STANDARD_NAME GSE15330_WT_VS_IKAROS_KO_HSC_DN SYSTEMATIC_NAME M7036 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE15330_WT_VS_IKAROS_KO_HSC_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in hematopoietic stem cells: wildtype versus IKZF1 [GeneID=10320] knockout. DESCRIPTION_FULL Regulation of lineage potential and transcriptional priming by Ikaros. New insight is provided into a bivalent regulation of lineage priming in the HSC and its lympho-myeloid restricted progeny the LMPP by the lymphoid lineage-determining factor Ikaros Whereas Ikaros is responsible for the activation of a cascade of lymphoid expression programs and for the establishment of lymphoid potential from the HSC to the LMPP it is also responsible for the repression of stem cell and erythroid genetic programs that are incompatible with further lineage restrictions emanating from the LMPP PMID 19345118 GEOID GSE15330 AUTHORS Ng SY,Yoshida T,Zhang J,Georgopoulos K CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE15330_2827_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG1,AES,AKR1C3,ANAPC16,ANKH,ANKS1A,ANXA4,ARFGAP1,ARPC1B,ATL2,ATL3,ATP6AP2,ATP6V1D,AURKB,B4GALT7,BIK,C16orf53,C17orf85,C18orf1,C19orf25,C1orf86,C2CD2L,C9orf89,CABLES2,CAMKK1,CAPN1,CAPN2,CASKIN2,CCDC23,CCDC88C,CCDC92,CCNC,CCRN4L,CDC42EP3,CDC6,CDK16,CDK5,CDKN1B,CERK,CHD7,CLIC1,CLTC,COMMD4,CORO1C,CREB3L2,CRIPT,CRK,CTDP1,CTSA,CXCL10,CXCR6,DAO,DCTN5,DENND4B,DGAT1,DNAJA4,DNAJB6,DNM2,DYNC1H1,EFHD2,EHD4,EIF2B2,ELOVL1,ESRRA,ETV6,FAM151A,FAM64A,FAM89B,FBXO21,FTH1,GDI2,GJA1,GLB1,GLUD1,GMFG,GNG2,GRIA4,GSTK1,GTF2IRD1,HDAC1,HIPK2,ID1,IER5,IFFO2,IL17RA,IL9,IMPDH1,INHA,INO80C,ITGB3,ITSN2,JAK3,KAT2B,KDELR1,KIF5C,KIFAP3,KLB,KLF13,KLK4,KRT1,LAIR1,LBP,LOC152217,LRRC8A,LRRC8C,LSM14A,LUC7L2,MBD1,ME2,MFSD10,MGST3,MINA,MTMR6,MUM1,MXD3,MYBL2,MYO5A,MYOF,NAB1,NCKAP1,NGFRAP1,NLGN2,NR1D2,NT5C,OAF,PAFAH1B1,PAFAH1B2,PANX1,PC,PEA15,PITPNB,PLA2G15,PLCG2,PLEKHA2,PNKP,PPP1CC,PREB,PRKRIR,PYCR1,PYY,RAB20,RACGAP1,RAP1B,RDM1,RNH1,RPL24,RPL5,RRAS,RRBP1,SAP30,SBK1,SEC14L1,SEC24D,SEMA4D,SEPT10,SERPINF1,SF3A2,SF3B14,SHROOM3,SIGIRR,SLC12A7,SLC15A3,SLC25A15,SLC33A1,SLC44A1,SLC4A2,SLC6A1,SMAD4,SMAP2,SMPD2,SMTN,SNX14,SNX2,SOLH,SOX5,SPC25,SSX2IP,ST3GAL4,STAT3,STK17B,SYNE1,TAB2,TBCD,TM9SF2,TMED10,TMEM167A,TMEM199,TPSB2,TRPC4AP,TWF2,UBE2B,UBE2Z,UBTD1,ULK1,VPS35,WASF2,ZBTB45,ZC3H12C,ZDHHC20,ZFAND2B GENE_SYMBOLS ABCG1,TLE5,AKR1C3,ANAPC16,ANKH,ANKS1A,ANXA4,ARFGAP1,ARPC1B,ATL2,ATL3,ATP6AP2,ATP6V1D,AURKB,B4GALT7,BIK,PAGR1,NCBP3,LDLRAD4,C19orf25,FAAP20,C2CD2L,CARD19,CABLES2,CAMKK1,CAPN1,CAPN2,CASKIN2,SVBP,CCDC88C,CCDC92,CCNC,NOCT,CDC42EP3,CDC6,CDK16,CDK5,CDKN1B,CERK,CHD7,CLIC1,CLTC,COMMD4,CORO1C,CREB3L2,CRIPT,CRK,CTDP1,CTSA,CXCL10,CXCR6,DAO,DCTN5,DENND4B,DGAT1,DNAJA4,DNAJB6,DNM2,DYNC1H1,EFHD2,EHD4,EIF2B2,ELOVL1,ESRRA,ETV6,FAM151A,PIMREG,FAM89B,FBXO21,FTH1,GDI2,GJA1,GLB1,GLUD1,GMFG,GNG2,GRIA4,GSTK1,GTF2IRD1,HDAC1,HIPK2,ID1,IER5,IFFO2,IL17RA,IL9,IMPDH1,INHA,INO80C,ITGB3,ITSN2,JAK3,KAT2B,KDELR1,KIF5C,KIFAP3,KLB,KLF13,KLK4,KRT1,LAIR1,LBP,NCBP2AS2,LRRC8A,LRRC8C,LSM14A,LUC7L2,MBD1,ME2,MFSD10,MGST3,RIOX2,MTMR6,IRF4,MXD3,MYBL2,MYO5A,MYOF,NAB1,NCKAP1,BEX3,NLGN2,NR1D2,NT5C,OAF,PAFAH1B1,PAFAH1B2,PANX1,PC,PEA15,PITPNB,PLA2G15,PLCG2,PLEKHA2,PNKP,PPP1CC,PREB,THAP12,PYCR1,PYY,RAB20,RACGAP1,RAP1B,RDM1,RNH1,RPL24,RPL5,RRAS,RRBP1,SAP30,SBK1,SEC14L1,SEC24D,SEMA4D,SEPTIN10,SERPINF1,SF3A2,,SHROOM3,SIGIRR,SLC12A7,SLC15A3,SLC25A15,SLC33A1,SLC44A1,SLC4A2,SLC6A1,SMAD4,SMAP2,SMPD2,SMTN,SNX14,SNX2,CAPN15,SOX5,SPC25,SSX2IP,ST3GAL4,STAT3,STK17B,SYNE1,TAB2,TBCD,TM9SF2,TMED10,TMEM167A,TMEM199,TPSB2,TRPC4AP,TWF2,UBE2B,UBE2Z,UBTD1,ULK1,VPS35,WASF2,ZBTB45,ZC3H12C,ZDHHC20,ZFAND2B FOUNDER_NAMES