP2,CLTA,CSK,CTNNAL1,CTSD,DCP2,DCTPP1,DDIT4,DDX21,DEPDC1,DHFR,DLGAP5,DNMT1,DPP3,DTL,DUSP2,EDRF1,EHD4,ENO2,ESPL1,EZH2,FABP5,FADS3,FAM120A,FANCI,FANCL,FEN1,FNDC3B,FOXM1,FUCA1,GINS2,GLRX5,GRB2,GRHPR,GSN,H2AC17,H2AX,HMCES,HMGA1,HMGB1,HMGN2,HNRNPA2B1,HSPA5,HSPA8,IPO9,ITPR3,JPT1,KANK1,KIF11,KIF15,KIF20A,KIF23,KIF4A,KLHL18,LANCL2,LGMN,LNPEP,LPIN1,LPXN,LRRK1,MAD2L1,MAFB,MAGED1,MANF,MAP3K8,MARCHF6,MCM10,MCM7,MCTP2,MDC1,MELK,METAP2,MFAP1,MKI67,MME,MORF4L2,MRPL35,MTF2,MTHFD2,MYB,NANS,NCAPD2,NCAPG,NCAPG2,NCL,NDC1,NFATC2IP,NME1,NREP,NT5DC2,ODR4,ORC1,PAQR4,PBK,PDGFD,PGAM1,PHGDH,PKD2,PLA2G7,PLIN3,PLXNB2,POLD1,PPIA,PPIF,PRRC2C,PTGDS,PTTG1,RAB11FIP1,RACGAP1,RAD51AP1,RAD54L,RARRES1,RASA2,RBBP8,RER1,RFWD3,RFX7,RNASE1,RNF103,ROCK1,RPLP0,RUVBL1,SAC3D1,SCAF11,SEC14L1,SEPHS1,SEPTIN11,SF3B4,SFPQ,SH2B3,SHCBP1,SKA1,SLC1A4,SLC43A3,SMARCA4,SMC2,SMPDL3A,SNTB2,SPAG5,SPATS2,SPC25,SPDL1,SRP54,SRSF1,SUMO4,TACC3,TBC1D4,TERF2,TFDP1,TNS3,TRIP13,TRMT5,TSFM,TUBB2A,TUBG1,TUT4,UBE2C,UBR5,USP14,VGLL4,VNN2,WSB1,XPNPEP1,YWHAE,ZNF160,ZNF331" MEMBERS_EZID="100,10019,10072,10102,10105,10109,10112,1019,10226,10262,10299,1033,10460,10541,10592,10615,1062,10635,10797,10924,10988,11065,11079,11116,1175,1211,124222,1326,1445,1509,167227,1719,1786,1844,2026,2146,2171,220134,2237,22823,22929,22948,2305,23122,23175,23189,23196,23215,23276,23318,23468,23654,24137,2517,259266,26098,26118,26227,27299,2885,29015,29127,2934,29901,3014,30844,3146,3151,3159,3181,329,3309,3312,3710,3832,387082,3995,4012,4085,4176,4236,4288,4311,4602,4691,475,4830,4998,51155,51218,51318,51366,51514,51566,51659,5223,523,5311,54187,5424,54541,5478,54892,54908,54953,55120,55159,55215,55388,55422,55635,55705,55706,55752,55784,55872,55915,5641,56941,56992,5730,57405,57570,5832,5918,5922,5932,6035,6093,6175,637,6397,64151,6421,6426,64759,64778,64864,64943,6509,65244,6597,6645,6729,675,7014,7027,7280,7283,7511,7531,7844,7873,79077,7941,7965,79705,79801,80223,80310,81611,8318,8336,836,8412,8438,84901,8536,8607,8727,8815,8875,891,90338,90956,9097,9133,9169,91860,9188,9212,9232,9315,9319,9380,9404,9493,9500,9643,9656,9686,969,9700,9787,9833,9882,990,991,9918,9935" MEMBERS_MAPPING="ADA,ADA,100|ADAMDEC1,ADAMDEC1,27299|ADCK2,ADCK2,90956|AIMP2,AIMP2,7965|ALDH18A1,ALDH18A1,5832|ANP32B,ANP32B,10541|ANP32E,ANP32E,81611|AP2S1,AP2S1,1175|ARMCX3,ARMCX3,51566|ARPC2,ARPC2,10109|ASPM,ASPM,259266|ATOX1,ATOX1,475|ATP6V1A,ATP6V1A,523|AURKB,AURKB,9212|BANF1,BANF1,8815|BCAR3,BCAR3,8412|BID,BID,637|BIRC2,BIRC2,329|BRCA2,BRCA2,675|C10orf137,EDRF1,26098|C1orf27,ODR4,54953|C3orf37,HMCES,56941|C5orf13,NREP,9315|CALML4,CALML4,91860|CAMK1,CAMK1,8536|CASP3,CASP3,836|CBX5,CBX5,23468|CCDC99,SPDL1,54908|CCNB1,CCNB1,891|CCNB2,CCNB2,9133|CCT5,CCT5,22948|CD69,CD69,969|CDC20,CDC20,991|CDC45,CDC45,8318|CDC6,CDC6,990|CDK4,CDK4,1019|CDKN3,CDKN3,1033|CENPE,CENPE,1062|CLASP2,CLASP2,23122|CLTA,CLTA,1211|CSK,CSK,1445|CTNNAL1,CTNNAL1,8727|CTSD,