STANDARD_NAME GSE19198_1H_VS_24H_IL21_TREATED_TCELL_UP SYSTEMATIC_NAME M7234 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE19198_1H_VS_24H_IL21_TREATED_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in T cells treated with IL21 [GeneID=59067]: 1h versus 24h. DESCRIPTION_FULL Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. We identified an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF4, which are required for optimal Prdm1 expression. Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo, and furthermore, revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. Comparing genome-wide expression array data to binding sites revealed that most IL-21-regulated genes were associated with combined STAT3-IRF4 sites rather than pure STAT3 sites. Correspondingly, ChIP-Seq analysis of Irf4_/_ T cells showed greatly diminished STAT3 binding after IL-21 treatment, and Irf4_/_ mice showed impaired IL- 21-induced Tfh cell differentiation in vivo. These results reveal broad cooperative gene regulation by STAT3 and IRF4. PMID 20064451 GEOID GSE19198 AUTHORS Kwon H,Thierry-Mieg D,Thierry-Mieg J,Kim HP,Oh J,Tunyaplin C,Carotta S,Donovan CE,Goldman ML,Tailor P,Ozato K,Levy DE,Nutt SL,Calame K,Leonard WJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE19198_2368_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCD1,ACAA2,ACAT1,ADAMTS10,ADD3,ADRB1,AES,AKR7A2,ALDH3B1,ANGPTL2,ANKMY2,ANKRD44,ANTXR1,ANTXR2,APCDD1,APOBR,ARHGAP18,ARHGAP21,ARHGAP4,ARHGAP9,ASAP1,ATP13A2,ATP2A3,B3GNT9,BET1,BMP2,BVES,C1orf93,C4orf34,C6orf57,CAB39L,CARD10,CAV1,CAV2,CBX7,CD300A,CD3G,CD96,CD97,CEACAM21,CLEC6A,CLEC7A,COG6,COTL1,CRIP2,CSF1R,CTNND1,CX3CR1,CXCR2,CYB5R1,CYP4A22,DBP,DES,DGKA,DHRS1,DHRS7,EBPL,EML3,ENO3,EPB41L2,ERO1LB,ESYT1,EVI2A,EVI2B,EXT2,FAM105A,FAM198B,FGF13,FHL1,FMO5,FPR1,FUCA1,FYCO1,GDPD2,GOLIM4,GRHPR,H1F0,HADH,HFE,HGSNAT,HINT2,HIP1,HLA-A,HSD17B4,ID4,IDH1,ITCH,ITGAL,ITGAX,ITGB7,KCNAB2,KCNJ10,LCK,LDB2,LIMCH1,LIPA,LPIN1,LRG1,LRMP,LRRN1,MAFB,MAN2B1,MAPK3,MDP1,METTL22,MID2,MSX1,MTMR6,MXRA8,MYADM,MYO1F,NAAA,NADK,NCF2,NGFR,NHSL1,NNT,NR1H3,NRM,PAPSS1,PARVG,PDLIM2,PGRMC1,PIGP,PILRA,PLBD1,PLCE1,PLEKHO2,PLOD2,PLVAP,PLXNB2,PPDPF,PPP3CA,PRCP,PRKACA,PRKCB,PRKCD,PRPSAP2,PRRX2,PTK7,PTPRF,PTPRM,RAB6B,RAMP1,RARG,RASA3,RASD2,RASGRP4,RECK,RFNG,RNF130,RNF38,RUFY1,RUNX1T1,SCP2,SDPR,SEMA5A,SH2D3C,SH3KBP1,SIAE,SLC40A1,SLC46A3,SMPD5,SMPDL3A,SPNS2,SRD5A3,SREBF2,SRPK3,SSPN,STAB2,STAP1,STAR,STK11IP,SUCNR1,SULF2,SVIL,SYNE2,TCF21,TEC,TECR,TEK,TGFB1,TGFBI,TGM1,TIMP2,TLX1,TMEM176B,TMEM35,TMEM71,TNXB,TSC22D1,TSPAN7,TTC35,UGP2,USHBP1,UVRAG,VANGL1,VAV2,WBP1,ZNF521 GENE_SYMBOLS ABCD1,ACAA2,ACAT1,ADAMTS10,ADD3,ADRB1,TLE5,AKR7A2,ALDH3B1,ANGPTL2,ANKMY2,ANKRD44,ANTXR1,ANTXR2,APCDD1,APOBR,ARHGAP18,ARHGAP21,ARHGAP4,ARHGAP9,ASAP1,ATP13A2,ATP2A3,B3GNT9,BET1,BMP2,BVES,PRXL2B,SMIM14,SDHAF4,CAB39L,CARD10,CAV1,CAV2,CBX7,CD300A,CD3G,CD96,ADGRE5,CEACAM21,CLEC6A,CLEC7A,COG6,COTL1,CRIP2,CSF1R,CTNND1,CX3CR1,CXCR2,CYB5R1,CYP4A22,DBP,DES,DGKA,DHRS1,DHRS7,EBPL,EML3,ENO3,EPB41L2,ERO1B,ESYT1,EVI2A,EVI2B,EXT2,OTULINL,GASK1B,FGF13,FHL1,FMO5,FPR1,FUCA1,FYCO1,GDPD2,GOLIM4,GRHPR,H1-0,HADH,HFE,HGSNAT,HINT2,HIP1,HLA-A,HSD17B4,ID4,IDH1,ITCH,ITGAL,ITGAX,ITGB7,KCNAB2,KCNJ10,LCK,LDB2,LIMCH1,LIPA,LPIN1,LRG1,IRAG2,LRRN1,MAFB,MAN2B1,MAPK3,MDP1,METTL22,MID2,MSX1,MTMR6,MXRA8,MYADM,MYO1F,NAAA,NADK,NCF2,NGFR,NHSL1,NNT,NR1H3,NRM,PAPSS1,PARVG,PDLIM2,PGRMC1,PIGP,PILRA,PLBD1,PLCE1,PLEKHO2,PLOD2,PLVAP,PLXNB2,PPDPF,PPP3CA,PRCP,PRKACA,PRKCB,PRKCD,PRPSAP2,PRRX2,PTK7,PTPRF,PTPRM,RAB6B,RAMP1,RARG,RASA3,RASD2,RASGRP4,RECK,RFNG,RNF130,RNF38,RUFY1,RUNX1T1,SCP2,CAVIN2,SEMA5A,SH2D3C,SH3KBP1,SIAE,SLC40A1,SLC46A3,SMPD5,SMPDL3A,SPNS2,SRD5A3,SREBF2,SRPK3,SSPN,STAB2,STAP1,STAR,STK11IP,SUCNR1,SULF2,SVIL,SYNE2,TCF21,TEC,TECR,TEK,TGFB1,TGFBI,TGM1,TIMP2,TLX1,TMEM176B,TMEM35A,TMEM71,TNXB,TSC22D1,TSPAN7,EMC2,UGP2,USHBP1,UVRAG,VANGL1,VAV2,WBP1,ZNF521 FOUNDER_NAMES