STANDARD_NAME	GSE15330_HSC_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_IKAROS_KO_DN
SYSTEMATIC_NAME	M7025
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE15330_HSC_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_IKAROS_KO_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in IKZF1 [GeneID=10320] knockout: hematopoietic stem cells versus granulo-monocyte progenitors.
DESCRIPTION_FULL	Regulation of lineage potential and transcriptional priming by Ikaros. New insight is provided into a bivalent regulation of lineage priming in the HSC and its lympho-myeloid restricted progeny the LMPP by the lymphoid lineage-determining factor Ikaros Whereas Ikaros is responsible for the activation of a cascade of lymphoid expression programs and for the establishment of lymphoid potential from the HSC to the LMPP it is also responsible for the repression of stem cell and erythroid genetic programs that are incompatible with further lineage restrictions emanating from the LMPP
PMID	19345118
GEOID	GSE15330
AUTHORS	Ng SY,Yoshida T,Zhang J,Georgopoulos K
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE15330_2826_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ADAMTS10,ADH1C,ADH5,ADPGK,ADSL,APOE,ASAP1,ASB11,ASH2L,B3GNT2,BIN3,BLMH,BMI1,BSPRY,C11orf31,C14orf102,C1orf189,C20orf43,C4orf14,C6orf115,CA2,CBR4,CCNK,CCT5,CD3G,CD40LG,CD52,CDK1,CHKB,CLYBL,CMBL,COMTD1,COPB1,COQ9,COX7A2L,CSAD,CSK,CXorf26,CYB5R1,DBNL,DDX26B,DGUOK,DHRS3,DLG3,DLX1,DOCK2,DPP8,DPYSL2,ECD,EIF3C,EIF4E,ELAVL3,ELP3,EP400,EPHX1,EXOSC10,EXTL3,FAAH,FAF1,FAM114A2,FCGR2A,FLCN,FTSJ2,FYN,GC,GEMIN6,GLCE,GLI2,GLMN,GLOD4,GLRX,GNAQ,GNPAT,GPAA1,GPR12,GRK1,GTF2E2,HBP1,HMG20A,HMGCS1,HMGN3,HMP19,HOMER1,HOPX,HOXB3,HPCAL1,HSD17B10,IARS2,ID3,IFI27L2,IGF2BP3,IMMT,INTS6,KAT2A,KIAA1429,KLHDC3,KPTN,LAG3,LIMD1,LRRIQ4,LSM10,LYRM2,MANBA,MCOLN2,MCTS1,MESDC2,MLST8,MND1,MOSC2,MRPS2,MSI2,MSRA,MYLIP,MYST3,NAMPT,NEK9,NME7,NPTXR,NR4A1,NUDT4,NUP43,OCIAD1,OR7C1,ORMDL1,OSBPL9,PACS2,PACSIN1,PARVG,PDK1,PFN1,PGRMC1,PHPT1,PLA2G16,PLEKHG6,POU2F2,PPAP2A,PPCDC,PPP2R5A,PRMT3,PSMD10,PSPH,PTGER4,PTMS,PTPRC,PURA,PYROXD1,QPRT,RAB34,RAB8B,RARS,RCN1,RGS2,RIPK2,RPAP1,RYR1,SDF4,SELS,SF3A2,SLAIN1,SLAMF1,SLC25A29,SLC30A9,SLC9A8,SLFN12L,SLFN13,SMPDL3A,SNX19,SRRT,SRSF6,SSRP1,ST6GAL1,STAG2,STAT4,STK39,SUCLG1,SWAP70,SYNE2,SYTL2,TACC2,TBCD,TCF7,TFB1M,THOC6,THOC7,THY1,TMEM126A,TNNT2,TP53RK,TPRKB,TRAP1,TRIM54,TSC22D1,TSPAN3,TSR2,UNK,USP47,VPS25,WNT16,ZNF354B,ZYG11B
GENE_SYMBOLS	ADAMTS10,ADH1C,ADH5,ADPGK,ADSL,APOE,ASAP1,ASB11,ASH2L,B3GNT2,BIN3,BLMH,BMI1,BSPRY,SELENOH,NRDE2,CFAP141,RTF2,NOA1,ABRACL,CA2,CBR4,CCNK,CCT5,CD3G,CD40LG,CD52,CDK1,CHKB,CLYBL,CMBL,COMTD1,COPB1,COQ9,COX7A2L,CSAD,CSK,PBDC1,CYB5R1,DBNL,INTS6L,DGUOK,DHRS3,DLG3,DLX1,DOCK2,DPP8,DPYSL2,ECD,EIF3C,EIF4E,ELAVL3,ELP3,EP400,EPHX1,EXOSC10,EXTL3,FAAH,FAF1,FAM114A2,FCGR2A,FLCN,MRM2,FYN,GC,GEMIN6,GLCE,GLI2,GLMN,GLOD4,GLRX,GNAQ,GNPAT,GPAA1,GPR12,GRK1,GTF2E2,HBP1,HMG20A,HMGCS1,HMGN3,NSG2,HOMER1,HOPX,HOXB3,HPCAL1,HSD17B10,IARS2,ID3,IFI27L2,IGF2BP3,IMMT,INTS6,KAT2A,VIRMA,KLHDC3,KPTN,LAG3,LIMD1,LRRIQ4,LSM10,LYRM2,MANBA,MCOLN2,MCTS1,MESD,MLST8,MND1,MTARC2,MRPS2,MSI2,MSRA,MYLIP,KAT6A,NAMPT,NEK9,NME7,NPTXR,NR4A1,NUDT4,NUP43,OCIAD1,OR7C1,ORMDL1,OSBPL9,PACS2,PACSIN1,PARVG,PDK1,PFN1,PGRMC1,PHPT1,PLAAT3,PLEKHG6,POU2F2,PLPP1,PPCDC,PPP2R5A,PRMT3,PSMD10,PSPH,PTGER4,PTMS,PTPRC,PURA,PYROXD1,QPRT,RAB34,RAB8B,RARS1,RCN1,RGS2,RIPK2,RPAP1,RYR1,SDF4,SELENOS,SF3A2,SLAIN1,SLAMF1,SLC25A29,SLC30A9,SLC9A8,SLFN12L,SLFN13,SMPDL3A,SNX19,SRRT,SRSF6,SSRP1,ST6GAL1,STAG2,STAT4,STK39,SUCLG1,SWAP70,SYNE2,SYTL2,TACC2,TBCD,TCF7,TFB1M,THOC6,THOC7,THY1,TMEM126A,TNNT2,TP53RK,TPRKB,TRAP1,TRIM54,TSC22D1,TSPAN3,TSR2,UNK,USP47,VPS25,WNT16,ZNF354B,ZYG11B
FOUNDER_NAMES