STANDARD_NAME GSE15624_3H_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_DN SYSTEMATIC_NAME M7109 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE15624_3H_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD4 [GeneID=920] T cells treated with halofuginone [PubChem=400772]: 3h versus 6h. DESCRIPTION_FULL T cell differentiation to the Th17 effector subset requires stimulation through the T cell and co-stimulatory receptors, together with cytokine stimulation by TGFb and IL-6. The small molecule halofuginone (HF) inhibits Th17 cell development and induces a pattern of stress-regulated gene expression that mimics amino acid starvation. We used global transcript profiling to ask how halofuginone modulates gene expression induced during T cell activaiton and Th17 differentiation PMID 19498172 GEOID GSE15624 AUTHORS Sundrud MS,Koralov SB,Feuerer M,Calado DP,Kozhaya AE,Rhule-Smith A,Lefebvre RE,Unutmaz D,Mazitschek R,Waldner H,Whitman M,Keller T,Rao A CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE15624_2677_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 2210021J22Rik,2310016G11Rik,2810416G20Rik,2900073G15Rik,4930579G22Rik,5330426P16Rik,6430598A04Rik,A430072C10Rik,AA474408,ABHD15,ACOX1,AEBP2,AHCYL2,AI452195,ANKRD50,APOL7E,APPBP2,ARHGAP10,ARID1B,ART4,BIRC3,BRAP,C78339,CALM4,CBR1,CCR7,CEACAM14,CGGBP1,CLDN23,CLSTN1,CORO2A,CRIM1,CSRNP1,CTLA2A,D1ERTD448E,D630045J12Rik,DAGLA,DBR1,DGKE,DHX38,DIRC2,DNAHC3,DUSP15,EPB4.1,EXOSC4,FAM117B,FAM32A,FAM92A,FBXW11,FGF11,FGG,FHL4,FOLR4,FOXRED2,FURIN,GABRA3,GALNS,GALNT10,GBP2,GLIS1,GM10560,GM10726,GM10830,GM12482,GM15470,GM16425,GM5045,GM5191,GM527,GM7194,GM7275,GM9643,GM9763,GM9900,GPBP1,GPN2,GRID1,GRWD1,GSDMCL-PS,GTF2I,HAO1,HIF1AN,HNRNPC,IFNE,IGF2R,IL2RB,ING3,KDM2B,KRTAP24-1,LARP1,LCE1G,LCP1,LIF,LOC641050,LRIG1,LRIG3,LYG1,LYZL4,MAP3K4,MED22,MFF,MIR129-2,MIR155,MPHOSPH10,MSRA,MYO16,NEU3,NFYA,NGRN,NPW,NPY2R,NRARP,OLFR1049,OLFR1188,OLFR1356,OLFR1366,OLFR531,OLFR549,OLFR76,OLFR768,OLFR960,OLFR979,OTOP3,PAG1,PARP3,PDE2A,PERP,PFKL,PHC1,PINK1,PLAG1,PLEKHB2,PLEKHG6,PLXNB3,PPM1G,PPP1CB,PPP1R9B,PRAMEF8,PRDX6,PRKG1,PRKRIR,PRMT6,PSMB6,PSMD11,RAB27A,RACGAP1,RAD23B,RAD51L3,RASGRF1,RBM17,RGS1,RNF114,RNF145,SAR1A,SEC11A,SEC13,SESN3,SF3A3,SH2D2A,SKIL,SLC23A2,SLC3A2,SLMO2,STAT3,TAPBP,TFPI2,TGFBRAP1,TMEM179,TMEM33,TMEM59,TNFRSF10B,TPO,TRAPPC10,TRIM25,TRIM26,TSC22D3,TTC4,TUT1,UBE2O,UBQLN2,UNC13A,USP10,USP12,VMN1R205,VMN2R110,VPS37B,WAP,WBP11,WEE2,ZDHHC5,ZFP1,ZFP110,ZFP161,ZFP39,ZFP672,ZFP828,ZFP868,ZFYVE20,ZKSCAN1,ZYG11B GENE_SYMBOLS ,,,,,,,,,ABHD15,ACOX1,AEBP2,AHCYL2,PDE4D,ANKRD50,,APPBP2,ARHGAP10,ARID1B,ART4,BIRC3,BRAP,FAM8A1,,CBR1,CCR7,,CGGBP1,CLDN23,CLSTN1,CORO2A,CRIM1,CSRNP1,,,,DAGLA,DBR1,DGKE,DHX38,SLC49A4,,DUSP15,,EXOSC4,FAM117B,FAM32A,CIBAR1,FBXW11,FGF11,FGG,,IZUMO1R,FOXRED2,FURIN,GABRA3,GALNS,GALNT10,GBP2,GLIS1,,,,,,,,,,,,,,,GPBP1,GPN2,GRID1,GRWD1,,GTF2I,HAO1,HIF1AN,HNRNPC,IFNE,IGF2R,IL2RB,ING3,KDM2B,KRTAP24-1,LARP1,,LCP1,LIF,,LRIG1,LRIG3,LYG1,LYZL4,MAP3K4,MED22,MFF,MIR129-2,MIR155,MPHOSPH10,MSRA,MYO16,NEU3,NFYA,NGRN,NPW,NPY2R,NRARP,,,,,,,,,,,OTOP3,PAG1,PARP3,PDE2A,PERP,PFKL,PHC1,PINK1,PLAG1,PLEKHB2,PLEKHG6,PLXNB3,PPM1G,PPP1CB,PPP1R9B,PRAMEF8,PRDX6,PRKG1,THAP12,PRMT6,PSMB6,PSMD11,RAB27A,RACGAP1,RAD23B,RAD51D,RASGRF1,RBM17,RGS1,RNF114,RNF145,SAR1A,SEC11A,SEC13,SESN3,SF3A3,SH2D2A,SKIL,SLC23A2,SLC3A2,PRELID3B,STAT3,TAPBP,TFPI2,TGFBRAP1,TMEM179,TMEM33,TMEM59,TNFRSF10B,TPO,TRAPPC10,TRIM25,TRIM26,TSC22D3,TTC4,TUT1,UBE2O,UBQLN2,UNC13A,USP10,USP12,,,VPS37B,,WBP11,WEE2,ZDHHC5,ZFP1,,ZBTB14,,,,,RBSN,ZKSCAN1,ZYG11B FOUNDER_NAMES