STANDARD_NAME GSE13411_SWITCHED_MEMORY_BCELL_VS_PLASMA_CELL_UP SYSTEMATIC_NAME M3251 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE13411_SWITCHED_MEMORY_BCELL_VS_PLASMA_CELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of Ig isotype switched memory B cells versus plasma cells. DESCRIPTION_FULL Enhanced secondary Ab responses are a vital component of adaptive immunity, yet little is understood about the intrinsic and extrinsic regulators of naive and memory B cells that results in differences in their responses to Ag. Microarray analysis, together with surface and intracellular phenotyping, revealed that memory B cells have increased expression of members of the TNF receptor, SLAM, B7 and Bcl2 families, as well as the TLR-related molecule CD180 (RP105). Accordingly, memory B cells exhibited enhanced survival, proliferation and Ig secretion, as well as entered division more rapidly than naïve B cells in response to both T-dependent and T-independent stimuli. Furthermore, both IgM and isotype switched memory B cells, but not naïve B cells, co-stimulated CD4+ T cells in vitro through a mechanism dependent on their constitutive expression of CD80 and CD86. This study demonstrates that upregulation of genes involved in activation, co-stimulation and survival provides memory B cells with a unique ability to produce enhanced immune responses and contributes to the maintenance of the memory B cell pool. PMID 19124732 GEOID GSE13411 AUTHORS Good KL,Avery DT,Tangye SG CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE13411_1624_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ADAMDEC1,AIM1,AKAP10,ALDH5A1,ALOX5,ALOX5AP,ANXA1,AP1S2,AP3M2,APP,ARHGAP24,ARID4B,ATAD2B,ATP2B1,ATP6V0E2,ATP8A1,AUTS2,AVL9,BACE2,BAP1,BPTF,BTBD7,BTK,BTN2A1,C10orf2,C13orf18,C20orf111,C4orf41,CAPG,CAPRIN2,CBLB,CCNT2,CD19,CD22,CD74,CD79B,CDK13,CEP68,CHD1,CLK2,CORO1A,CRK,CSNK1G2,CTNNBL1,CYBB,DCLRE1C,DDAH2,DDX60,DEK,DENND2D,DET1,DGKA,DNAJB14,DPH5,DPY19L4,DUSP6,EIF2B5,EXT2,FAM192A,FBXL14,FIP1L1,FRAT1,GALT,GGPS1,GIT2,GOLGA8B,GSTM4,HCG4B,HHEX,HLA-DRB6,IL15,INPP5B,INPP5D,IQSEC1,JAM3,KDM3A,KLF4,LAT2,LBH,LCK,LPGAT1,LSM14A,MAML1,MAN2B2,MAP1LC3B,MAPK1,MCCC2,MCM9,MED14,MEGF9,METTL22,METTL8,MOBKL3,MORC3,MTR,MYC,MYD88,NAA40,NCOA1,NDRG3,NECAP2,NFKB1,NFRKB,NKRF,NPLOC4,NUDT3,OAZ2,OSGEP,PARP12,PARP8,PCNX,PDZD8,PEX26,PGS1,PHF16,PHF17,PHF20,PIBF1,PIK3R1,PISD,PLEKHF2,PLEKHO1,PMS2L2,POLR3C,PPFIA1,PPP1CB,PRKX,PRPF3,PTBP2,PTK2,PTK2B,PTPRK,RAPGEF6,RASSF1,REPIN1,RHOG,RHOH,RIPK2,RNF220,RNFT1,RPL31,RPS17P5,RPS6KA3,RSBN1,RUNDC2C,RUNX3,RYK,S100A10,SCPEP1,SEPT9,SGMS1,SH3BGRL3,SIAH1,SLC25A24,SLC25A36,SLC7A7,SMARCAL1,SMARCB1,SNAPC1,SNX10,SOCS1,SOS2,SP100,SPG11,SYNGR3,TARBP1,TCEAL1,TCF20,TGFBR2,TIPRL,TLK2,TMEM222,TMUB2,TNFRSF10B,TNFSF13,TP53BP2,TRAF3IP2,TRAF4,TRIM13,TRIM33,TRIM38,TRMT61B,TWF1,USE1,USP39,USP6NL,VPS13D,WDR47,YTHDC2,ZFP161,ZFYVE16,ZFYVE26,ZMAT3,ZMYND8,ZNF134,ZNF157,ZNF266,ZNF434,ZNF529,ZSCAN18 GENE_SYMBOLS ADAMDEC1,CRYBG1,AKAP10,ALDH5A1,ALOX5,ALOX5AP,ANXA1,AP1S2,AP3M2,APP,ARHGAP24,ARID4B,ATAD2B,ATP2B1,ATP6V0E2,ATP8A1,AUTS2,AVL9,BACE2,BAP1,BPTF,BTBD7,BTK,BTN2A1,TWNK,RUBCNL,OSER1,TRAPPC11,CAPG,CAPRIN2,CBLB,CCNT2,CD19,CD22,CD74,CD79B,CDK13,CEP68,CHD1,CLK2,CORO1A,CRK,CSNK1G2,CTNNBL1,CYBB,DCLRE1C,DDAH2,DDX60,DEK,DENND2D,DET1,DGKA,DNAJB14,DPH5,DPY19L4,DUSP6,EIF2B5,EXT2,PSME3IP1,FBXL14,FIP1L1,FRAT1,GALT,GGPS1,GIT2,GOLGA8B,GSTM4,HCG4B,HHEX,HLA-DRB6,IL15,INPP5B,INPP5D,IQSEC1,JAM3,KDM3A,KLF4,LAT2,LBH,LCK,LPGAT1,LSM14A,MAML1,MAN2B2,MAP1LC3B,MAPK1,MCCC2,MCM9,MED14,MEGF9,METTL22,METTL8,MOB4,MORC3,MTR,MYC,MYD88,NAA40,NCOA1,NDRG3,NECAP2,NFKB1,NFRKB,NKRF,NPLOC4,NUDT3,OAZ2,OSGEP,PARP12,PARP8,PCNX1,PDZD8,PEX26,PGS1,JADE3,JADE1,PHF20,PIBF1,PIK3R1,PISD,PLEKHF2,PLEKHO1,PMS2P2,POLR3C,PPFIA1,PPP1CB,PRKX,PRPF3,PTBP2,PTK2,PTK2B,PTPRK,RAPGEF6,RASSF1,REPIN1,RHOG,RHOH,RIPK2,RNF220,RNFT1,RPL31,RPS17P5,RPS6KA3,RSBN1,SNX29P2,RUNX3,RYK,S100A10,SCPEP1,SEPTIN9,SGMS1,SH3BGRL3,SIAH1,SLC25A24,SLC25A36,SLC7A7,SMARCAL1,SMARCB1,SNAPC1,SNX10,SOCS1,SOS2,SP100,SPG11,SYNGR3,TARBP1,TCEAL1,TCF20,TGFBR2,TIPRL,TLK2,TMEM222,TMUB2,TNFRSF10B,TNFSF13,TP53BP2,TRAF3IP2,TRAF4,TRIM13,TRIM33,TRIM38,TRMT61B,TWF1,USE1,USP39,USP6NL,VPS13D,WDR47,YTHDC2,ZBTB14,ZFYVE16,ZFYVE26,ZMAT3,ZMYND8,ZNF134,ZNF157,ZNF266,ZSCAN32,ZNF529,ZSCAN18 FOUNDER_NAMES