STANDARD_NAME GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_UP SYSTEMATIC_NAME M3493 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 40 min. DESCRIPTION_FULL The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-κB, C/EBPδ, and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally validated the prediction that the combination of an initiator (NF-κB), an amplifier (C/EBPδ) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately. PMID 19270711 GEOID GSE14769 AUTHORS Litvak V,Ramsey SA,Rust AG,Zak DE,Kennedy KA,Lampano AE,Nykter M,Shmulevich I,Aderem A CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE14769_1130_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AAGAB,ACTL7A,ACVR2B,ADIPOQ,AKR1C2,APOA1,ARL16,ATP4B,ATP6AP1,BBS10,BBS2,BCLAF1,BMF,BRS3,BVES,C10orf35,C12orf49,C17orf53,C1orf52,C1orf63,C8G,CACNA1A,CALCR,CASP2,CBX7,CCDC115,CCDC40,CD300LB,CDC25B,CDC37L1,CDK20,CERK,CPT1A,CPXM2,CRYAB,CTLA4,CYGB,CYLC2,CYP27B1,DAPL1,DBI,DDIT3,DDX17,DLX3,DNAI1,DNAJC5B,DOCK7,DYNC1LI2,EFCAB1,EFEMP2,EFNB1,EGFR,EHD4,EIF3I,EIF4B,ELK4,ELMOD3,ELOVL1,ENPP2,EPB41L2,EPM2AIP1,EXOC5,FAF2,FAM40A,FGF9,FOXF2,GALR2,GCNT2,GDI1,GNA14,GPATCH4,GRIA2,GRIP1,GRM5,GTPBP5,GTPBP8,HAGH,HDGFRP2,HES1,HOXC5,HSDL1,HTR1B,IFI44,IRAK1BP1,ISL1,KCNC3,KCNK16,KCNS1,KIAA0114,KIAA0513,KLF14,KPTN,LEFTY2,LEPREL4,LHFPL3,LMCD1,LNPEP,LOC100287482,LOC100506804,LOC388796,LONRF2,LRRC45,LRRK2,MAP6D1,MB,MBLAC2,MDGA2,MDH1,MED17,MEGF11,MEP1A,MESDC2,METTL17,MFAP3,MFSD4,MFSD5,MIXL1,MRPL4,MUC13,MUS81,MYOF,NAV1,NAV3,NEK9,NF1,NHLRC3,NKX6-1,NPHS2,NR2F1,NSRP1,ODAM,OGFOD2,OGT,OPALIN,ORAOV1,PEX10,PFN3,PHF21B,PHKA2,PIDD,PLCB2,PLEKHH1,PRKAB1,PTPRN2,RCN3,RIIAD1,RPS11,RPUSD4,RTBDN,SAMD7,SCARNA13,SFI1,SGPL1,SH3BP2,SLC16A2,SLC1A6,SLC20A2,SLC24A6,SLC25A1,SLC2A13,SNHG10,SPACA7,SPINK4,SPTLC2,ST8SIA5,STAB1,STX2,STYK1,SYS1,TAGLN3,TEAD3,TEX261,TLE2,TMED4,TMED6,TMEM117,TMEM216,TMEM41A,TMEM80,TMEM88B,TPO,TRIL,TRIM11,TRPC4,TRPM3,TSKS,TSLP,TTC14,TWIST2,TXNIP,VARS2,WWC2,XIRP1,YBX1,YWHAH,ZDBF2,ZFR2,ZNF276,ZNF334,ZRANB2 GENE_SYMBOLS AAGAB,ACTL7A,ACVR2B,ADIPOQ,AKR1C2,APOA1,ARL16,ATP4B,ATP6AP1,BBS10,BBS2,BCLAF1,BMF,BRS3,BVES,FAM241B,SPRING1,HROB,C1orf52,RSRP1,C8G,CACNA1A,CALCR,CASP2,CBX7,CCDC115,CCDC40,CD300LB,CDC25B,CDC37L1,CDK20,CERK,CPT1A,CPXM2,CRYAB,CTLA4,CYGB,CYLC2,CYP27B1,DAPL1,DBI,DDIT3,DDX17,DLX3,DNAI1,DNAJC5B,DOCK7,DYNC1LI2,CLXN,EFEMP2,EFNB1,EGFR,EHD4,EIF3I,EIF4B,ELK4,ELMOD3,ELOVL1,ENPP2,EPB41L2,EPM2AIP1,EXOC5,FAF2,STRIP1,FGF9,FOXF2,GALR2,GCNT2,GDI1,GNA14,GPATCH4,GRIA2,GRIP1,GRM5,MTG2,GTPBP8,HAGH,,HES1,HOXC5,HSDL1,HTR1B,IFI44,IRAK1BP1,ISL1,KCNC3,KCNK16,KCNS1,DANCR,KIAA0513,KLF14,KPTN,LEFTY2,P3H4,LHFPL3,LMCD1,LNPEP,SMKR1,TMEM30A-DT,SNHG17,LONRF2,LRRC45,LRRK2,MAP6D1,MB,MBLAC2,MDGA2,MDH1,MED17,MEGF11,MEP1A,MESD,METTL17,MFAP3,MFSD4A,MFSD5,MIXL1,MRPL4,MUC13,MUS81,MYOF,NAV1,NAV3,NEK9,NF1,NHLRC3,NKX6-1,NPHS2,NR2F1,NSRP1,ODAM,OGFOD2,OGT,OPALIN,LTO1,PEX10,PFN3,PHF21B,PHKA2,PIDD1,PLCB2,PLEKHH1,PRKAB1,PTPRN2,RCN3,RIIAD1,RPS11,RPUSD4,RTBDN,SAMD7,SCARNA13,SFI1,SGPL1,SH3BP2,SLC16A2,SLC1A6,SLC20A2,SLC8B1,SLC25A1,SLC2A13,SNHG10,SPACA7,SPINK4,SPTLC2,ST8SIA5,STAB1,STX2,STYK1,SYS1,TAGLN3,TEAD3,TEX261,TLE2,TMED4,TMED6,TMEM117,TMEM216,TMEM41A,TMEM80,TMEM88B,TPO,TRIL,TRIM11,TRPC4,TRPM3,TSKS,TSLP,TTC14,TWIST2,TXNIP,VARS2,WWC2,XIRP1,YBX1,YWHAH,ZDBF2,ZFR2,ZNF276,ZNF334,ZRANB2 FOUNDER_NAMES