STANDARD_NAME GSE14350_TREG_VS_TEFF_DN SYSTEMATIC_NAME M3418 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE14350_TREG_VS_TEFF_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of regulatory T cell (Treg) versus effector T cells. DESCRIPTION_FULL Interleukin-2 receptor (IL-2R) signaling is essential for T regulatory (Treg) cell development and homeostasis. Here we show that expression of IL-2Rbeta chains that lack tyrosine residues important for the association of the adaptor Shc and the transcription factor STAT5 in IL-2Rbeta-deficient mice resulted in production of a normal proportion of natural Treg cells that suppressed severe autoimmunity related with deficiency in IL-2 or IL-2R. These mutant IL-2Rbeta chains supported suboptimal and transient STAT5 activation that upregulate the transcription factor Foxp3 to normal amounts in natural, but not induced, Treg cells. Using cells T cell obtained from normal C57BL/6 mice and mice harboring Treg cells with impaired IL-2R signaling, gene expression profiling revealed many targets in peripheral natural Treg cells that were IL-2-dependent and a substantial overlap between the Treg cell IL-2-dependent gene program and the Treg cell transcriptional signature. Collectively, these findings demonstrate that a critical, and perhaps minor, subset of IL-2-dependent targets in Treg cells is indexed to a low IL-2R signaling threshold and that a substantial proportion of the Treg cell gene program is regulated by IL-2. CD4 T effector cells also showed many IL-2R-dependent gene and these also overlapped in a distintive manner with the IL-2-dependent genes of Treg cells and the Treg gene signature. PMID 19185518 GEOID GSE14350 AUTHORS Yu A,Zhu L,Altman NH,Malek TR CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE14350_1118_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCB10,ACOX2,AGPAT3,ALDH1L2,ALPPL2,ANGPTL4,ANKRD56,ATF7,ATP5F1,BAAT,BBS5,BCAN,BCL2L10,BEND4,BTNL2,C11orf92,C1orf105,C3orf26,C3orf39,CAV1,CBLC,CBLN1,CCHCR1,CCNK,CELF3,CENPN,CHAC1,CHRNA2,CKB,CLCN1,CLTA,CPB1,CRTAC1,CSMD2,CTF1,CXCL17,CYP26A1,DCUN1D5,DENND5B,DOK7,DRD2,DUSP22,E2F1,EIF3C,EIF4EBP1,EPHB1,ERH,EVC2,FAM188A,FAM54A,FBXL7,FDFT1,FES,FFAR2,FGFR2,FLT3,FOXH1,FZD2,GAD1,GINS4,GJB5,GLMN,GLRX3,GNAO1,GPI,GPR173,GRHPR,GRID2,GRK1,GSDMC,GZMA,HCN3,HES5,HGS,HIC1,HOGA1,HOXB7,HPRT1,INSC,INSRR,IRGM,IRX1,ITGB3,KANK2,KCTD1,KERA,KITLG,KRTAP12-2,LCE2B,LOC100505767,MAD1L1,MAP3K9,MAP9,MARK1,MBL2,MBOAT7,MICAL2,MMS22L,MPP2,MPV17L,MS4A3,MTUS2,NAP1L1,NECAB3,NEO1,NF1,NICN1,NOVA2,NPTX1,NPY5R,NR1I2,NUP133,NUP62,OR10AD1,OTOF,PAOX,PCBD1,PCGF5,PDSS2,PFKM,PHOX2A,PKIG,PLA2G12A,PLAC1,PLCD4,PML,PMVK,POLA1,POLDIP2,PPP1R13L,PRIMA1,PRODH2,PTGFR,PTGFRN,RAB36,RABL2A,RBPJ,REEP1,REEP4,RNASEH2B,RNF182,RPA2,RPH3A,RRBP1,RRM1,SCEL,SCN2B,SCRN3,SDF2L1,SEMA3B,SEMA3F,SEMA7A,SH3GL2,SH3PXD2B,SHH,SHISA9,SHROOM4,SIRT3,SKA3,SLC28A3,SLC35A4,SLC37A4,SLC7A3,SLC9A5,SMC1B,SOAT2,SOX21,SPEG,SRXN1,SUCLG1,SUV39H1,SYCE2,SYT1,SYTL3,TFF2,TFG,THOC3,TIRAP,TKT,TM9SF4,TMEM121,TMEM144,TNFRSF13C,TRIM10,TSPO2,TUBA8,TUBB6,UBE2T,UGT8,USP13,VANGL1,WBP11,WDR12,WIBG,WNT10B,WNT16,WNT7A,WNT8B,ZDBF2,ZG16 GENE_SYMBOLS ABCB10,ACOX2,AGPAT3,ALDH1L2,ALPG,ANGPTL4,SOWAHB,ATF7,ATP5PB,BAAT,BBS5,BCAN,BCL2L10,BEND4,BTNL2,COLCA1,C1orf105,CMSS1,POMGNT2,CAV1,CBLC,CBLN1,CCHCR1,CCNK,CELF3,CENPN,CHAC1,CHRNA2,CKB,CLCN1,CLTA,CPB1,CRTAC1,CSMD2,CTF1,CXCL17,CYP26A1,DCUN1D5,DENND5B,DOK7,DRD2,DUSP22,E2F1,EIF3C,EIF4EBP1,EPHB1,ERH,EVC2,MINDY3,MTFR2,FBXL7,FDFT1,FES,FFAR2,FGFR2,FLT3,FOXH1,FZD2,GAD1,GINS4,GJB5,GLMN,GLRX3,GNAO1,GPI,GPR173,GRHPR,GRID2,GRK1,GSDMC,GZMA,HCN3,HES5,HGS,HIC1,HOGA1,HOXB7,HPRT1,INSC,INSRR,IRGM,IRX1,ITGB3,KANK2,KCTD1,KERA,KITLG,KRTAP12-2,LCE2B,SPDYE18,MAD1L1,MAP3K9,MAP9,MARK1,MBL2,MBOAT7,MICAL2,MMS22L,MPP2,MPV17L,MS4A3,MTUS2,NAP1L1,NECAB3,NEO1,NF1,NICN1,NOVA2,NPTX1,NPY5R,NR1I2,NUP133,NUP62,OR10AD1,OTOF,PAOX,PCBD1,PCGF5,PDSS2,PFKM,PHOX2A,PKIG,PLA2G12A,PLAC1,PLCD4,PML,PMVK,POLA1,POLDIP2,PPP1R13L,PRIMA1,PRODH2,PTGFR,PTGFRN,RAB36,RABL2A,RBPJ,REEP1,REEP4,RNASEH2B,RNF182,RPA2,RPH3A,RRBP1,RRM1,SCEL,SCN2B,SCRN3,SDF2L1,SEMA3B,SEMA3F,SEMA7A,SH3GL2,SH3PXD2B,SHH,SHISA9,SHROOM4,SIRT3,SKA3,SLC28A3,SLC35A4,SLC37A4,SLC7A3,SLC9A5,SMC1B,SOAT2,SOX21,SPEG,SRXN1,SUCLG1,SUV39H1,SYCE2,SYT1,SYTL3,TFF2,TFG,THOC3,TIRAP,TKT,TM9SF4,TMEM121,TMEM144,TNFRSF13C,TRIM10,TSPO2,TUBA8,TUBB6,UBE2T,UGT8,USP13,VANGL1,WBP11,WDR12,PYM1,WNT10B,WNT16,WNT7A,WNT8B,ZDBF2,ZG16 FOUNDER_NAMES