STANDARD_NAME GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_2H_DN SYSTEMATIC_NAME M2988 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_2H_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in B lymphocytes stimulated by anti-IgM for 2h: wildtype versus ZFX [GeneID=7543] knockout. DESCRIPTION_FULL The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeostasis. Conditional Zfx deletion in the bone marrow blocked B cell development at the pre-BCR selection checkpoint. Zfx deficiency in peripheral B cells caused impaired generation of the B-1 cell lineage, accelerated B cell turnover, depletion of mature recirculating cells, and delayed T-dependent antibody responses. Zfx-deficient B cells showed normal proximal BCR signaling, but impaired BCR-induced proliferation and survival. This was accompanied by aberrantly enhanced and prolonged integrated stress response, and delayed induction of Cyclin D2 and Bcl-xL proteins. Thus, Zfx restrains the stress response and couples antigen receptor signaling to B cell expansion and maintenance during development and peripheral homeostasis. PMID 19329779 GEOID GSE13547 AUTHORS Arenzana TL,Smith-Raska MR,Reizis B CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE13547_3169_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1200011M11Rik,2310016C08Rik,2310016M24Rik,2310044G17Rik,2310061I04Rik,2410002F23Rik,2810408P10Rik,2810422O20Rik,2810453I06Rik,4930473A06Rik,4930518I15Rik,4932422M17Rik,5830405N20Rik,6430601O08Rik,AA408296,AATF,ABHD14B,ADAMTS15,ADCK2,AMD1,APTX,AW554918,BAG5,BAMBI,BC050254,BOLA2,BTG2,CAML,CBR1,CCL9,CCR7,CD55,CD7,CD72,CDC42EP3,CHCHD2,CLCF1,CLEC4G,COQ10B,CREBL2,CUX1,CXCR4,CXCR6,D030047H15Rik,D130062J21Rik,D930016D06Rik,DCI,DDX24,DGUOK,DHX34,DMRTA1,DPH5,DZIP1,EARS2,EBAG9,EFHA2,EGLN2,ENPEP,EVI5L,EVL,EZH1,F2RL1,FAM120B,FAM50A,FASTKD3,FCHSD2,FOXP1,FYTTD1,GBE1,GM10473,GM12760,GM13895,GM5965,GM7075,GM7567,GM9,GM9856,GNG5,GNL1,GPR18,GPR183,GRLF1,H2-KE6,HERPUD2,HEXIM1,HIGD1A,HINT2,HSH2D,ICAM2,IL16,IL7R,IMP3,IRF7,ITM2A,JMJD6,KBTBD11,KCNJ8,KCNK1,KLF2,KLK8,KLRB1C,KLRK1,LOC100134980,LOC640965,MAFF,MAML2,MBLAC2,MDC1,MDN1,MESDC2,MPHOSPH6,MYST4,NDFIP1,NDUFAF4,NDUFS7,NEURL3,NFIL3,NFU1,NOBOX,NOP10,NOP14,NR1D2,NSG2,OLFR1062,OLFR463,P2RY10,PARP8,PCCA,PDCD2L,PEA15A,PER1,PFN2,PIK3IP1,PLEKHA1,POLR1C,POLR2E,POLR3E,PRPF6,PTGES3,PVR,QTRT1,R3HCC1,RGNEF,RNF138,RNF167,RPL13,RPL30,RPL36A,RPS19,RPTOR,RUNDC3B,S1PR1,SAMD3,SETD3,SFT2D3,SIAH1A,SIDT1,SLC16A5,SLC25A36,SLC4A1AP,SMNDC1,SMYD3,SNX30,STXBP4,SYN3,SYS1,TAAR7E,TAF4B,TANC1,TCEAL1,TCF7,TCP11L2,TMEM33,TMEM55A,TMEM59,TMEM9B,TNFRSF11B,TNFRSF22,TOB1,TOB2,TRIM13,TRMT112,TSC22D3,USE1,VIPR1,VKORC1,VPS28,WDR74,XCL1,ZBTB4,ZFP1,ZFP398,ZFP551,ZFP61,ZFP831,ZKSCAN14,ZNHIT6,ZNRD1,ZNRF1,ZSWIM7 GENE_SYMBOLS ,,,,,,,,,,,,,,UTP25,AATF,ABHD14B,ADAMTS15,ADCK2,AMD1,APTX,KIAA1328,BAG5,BAMBI,,BOLA2,BTG2,CAMLG,CBR1,,CCR7,CD55,CD7,CD72,CDC42EP3,CHCHD2,CLCF1,CLEC4G,COQ10B,CREBL2,CUX1,CXCR4,CXCR6,,,,ECI1,DDX24,DGUOK,DHX34,DMRTA1,DPH5,DZIP1,EARS2,EBAG9,MICU3,EGLN2,ENPEP,EVI5L,EVL,EZH1,F2RL1,FAM120B,FAM50A,FASTKD3,FCHSD2,FOXP1,FYTTD1,GBE1,,,,,,,,,GNG5,GNL1,GPR18,GPR183,ARHGAP35,HSD17B8,HERPUD2,HEXIM1,HIGD1A,HINT2,HSH2D,ICAM2,IL16,IL7R,IMP3,IRF7,ITM2A,JMJD6,KBTBD11,KCNJ8,KCNK1,KLF2,KLK8,,KLRK1,,,MAFF,MAML2,MBLAC2,MDC1,MDN1,MESD,MPHOSPH6,KAT6B,NDFIP1,NDUFAF4,NDUFS7,NEURL3,NFIL3,NFU1,NOBOX,NOP10,NOP14,NR1D2,NSG2,,,P2RY10,PARP8,PCCA,PDCD2L,,PER1,PFN2,PIK3IP1,PLEKHA1,POLR1C,POLR2E,POLR3E,PRPF6,PTGES3,PVR,QTRT1,R3HCC1,ARHGEF28,RNF138,RNF167,RPL13,RPL30,RPL36A,RPS19,RPTOR,RUNDC3B,S1PR1,SAMD3,SETD3,SFT2D3,,SIDT1,SLC16A5,SLC25A36,SLC4A1AP,SMNDC1,SMYD3,SNX30,STXBP4,SYN3,SYS1,,TAF4B,TANC1,TCEAL1,TCF7,TCP11L2,TMEM33,PIP4P2,TMEM59,TMEM9B,TNFRSF11B,,TOB1,TOB2,TRIM13,TRMT112,TSC22D3,USE1,VIPR1,VKORC1,VPS28,WDR74,XCL1,ZBTB4,ZFP1,,,,,ZNF394,ZNHIT6,POLR1H,ZNRF1,ZSWIM7 FOUNDER_NAMES