CTSD,1509|DCP2,DCP2,167227|DCTPP1,DCTPP1,79077|DDIT4,DDIT4,54541|DDX21,DDX21,9188|DEPDC1,DEPDC1,55635|DHFR,DHFR,1719|DLGAP5,DLGAP5,9787|DNMT1,DNMT1,1786|DPP3,DPP3,10072|DTL,DTL,51514|DUSP2,DUSP2,1844|EHD4,EHD4,30844|ENO2,ENO2,2026|ESPL1,ESPL1,9700|EZH2,EZH2,2146|FABP5,FABP5,2171|FADS3,FADS3,3995|FAM120A,FAM120A,23196|FANCI,FANCI,55215|FANCL,FANCL,55120|FEN1,FEN1,2237|FGFR1OP,CEP43,11116|FNDC3B,FNDC3B,64778|FOXM1,FOXM1,2305|FUCA1,FUCA1,2517|GINS2,GINS2,51659|GLRX5,GLRX5,51218|GRB2,GRB2,2885|GRHPR,GRHPR,9380|GSN,GSN,2934|H2AFX,H2AX,3014|HIST1H2AM,H2AC17,8336|HMGA1,HMGA1,3159|HMGB1,HMGB1,3146|HMGN2,HMGN2,3151|HN1,JPT1,51155|HNRNPA2B1,HNRNPA2B1,3181|HSPA5,HSPA5,3309|HSPA8,HSPA8,3312|IPO9,IPO9,55705|ITPR3,ITPR3,3710|KANK1,KANK1,23189|KIF11,KIF11,3832|KIF15,KIF15,56992|KIF20A,KIF20A,10112|KIF23,KIF23,9493|KIF4A,KIF4A,24137|KLHL18,KLHL18,23276|LANCL2,LANCL2,55915|LGMN,LGMN,5641|LNPEP,LNPEP,4012|LPIN1,LPIN1,23175|LPXN,LPXN,9404|LRRK1,LRRK1,79705|MAD2L1,MAD2L1,4085|MAFB,MAFB,9935|MAGED1,MAGED1,9500|MANF,MANF,7873|MAP3K8,MAP3K8,1326|MARCH6,MARCHF6,10299|MCM10,MCM10,55388|MCM7,MCM7,4176|MCTP2,MCTP2,55784|MDC1,MDC1,9656|MELK,MELK,9833|METAP2,METAP2,10988|MFAP1,MFAP1,4236|MKI67,MKI67,4288|MME,MME,4311|MORF4L2,MORF4L2,9643|MRPL35,MRPL35,51318|MTF2,MTF2,22823|MTHFD2,MTHFD2,10797|MYB,MYB,4602|NANS,NANS,54187|NCAPD2,NCAPD2,9918|NCAPG,NCAPG,64151|NCAPG2,NCAPG2,54892|NCL,NCL,4691|NFATC2IP,NFATC2IP,84901|NME1,NME1,4830|NT5DC2,NT5DC2,64943|ORC1,ORC1,4998|PAQR4,PAQR4,124222|PBK,PBK,55872|PDGFD,PDGFD,80310|PGAM1,PGAM1,5223|PHGDH,PHGDH,26227|PKD2,PKD2,5311|PLA2G7,PLA2G7,7941|PLIN3,PLIN3,10226|PLXNB2,PLXNB2,23654|POLD1,POLD1,5424|PPIA,PPIA,5478|PPIF,PPIF,10105|PRRC2C,PRRC2C,23215|PTGDS,PTGDS,5730|PTTG1,PTTG1,9232|RAB11FIP1,RAB11FIP1,80223|RACGAP1,RACGAP1,29127|RAD51AP1,RAD51AP1,10635|RAD54L,RAD54L,8438|RARRES1,RARRES1,5918|RASA2,RASA2,5922|RBBP8,RBBP8,5932|RER1,RER1,11079|RFWD3,RFWD3,55159|RFX7,RFX7,64864|RNASE1,RNASE1,6035|RNF103,RNF103,7844|ROCK1,ROCK1,6093|RPLP0,RPLP0,6175|RUVBL1,RUVBL1,8607|SAC3D1,SAC3D1,29901|SCAF11,SCAF11,9169|SEC14L1,SEC14L1,6397|SEPHS1,SEPHS1,22929|SEPT11,SEPTIN11,55752|SF3B4,SF3B4,10262|SFPQ,SFPQ,6421|SH2B3,SH2B3,10019|SHCBP1,SHCBP1,79801|SKA1,SKA1,220134|SLC1A4,SLC1A4,6509|SLC43A3,SLC43A3,29015|SMARCA4,SMARCA4,6597|SMC2,SMC2,10592|SMPDL3A,SMPDL3A,10924|SNTB2,SNTB2,6645|SPAG5,SPAG5,10615|SPATS2,SPATS2,65244|SPC25,SPC25,57405|SRP54,SRP54,6729|SRSF1,SRSF1,6426|SUMO4,SUMO4,387082|TACC3,TACC3,10460|TBC1D4,TBC1D4,9882|TERF2,TERF2,7014|TFDP1,TFDP1,7027|TMEM48,NDC1,55706|TNS3,TNS3,64759|TRIP13,TRIP13,9319|TRMT5,TRMT5,57570|TSFM,TSFM,10102|TUBB2A,TUBB2A,7280|TUBG1,TUBG1,7283|UBE2C,UBE2C,11065|UBR5,UBR5,51366|USP14,USP14,9097|VGLL4,VGLL4,9686|VNN2,VNN2,8875|WSB1,WSB1,26118|XPNPEP1,XPNPEP1,7511|YWHAE,YWHAE,7531|ZCCHC11,TUT4,23318|ZNF160,ZNF160,90338|ZNF331,ZNF331,55422" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
