STANDARD_NAME GSE15930_NAIVE_VS_72H_IN_VITRO_STIM_IFNAB_CD8_TCELL_UP SYSTEMATIC_NAME M3612 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE15930_NAIVE_VS_72H_IN_VITRO_STIM_IFNAB_CD8_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with antigen-B7-1. DESCRIPTION_FULL Differentiation of naive CD8 T cells into cytotoxic effector cells requires three distinct signals- antigen (signal 1), costimulation -B7-1 (signal 2) and cytokine, either interleukin-12 or interferon-a/b (signal 3). Interaction of naive CD8 T cells with antigen and B7-1 programs cell division and proliferation whereas the presence of cytokines- IL-12 or IFNa/b promote survival, differentiation and memory establishment. In the absence of signal 3, the cells interacting with antigen/B7-1 undergo tolerance induction. The objective of this study was to elucidate the mechanisms how the provision of signal 3 promotes differentiation and averts tolerance induction in CD8 T cells. Trichostatin A is a pharmacological agent that inhibits histone deacetylase activity, hence regulating chromatin structure and gene expression and differentiation in many cell types. Gene signature profiles of IL-12, IFNa/b and trichostatin A stimulated cells were compared to elucidate the molecular mechanisms of gene regulation. Oligonucleotide microarray analysis is carried out to determine the extent and molecular nature of the CD8 T cell differentiation program induced by IL-12 or IFNa/b in concert with antigen and B7-1 signal. PMID 19592655 GEOID GSE15930 AUTHORS Agarwal P,Raghavan A,Nandiwada SL,Curtsinger JM,Bohjanen PR,Mueller DL,Mescher MF CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE15930_1355_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG1,ACTR1B,ADRB2,AKAP7,AKIRIN1,AP1B1,APC,APOBEC2,APP,ARHGEF7,ARID3B,ASGR2,ATP9A,AZI2,BLCAP,BMP6,BPNT1,BRWD3,BSDC1,BTC,C19orf48,C9orf91,CA2,CALR,CANT1,CCDC152,CCDC94,CCKBR,CCR9,CD1D,CD79B,CEL,CELA2A,CFH,CHMP1B,CLTB,COL6A2,COQ10A,CREG1,CRY2,CTNNAL1,CWC22,CXCR7,CYP2E1,CYP3A43,DDA1,DFFA,DLX1,DNAJA2,DNAJB4,DUSP12,DVL1,EIF4H,EML5,EPHB2,ERCC2,EYA2,F9,FABP7,FAM101B,FAM134A,FAM54B,FBXW4,FGD3,FRAT1,GABRR2,GADD45G,GBF1,GPR97,GREM2,GRIA3,HAO2,HCRT,HES2,HGF,HOXA3,HR,HRH2,HYOU1,ICAM2,IGFBP1,INSM1,JARID2,KITLG,KLHL21,KRT1,KRT7,LALBA,LHCGR,LMX1B,LPHN1,MAP1LC3A,MAP3K3,MAP4K3,MCART1,MEST,METTL1,MIP,MPL,MSL2,MYH7,MYL6,MYOM2,NCOA3,NDUFAF4,NECAP1,NEDD4L,NEURL4,NFIX,NR1D2,NRTN,PAPSS2,PCSK7,PEA15,PHF1,PHRF1,PI4K2A,PITPNA,PKD1,PMPCA,POLG2,POLR3D,POMC,PPFIBP2,PRCC,PSAP,RAB17,RAB33B,RAD9A,RAE1,RALGPS2,RANBP10,RAPGEF4,RBM4B,RCVRN,RECQL,REXO1,RFX2,RPL12,RPL37A,RPS6KA2,RRP9,SCMH1,SEC11C,SEMA4F,SF3A2,SH2B3,SH3GL1,SIAH1,SKIV2L2,SLC22A1,SLC25A25,SLC39A4,SLC6A8,SLFN12,SNX17,SOX11,SOX4,SPINK4,SPPL2B,SPR,SPRYD4,SPSB1,ST3GAL1,STAT5A,STK40,STRN4,SUB1,SUMO2P7,SURF4,SVIL,SYT9,TCEA2,TCF20,TCN2,TFPI2,TGIF2,THYN1,TIMP2,TLE4,TMEM115,TMEM183A,TNF,TNNI2,TRAF2,TRIM13,TSG101,TSSK2,UBE2E3,UCK1,USF2,USP2,USP21,USP34,VIP,WBP1,ZBTB20,ZDHHC5,ZKSCAN1,ZYG11B GENE_SYMBOLS ABCG1,ACTR1B,ADRB2,AKAP7,AKIRIN1,AP1B1,APC,APOBEC2,APP,ARHGEF7,ARID3B,ASGR2,ATP9A,AZI2,BLCAP,BMP6,BPNT1,BRWD3,BSDC1,BTC,C19orf48P,TMEM268,CA2,CALR,CANT1,CCDC152,YJU2,CCKBR,CCR9,CD1D,CD79B,CEL,CELA2A,CFH,CHMP1B,CLTB,COL6A2,COQ10A,CREG1,CRY2,CTNNAL1,CWC22,ACKR3,CYP2E1,CYP3A43,DDA1,DFFA,DLX1,DNAJA2,DNAJB4,DUSP12,DVL1,EIF4H,EML5,EPHB2,ERCC2,EYA2,F9,FABP7,RFLNB,RETREG2,MTFR1L,FBXW4,FGD3,FRAT1,GABRR2,GADD45G,GBF1,ADGRG3,GREM2,GRIA3,HAO2,HCRT,HES2,HGF,HOXA3,HR,HRH2,HYOU1,ICAM2,IGFBP1,INSM1,JARID2,KITLG,KLHL21,KRT1,KRT7,LALBA,LHCGR,LMX1B,ADGRL1,MAP1LC3A,MAP3K3,MAP4K3,SLC25A51,MEST,METTL1,MIP,MPL,MSL2,MYH7,MYL6,MYOM2,NCOA3,NDUFAF4,NECAP1,NEDD4L,NEURL4,NFIX,NR1D2,NRTN,PAPSS2,PCSK7,PEA15,PHF1,PHRF1,PI4K2A,PITPNA,PKD1,PMPCA,POLG2,POLR3D,POMC,PPFIBP2,PRCC,PSAP,RAB17,RAB33B,RAD9A,RAE1,RALGPS2,RANBP10,RAPGEF4,RBM4B,RCVRN,RECQL,REXO1,RFX2,RPL12,RPL37A,RPS6KA2,RRP9,SCMH1,SEC11C,SEMA4F,SF3A2,SH2B3,SH3GL1,SIAH1,MTREX,SLC22A1,SLC25A25,SLC39A4,SLC6A8,SLFN12,SNX17,SOX11,SOX4,SPINK4,SPPL2B,SPR,SPRYD4,SPSB1,ST3GAL1,STAT5A,STK40,STRN4,SUB1,SUMO2P7,SURF4,SVIL,SYT9,TCEA2,TCF20,TCN2,TFPI2,TGIF2,THYN1,TIMP2,TLE4,TMEM115,TMEM183A,TNF,TNNI2,TRAF2,TRIM13,TSG101,TSSK2,UBE2E3,UCK1,USF2,USP2,USP21,USP34,VIP,WBP1,ZBTB20,ZDHHC5,ZKSCAN1,ZYG11B FOUNDER_NAMES