<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE14308_TH1_VS_NATURAL_TREG_UP" SYSTEMATIC_NAME="M3380" HISTORICAL_NAMES="" PMID="19144320" AUTHORS="Wei G,Wei L,Zhu J,Zang C,Hu-Li J,Yao Z,Cui K,Kanno Y,Roh TY,Watford WT,Schones DE,Peng W,Sun HW,Paul WE,O'Shea JJ,Zhao K" GEOID="GSE14308" EXACT_SOURCE="GSE14308_1111_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in comparison of Th1 cells versus natural regulatory T cell (Treg)." DESCRIPTION_FULL="Multipotential naïve CD4+ T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or plasticity in T cell responses. We generated genome-wide histone H3 lysine 4 (H3K4) and lysine 27 (H3K27) trimethylation maps in naïve, Th1, Th2, Th17, iTreg, and natural (n)Treg cells. We found that although modifications of signature cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, critical transcription factors such as Tbx21 exhibit a broad spectrum of epigenetic states, consistent with our demonstration of T-bet and IFN-gamma induction in nTreg cells. Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4+ T helper cell differentiation." TAGS="" MEMBERS="ABCB9,ABT1,ACCN2,ACPL2,ACTR3B,AGBL3,AKAP1,AKIP1,ALOXE3,ANGPTL4,ANKRD28,ANP32B,ARID5A,ARPC1A,ATN1,BAG5,BET1,BICD2,BIK,C10orf32,C12orf24,C15orf39,C16orf13,C19orf38,C6orf118,CAMK2B,CCDC53,CD69,CDC123,CDR2,CEP135,CEP76,CHCHD2,CHMP2A,CIT,CMPK1,COMMD10,COPS5,CORO1C,CSNK2B,CTNNBIP1,CTSF,CUZD1,DCAF12,DCTD,DHDH,DHRS13,DRAM2,DUSP16,EMD,ENPP4,F5,FAM127C,FAM160A2,FAM19A3,FAM90A13,FANCD2,FNIP2,GCAT,GINS4,GMPR2,GPC1,GPR108,GSS,GSTT2,HAGHL,HDGF,HEATR2,HRAS,HRC,HUS1,IDH2,IL4R,ITGB5,JMJD6,KANK3,KARS,KCTD20,KLHL30,KPTN,LOC100506804,LONRF3,LRRC18,LSG1,LZTR1,MANBA,MAP2K6,MAP9,MAPKAPK2,MED8,MEMO1,MIB1,MIB2,MIS18A,MOV10,MRPL19,MRPL34,MRPL55,MRPS16,MTERFD2,NAAA,NDUFB2,NDUFC1,NDUFV2,NHP2,NICN1,NKIRAS2,NOBOX,NSMCE1,NUDT9,NUPR1,OLFM1,OTOS,PDIK1L,PDK1,PGC,PGLS,PIF1,PIGF,PIGY,PLCB2,PLXNB3,POC1A,PON1,POP1,PPP1R15B,PRKCSH,PROSC,PRSS23,PSMA5,PTGES,PTPRG,RAB27B,RAD54B,RAP1GAP2,RBKS,RBM8A,RBMXL1,REEP4,RIT1,RNF115,RPL24,RPS6KA5,RSL24D1,RUVBL1,SARS,SCFD2,SEC24D,SELM,SETD4,SIRT2,SLC25A40,SLC2A8,SLC48A1,SMC5,SMTN,SNRPF,SOX5,SPATS2,SPO11,SPRY2,STK11,STK16,STRA13,