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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE19198_CTRL_VS_IL21_TREATED_TCELL_6H_UP" SYSTEMATIC_NAME="M7221" HISTORICAL_NAMES="" PMID="20064451" AUTHORS="Kwon H,Thierry-Mieg D,Thierry-Mieg J,Kim HP,Oh J,Tunyaplin C,Carotta S,Donovan CE,Goldman ML,Tailor P,Ozato K,Levy DE,Nutt SL,Calame K,Leonard WJ" GEOID="GSE19198" EXACT_SOURCE="GSE19198_2365_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in T cells: control (0h) versus IL21 [GeneID=59067] treatment for 6h." DESCRIPTION_FULL="Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. We identified an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF4, which are required for optimal Prdm1 expression. Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo, and furthermore, revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. Comparing genome-wide expression array data to binding sites revealed that most IL-21-regulated genes were associated with combined STAT3-IRF4 sites rather than pure STAT3 sites. Correspondingly, ChIP-Seq analysis of Irf4_/_ T cells showed greatly diminished STAT3 binding after IL-21 treatment, and Irf4_/_ mice showed impaired IL- 21-induced Tfh cell differentiation in vivo. These results reveal broad cooperative gene regulation by STAT3 and IRF4." TAGS="" MEMBERS="ADAT2,ADCK3,AFF1,AHCY,AIF1,AMICA1,ANKS1A,ARAP2,ARHGAP4,ARL2,ATM,ATP5B,ATP5D,ATP8B4,BCAR3,BIRC3,BLVRA,BLVRB,BTF3L4,BZW2,C14orf159,C17orf90,C17orf96,C3orf21,C6orf108,C9orf72,CAPNS1,CBR3,CCDC85B,CCL13,CCL23,CCT3,CD209,CD33,CD48,CDC123,CDK6,CHST15,CLIP2,CMAHP,CORO1A,CSF2RB,CUL9,CXCL2,CYC1,CYSLTR1,CYTH4,DAGLA,DAP,DARS,DCLRE1B,DCTPP1,DHRS9,DTD1,EHD1,EHD4,EMB,EMILIN2,ENTPD6,EXT1,FAR2,FCER2,FCGR2B,FIGNL1,FIS1,FLI1,FNBP1,FRMD4B,GALK1,GATM,GGTA1P,GIMAP5,GINS1,GMFG,GNAI2,GPI,HCST,HLX,HMHA1,HN1L,HRH1,HSPA6,IDH3G,IFI16,IFITM2,IFITM3,IL10RA,IL18BP,IL2RG,IMP4,INPP5D,IPO4,ITSN1,JUP,KIAA0889,LILRB2,LRRC25,LRRC33,MAP3K1,MARCH1,MCM6,METRNL,MGRN1,MIF,MLLT6,MOBKL1B,MOBKL2C,MPEG1,MPP1,MRPL15,MRPL24,MYC,NAIP,NAMPT,NCF4,NDUFV1,NECAP2,NHP2L1,NME1,NOB1,NRP2,NUCKS1,OAS2,OBFC2A,OGDH,OXCT1,P2RY12,P2RY13,P2RY14,PAPSS2,PARL,PDCD4,PDLIM2,PFKM,PFKP,PHTF2,PIGX,PIK3R6,PLEK,POLD2,PPARGC1B,PPP2R4,PRDX4,PRKACB,PRMT1,PRSS23,QTRT1,RAB33A,RAN,RBPJ,RCSD1,RNF125,RNF128,RNF144B,RUVBL1,SCARB1,SCFD2,SECTM1,SELPLG,SETD7,SFXN4,SIGLEC1,SLC16A7,SLC25A12,SLC25A5,SLC46A3,SLCO3A1,SLITRK4,SNAP23,SNX6,SRI,SRM,ST3GAL5,SUCLG1,SULF2,SYNE1,TBC1D14,TBC1D2B,TBCB,TCF4,THOC1,TMEM173,TMOD2,TNFAIP2,TNFRSF1A,TNIP1,TRAF3,TRAP1,TRERF1,TRIM32,TSPAN4,TTYH2,TUBA1A,TUBB,TXN2,UBAC1,UROS,VARS,WASF2,XPO6" MEMBERS_SYMBOLIZED="ADAT2,AFF1,AHCY,AIF1,ANKS1A,ARAP2,ARHGAP4,ARHGAP45,ARL2,ATM,ATP5F1B,ATP5F1D,ATP8B4,BCAR3,BIRC3,BLVRA,BLVRB,BTF3L4,BZW2,C9orf72,CAPNS1,CBR3,CCDC85B,CCL13,CCL23,CCT3,CD209,CD33,CD48,CDC123,CDK6,CHST15,CLIP2,CMAHP,COQ8A,CORO1A,CSF2RB,CUL9,CXCL2,CYC1,CYSLTR1,CYTH4,DAGLA,DAP,DARS1,DCLRE1B,DCTPP1,DGLUCY,DHRS9,DNPH1,DTD1,EHD1,EHD4,EMB,EMILIN2,ENTPD6,EPOP,EXT1,FAR2,FCER2,FCGR2B,FIGNL1,FIS1,FLI1,FNBP1,FRMD4B,GALK1,GATM,GGTA1,GIMAP5,GINS1,GMFG,GNAI2,GPI,HCST,HLX,HRH1,HSPA6,IDH3G,IFI16,IFITM2,IFITM3,IL10RA,IL18BP,IL2RG,IMP4,INPP5D,IPO4,ITSN1,JAML,JPT2,JUP,LILRB2,LRRC25,MAP3K1,MARCHF1,MCM6,METRNL,MGRN1,MIF,MLLT6,MOB1A,MOB3C,MPEG1,MPP1,MRPL15,MRPL24,MTCL2,MYC,NABP1,NAIP,NAMPT,NCF4,NDUFV1,NECAP2,NME1,NOB1,NRP2,NRROS,NUCKS1,OAS2,OGDH,OXCT1,OXLD1,P2RY12,P2RY13,P2RY14,PAPSS2,PARL,PDCD4,PDLIM2,PFKM,PFKP,PHTF2,PIGX,PIK3R6,PLEK,POLD2,PPARGC1B,PRDX4,PRKACB,PRMT1,PRSS23,PTPA,QTRT1,RAB33A,RAN,RBPJ,RCSD1,RNF125,RNF128,RNF144B,RUVBL1,SCARB1,SCFD2,SECTM1,SELPLG,SETD7,SFXN4,SIGLEC1,SLC16A7,SLC25A12,SLC25A5,SLC46A3,SLCO3A1,SLITRK4,SNAP23,SNU13,SNX6,SRI,SRM,ST3GAL5,STING1,SUCLG1,SULF2,SYNE1,TBC1D14,TBC1D2B,TBCB,TCF4,THOC1,TMOD2,TNFAIP2,TNFRSF1A,TNIP1,TRAF3,TRAP1,TRERF1,TRIM32,TSPAN4,TTYH2,TUBA1A,TUBB,TXN2,UBAC1,UROS,VARS1,WASF2,XPO6,XXYLT1" MEMBERS_EZID="100170841,10068,10131,10135,10163,10170,1021,10288,10318,10410,10422,10549,10581,10591,10800,10870,10938,11007,11098,11151,1155,116984,119559,120425,126364,133418,133522,134637,139065,140710,1439,146850,148932,152002,152579,1537,1611,1615,191,199,203068,203228,2131,219972,2208,2213,22954,23048,23102,23113,2313,23150,23214,23294,23295,23345,23526,255488,25828,2584,2628,2681,27128,27250,2771,2821,28232,283537,284207,28969,28987,29088,292,2920,29767,30835,30844