STANDARD_NAME	GSE16385_UNTREATED_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_UP
SYSTEMATIC_NAME	M7889
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE16385_UNTREATED_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in macrophages (12h): control versus IFNG, TNF [GeneID=3458;7124] and rosiglitazone [PubChem=77999].
DESCRIPTION_FULL	Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 4, 12, 24, 72 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ng/ml) or left without activation. Simultaneously, macrophages were also treated with vehicle (DMSO:ethanol) or 1mM synthetic PPARg agonist, Rosiglitazone. We used Affymetrix microarrays (U133Plus 2.0) to analyze activation and PPARg-induced gene expression changes.
PMID	21093321
GEOID	GSE16385
AUTHORS	Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE16385_2267_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACCN5,ACSM1,ADAD1,ADO,AGRN,ANKRD42,ANXA9,APOA5,AQP9,ARL5B,B3GAT3,BCL2,BCL2L2,BTG3,C12orf44,C14orf129,C14orf28,C16orf90,C17orf81,C1R,C20orf103,C20orf96,C21orf91,C2orf88,C3orf71,C4orf48,C6orf170,C6orf192,C7orf23,C9orf68,CA1,CACNA1S,CACNG7,CCL4,CCNL1,CCR4,CD274,CD69,CD93,CDKN2B,CEND1,CEP135,CHRM4,COL5A2,CPEB3,CSF3,CUL9,DCT,DNAJB1,DPYSL3,DUSP2,DUSP5,DUSP6,EDA2R,EGR1,EGR2,EGR3,EIF1B,EMR1,ERO1LB,EVI2A,EXOSC10,EXOSC3,FAM122A,FAM71F1,FASLG,FASTKD5,FAT2,FBXO8,FILIP1L,FNDC5,FTMT,GABRG3,GATA3,GFI1,GJB5,GLIPR1,GLRA3,GML,GMPPB,GPR171,GRAMD3,GRHL3,GSC,HAS1,HLF,HOXB3,HS6ST3,HSPA1L,HSPB3,ID3,IER2,IFNB1,IKZF2,IL34,ITPKB,ITPRIP,JAM2,JRK,JUNB,KBTBD2,KCNQ5,KCNS3,KIF26A,KLK9,KRTAP4-6,LAMA1,LAMTOR1,LENG9,LIMA1,LRFN2,LRRC10B,LRRTM4,LYPLAL1,MAD2L1BP,MAFF,MALT1,MLLT11,MME,MYH11,MYOD1,NAB2,NCOA7,NFIB,NFKBID,NFKBIZ,NPAS2,NR4A1,NR4A2,NTSR2,OPALIN,PCDH9,PDCD1LG2,PDILT,PEBP4,PER1,PER3,PHF6,PLK3,POF1B,PPP1R11,PRDX6,PRKAB1,PRKAB2,PROM1,PTGER2,PTPN23,RAB3A,RANBP17,RANBP6,RASL10A,RCHY1,RINL,RNASE10,RPL3L,S100A5,SAG,SCN3A,SH2D2A,SHROOM1,SLC27A2,SLC6A18,SPESP1,SPINK4,SRFBP1,SRPR,STK17B,STX19,SV2A,SYT6,TCFL5,TDRD1,TFF3,TGIF2,TM6SF2,TMCC2,TMEM47,TNFRSF1B,TNRC6A,TOMM34,TRIM13,TRIM46,TRO,TSPYL4,TTC19,TUT1,TWF1,UPB1,USH2A,VAMP3,VN1R5,WISP1,WWOX,YRDC,ZEB1,ZFAND5,ZFP36,ZFP36L1,ZNF622,ZRSR2
GENE_SYMBOLS	ASIC5,ACSM1,ADAD1,ADO,AGRN,ANKRD42,ANXA9,APOA5,AQP9,ARL5B,B3GAT3,BCL2,BCL2L2,BTG3,ATG101,GSKIP,DORIP1,C16orf90,ELP5,C1R,LAMP5,C20orf96,C21orf91,C2orf88,ARIH2OS,NICOL1,TBC1D32,SLC18B1,TMEM243,SPATA6L,CA1,CACNA1S,CACNG7,CCL4,CCNL1,CCR4,CD274,CD69,CD93,CDKN2B,CEND1,CEP135,CHRM4,COL5A2,CPEB3,CSF3,CUL9,DCT,DNAJB1,DPYSL3,DUSP2,DUSP5,DUSP6,EDA2R,EGR1,EGR2,EGR3,EIF1B,ADGRE1,ERO1B,EVI2A,EXOSC10,EXOSC3,PABIR1,GARIN1B,FASLG,FASTKD5,FAT2,FBXO8,FILIP1L,FNDC5,FTMT,GABRG3,GATA3,GFI1,GJB5,GLIPR1,GLRA3,GML,GMPPB,GPR171,GRAMD2B,GRHL3,GSC,HAS1,HLF,HOXB3,HS6ST3,HSPA1L,HSPB3,ID3,IER2,IFNB1,IKZF2,IL34,ITPKB,ITPRIP,JAM2,JRK,JUNB,KBTBD2,KCNQ5,KCNS3,KIF26A,KLK9,KRTAP4-6,LAMA1,LAMTOR1,LENG9,LIMA1,LRFN2,LRRC10B,LRRTM4,LYPLAL1,MAD2L1BP,MAFF,MALT1,MLLT11,MME,MYH11,MYOD1,NAB2,NCOA7,NFIB,NFKBID,NFKBIZ,NPAS2,NR4A1,NR4A2,NTSR2,OPALIN,PCDH9,PDCD1LG2,PDILT,PEBP4,PER1,PER3,PHF6,PLK3,POF1B,PPP1R11,PRDX6,PRKAB1,PRKAB2,PROM1,PTGER2,PTPN23,RAB3A,RANBP17,RANBP6,RASL10A,RCHY1,RINL,RNASE10,RPL3L,S100A5,SAG,SCN3A,SH2D2A,SHROOM1,SLC27A2,SLC6A18,SPESP1,SPINK4,SRFBP1,SRPRA,STK17B,STX19,SV2A,SYT6,TCFL5,TDRD1,TFF3,TGIF2,TM6SF2,TMCC2,TMEM47,TNFRSF1B,TNRC6A,TOMM34,TRIM13,TRIM46,TRO,TSPYL4,TTC19,TUT1,TWF1,UPB1,USH2A,VAMP3,VN1R5,CCN4,WWOX,YRDC,ZEB1,ZFAND5,ZFP36,ZFP36L1,ZNF622,ZRSR2
FOUNDER_NAMES