STANDARD_NAME GSE14350_TREG_VS_TEFF_IN_IL2RB_KO_UP SYSTEMATIC_NAME M3419 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE14350_TREG_VS_TEFF_IN_IL2RB_KO_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of regulatory T cell (Treg) from IL2RB [GeneID=3560] defficient mice versus effector T cells from IL2RB [GeneID=3560] defficient mice. DESCRIPTION_FULL Interleukin-2 receptor (IL-2R) signaling is essential for T regulatory (Treg) cell development and homeostasis. Here we show that expression of IL-2Rbeta chains that lack tyrosine residues important for the association of the adaptor Shc and the transcription factor STAT5 in IL-2Rbeta-deficient mice resulted in production of a normal proportion of natural Treg cells that suppressed severe autoimmunity related with deficiency in IL-2 or IL-2R. These mutant IL-2Rbeta chains supported suboptimal and transient STAT5 activation that upregulate the transcription factor Foxp3 to normal amounts in natural, but not induced, Treg cells. Using cells T cell obtained from normal C57BL/6 mice and mice harboring Treg cells with impaired IL-2R signaling, gene expression profiling revealed many targets in peripheral natural Treg cells that were IL-2-dependent and a substantial overlap between the Treg cell IL-2-dependent gene program and the Treg cell transcriptional signature. Collectively, these findings demonstrate that a critical, and perhaps minor, subset of IL-2-dependent targets in Treg cells is indexed to a low IL-2R signaling threshold and that a substantial proportion of the Treg cell gene program is regulated by IL-2. CD4 T effector cells also showed many IL-2R-dependent gene and these also overlapped in a distintive manner with the IL-2-dependent genes of Treg cells and the Treg gene signature. PMID 19185518 GEOID GSE14350 AUTHORS Yu A,Zhu L,Altman NH,Malek TR CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE14350_1119_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AATF,ABCB1,ABR,ADAMTS10,ADCY7,ADD3,ADI1,ADNP,AGER,AIRN,AKAP8L,AKAP9,ANGPTL2,ANKHD1,ANKRD16,APC,ARHGAP15,ASXL2,ATP1B3,ATP9A,BAG3,BIN1,BMP2K,BRD8,BTG2,C16orf52,C20orf152,C20orf3,C2orf3,C4orf32,C5orf25,C6orf62,CA2,CASC4,CAST,CBFA2T2,CBL,CCDC126,CCDC62,CCNL2,CCNT2,CDK17,CDK5,CEBPB,CHD9