STX8,SURF1,SUV39H2,SYNE2,TBC1D24,TBRG4,TCTEX1D2,TECPR1,TFPI,THOC7,TIFAB,TIMM23,TMEM126A,TMEM143,TMEM41B,TMEM63C,TMEM86B,TMOD3,TNP2,UBE2J2,UGCG,UNC13C,USMG5,UTP11L,VIPR1,VPS37C,VPS8,WDR45,WEE1,WNT9B,WRN,XBP1,YDJC,YIF1A,ZNF141,ZNF239" MEMBERS_SYMBOLIZED="ABCB9,ABT1,ACTR3B,AGBL3,AKAP1,AKIP1,ALOXE3,ANGPTL4,ANKRD28,ANP32B,ARID5A,ARPC1A,ASIC1,ATN1,ATP5MK,BAG5,BET1,BHLHE40,BICD2,BIK,BORCS7,C15orf39,C19orf38,C6orf118,CAMK2B,CD69,CDC123,CDR2,CEP135,CEP76,CHCHD2,CHMP2A,CIT,CMPK1,COMMD10,COPS5,CORO1C,CSNK2B,CTNNBIP1,CTSF,CUZD1,DCAF12,DCTD,DHDH,DHRS13,DNAAF5,DRAM2,DUSP16,DYNLT2B,EMD,ENPP4,F5,FAM216A,FAM90A13,FANCD2,FHIP1B,FNIP2,GCAT,GINS4,GMPR2,GPC1,GPR108,GSS,GSTT2,HAGHL,HDGF,HRAS,HRC,HUS1,IDH2,IL4R,ITGB5,JMJD6,KANK3,KARS1,KCTD20,KLHL30,KPTN,LONRF3,LRRC18,LSG1,LZTR1,MANBA,MAP2K6,MAP9,MAPKAPK2,MED8,MEMO1,METTL26,MIB1,MIB2,MIS18A,MOV10,MRPL19,MRPL34,MRPL55,MRPS16,MTERF4,NAAA,NDUFB2,NDUFC1,NDUFV2,NHP2,NICN1,NKIRAS2,NOBOX,NSMCE1,NUDT9,NUPR1,OLFM1,OTOS,PDIK1L,PDK1,PGC,PGLS,PIF1,PIGF,PIGY,PLCB2,PLPBP,PLXNB3,POC1A,PON1,POP1,PPP1R15B,PRKCSH,PRSS23,PSMA5,PTGES,PTPRG,PXYLP1,RAB27B,RAD54B,RAP1GAP2,RBKS,RBM8A,RBMXL1,REEP4,RIT1,RNF115,RPL24,RPS6KA5,RSL24D1,RTL8B,RUVBL1,SARS1,SCFD2,SEC24D,SELENOM,SETD4,SIRT2,SLC25A40,SLC2A8,SLC48A1,SMC5,SMTN,SNRPF,SOX5,SPATS2,SPO11,SPRY2,STK11,STK16,STX8,SURF1,SUV39H2,SYNE2,TAFA3,TBC1D24,TBRG4,TECPR1,TFPI,THOC7,TIFAB,TIMM23,TMEM126A,TMEM143,TMEM30A-DT,TMEM41B,TMEM63C,TMEM86B,TMOD3,TNP2,UBE2J2,UGCG,UNC13C,UTP11,VIPR1,VPS37C,VPS8,WASHC3,WDR45,WEE1,WNT9B,WRN,XBP1,YDJC,YIF1A,ZNF141,ZNF239" MEMBERS_EZID="100287932,100506804,10253,10282,1039,10439,10541,10552,10865,10897,10940,10987,11098,11113,11133,11152,11212,112950,118424,119032,128308,128338,130916,135935,140606,142678,1460,147015,149420,150223,150677,152579,1635,168090,1822,197370,2010,2153,2177,222658,22875,22933,23108,23137,23210,23224,23243,23299,23355,23457,23464,23603,23626,255043,255758,255809,256949,25788,25796,25851,25853,25886,26471,27163,27243,27246,27294,2817,284467,28511,2937,2953,29766,29777,29902,29988,3068,3265,3270,3364,340351,3418,3566,3693,3735,377007,41,4126,4343,440026,440279,441314,441518,4708,4717,4729,474354,494115,497189,50624,51019,51021