STANDARD_NAME	GSE14308_TH17_VS_NATURAL_TREG_UP
SYSTEMATIC_NAME	M3388
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE14308_TH17_VS_NATURAL_TREG_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in comparison of Th17 cells versus natural regulatory T cell (Treg).
DESCRIPTION_FULL	Multipotential naïve CD4+ T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or plasticity in T cell responses. We generated genome-wide histone H3 lysine 4 (H3K4) and lysine 27 (H3K27) trimethylation maps in naïve, Th1, Th2, Th17, iTreg, and natural (n)Treg cells. We found that although modifications of signature cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, critical transcription factors such as Tbx21 exhibit a broad spectrum of epigenetic states, consistent with our demonstration of T-bet and IFN-gamma induction in nTreg cells. Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4+ T helper cell differentiation.
PMID	19144320
GEOID	GSE14308
AUTHORS	Wei G,Wei L,Zhu J,Zang C,Hu-Li J,Yao Z,Cui K,Kanno Y,Roh TY,Watford WT,Schones DE,Peng W,Sun HW,Paul WE,O'Shea JJ,Zhao K
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE14308_1114_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AAAS,ABCB6,ACAA2,ACTL6A,ADCY6,AEN,AGTRAP,AMMECR1L,ARHGAP19,ARNTL,ATP6V1G1,B3GALT5,B9D1,B9D2,BECN1,BSCL2,C10orf10,C10orf32,C11orf51,C11orf73,C14orf166,C14orf80,C1orf114,C6orf170,CAMK2B,CCDC34,CCDC92,CCNC,CD3G,CD4,CDC123,CDC14B,CDK14,CELA1,CHCHD2,CISD1,CISD3,CNIH,COMMD10,CSDA,CSF2RA,CTNNBIP1,CUL1,DBI,DCTN5,DDX6,DHDH,DHRS1,DIO3OS,DIRC2,DLEU7,DNAJC3,DOCK7,DOHH,DQX1,ECI2,ESRRB,EXOC6,FAM105B,FAM55C,FAM82A1,FANCD2,FBXO32,FDFT1,FMO2,FOXG1,FUCA2,GAB2,GALNT3,GAPDH,GAS8,GDI2,GGT7,GIN1,GNL2,GPRC5A,GSR,GYG1,HABP4,HADH,HCLS1,HDAC3,HMGB2,HS2ST1,HSPA8,IFT46,IGFBP3,IMMT,INHBA,ITGA3,IZUMO4,KAZALD1,KBTBD5,KIAA0895,KIAA1147,KIT,KLHL10,KPTN,LONP1,MAP1LC3A,MBOAT2,MCF2L,MED20,MED9,MEGF9,MFSD2A,MIB1,MIF,MINPP1,MOXD1,MRPS12,MRPS9,MRS2,MTA3,MTHFD2,NAAA,NDE1,NDUFA12,NDUFAB1,NDUFB2,NEDD8,NEMF,NRIP1,OGFRL1,OTUB2,PAICS,PAX6,PBLD,PDCD6IP,PDE7A,PES1,PIGZ,POLR1C,POLR2F,POLR3K,PON1,POP7,PPIL2,PPP3CC,PQLC3,PRDX5,PRKAR2A,PRKCSH,PRPF18,RAB33A,RAB8A,RAD51AP1,RBP1,RNF115,RNF19A,RPA3,RPS6KA3,RSPH3,RTCD1,RTKN2,S100A1,SBNO2,SCML2,SIRT4,SKA3,SKAP1,SLC26A11,SLC6A13,SNAI3,SNF8,SNRPN,SPAG4,SPEF2,SPSB2,SRI,SRSF10,STC2,STX7,TEN1,TFPI,THAP1,THOC7,TIPIN,TMEM159,TMEM18,TMEM45A,TOM1,TRAPPC2L,TRIM72,TSPYL4,TTL,TUBE1,TUBG2,TXNDC16,UBE2E2,UTP11L,UTP6,WAPAL,WDR53,XRN2,YIPF5,ZBTB44,ZHX3,ZNF414,ZSCAN12
GENE_SYMBOLS	AAAS,ABCB6,ACAA2,ACTL6A,ADCY6,AEN,AGTRAP,AMMECR1L,ARHGAP19,BMAL1,ATP6V1G1,B3GALT5,B9D1,B9D2,BECN1,BSCL2,DEPP1,BORCS7,ANAPC15,HIKESHI,RTRAF,TEDC1,CCDC181,TBC1D32,CAMK2B,CCDC34,CCDC92,CCNC,CD3G,CD4,CDC123,CDC14B,CDK14,CELA1,CHCHD2,CISD1,CISD3,CNIH1,COMMD10,YBX3,CSF2RA,CTNNBIP1,CUL1,DBI,DCTN5,DDX6,DHDH,DHRS1,DIO3OS,SLC49A4,DLEU7,DNAJC3,DOCK7,DOHH,DQX1,ECI2,ESRRB,EXOC6,OTULIN,NXPE3,RMDN2,FANCD2,FBXO32,FDFT1,FMO2,FOXG1,FUCA2,GAB2,GALNT3,GAPDH,GAS8,GDI2,GGT7,GIN1,GNL2,GPRC5A,GSR,GYG1,HABP4,HADH,HCLS1,HDAC3,HMGB2,HS2ST1,HSPA8,IFT46,IGFBP3,IMMT,INHBA,ITGA3,IZUMO4,KAZALD1,KLHL40,MATCAP2,DENND11,KIT,KLHL10,KPTN,LONP1,MAP1LC3A,MBOAT2,MCF2L,MED20,MED9,MEGF9,MFSD2A,MIB1,MIF,MINPP1,MOXD1,MRPS12,MRPS9,MRS2,MTA3,MTHFD2,NAAA,NDE1,NDUFA12,NDUFAB1,NDUFB2,NEDD8,NEMF,NRIP1,OGFRL1,OTUB2,PAICS,PAX6,PBLD,PDCD6IP,PDE7A,PES1,PIGZ,POLR1C,POLR2F,POLR3K,PON1,POP7,PPIL2,PPP3CC,SLC66A3,PRDX5,PRKAR2A,PRKCSH,PRPF18,RAB33A,RAB8A,RAD51AP1,RBP1,RNF115,RNF19A,RPA3,RPS6KA3,RSPH3,RTCA,RTKN2,S100A1,SBNO2,SCML2,SIRT4,SKA3,SKAP1,SLC26A11,SLC6A13,SNAI3,SNF8,SNRPN,SPAG4,SPEF2,SPSB2,SRI,SRSF10,STC2,STX7,TEN1,TFPI,THAP1,THOC7,TIPIN,LDAF1,TMEM18,TMEM45A,TOM1,TRAPPC2L,TRIM72,TSPYL4,TTL,TUBE1,TUBG2,TXNDC16,UBE2E2,UTP11,UTP6,WAPL,WDR53,XRN2,YIPF5,ZBTB44,ZHX3,ZNF414,ZSCAN12
FOUNDER_NAMES