<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE16385_UNTREATED_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_UP" SYSTEMATIC_NAME="M7889" HISTORICAL_NAMES="" PMID="21093321" AUTHORS="Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L" GEOID="GSE16385" EXACT_SOURCE="GSE16385_2267_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in macrophages (12h): control versus IFNG, TNF [GeneID=3458;7124] and rosiglitazone [PubChem=77999]." DESCRIPTION_FULL="Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 4, 12, 24, 72 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ng/ml) or left without activation. Simultaneously, macrophages were also treated with vehicle (DMSO:ethanol) or 1mM synthetic PPARg agonist, Rosiglitazone. We used Affymetrix microarrays (U133Plus 2.0) to analyze activation and PPARg-induced gene expression changes." TAGS="" MEMBERS="ACCN5,ACSM1,ADAD1,ADO,AGRN,ANKRD42,ANXA9,APOA5,AQP9,ARL5B,B3GAT3,BCL2,BCL2L2,BTG3,C12orf44,C14orf129,C14orf28,C16orf90,C17orf81,C1R,C20orf103,C20orf96,C21orf91,C2orf88,C3orf71,C4orf48,C6orf170,C6orf192,C7orf23,C9orf68,CA1,CACNA1S,CACNG7,CCL4,CCNL1,CCR4,CD274,CD69,CD93,CDKN2B,CEND1,CEP135,CHRM4,COL5A2,CPEB3,CSF3,CUL9,DCT,DNAJB1,DPYSL3,DUSP2,DUSP5,DUSP6,EDA2R,EGR1,EGR2,EGR3,EIF1B,EMR1,ERO1LB,EVI2A,EXOSC10,EXOSC3,FAM122A,FAM71F1,FASLG,FASTKD5,FAT2,FBXO8,FILIP1L,FNDC5,FTMT,GABRG3,GATA3,GFI1,GJB5,GLIPR1,GLRA3,GML,GMPPB,GPR171,GRAMD3,GRHL3,GSC,HAS1,HLF,HOXB3,HS6ST3,HSPA1L,HSPB3,ID3,IER2,IFNB1,IKZF2,IL34,ITPKB,ITPRIP,JAM2,JRK,JUNB,KBTBD2,KCNQ5,KCNS3,KIF26A,KLK9,KRTAP4-6,LAMA1,LAMTOR1,LENG9,LIMA1,LRFN2,LRRC10B,LRRTM4,LYPLAL1,MAD2L1BP,MAFF,MALT1,MLLT11,MME,MYH11,MYOD1,NAB2,NCOA7,NFIB,NFKBID,NFKBIZ,NPAS2,NR4A1,NR4A2,NTSR2,OPALIN,PCDH9,PDCD1LG2,PDILT,PEBP4,PER1,PER3,PHF6,PLK3,POF1B,PPP1R11,PRDX6,PRKAB1,PRKAB2,PROM1,PTGER2,PTPN23,RAB3A,RANBP17,RANBP6,RASL10A,RCHY1,RINL,RNASE10,RPL3L,S100A5,SAG,SCN3A,SH2D2A,SHROOM1,SLC27A2,SLC6A18,SPESP1,SPINK4,SRFBP1,SRPR,STK17B,STX19,SV2A,SYT6,TCFL5,TDRD1,TFF3,TGIF2,TM6SF2,TMCC2,TMEM47,TNFRSF1B,TNRC6A,TOMM34,TRIM13,TRIM46,TRO,TSPYL4,TTC19,TUT1,TWF1,UPB1,USH2A,VAMP3,VN1R5,WISP1,WWOX,YRDC,ZEB1,ZFAND5,ZFP36,ZFP36L1,ZNF622,ZRSR2" MEMBERS_SYMBOLIZED="ACSM1,ADAD1,ADGRE1,ADO,AGRN,ANKRD42,ANXA9,APOA5,AQP9,ARIH2OS,ARL5B,ASIC5,ATG101,B3GAT3,BCL2,BCL2L2,BTG3,C16orf90,C1R,C20orf96,C21orf91,C2orf88,CA1,CACNA1S,CACNG7,CCL4,CCN4,CCNL1,CCR4,CD274,CD69,CD93,CDKN2B,CEND1,CEP135,CHRM4,COL5A2,CPEB3,CSF3,CUL9,DCT,DNAJB1,DORIP1,DPYSL3,DUSP2,DUSP5,DUSP6,EDA2R,EGR1,EGR2,EGR3,EIF1B,ELP5,ERO1B,EVI2A,EXOSC10,EXOSC3,FASLG,FASTKD5,FAT2,FBXO8,FILIP1L,FNDC5,FTMT,GABRG3,GARIN1B,GATA3,GFI1,GJB5,GLIPR1,GLRA3,GML,GMPPB,GPR171,GRAMD2B,GRHL3,GSC,GSKIP,HAS1,HLF,HOXB3,HS6ST3,HSPA1L,HSPB3,ID3,IER2,IFNB1,IKZF2,IL34,ITPKB,ITPRIP,JAM2,JRK,JUNB,KBTBD2,KCNQ5,KCNS3,KIF26A,KLK9,KRTAP4-6,LAMA1,LAMP5,LAMTOR1,LENG9,LIMA1,LRFN2,LRRC10B,LRRTM4,LYPLAL1,MAD2L1BP,MAFF,MALT1,MLLT11,MME,MYH11,MYOD1,NAB2,NCOA7,NFIB,NFKBID,NFKBIZ,NICOL1,NPAS2,NR4A1,NR4A2,NTSR2,OPALIN,PABIR1,PCDH9,PDCD1LG2,PDILT,PEBP4,PER1,PER3,PHF6,PLK3,POF1B,PPP1R11,PRDX6,PRKAB1,PRKAB2,PROM1,PTGER2,PTPN23,RAB3A,RANBP17,RANBP6,RASL10A,RCHY1,RINL,RNASE10,RPL3L,S100A5,SAG,SCN3A,SH2D2A,SHROOM1,SLC18B1,SLC27A2,SLC6A18,SPATA6L,SPESP1,SPINK4,SRFBP1,SRPRA,STK17B,STX19,SV2A,SYT6,TBC1D32,TCFL5,TDRD1,TFF3,TGIF2,TM6SF2,TMCC2,TMEM243,TMEM47,TNFRSF1B,TNRC6A,TOMM34,TRIM13,TRIM46,TRO,TSPYL4,TTC19,TUT1,TWF1,UPB1,USH2A,VAMP3,VN1R5,WWOX,YRDC,ZEB1,ZFAND5,ZFP36,ZFP36L1,ZNF622,ZRSR2" MEMBERS_EZID="10206,10289,1030,10633,10732,10892,10950,10953,10962,11001,11010,11259,1132,116224,116285,116519,116843,122525,1233,1263,126432,127018,1290,132612,134549,135112,140680,1440,145258,146433,148281,153443,157310,1638,1809,1844,1847,1848,1958,1959,1960,2015,204474,2123,2196,221079,221322,22807,22849,22918,23113,23270,23587,23620,23764,24141,246777,252995,2567,25898,25930,25948,26153,26229,2625,26269,266722,2672,26953,2709,27290,27327,2765,284217,284366,29126,29909,29925,3036,3131,3164,317705,3213,3305,3337,338699,338879,3399,3456,348932,356,366,3707,3726,375790,3790,390205,401115,415117,4311,4629,4654,4665,4781,4862,4929,5101,51010,51286,51474,51527,51733,51741,51802,5187,53345,5394,54149,54902,55004,55064,5564,