STANDARD_NAME GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_2H_UP SYSTEMATIC_NAME M2994 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_2H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in B lymphocytes stimulated by anti-IgM for 2h: wildtype versus ZFX [GeneID=7543] knockout. DESCRIPTION_FULL The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeostasis. Conditional Zfx deletion in the bone marrow blocked B cell development at the pre-BCR selection checkpoint. Zfx deficiency in peripheral B cells caused impaired generation of the B-1 cell lineage, accelerated B cell turnover, depletion of mature recirculating cells, and delayed T-dependent antibody responses. Zfx-deficient B cells showed normal proximal BCR signaling, but impaired BCR-induced proliferation and survival. This was accompanied by aberrantly enhanced and prolonged integrated stress response, and delayed induction of Cyclin D2 and Bcl-xL proteins. Thus, Zfx restrains the stress response and couples antigen receptor signaling to B cell expansion and maintenance during development and peripheral homeostasis. PMID 19329779 GEOID GSE13547 AUTHORS Arenzana TL,Smith-Raska MR,Reizis B CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE13547_3169_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1110004F10Rik,1200014J11Rik,1500031L02Rik,2310008H09Rik,2610318N02Rik,2700007P21Rik,2700029M09Rik,2810417H13Rik,4930524J08Rik,ACAA2,ADSS,AHCY,AKAP1,ANXA2,AP1S1,ARL6IP4,ATAD5,ATP8B4,ATR,BANF1,BIRC5,BLMH,BRI3BP,BRIP1,BZW1,C1QBP,CAPZA2,CASC4,CASC5,CCDC41,CCDC58,CCNB2,CDC25C,CDC6,CDC7,CDCA3,CENPH,CENPP,CHML,CINP,CIRBP,CLNK,CLNS1A,COMMD9,COPS5,COX10,COX5B,COX7A2,COX7B,CPSF6,CSF2,D2ERTD750E,DBI,DDX1,DDX21,DDX52,DEPDC1A,DKC1,DLD,DNAJC15,DPY19L1,DTL,E2F8,EIF1A,EIF2A,EMB,EPRS,ESM1,ETFDH,EXO1,EXOSC9,FAM105B,FAM54A,FIGNL1,FKBP5,FMC1,GALNT3,GGH,GM16494,GM3338,GM5177,GM5263,GM6651,GM9081,GMPS,GTF2F1,GZMC,HARS,HAT1,HIST1H2BM,HIST1H4F,HMGB1,HMGB3,HMGCS1,HMGN2,HSD17B12,IGF2BP3,IL18R1,IL1RL1,IL2RA,IL7R,IMMT,IPO5,IRAK3,ITGA1,KCTD20,KIF23,KLF11,KLHDC4,KLRK1,LRPPRC,LTV1,LY6E,MAD2L1,MCM10,MCM3,MCM4,MEMO1,MPP6,MRPL1,MRPS14,MRPS28,MRPS9,MT1,MT2,MTMR1,MTPN,NAA50,NOC3L,NRM,NUP133,PA2G4,PDHX,PGAM1,PLA2G12A,PLAA,PLK4,PMF1,POLR2B,POLR2D,PPAT,PPP1R8,PRELID1,PRKAG1,PRMT5,PSMB2,PSMC1,PSMD12,RACGAP1,RAD51,RARS,RBM3,RBMXRT,RNMT,RPA3,RPF2,RPL10,RQCD1,RRAS2,RRM1,RRM2,RRP15,SAE1,SATB1,SDHD,SEPT2,SERPINB9,SLC30A4,SLC35A3,SNRPA,SNRPA1,SNRPD1,SPC24,SRP72,STMN1,SYCE2,TACC3,TAGLN2,TCP1,THY1,THYN1,TIMM50,TMPO,TOMM5,TPI1,TRIP13,TYMS-PS,UBA2,UBE2V1,UCHL5,UHRF1BP1L,USP3,UTP20,VIM,WDR12,WDR76,WEE1,XPO1,YBX1,ZBTB32 GENE_SYMBOLS ,,,,,,,,,ACAA2,ADSS2,AHCY,AKAP1,ANXA2,AP1S1,ARL6IP4,ATAD5,ATP8B4,ATR,BANF1,BIRC5,BLMH,BRI3BP,BRIP1,BZW1,C1QBP,CAPZA2,GOLM2,KNL1,CEP83,MIX23,CCNB2,CDC25C,CDC6,CDC7,CDCA3,CENPH,CENPP,CHML,CINP,CIRBP,CLNK,CLNS1A,COMMD9,COPS5,COX10,COX5B,COX7A2,COX7B,CPSF6,CSF2,,DBI,DDX1,DDX21,DDX52,DEPDC1,DKC1,DLD,DNAJC15,DPY19L1,DTL,E2F8,EIF1AX,EIF2A,EMB,EPRS1,ESM1,ETFDH,EXO1,EXOSC9,OTULIN,MTFR2,FIGNL1,FKBP5,FMC1,GALNT3,GGH,,,,,,,GMPS,GTF2F1,,HARS1,HAT1,H2BC14,H4C6,HMGB1,HMGB3,HMGCS1,HMGN2,HSD17B12,IGF2BP3,IL18R1,IL1RL1,IL2RA,IL7R,IMMT,IPO5,IRAK3,ITGA1,KCTD20,KIF23,KLF11,KLHDC4,KLRK1,LRPPRC,LTV1,LY6E,MAD2L1,MCM10,MCM3,MCM4,MEMO1,PALS2,MRPL1,MRPS14,MRPS28,MRPS9,MT1A,MT2A,MTMR1,MTPN,NAA50,NOC3L,NRM,NUP133,PA2G4,PDHX,PGAM1,PLA2G12A,PLAA,PLK4,PMF1,POLR2B,POLR2D,PPAT,PPP1R8,PRELID1,PRKAG1,PRMT5,PSMB2,PSMC1,PSMD12,RACGAP1,RAD51,RARS1,RBM3,,RNMT,RPA3,RPF2,RPL10,CNOT9,RRAS2,RRM1,RRM2,RRP15,SAE1,SATB1,SDHD,SEPTIN2,SERPINB9,SLC30A4,SLC35A3,SNRPA,SNRPA1,SNRPD1,SPC24,SRP72,STMN1,SYCE2,TACC3,TAGLN2,TCP1,THY1,THYN1,TIMM50,TMPO,TOMM5,TPI1,TRIP13,,UBA2,UBE2V1,UCHL5,BLTP3B,USP3,UTP20,VIM,WDR12,WDR76,WEE1,XPO1,YBX1,ZBTB32 FOUNDER_NAMES