STANDARD_NAME GSE14350_IL2RB_KO_VS_WT_TEFF_UP SYSTEMATIC_NAME M3423 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE14350_IL2RB_KO_VS_WT_TEFF_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of effector T cells from IL2RB [GeneID=3560] defficient mice versus effector T cells from wild type animals. DESCRIPTION_FULL Interleukin-2 receptor (IL-2R) signaling is essential for T regulatory (Treg) cell development and homeostasis. Here we show that expression of IL-2Rbeta chains that lack tyrosine residues important for the association of the adaptor Shc and the transcription factor STAT5 in IL-2Rbeta-deficient mice resulted in production of a normal proportion of natural Treg cells that suppressed severe autoimmunity related with deficiency in IL-2 or IL-2R. These mutant IL-2Rbeta chains supported suboptimal and transient STAT5 activation that upregulate the transcription factor Foxp3 to normal amounts in natural, but not induced, Treg cells. Using cells T cell obtained from normal C57BL/6 mice and mice harboring Treg cells with impaired IL-2R signaling, gene expression profiling revealed many targets in peripheral natural Treg cells that were IL-2-dependent and a substantial overlap between the Treg cell IL-2-dependent gene program and the Treg cell transcriptional signature. Collectively, these findings demonstrate that a critical, and perhaps minor, subset of IL-2-dependent targets in Treg cells is indexed to a low IL-2R signaling threshold and that a substantial proportion of the Treg cell gene program is regulated by IL-2. CD4 T effector cells also showed many IL-2R-dependent gene and these also overlapped in a distintive manner with the IL-2-dependent genes of Treg cells and the Treg gene signature. PMID 19185518 GEOID GSE14350 AUTHORS Yu A,Zhu L,Altman NH,Malek TR CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE14350_1121_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA3,ABCD3,ACADVL,ADH1C,ADH4,ADIPOR2,AFF3,ANKRD12,ANKRD50,ANKRD57,ARFIP1,ARHGAP20,ATL3,ATP9B,ATXN1,BACH2,BATF,BCAS1,BCL2L14,BICD2,BMPR2,BPHL,BTBD2,BTLA,C11orf74,C12orf62,C14orf159,C1orf86,C6orf132,C6orf170,C6orf57,C9orf95,CCDC122,CCDC28B,CCDC64,CCR6,CCR7,CD4,CD74,CD96,CDC37,CHMP1A,CLEC1A,CLK1,CNPY3,CTSS,CUEDC1,CYBA,DAPL1,DBNDD2,DCLK1,DCLK2,DCTN2,DENND5A,DIP2B,DIP2C,DPEP3,DUSP19,DVL1,DYNLT3,DYX1C1,ERGIC1,ERGIC3,FOXN3,FYN,GLTSCR2,GPR174,GRAMD1B,GRINL1A,GSTM4,HAO2,HERPUD2,HEXIM1,HLA-DOA,HLA-DRB1,HLA-G,HOXA7,HVCN1,ICK,ID3,IER3IP1,IFIH1,IGF1R,IGFLR1,IL1R2,IVD,IZUMO4,JOSD2,KCNK10,KCNMB4,KDELR1,KIAA1211,KIAA1530,KIF13A,LANCL1,LDOC1L,LNPEP,LOC550643,LRIG1,LRIG2,MAP4K3,MAPK8,MAPRE3,MARCKSL1,MAST2,MAST4,MCOLN2,MKL2,MORN1,MUTED,MYH10,MYO1E,MYPOP,NCF4,NCKIPSD,NCOA7,NDUFA3,NEK9,NFAT5,NFKB2,NHEDC2,NKX6-1,NLRX1,NR4A2,NSUN4,OTX1,P4HTM,PARP3,PARP8,PCBD2,PDK2,PER1,PHF20L1,PHKA2,PLAGL1,PLXNC1,POLK,POU2AF1,PRDX2,PRKCE,PSME2,PSRC1,PTOV1,PTPRS,RAB11FIP5,RAB43,RERE,RFX5,RIC8A,RIC8B,RILPL2,RNF11,RNF122,RNF216,RNF43,RORA,RPL13A,S100A8,SCIN,SCN1A,SEMA4F,SH3BP4,SIAH2,SLC27A4,SLC29A3,SLC9A9,SQRDL,SSH2,ST8SIA6,STON1,STYX,TACC1,TBC1D5,TGIF1,THRSP,TIAM1,TM4SF5,TMED4,TMEM154,TMEM42,TMEM50B,TNFSF11,TNFSF4,TNFSF8,TNNI1,TRPA1,TSPAN3,UBE2J1,UHRF1BP1L,VPS13A,VPS39,WDFY1,ZBTB7A,ZC3H12D,ZCCHC18,ZHX2,ZMIZ2,ZNF445,ZNF703,ZNRF1 GENE_SYMBOLS ABCA3,ABCD3,ACADVL,ADH1C,ADH4,ADIPOR2,AFF3,ANKRD12,ANKRD50,SOWAHC,ARFIP1,ARHGAP20,ATL3,ATP9B,ATXN1,BACH2,BATF,BCAS1,BCL2L14,BICD2,BMPR2,BPHL,BTBD2,BTLA,IFTAP,COX14,DGLUCY,FAAP20,C6orf132,TBC1D32,SDHAF4,NMRK1,CCDC122,CCDC28B,BICDL1,CCR6,CCR7,CD4,CD74,CD96,CDC37,CHMP1A,CLEC1A,CLK1,CNPY3,CTSS,CUEDC1,CYBA,DAPL1,DBNDD2,DCLK1,DCLK2,DCTN2,DENND5A,DIP2B,DIP2C,DPEP3,DUSP19,DVL1,DYNLT3,DNAAF4,ERGIC1,ERGIC3,FOXN3,FYN,NOP53,GPR174,GRAMD1B,POLR2M,GSTM4,HAO2,HERPUD2,HEXIM1,HLA-DOA,HLA-DRB1,HLA-G,HOXA7,HVCN1,CILK1,ID3,IER3IP1,IFIH1,IGF1R,IGFLR1,IL1R2,IVD,IZUMO4,JOSD2,KCNK10,KCNMB4,KDELR1,CRACD,UVSSA,KIF13A,LANCL1,RTL6,LNPEP,NBDY,LRIG1,LRIG2,MAP4K3,MAPK8,MAPRE3,MARCKSL1,MAST2,MAST4,MCOLN2,MRTFB,MORN1,BLOC1S5,MYH10,MYO1E,MYPOP,NCF4,NCKIPSD,NCOA7,NDUFA3,NEK9,NFAT5,NFKB2,SLC9B2,NKX6-1,NLRX1,NR4A2,NSUN4,OTX1,P4HTM,PARP3,PARP8,PCBD2,PDK2,PER1,PHF20L1,PHKA2,PLAGL1,PLXNC1,POLK,POU2AF1,PRDX2,PRKCE,PSME2,PSRC1,PTOV1,PTPRS,RAB11FIP5,RAB43,RERE,RFX5,RIC8A,RIC8B,RILPL2,RNF11,RNF122,RNF216,RNF43,RORA,RPL13A,S100A8,SCIN,SCN1A,SEMA4F,SH3BP4,SIAH2,SLC27A4,SLC29A3,SLC9A9,SQOR,SSH2,ST8SIA6,STON1,STYX,TACC1,TBC1D5,TGIF1,THRSP,TIAM1,TM4SF5,TMED4,TMEM154,TMEM42,TMEM50B,TNFSF11,TNFSF4,TNFSF8,TNNI1,TRPA1,TSPAN3,UBE2J1,BLTP3B,VPS13A,VPS39,WDFY1,ZBTB7A,ZC3H12D,ZCCHC18,ZHX2,ZMIZ2,ZNF445,ZNF703,ZNRF1 FOUNDER_NAMES