STANDARD_NAME	GSE15659_CD45RA_NEG_CD4_TCELL_VS_RESTING_TREG_UP
SYSTEMATIC_NAME	M3551
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE15659_CD45RA_NEG_CD4_TCELL_VS_RESTING_TREG_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus PTPRC+ [GeneID=5788] resting regulatory T cell (Treg).
DESCRIPTION_FULL	Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of three phenotypically and functionally distinct subpopulations: CD45RA+FoxP3low resting Tregs (rTregs) and CD45RA-FoxP3high activated Tregs (aTregs), both of which are suppressive in vitro, and cytokine-secreting CD45RA-FoxP3low non-suppressive T cells. The proportion of the three subpopulations characteristically altered in cord blood, aged individuals, and patients with immunological diseases. Terminally differentiated aTregs rapidly die while rTregs proliferate and convert into aTregs in vitro and in vivo as shown by the transfer of rTregs into NOD-scid-common gamma-chain-knockout mice and by TCR sequence-based T cell clonotype tracing in peripheral blood of normal individuals. Taken together, the dissection of FoxP3+ cells into subsets enables one to analyze Treg differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP3+ subpopulations.
PMID	19464196
GEOID	GSE15659
AUTHORS	Miyara M,Yoshioka Y,Kitoh A,Shima T,Wing K,Niwa A,Parizot C,Taflin C,Heike T,Valeyre D,Mathian A,Nakahata T,Yamaguchi T,Nomura T,Ono M,Amoura Z,Gorochov G,Sakaguchi S
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE15659_1420_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABAT,ACAT1,ACY3,ADAM9,ADAMDEC1,ADAMTS5,ADAMTSL3,ADCY7,ADCY9,ADHFE1,AFAP1,AGK,AGPAT6,AGPS,AIM1,ALDH16A1,ALDH1L2,ALX4,AMPD2,ANGPT4,ANK1,ANXA4,AP1M1,AP3M1,ARHGAP29,ARHGAP35,ARHGEF19,ARHGEF5,ARL6IP6,ARNTL,ART4,ASAP2,ASB15,ASCL3,ASF1A,ASMTL-AS1,ATF7,ATP6AP1,ATP6V0C,ATRN,ATXN1,ATXN3L,AVEN,BAHD1,BAZ1A,BBOX1,BCL2L14,BCL3,BDNF,BEND4,BHLHE22,BID,BMS1P5,BOLA3,BPA-1,BPI,C10orf27,C12orf32,C12orf49,C14orf80,C15orf38,C17orf62,C18orf12,C1orf122,C1orf210,C1orf38,C1QTNF7,C22orf24,C2orf15,C2orf19,C4orf21,C4orf31,C4orf36,C4orf7,C5orf48,C6orf164,C6orf223,C6orf35,C7orf13,C9orf85,CABLES1,CABP2,CABS1,CACNG7,CALCA,CAMK1D,CASP3,CASP8,CBWD1,CBY3,CC2D1B,CCDC109B,CCDC136,CCDC152,CCDC33,CCDC56,CCDC72,CCDC88C,CCDC97,CCNF,CCRN4L,CD248,CD40LG,CD8B,CDH19,CDIPT,CDK1,CECR2,CENPE,CENPN,CEP164,CES1,CETN2,CHPF,CHRNA1,CHRNA4,CHST12,CHUK,CLDN2,CLEC14A,CLEC7A,CLU,CMTM5,CNPY1,COL5A1,COMMD5,COMMD7,COPG,COTL1,COX7A1,CPLX2,CPNE3,CPNE9,CR2,CRBN,CSNK1G3,CSPG5,CST11,CST3,CTAG2,CTNS,CUBN,CXCL14,CXorf30,CXXC1P1,CYP2E1,CYP4Z1,DCP2,DGCR9,DNAJB14,DNAJC28,DNAJC9,DNASE1L2,DOC2A,DOHH,DPCR1,DPYS,DUSP14,E2F1,EEF1E1,EFCAB10,EFR3A,EIF3J,EIF3K,EIF5A2,ELAC1,ELMO1,ENTPD1,ENTPD3,EOMES,EPB49,ERLEC1,ETV6,ETV7,EXOC2,EXOSC1,EYA3,FAIM,FAM118B,FAM123A,FAM47A,FAM47C,FAM82A2,FAM83C,FAM85A,FBXL14,FBXO45,FBXW5,FBXW9,FHL1,FLJ11292,FLJ33996,FLJ34503,FLJ35700,FOS,G3BP2,HTR5A,INHBE,LOC399884,PRAMEF12
GENE_SYMBOLS	ABAT,ACAT1,ACY3,ADAM9,ADAMDEC1,ADAMTS5,ADAMTSL3,ADCY7,ADCY9,ADHFE1,AFAP1,AGK,GPAT4,AGPS,CRYBG1,ALDH16A1,ALDH1L2,ALX4,AMPD2,ANGPT4,ANK1,ANXA4,AP1M1,AP3M1,ARHGAP29,ARHGAP35,ARHGEF19,ARHGEF5,ARL6IP6,BMAL1,ART4,ASAP2,ASB15,ASCL3,ASF1A,ASMTL-AS1,ATF7,ATP6AP1,ATP6V0C,ATRN,ATXN1,ATXN3L,AVEN,BAHD1,BAZ1A,BBOX1,BCL2L14,BCL3,BDNF,BEND4,BHLHE22,BID,BMS1P1,BOLA3,,BPI,TBATA,RHNO1,SPRING1,TEDC1,ARPIN,CYBC1,ZBTB7C-AS2,C1QTNF7,C1orf122,C1orf210,THEMIS2,YWHAH-AS1,C2orf15,KLHL30-AS1,ZGRF1,NDNF,C4orf36,FDCSP,SPMIP10,,LINC03040,TMEM242,RNF32-DT,C9orf85,CABLES1,CABP2,CABS1,CACNG7,CALCA,CAMK1D,CASP3,CASP8,ZNG1A,CBY3,CC2D1B,MCUB,CCDC136,CCDC152,CCDC33,COA3,TMA7,CCDC88C,CCDC97,CCNF,NOCT,CD248,CD40LG,CD8B,CDH19,CDIPT,CDK1,CECR2,CENPE,CENPN,CEP164,CES1,CETN2,CHPF,CHRNA1,CHRNA4,CHST12,CHUK,CLDN2,CLEC14A,CLEC7A,CLU,CMTM5,CNPY1,COL5A1,COMMD5,COMMD7,COPG1,COTL1,COX7A1,CPLX2,CPNE3,CPNE9,CR2,CRBN,CSNK1G3,CSPG5,CST11,CST3,CTAG2,CTNS,CUBN,CXCL14,CXXC1P1,CFAP47,CYP2E1,CYP4Z1,DCP2,DGCR5,DNAJB14,DNAJC28,DNAJC9,DNASE1L2,DOC2A,DOHH,MUCL3,DPYS,DUSP14,E2F1,EEF1E1,EFCAB10,EFR3A,EIF3J,EIF3K,EIF5A2,ELAC1,ELMO1,ENTPD1,ENTPD3,EOMES,DMTN,ERLEC1,ETV6,ETV7,EXOC2,EXOSC1,EYA3,FAIM,FAM118B,AMER2,FAM47A,FAM47C,RMDN3,FAM83C,,FBXL14,FBXO45,FBXW5,FBXW9,FHL1,LINC01949,SCN8A,LINC02880,,FOS,G3BP2,HTR5A,INHBE,,PRAMEF12
FOUNDER_NAMES