,51072,51118,51129,51142,51187,51292,51397,5163,51727,5225,5281,5330,53343,5365,54069,54093,5444,54919,55048,55260,55341,55651,55652,5589,55972,5608,56672,5686,56905,56927,56998,57156,57180,57465,57534,57600,5793,5874,59344,6016,6152,6301,638,64080,64981,65244,6525,6636,6660,6794,6834,7035,7142,7357,7433,7465,7484,7486,7494,7700,79723,79836,79884,79959,80119,80145,80346,80824,816,8165,8187,8216,84067,84233,84264,84276,84296,84326,84833,84919,84992,8553,8576,8607,8722,8872,92370,9238,9252,9261,9482,9529,9536,9662,969,9801,9871,9939" MEMBERS_MAPPING="ABCB9,ABCB9,23457|ABT1,ABT1,29777|ACCN2,ASIC1,41|ACPL2,PXYLP1,92370|ACTR3B,ACTR3B,57180|AGBL3,AGBL3,340351|AKAP1,AKAP1,8165|AKIP1,AKIP1,56672|ALOXE3,ALOXE3,59344|ANGPTL4,ANGPTL4,51129|ANKRD28,ANKRD28,23243|ANP32B,ANP32B,10541|ARID5A,ARID5A,10865|ARPC1A,ARPC1A,10552|ATN1,ATN1,1822|BAG5,BAG5,9529|BET1,BET1,10282|BICD2,BICD2,23299|BIK,BIK,638|C10orf32,BORCS7,119032|C12orf24,FAM216A,29902|C15orf39,C15orf39,56905|C16orf13,METTL26,84326|C19orf38,C19orf38,255809|C6orf118,C6orf118,168090|CAMK2B,CAMK2B,816|CCDC53,WASHC3,51019|CD69,CD69,969|CDC123,CDC123,8872|CDR2,CDR2,1039|CEP135,CEP135,9662|CEP76,CEP76,79959|CHCHD2,CHCHD2,51142|CHMP2A,CHMP2A,27243|CIT,CIT,11113|CMPK1,CMPK1,51727|COMMD10,COMMD10,51397|COPS5,COPS5,10987|CORO1C,CORO1C,23603|CSNK2B,CSNK2B,1460|CTNNBIP1,CTNNBIP1,56998|CTSF,CTSF,8722|CUZD1,CUZD1,50624|DCAF12,DCAF12,25853|DCTD,DCTD,1635|DHDH,DHDH,27294|DHRS13,DHRS13,147015|DRAM2,DRAM2,128338|DUSP16,DUSP16,80824|EMD,EMD,2010|ENPP4,ENPP4,22875|F5,F5,2153|FAM127C,RTL8B,441518|FAM160A2,FHIP1B,84067|FAM19A3,TAFA3,284467|FAM90A13,FAM90A13,441314|FANCD2,FANCD2,2177|FNIP2,FNIP2,57600|GCAT,GCAT,23464|GINS4,GINS4,84296|GMPR2,GMPR2,51292|GPC1,GPC1,2817|GPR108,GPR108,56927|GSS,GSS,2937|GSTT2,GSTT2,2953|HAGHL,HAGHL,84264|HDGF,HDGF,3068|HEATR2,DNAAF5,54919|HRAS,HRAS,3265|HRC,HRC,3270|HUS1,HUS1,3364|IDH2,IDH2,3418|IL4R,IL4R,3566|ITGB5,ITGB5,3693|JMJD6,JMJD6,23210|KANK3,KANK3,256949|KARS,KARS1,3735|KCTD20,KCTD20,222658|KLHL30,KLHL30,377007|KPTN,KPTN,11133|LOC100506804,TMEM30A-DT,100506804|LONRF3,LONRF3,79836|LRRC18,LRRC18,474354|LSG1,LSG1,55341|LZTR1,LZTR1,8216|MANBA,MANBA,4126|MAP2K6,