STANDARD_NAME GSE17812_WT_VS_THPOK_KO_MEMORY_CD8_TCELL_DN SYSTEMATIC_NAME M7164 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE17812_WT_VS_THPOK_KO_MEMORY_CD8_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in memory CD8 T cells: wildtype wt versus ZBTB7B [GeneID=51043] knockout. DESCRIPTION_FULL We noticed that ThPOK repression is readily abrogated upon in vitro TCR stimulation of peripheral CD8 T cells. This observation prompted us to investigate a role of ThPOK in the CD8 T cell response to an acute viral infection. We observed that clonal expansion is significantly less in both primary and secondary CD8 T cell responses in the absence of functional ThPOK. To approach this mechanism, we carried out a microarray analysis for comparison of gene expression between ThPOKhd/hd and ThPOKwt/wt P14 memory T cells. PMID 19734230 GEOID GSE17812 AUTHORS Setoguchi R,Taniuchi I,Bevan MJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE17812_2733_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABI3,ACTR1B,ADAM11,ADAM17,ADORA2B,AKT1,ANP32E,AP1S2,APITD1,APOBEC3B,APP,ARHGAP21,ASAP2,ASB2,ATAD2,ATF6,ATPIF1,AURKA,AURKB,B4GALT4,BACH1,BID,BIRC3,BRI3,BUB1,BZRAP1,C11orf54,C19orf28,C7orf43,CA9,CACNB3,CADM3,CCNA2,CCNF,CCRL2,CD40,CD79B,CDC42EP3,CDCP1,CDK1,CDYL2,CEBPD,CENPF,CEP55,CHKA,CHTF18,CKS2,CRLF2,CSGALNACT2,CTBP2,CXCL10,CYBA,CYTH4,DECR1,DEK,DIAPH2,DLGAP5,DNAJB14,DOCK1,DUSP16,EEPD1,ELAC1,ELL2,ELMO1,EME1,EML3,EPS15L1,ERLIN1,ESCO2,FAM174A,FAM190A,FAR1,FBXW8,FCGRT,FCHO2,FIGNL1,FLVCR1,GCNT2,GFPT1,GKAP1,GNG2,GPX1,GSG1,HAT1,HAUS5,HIATL1,HSD17B12,IAH1,ID2,IFT172,IMMP2L,IQGAP1,ISCU,ITGA4,ITPR1,KCNE3,KRT80,LAIR1,LAMTOR1,LANCL2,LIPE,LITAF,LMAN2,LPCAT2,LRRC16A,MALT1,MAP3K14,MAP4K5,MAPRE2,MCM4,MCM7,MED30,MFSD10,MOBKL1B,MYO1H,N4BP3,NAGPA,NAP1L1,NCAPG2,NCKAP1L,NDST1,NEURL2,NFKBIE,NLRP3,NOD1,NOSTRIN,NPC1,NRM,PAICS,PAPSS1,PDGFB,PFKFB4,PLA2G4A,PLK4,POLD4,PRKCB,PRKRA,PRRC1,PTGR1,PTK2,PTPN3,RAB31,RAP1GAP2,RASGRP3,RBPJ,RCAN1,RFC2,RNF135,RNF149,RRAGC,RRBP1,SBNO2,SEMA4D,SERINC3,SH3BGRL,SIGLEC7,SLAMF7,SLBP,SLC25A39,SLC2A3,SLC4A8,SLC6A12,SMC2,SNORD89,SNX10,SORL1,SPAG5,SPC25,STMN1,SULF2,SUPT3H,SYCE2,TAX1BP3,TBC1D4,TCTEX1D2,TEX9,TFDP1,TK1,TMED3,TMEM100,TMEM206,TMEM8A,TNFAIP8,TOPBP1,TPX2,TRIM36,TRIT1,TSPAN31,TTK,TYMS,UBE2E3,UGDH,UGGT1,USP11,VAMP8,WDR13,WDR41,WHSC1,ZCCHC3,ZNF516 GENE_SYMBOLS ABI3,ACTR1B,ADAM11,ADAM17,ADORA2B,AKT1,ANP32E,AP1S2,CENPS,APOBEC3B,APP,ARHGAP21,ASAP2,ASB2,ATAD2,ATF6,ATP5IF1,AURKA,AURKB,B4GALT4,BACH1,BID,BIRC3,BRI3,BUB1,TSPOAP1,C11orf54,MFSD12,TRAPPC14,CA9,CACNB3,CADM3,CCNA2,CCNF,CCRL2,CD40,CD79B,CDC42EP3,CDCP1,CDK1,CDYL2,CEBPD,CENPF,CEP55,CHKA,CHTF18,CKS2,CRLF2,CSGALNACT2,CTBP2,CXCL10,CYBA,CYTH4,DECR1,DEK,DIAPH2,DLGAP5,DNAJB14,DOCK1,DUSP16,EEPD1,ELAC1,ELL2,ELMO1,EME1,EML3,EPS15L1,ERLIN1,ESCO2,FAM174A,CCSER1,FAR1,FBXW8,FCGRT,FCHO2,FIGNL1,FLVCR1,GCNT2,GFPT1,GKAP1,GNG2,GPX1,GSG1,HAT1,HAUS5,MFSD14B,HSD17B12,IAH1,ID2,IFT172,IMMP2L,IQGAP1,ISCU,ITGA4,ITPR1,KCNE3,KRT80,LAIR1,LAMTOR1,LANCL2,LIPE,LITAF,LMAN2,LPCAT2,CARMIL1,MALT1,MAP3K14,MAP4K5,MAPRE2,MCM4,MCM7,MED30,MFSD10,MOB1A,MYO1H,N4BP3,NAGPA,NAP1L1,NCAPG2,NCKAP1L,NDST1,NEURL2,NFKBIE,NLRP3,NOD1,NOSTRIN,NPC1,NRM,PAICS,PAPSS1,PDGFB,PFKFB4,PLA2G4A,PLK4,POLD4,PRKCB,PRKRA,PRRC1,PTGR1,PTK2,PTPN3,RAB31,RAP1GAP2,RASGRP3,RBPJ,RCAN1,RFC2,RNF135,RNF149,RRAGC,RRBP1,SBNO2,SEMA4D,SERINC3,SH3BGRL,SIGLEC7,SLAMF7,SLBP,SLC25A39,SLC2A3,SLC4A8,SLC6A12,SMC2,SNORD89,SNX10,SORL1,SPAG5,SPC25,STMN1,SULF2,SUPT3H,SYCE2,TAX1BP3,TBC1D4,DYNLT2B,TEX9,TFDP1,TK1,TMED3,TMEM100,PACC1,PGAP6,TNFAIP8,TOPBP1,TPX2,TRIM36,TRIT1,TSPAN31,TTK,TYMS,UBE2E3,UGDH,UGGT1,USP11,VAMP8,WDR13,WDR41,NSD2,ZCCHC3,ZNF516 FOUNDER_NAMES