STANDARD_NAME GSE14308_TH2_VS_TH1_DN SYSTEMATIC_NAME M3360 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE14308_TH2_VS_TH1_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of Th2 cells versus Th1 cells. DESCRIPTION_FULL Multipotential naïve CD4+ T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or plasticity in T cell responses. We generated genome-wide histone H3 lysine 4 (H3K4) and lysine 27 (H3K27) trimethylation maps in naïve, Th1, Th2, Th17, iTreg, and natural (n)Treg cells. We found that although modifications of signature cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, critical transcription factors such as Tbx21 exhibit a broad spectrum of epigenetic states, consistent with our demonstration of T-bet and IFN-gamma induction in nTreg cells. Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4+ T helper cell differentiation. PMID 19144320 GEOID GSE14308 AUTHORS Wei G,Wei L,Zhu J,Zang C,Hu-Li J,Yao Z,Cui K,Kanno Y,Roh TY,Watford WT,Schones DE,Peng W,Sun HW,Paul WE,O'Shea JJ,Zhao K CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE14308_1103_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABHD11,ABL2,ACOX3,AGFG1,AHI1,AIM2,AKAP13,AKNA,ALDH7A1,ALS2CR12,ANKRD28,ARF6,ARRDC2,ARSK,B3GALT5,B3GNT2,BAIAP2,BCL6,BST1,BST2,C10orf54,C11orf49,C16orf13,C1GALT1,C5orf30,C5orf34,C6orf132,C6orf35,CDC14A,CDC14B,CELF1,CENPH,CHAT,CHD7,CHL1,CITED2,CLUAP1,COX7A1,CPNE3,CTU1,CYTH4,DEPDC1B,DGKH,DHRS7,DHX58,DKKL1,DNAJC3,DYX1C1,ECHDC2,EMP3,EPHX4,EPS8,ERAP1,ERI1,FAM120B,FAM133B,FAM55C,FAM92A1,FAM98B,FBXO32,FGD5,GLIPR1L2,GNA11,GNB4,GOLGA7,GPR65,GPRIN3,GRIN3A,GSPT2,HARBI1,HERPUD1,HRH2,HSD17B12,ICAM2,IFNAR1,INSL5,IRF7,ITGA7,ITGB2,JAK1,KCNK6,KLF10,KLF7,KLHDC5,KRT222,LARP1,LIMS3L,LOC144486,LRRC8A,LSP1,MAP7D1,MAPK1,MCF2,MEF2D,MIB2,MNAT1,MOB2,MORC1,MORC3,MORN4,MOV10,MRPS34,MTSS1,MXD1,NDFIP2,NEIL1,NEK3,NFKBID,NHEDC1,NHSL2,NOTCH4,NPM3,NUDCD1,OAS1,OBFC1,OSBPL3,OSBPL5,OSBPL9,PAICS,PAK1IP1,PDHA2,PDLIM5,PHOX2A,PI4K2B,PIK3R5,PLCG1,PLCH1,PLP1,PLXDC2,PNPT1,POGK,PPCDC,PRCC,PTPRC,PTPRG,PYCR2,QTRTD1,RAD52,RAMP1,RAP1GAP2,RASL11A,RBL1,RFESD,RHBDL3,RIOK1,RRM2B,S100A1,SAMD9L,SCO1,SELP,SENP7,SEPHS2,SEPT6,SESN3,SFRP2,SFT2D2,SLC15A4,SLCO3A1,SOCS2,SQLE,SS18,STARD6,STIM2,SURF1,SUSD3,TBC1D10C,TES,THAP2,THAP4,TIFAB,TMEM18,TMEM50B,TOR3A,TP53,TPST2,TTC9C,TTLL12,TTLL4,TXNDC9,UCHL1,UCK1,UCP1,VAMP4,WDR45,WIPI2,XIRP1,YIPF7,ZBTB11,ZCCHC11,ZDHHC20,ZDHHC4,ZFP36L1,ZMYND17,ZNF141,ZNF207,ZNF260,ZNF322A,ZNF354C,ZNF565,ZNF704 GENE_SYMBOLS ABHD11,ABL2,ACOX3,AGFG1,AHI1,AIM2,AKAP13,AKNA,ALDH7A1,FLACC1,ANKRD28,ARF6,ARRDC2,ARSK,B3GALT5,B3GNT2,BAIAP2,BCL6,BST1,BST2,VSIR,CSTPP1,METTL26,C1GALT1,MACIR,C5orf34,C6orf132,TMEM242,CDC14A,CDC14B,CELF1,CENPH,CHAT,CHD7,CHL1,CITED2,CLUAP1,COX7A1,CPNE3,CTU1,CYTH4,DEPDC1B,DGKH,DHRS7,DHX58,DKKL1,DNAJC3,DNAAF4,ECHDC2,EMP3,EPHX4,EPS8,ERAP1,ERI1,FAM120B,FAM133B,NXPE3,CIBAR1,FAM98B,FBXO32,FGD5,GLIPR1L2,GNA11,GNB4,GOLGA7,GPR65,GPRIN3,GRIN3A,GSPT2,HARBI1,HERPUD1,HRH2,HSD17B12,ICAM2,IFNAR1,INSL5,IRF7,ITGA7,ITGB2,JAK1,KCNK6,KLF10,KLF7,KLHL42,KRT222,LARP1,LIMS4,CEP83-DT,LRRC8A,LSP1,MAP7D1,MAPK1,MCF2,MEF2D,MIB2,MNAT1,MOB2,MORC1,MORC3,MORN4,MOV10,MRPS34,MTSS1,MXD1,NDFIP2,NEIL1,NEK3,NFKBID,SLC9B1,NHSL2,NOTCH4,NPM3,NUDCD1,OAS1,STN1,OSBPL3,OSBPL5,OSBPL9,PAICS,PAK1IP1,PDHA2,PDLIM5,PHOX2A,PI4K2B,PIK3R5,PLCG1,PLCH1,PLP1,PLXDC2,PNPT1,POGK,PPCDC,PRCC,PTPRC,PTPRG,PYCR2,QTRT2,RAD52,RAMP1,RAP1GAP2,RASL11A,RBL1,RFESD,RHBDL3,RIOK1,RRM2B,S100A1,SAMD9L,SCO1,SELP,SENP7,SEPHS2,SEPTIN6,SESN3,SFRP2,SFT2D2,SLC15A4,SLCO3A1,SOCS2,SQLE,SS18,STARD6,STIM2,SURF1,SUSD3,TBC1D10C,TES,THAP2,THAP4,TIFAB,TMEM18,TMEM50B,TOR3A,TP53,TPST2,TTC9C,TTLL12,TTLL4,TXNDC9,UCHL1,UCK1,UCP1,VAMP4,WDR45,WIPI2,XIRP1,YIPF7,ZBTB11,TUT4,ZDHHC20,ZDHHC4,ZFP36L1,MSS51,ZNF141,ZNF207,ZNF260,ZNF322,ZNF354C,ZNF565,ZNF704 FOUNDER_NAMES