MAP2K6,5608|MAP9,MAP9,79884|MAPKAPK2,MAPKAPK2,9261|MED8,MED8,112950|MEMO1,MEMO1,51072|MIB1,MIB1,57534|MIB2,MIB2,142678|MIS18A,MIS18A,54069|MOV10,MOV10,4343|MRPL19,MRPL19,9801|MRPL34,MRPL34,64981|MRPL55,MRPL55,128308|MRPS16,MRPS16,51021|MTERFD2,MTERF4,130916|NAAA,NAAA,27163|NDUFB2,NDUFB2,4708|NDUFC1,NDUFC1,4717|NDUFV2,NDUFV2,4729|NHP2,NHP2,55651|NICN1,NICN1,84276|NKIRAS2,NKIRAS2,28511|NOBOX,NOBOX,135935|NSMCE1,NSMCE1,197370|NUDT9,NUDT9,53343|NUPR1,NUPR1,26471|OLFM1,OLFM1,10439|OTOS,OTOS,150677|PDIK1L,PDIK1L,149420|PDK1,PDK1,5163|PGC,PGC,5225|PGLS,PGLS,25796|PIF1,PIF1,80119|PIGF,PIGF,5281|PIGY,PIGY,84992|PLCB2,PLCB2,5330|PLXNB3,PLXNB3,5365|POC1A,POC1A,25886|PON1,PON1,5444|POP1,POP1,10940|PPP1R15B,PPP1R15B,84919|PRKCSH,PRKCSH,5589|PROSC,PLPBP,11212|PRSS23,PRSS23,11098|PSMA5,PSMA5,5686|PTGES,PTGES,9536|PTPRG,PTPRG,5793|RAB27B,RAB27B,5874|RAD54B,RAD54B,25788|RAP1GAP2,RAP1GAP2,23108|RBKS,RBKS,64080|RBM8A,RBM8A,9939|RBMXL1,RBMXL1,494115|REEP4,REEP4,80346|RIT1,RIT1,6016|RNF115,RNF115,27246|RPL24,RPL24,6152|RPS6KA5,RPS6KA5,9252|RSL24D1,RSL24D1,51187|RUVBL1,RUVBL1,8607|SARS,SARS1,6301|SCFD2,SCFD2,152579|SEC24D,SEC24D,9871|SELM,SELENOM,140606|SETD4,SETD4,54093|SIRT2,SIRT2,22933|SLC25A40,SLC25A40,55972|SLC2A8,SLC2A8,29988|SLC48A1,SLC48A1,55652|SMC5,SMC5,23137|SMTN,SMTN,6525|SNRPF,SNRPF,6636|SOX5,SOX5,6660|SPATS2,SPATS2,65244|SPO11,SPO11,23626|SPRY2,SPRY2,10253|STK11,STK11,6794|STK16,STK16,8576|STRA13,BHLHE40,8553|STX8,STX8,9482|SURF1,SURF1,6834|SUV39H2,SUV39H2,79723|SYNE2,SYNE2,23224|TBC1D24,TBC1D24,57465|TBRG4,TBRG4,9238|TCTEX1D2,DYNLT2B,255758|TECPR1,TECPR1,25851|TFPI,TFPI,7035|THOC7,THOC7,80145|TIFAB,TIFAB,497189|TIMM23,TIMM23,100287932|TMEM126A,TMEM126A,84233|TMEM143,TMEM143,55260|TMEM41B,TMEM41B,440026|TMEM63C,TMEM63C,57156|TMEM86B,TMEM86B,255043|TMOD3,TMOD3,29766|TNP2,TNP2,7142|UBE2J2,UBE2J2,118424|UGCG,UGCG,7357|UNC13C,UNC13C,440279|USMG5,ATP5MK,84833|UTP11L,UTP11,51118|VIPR1,VIPR1,7433|VPS37C,VPS37C,55048|VPS8,VPS8,23355|WDR45,WDR45,11152|WEE1,WEE1,7465|WNT9B,WNT9B,7484|WRN,WRN,7486|XBP1,XBP1,7494|YDJC,YDJC,150223|YIF1A,YIF1A,10897|ZNF141,ZNF141,7700|ZNF239,ZNF239,8187" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