,CLCF1,CRTC3,CYP4V2,DAPP1,DDB2,DET1,DGKA,DGUOK,DHRS11,DHX33,DHX8,DIRC2,DPP4,DYRK1A,E4F1,EIF3E,ELMO3,ESYT2,EXD2,FAM105A,FAM110B,FAM168B,FAM179B,FAM76B,FBXO33,FMNL3,FNBP4,FOXN2,FYCO1,FYN,GBP6,GIMAP5,GLIPR2,GNS,GOLGA5,GPR83,GRAMD1A,GSK3B,HIST3H2A,HLCS,HOPX,IFIT1,IK,IKBKE,IL27RA,ITGB7,JHDM1D,KBTBD2,KCTD18,KIAA0114,KIAA1598,KLF9,LAT,LCK,LMTK2,LPAR6,LRRC45,LTA,LY6E,MAGEF1,MAPK8IP3,MAT2A,MBNL1,MED1,MED15,MFAP1,MORC2,MS4A6A,MTERFD1,NEMF,NLRC3,NMB,NRBP1,NT5C3,NUDCD3,OSGIN1,OSTM1,OXR1,PAPD5,PARP6,PARP8,PDE2A,PDP1,PHC3,PHF17,PIK3C2A,PKD1,PKP4,PLEKHG2,PPP1R3F,PRKCE,PRKCZ,PUM2,RAB11FIP2,RABAC1,RBL2,RCAN3,RDH10,RFFL,RFX7,RFXANK,RHOH,RNF139,RNF145,RUFY1,RWDD3,SBF1,SLC35B3,SLC35D2,SNAPC5,SNRK,SNRNP48,SP1,SPACA1,SPATA5L1,SPIN1,SRPK1,STX17,SULF2,SYTL1,TAF5L,TAPT1,TBC1D8B,TEX264,TMC6,TMEM106B,TMEM81,TNFRSF13B,TPCN1,TRAPPC10,TRAPPC2,TRIB1,TRIM26,TTC7A,TTLL3,TTLL4,TUBA4A,UBR3,UBR5,USE1,USP48,VPS13D,VPS16,WDR44,WDYHV1,XPO6,ZBTB11,ZBTB4,ZC3H12A,ZC3H13,ZMYM4,ZNF281,ZNF493,ZNF639,ZYG11B GENE_SYMBOLS AATF,ABCB1,ABR,ADAMTS10,ADCY7,ADD3,ADI1,ADNP,AGER,AIRN,AKAP8L,AKAP9,ANGPTL2,ANKHD1,ANKRD16,APC,ARHGAP15,ASXL2,ATP1B3,ATP9A,BAG3,BIN1,BMP2K,BRD8,BTG2,MOSMO,CNBD2,APMAP,GCFC2,FAM241A,SIMC1,C6orf62,CA2,GOLM2,CAST,CBFA2T2,CBL,CCDC126,CCDC62,CCNL2,CCNT2,CDK17,CDK5,CEBPB,CHD9,CLCF1,CRTC3,CYP4V2,DAPP1,DDB2,DET1,DGKA,DGUOK,DHRS11,DHX33,DHX8,SLC49A4,DPP4,DYRK1A,E4F1,EIF3E,ELMO3,ESYT2,EXD2,OTULINL,FAM110B,FAM168B,TOGARAM1,FAM76B,FBXO33,FMNL3,FNBP4,FOXN2,FYCO1,FYN,GBP6,GIMAP5,GLIPR2,GNS,GOLGA5,GPR83,GRAMD1A,GSK3B,H2AC25,HLCS,HOPX,IFIT1,IK,IKBKE,IL27RA,ITGB7,KDM7A,KBTBD2,KCTD18,DANCR,SHTN1,KLF9,LAT,LCK,LMTK2,LPAR6,LRRC45,LTA,LY6E,MAGEF1,MAPK8IP3,MAT2A,MBNL1,MED1,MED15,MFAP1,MORC2,MS4A6A,MTERF3,NEMF,NLRC3,NMB,NRBP1,NT5C3A,NUDCD3,OSGIN1,OSTM1,OXR1,TENT4B,PARP6,PARP8,PDE2A,PDP1,PHC3,JADE1,PIK3C2A,PKD1,PKP4,PLEKHG2,PPP1R3F,PRKCE,PRKCZ,PUM2,RAB11FIP2,RABAC1,RBL2,RCAN3,RDH10,RFFL,RFX7,RFXANK,RHOH,RNF139,RNF145,RUFY1,RWDD3,SBF1,SLC35B3,SLC35D2,SNAPC5,SNRK,SNRNP48,SP1,SPACA1,SPATA5L1,SPIN1,SRPK1,STX17,SULF2,SYTL1,TAF5L,TAPT1,TBC1D8B,TEX264,TMC6,TMEM106B,TMEM81,TNFRSF13B,TPCN1,TRAPPC10,TRAPPC2,TRIB1,TRIM26,TTC7A,TTLL3,TTLL4,TUBA4A,UBR3,UBR5,USE1,USP48,VPS13D,VPS16,WDR44,NTAQ1,XPO6,ZBTB11,ZBTB4,ZC3H12A,ZC3H13,ZMYM4,ZNF281,ZNF493,ZNF639,ZYG11B FOUNDER_NAMES