STANDARD_NAME GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_129_MOUSE_DN SYSTEMATIC_NAME M2917 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_129_MOUSE_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in skin from 129S1 mice after injection of: control versus Trypanosoma cruzi (strain Y). DESCRIPTION_FULL To investigate the early host response triggered by three different strains of Trypanosoma cruzi at a local infection site, changes in host gene expression were monitored in a murine intradermal infection model using Affymetrix oligonucleotide arrays. Robust induction of IFN-stimulated genes (ISGs) was observed in excised skin 24 hours post-infection where the level of ISG induction was parasite strain-dependent with the least virulent strain triggering a muted IFN response. Infection of mice immunodepleted of IFNγ-producing cells or infection of IFNγ-deficient mice had minimal impact on the IFN response generated in T. cruzi infected mice. In contrast, infection of mice lacking the type I IFN receptor demonstrated that type I IFNs are largely responsible for the IFN response generated at the site of infection. These data highlight type I IFNs as important components of the innate immune response to T. cruzi the site of inoculation and their role in shaping the early transcriptional response to this pathogen. We used microarrays to detail the local host transcriptional response to intradermal T. cruzi infection in WT mice and mice depleted of NK cells, or deficient in IFN-gamma or type I IFN responses. Additionally we compared the local host-transcriptional response generated to infection with 3 different strains of Trypanosoma cruzi (Y, Brazil, and G). PMID 19201883 GEOID GSE13522 AUTHORS Chessler AD,Unnikrishnan M,Bei AK,Daily JP,Burleigh BA CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE13522_3074_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA2,ADAMTS6,ADORA2A,AHCYL2,ANKRD2,ANKRD29,ARHGEF11,ARHGEF16,ARMCX4,ARMCX6,ASCL1,ATP10D,ATP1B3,B3GNT5,BARHL2,BCL2L1,BIN1,BIRC2,BRF2,C1orf63,C20orf54,C5orf52,C8orf74,CAMK2N1,CAST,CCDC116,CCDC160,CCDC92,CCT6B,CD5,CD81,CDC42SE2,CERK,CLVS1,COL19A1,COL4A4,CREBL2,CRH,CRKL,CTDSP2,CUBN,CYBRD1,CYP3A7,CYP4V2,DBC1,DDX41,DDX47,DNAH7,DSCR6,DSPP,EDEM2,ENO3,ESYT2,F7,FAM118B,FAM53B,FAM98C,FBXO31,FBXO45,FCHSD2,FHL1,FLOT1,FNDC9,G6PC2,GLIS3,GMCL1,GPR133,GPR143,GPRASP2,H2AFY2,HNRNPC,HOMER2,HSF4,ID3,ID4,IGF1R,IGF2R,IGSF3,ITGA7,ITGB6,JMJD5,KCNA5,KCNJ9,KCTD20,KIAA1161,KIF5C,KIF9,KLF9,LAD1,LAPTM4B,LASS4,LOC100506339,LPAR4,LRRC8C,LYSMD2,MAGED1,MAT2B,MEX3B,MFSD2B,MKL2,MTMR11,MTMR3,NAP1L3,NECAP2,NFIB,NHLH2,NLRP4,NOL3,NUDCD3,OCRL,OLIG1,PATL2,PCMTD1,PCTP,PDGFA,PDZD9,PEAK1,PELI2,PFAS,PFN2,PHF23,PHLPP1,PIR,PITPNB,PLCL1,POPDC2,PRDM2,PRKAG2,PRKX,PRNP,PROX1,PRPH2,PRSS46,PTDSS1,PTF1A,PTPN13,PTPN5,PTRF,RALGDS,RASSF9,RBPMS2,RECK,RELB,RFXANK,RHBDL2,RPL5,RPRML,RRAGD,RXRA,S100G,SAV1,SCN11A,SELL,SELM,SETX,SFXN3,SHC4,SKIL,SLAMF9,SLC12A6,SLC25A31,SLC37A2,SMOX,SNX18,SNX33,SOX30,SPAG4,SPHK2,SRRM1,STAG1,STAM2,STAT5B,STON1,SUPT7L,SUSD2,SWAP70,TAB2,TAS1R1,TCF25,TCF7L1,TMEM146,TMEM222,TMTC2,TNP1,TOM1L2,TPPP3,TRDN,TRIM40,TRIM62,TXNDC3,UGT3A2,VASN,WNT3,YPEL3,ZBED3,ZFP64,ZNF354A,ZNF521,ZNF585A,ZNF642 GENE_SYMBOLS ABCA2,ADAMTS6,ADORA2A,AHCYL2,ANKRD2,ANKRD29,ARHGEF11,ARHGEF16,ARMCX4,ARMCX6,ASCL1,ATP10D,ATP1B3,B3GNT5,BARHL2,BCL2L1,BIN1,BIRC2,BRF2,RSRP1,SLC52A3,C5orf52,C8orf74,CAMK2N1,CAST,CCDC116,CCDC160,CCDC92,CCT6B,CD5,CD81,CDC42SE2,CERK,CLVS1,COL19A1,COL4A4,CREBL2,CRH,CRKL,CTDSP2,CUBN,CYBRD1,CYP3A7,CYP4V2,BRINP1,DDX41,DDX47,DNAH7,RIPPLY3,DSPP,EDEM2,ENO3,ESYT2,F7,FAM118B,FAM53B,FAM98C,FBXO31,FBXO45,FCHSD2,FHL1,FLOT1,FNDC9,G6PC2,GLIS3,GMCL1,ADGRD1,GPR143,GPRASP2,MACROH2A2,HNRNPC,HOMER2,HSF4,ID3,ID4,IGF1R,IGF2R,IGSF3,ITGA7,ITGB6,KDM8,KCNA5,KCNJ9,KCTD20,MYORG,KIF5C,KIF9,KLF9,LAD1,LAPTM4B,CERS4,CCDC162P,LPAR4,LRRC8C,LYSMD2,MAGED1,MAT2B,MEX3B,MFSD2B,MRTFB,MTMR11,MTMR3,NAP1L3,NECAP2,NFIB,NHLH2,NLRP4,NOL3,NUDCD3,OCRL,OLIG1,PATL2,PCMTD1,PCTP,PDGFA,PDZD9,PEAK1,PELI2,PFAS,PFN2,PHF23,PHLPP1,PIR,PITPNB,PLCL1,POPDC2,PRDM2,PRKAG2,PRKX,PRNP,PROX1,PRPH2,PRSS46P,PTDSS1,PTF1A,PTPN13,PTPN5,CAVIN1,RALGDS,RASSF9,RBPMS2,RECK,RELB,RFXANK,RHBDL2,RPL5,RPRML,RRAGD,RXRA,S100G,SAV1,SCN11A,SELL,SELENOM,SETX,SFXN3,SHC4,SKIL,SLAMF9,SLC12A6,SLC25A31,SLC37A2,SMOX,SNX18,SNX33,SOX30,SPAG4,SPHK2,SRRM1,STAG1,STAM2,STAT5B,STON1,SUPT7L,SUSD2,SWAP70,TAB2,TAS1R1,TCF25,TCF7L1,CATSPERD,TMEM222,TMTC2,TNP1,TOM1L2,TPPP3,TRDN,TRIM40,TRIM62,NME8,UGT3A2,VASN,WNT3,YPEL3,ZBED3,ZFP64,ZNF354A,ZNF521,ZNF585A,ZFP69 FOUNDER_NAMES