,3142,3269,3276,330,3310,339229,340061,3421,3428,3516,3561,3587,3635,3728,375387,393,402,4175,4214,4282,4299,4302,4354,4609,4671,4689,472,4723,4809,4830,4939,4967,5019,506,51024,513,51363,5213,5214,5341,53829,5425,54941,54965,55016,55233,5524,55340,55486,5567,55707,55711,55809,55959,56997,57157,57533,58533,5901,6357,6368,63979,6398,6404,64236,644,645,6453,64710,64805,64858,64859,6614,6717,6723,6925,7106,7127,7132,7187,7203,7390,7407,7461,747,7846,79077,79589,79590,79711,79895,80017,80854,81890,826,84034,8412,8418,8604,8607,874,8773,8802,8828,8869,8872,9060,90861,91408,9194,92241,92675,92856,9363,94015,945,949,9535,955,962,9837,9934,9984" MEMBERS_MAPPING="ADAT2,ADAT2,134637|ADCK3,COQ8A,56997|AFF1,AFF1,4299|AHCY,AHCY,191|AIF1,AIF1,199|AMICA1,JAML,120425|ANKS1A,ANKS1A,23294|ARAP2,ARAP2,116984|ARHGAP4,ARHGAP4,393|ARL2,ARL2,402|ATM,ATM,472|ATP5B,ATP5F1B,506|ATP5D,ATP5F1D,513|ATP8B4,ATP8B4,79895|BCAR3,BCAR3,8412|BIRC3,BIRC3,330|BLVRA,BLVRA,644|BLVRB,BLVRB,645|BTF3L4,BTF3L4,91408|BZW2,BZW2,28969|C14orf159,DGLUCY,80017|C17orf90,OXLD1,339229|C17orf96,EPOP,100170841|C3orf21,XXYLT1,152002|C6orf108,DNPH1,10591|C9orf72,C9orf72,203228|CAPNS1,CAPNS1,826|CBR3,CBR3,874|CCDC85B,CCDC85B,11007|CCL13,CCL13,6357|CCL23,CCL23,6368|CCT3,CCT3,7203|CD209,CD209,30835|CD33,CD33,945|CD48,CD48,962|CDC123,CDC123,8872|CDK6,CDK6,1021|CHST15,CHST15,51363|CLIP2,CLIP2,7461|CMAHP,CMAHP,8418|CORO1A,CORO1A,11151|CSF2RB,CSF2RB,1439|CUL9,CUL9,23113|CXCL2,CXCL2,2920|CYC1,CYC1,1537|CYSLTR1,CYSLTR1,10800|CYTH4,CYTH4,27128|DAGLA,DAGLA,747|DAP,DAP,1611|DARS,DARS1,1615|DCLRE1B,DCLRE1B,64858|DCTPP1,DCTPP1,79077|DHRS9,DHRS9,10170|DTD1,DTD1,92675|EHD1,EHD1,10938|EHD4,EHD4,30844|EMB,EMB,133418|EMILIN2,EMILIN2,84034|ENTPD6,ENTPD6,955|EXT1,EXT1,2131|FAR2,FAR2,55711|FCER2,FCER2,2208|FCGR2B,FCGR2B,2213|FIGNL1,FIGNL1,63979|FIS1,FIS1,51024|FLI1,FLI1,2313|FNBP1,FNBP1,23048|FRMD4B,FRMD4B,23150|GALK1,GALK1,2584|GATM,GATM,2628|GGTA1P,GGTA1,2681|GIMAP5,GIMAP5,55340|GINS1,GINS1,9837|GMFG,GMFG,9535|GNAI2,GNAI2,2771|GPI,GPI,2821|HCST,HCST,10870|HLX,HLX,3142|HMHA1,ARHGAP45,23526|HN1L,JPT2,90861|HRH1,HRH1,3269|HSPA6,HSPA6,3310|IDH3G,IDH3G,3421|IFI16,IFI16,3428|IFITM2,IFITM2,10581|IFITM3,IFITM3,10410|IL10RA,IL10RA,3587|IL18BP,IL18BP,10068|IL2RG,IL2RG,3561|IMP4,IMP4,92856|INPP5D,INPP5D,3635|IPO4,IPO4,79711|ITSN1,ITSN1,6453|JUP,JUP,3728|KIAA0889,MTCL2,140710|LILRB2,LILRB2,10288|LRRC25,LRRC25,126364|LRRC33,NRROS,375387|MAP3K1,MAP3K1,4214|MARCH1,MARCHF1,55016|MCM6,MCM6,4175|METRNL,METRNL,284207|MGRN1,MGRN1,23295|MIF,MIF,4282|MLLT6,MLLT6,4302|MOBKL1B,MOB1A,55233|MOBKL2C,MOB3C,148932|MPEG1,MPEG1,219972|MPP1,MPP1,4354|MRPL15,MRPL15,29088|MRPL24,MRPL24,79590|MYC,MYC,4609|NAIP,NAIP,4671|NAMPT,NAMPT,10135|NCF4,NCF4,4689|NDUFV1,NDUFV1,4723|NECAP2,NECAP2,55707|NHP2L1,SNU13,4809|NME1,NME1,4830|NOB1,NOB1,28987|NRP2,NRP2,8828|NUCKS1,NUCKS1,64710|OAS2,OAS2,4939|OBFC2A,NABP1,64859|OGDH,OGDH,4967|OXCT1,OXCT1,5019|P2RY12,P2RY12,64805|P2RY13,P2RY13,53829|P2RY14,P2RY14,9934|PAPSS2,PAPSS2,9060|PARL,PARL,55486|PDCD4,PDCD4,27250|PDLIM2,PDLIM2,64236|PFKM,PFKM,5213|PFKP,PFKP,5214|PHTF2,PHTF2,57157|PIGX,PIGX,54965|PIK3R6,PIK3R6,146850|PLEK,PLEK,5341|POLD2,POLD2,5425|PPARGC1B,PPARGC1B,133522|PPP2R4,PTPA,5524|PRDX4,PRDX4,10549|PRKACB,PRKACB,5567|PRMT1,PRMT1,3276|PRSS23,PRSS23,11098|QTRT1,QTRT1,81890|RAB33A,RAB33A,9363|RAN,RAN,5901|RBPJ,RBPJ,3516|RCSD1,RCSD1,92241|RNF125,RNF125,54941|RNF128,RNF128,79589|RNF144B,RNF144B,255488|RUVBL1,RUVBL1,8607|SCARB1,SCARB1,949|SCFD2,SCFD2,152579|SECTM1,SECTM1,6398|SELPLG,SELPLG,6404|SETD7,SETD7,80854|SFXN4,SFXN4,119559|SIGLEC1,SIGLEC1,6614|SLC16A7,SLC16A7,9194|SLC25A12,SLC25A12,8604|SLC25A5,SLC25A5,292|SLC46A3,SLC46A3,283537|SLCO3A1,SLCO3A1,28232|SLITRK4,SLITRK4,139065|SNAP23,SNAP23,8773|SNX6,SNX6,58533|SRI,SRI,6717|SRM,SRM,6723|ST3GAL5,ST3GAL5,8869|SUCLG1,SUCLG1,8802|SULF2,SULF2,55959|SYNE1,SYNE1,23345|TBC1D14,TBC1D14,57533|TBC1D2B,TBC1D2B,23102|TBCB,TBCB,1155|TCF4,TCF4,6925|THOC1,THOC1,9984|TMEM173,STING1,340061|TMOD2,TMOD2,29767|TNFAIP2,TNFAIP2,7127|TNFRSF1A,TNFRSF1A,7132|TNIP1,TNIP1,10318|TRAF3,TRAF3,7187|TRAP1,TRAP1,10131|TRERF1,TRERF1,55809|TRIM32,TRIM32,22954|TSPAN4,TSPAN4,7106|TTYH2,TTYH2,94015|TUBA1A,TUBA1A,7846|TUBB,TUBB,203068|TXN2,TXN2,25828|UBAC1,UBAC1,10422|UROS,UROS,7390|VARS,VARS1,7407|WASF2,WASF2,10163|XPO6,XPO6,23214" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