5565,56165,56479,56605,57018,5732,57497,5756,57822,58494,5864,59284,596,599,60401,60436,60493,60673,6123,6276,6295,6328,6351,64332,646174,646450,64852,64901,65983,6734,677,6935,6992,7033,7133,715,7216,7399,7538,759,7763,779,79161,79693,79983,8001,80059,80128,80380,81871,8233,83604,8416,84281,84295,84691,84807,84890,85450,8629,8840,8842,8863,8988,90441,9047,9262,93377,9341,94033,94059,9587,9588,9592,9662,969,9900,9911" MEMBERS_MAPPING="ACCN5,ASIC5,51802|ACSM1,ACSM1,116285|ADAD1,ADAD1,132612|ADO,ADO,84890|AGRN,AGRN,375790|ANKRD42,ANKRD42,338699|ANXA9,ANXA9,8416|APOA5,APOA5,116519|AQP9,AQP9,366|ARL5B,ARL5B,221079|B3GAT3,B3GAT3,26229|BCL2,BCL2,596|BCL2L2,BCL2L2,599|BTG3,BTG3,10950|C12orf44,ATG101,60673|C14orf129,GSKIP,51527|C14orf28,DORIP1,122525|C16orf90,C16orf90,646174|C17orf81,ELP5,23587|C1R,C1R,715|C20orf103,LAMP5,24141|C20orf96,C20orf96,140680|C21orf91,C21orf91,54149|C2orf88,C2orf88,84281|C3orf71,ARIH2OS,646450|C4orf48,NICOL1,401115|C6orf170,TBC1D32,221322|C6orf192,SLC18B1,116843|C7orf23,TMEM243,79161|C9orf68,SPATA6L,55064|CA1,CA1,759|CACNA1S,CACNA1S,779|CACNG7,CACNG7,59284|CCL4,CCL4,6351|CCNL1,CCNL1,57018|CCR4,CCR4,1233|CD274,CD274,29126|CD69,CD69,969|CD93,CD93,22918|CDKN2B,CDKN2B,1030|CEND1,CEND1,51286|CEP135,CEP135,9662|CHRM4,CHRM4,1132|COL5A2,COL5A2,1290|CPEB3,CPEB3,22849|CSF3,CSF3,1440|CUL9,CUL9,23113|DCT,DCT,1638|DNAJB1,DNAJB1,3337|DPYSL3,DPYSL3,1809|DUSP2,DUSP2,1844|DUSP5,DUSP5,1847|DUSP6,DUSP6,1848|EDA2R,EDA2R,60401|EGR1,EGR1,1958|EGR2,EGR2,1959|EGR3,EGR3,1960|EIF1B,EIF1B,10289|EMR1,ADGRE1,2015|ERO1LB,ERO1B,56605|EVI2A,EVI2A,2123|EXOSC10,EXOSC10,5394|EXOSC3,EXOSC3,51010|FAM122A,PABIR1,116224|FAM71F1,GARIN1B,84691|FASLG,FASLG,356|FASTKD5,FASTKD5,60493|FAT2,FAT2,2196|FBXO8,FBXO8,26269|FILIP1L,FILIP1L,11259|FNDC5,FNDC5,252995|FTMT,FTMT,94033|GABRG3,GABRG3,2567|GATA3,GATA3,2625|GFI1,GFI1,2672|GJB5,GJB5,2709|GLIPR1,GLIPR1,11010|GLRA3,GLRA3,8001|GML,GML,2765|GMPPB,GMPPB,29925|GPR171,GPR171,29909|GRAMD3,GRAMD2B,65983|GRHL3,GRHL3,57822|GSC,GSC,145258|HAS1,HAS1,3036|HLF,HLF,3131|HOXB3,HOXB3,3213|HS6ST3,HS6ST3,266722|HSPA1L,HSPA1L,3305|HSPB3,HSPB3,8988|ID3,ID3,3399|IER2,IER2,9592|IFNB1,IFNB1,3456|IKZF2,IKZF2,22807|IL34,IL34,146433|ITPKB,ITPKB,3707|ITPRIP,ITPRIP,85450|JAM2,JAM2,58494|JRK,JRK,8629|JUNB,JUNB,3726|KBTBD2,KBTBD2,25948|KCNQ5,KCNQ5,56479|KCNS3,KCNS3,3790|KIF26A,KIF26A,26153|KLK9,KLK9,284366|KRTAP4-6,KRTAP4-6,81871|LAMA1,LAMA1,284217|LAMTOR1,LAMTOR1,55004|LENG9,LENG9,94059|LIMA1,LIMA1,51474|LRFN2,LRFN2,57497|LRRC10B,LRRC10B,390205|LRRTM4,LRRTM4,80059|LYPLAL1,LYPLAL1,127018|MAD2L1BP,MAD2L1BP,9587|MAFF,MAFF,23764|MALT1,MALT1,10892|MLLT11,MLLT11,10962|MME,MME,4311|MYH11,MYH11,4629|MYOD1,MYOD1,4654|NAB2,NAB2,4665|NCOA7,NCOA7,135112|NFIB,NFIB,4781|NFKBID,NFKBID,84807|NFKBIZ,NFKBIZ,64332|NPAS2,NPAS2,4862|NR4A1,NR4A1,3164|NR4A2,NR4A2,4929|NTSR2,NTSR2,23620|OPALIN,OPALIN,93377|PCDH9,PCDH9,5101|PDCD1LG2,PDCD1LG2,80380|PDILT,PDILT,204474|PEBP4,PEBP4,157310|PER1,PER1,5187|PER3,PER3,8863|PHF6,PHF6,84295|PLK3,PLK3,1263|POF1B,POF1B,79983|PPP1R11,PPP1R11,6992|PRDX6,PRDX6,9588|PRKAB1,PRKAB1,5564|PRKAB2,PRKAB2,5565|PROM1,PROM1,8842|PTGER2,PTGER2,5732|PTPN23,PTPN23,25930|RAB3A,RAB3A,5864|RANBP17,RANBP17,64901|RANBP6,RANBP6,26953|RASL10A,RASL10A,10633|RCHY1,RCHY1,25898|RINL,RINL,126432|RNASE10,RNASE10,338879|RPL3L,RPL3L,6123|S100A5,S100A5,6276|SAG,SAG,6295|SCN3A,SCN3A,6328|SH2D2A,SH2D2A,9047|SHROOM1,SHROOM1,134549|SLC27A2,SLC27A2,11001|SLC6A18,SLC6A18,348932|SPESP1,SPESP1,246777|SPINK4,SPINK4,27290|SRFBP1,SRFBP1,153443|SRPR,SRPRA,6734|STK17B,STK17B,9262|STX19,STX19,415117|SV2A,SV2A,9900|SYT6,SYT6,148281|TCFL5,TCFL5,10732|TDRD1,TDRD1,56165|TFF3,TFF3,7033|TGIF2,TGIF2,60436|TM6SF2,TM6SF2,53345|TMCC2,TMCC2,9911|TMEM47,TMEM47,83604|TNFRSF1B,TNFRSF1B,7133|TNRC6A,TNRC6A,27327|TOMM34,TOMM34,10953|TRIM13,TRIM13,10206|TRIM46,TRIM46,80128|TRO,TRO,7216|TSPYL4,TSPYL4,23270|TTC19,TTC19,54902|TUT1,TUT1,64852|TWF1,TWF1,5756|UPB1,UPB1,51733|USH2A,USH2A,7399|VAMP3,VAMP3,9341|VN1R5,VN1R5,317705|WISP1,CCN4,8840|WWOX,WWOX,51741|YRDC,YRDC,79693|ZEB1,ZEB1,6935|ZFAND5,ZFAND5,7763|ZFP36,ZFP36,7538|ZFP36L1,ZFP36L1,677|ZNF622,ZNF622,90441|ZRSR2,ZRSR2,8233" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
