STANDARD_NAME GSE19772_CTRL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_UP SYSTEMATIC_NAME M7288 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE19772_CTRL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in monocytes pre-treated with Ly294002 [PubChem=3973]: control versus HCMV infection. DESCRIPTION_FULL Human cytomegalovirus (HCMV) induces pro-inflammatory monocytes following infection and we have evidence that phosphatidylinositol 3-kinase [PI(3)K] is a key mediator in this activation. To begin to address how this signalling pathway is responsible for the functional changes in infected monocytes, we examined the role this pathway played in the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number of genes were regulated in a PI(3)K-dependent manner, identifying this pathway as a key cellular control point in the conversion of monocytes to an activated pro-inflammatory state following HCMV infection. PMID 20173022 GEOID GSE19772 AUTHORS Chan G,Nogalski MT,Bentz GL,Smith MS,Parmater A,Yurochko AD CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE19772_3042_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABL2,ACCN2,ACSM2A,AKAP8,ALG13,APOA5,ARL2BP,ATG4D,ATP1A2,ATP2A2,BET1L,BIRC2,BIRC3,BMS1,BTLA,C12orf29,C13orf27,C16orf42,C1orf100,C1orf162,C20orf24,C2CD2L,C7orf45,C9orf152,CBFB,CBR1,CCDC12,CCIN,CCNJ,CDH12,CHPF2,CHRNA1,CHRND,CLIP2,CLSTN2,COQ10B,COX4NB,CREB5,CTCF,CTTNBP2NL,CYCS,DAZAP1,DBNL,DCP1A,DCUN1D5,DDI2,DDX27,DEXI,DHRS2,DTHD1,EBNA1BP2,ENTPD7,EPT1,FAM105B,FAM203A,FASN,FBXO28,GAN,GLRX2,GLYATL1,GOLGA2,GOLPH3,GOPC,GPR172A,GPR50,GSK3A,H2AFX,HDHD1,HES6,HIST1H2AJ,HIST1H4I,IL17RA,INSC,IPPK,JAGN1,KCNJ16,KIAA0319,KLHDC5,LAMC2,LANCL2,LEMD3,LIN37,LMNB2,LMO1,LOC100129112,LOC100287584,LOC100506388,LOC253962,LOC284551,LOC285548,LOC494558,LOC642426,LOC644852,LOC645722,LOC729680,LPP,LPPR2,LRRC2,LRRC8E,LSG1,MAGEB6,MGC4294,MICALL1,MIER2,MLF2,MPHOSPH6,MRPS18C,MRPS22,MTMR9,MYBBP1A,MYO10,MYO9B,NFKBIZ,NKX3-1,NOL6,NUDC,NUP54,OBFC2A,ODF3L1,OPA3,OR3A3,PATE2,PDE4B,PIGA,PIK3CD,PNPLA1,POLE3,POLR3A,POLR3G,POU4F2,PPP1R8,PPP2CA,PPP2R2D,PREB,PRF1,PRPF3,PRPF40A,PRPF6,PRRC1,RCSD1,REEP2,RIC8A,RPP40,RRN3P3,RTKN,S1PR5,SAMD4B,SCN3B,SDHC,SEC23IP,SGPL1,SGSM3,SH3RF3,SHROOM1,SLC25A44,SLC2A6,SLC35A2,SMCR7L,SMTN,SOCS4,SPRNP1,SPRYD5,SPZ1,SRM,SRP54,SRP68,SSTR4,ST20,STAR,STARD13,STARD8,SYNCRIP,TCEB3,TCF24,TMEM188,TMEM33,TMEM41B,TOE1,TP53INP2,TPCN2,TRIB1,TRIM61,TRIM62,TSTD2,TUBA1B,TUBA1C,UBE2S,UPB1,USP36,USP7,VENTX,WDR26,ZBTB11,ZNF322A,ZNF398,ZNF407,ZNF417,ZNF777,ZNF791,ZZEF1 GENE_SYMBOLS ABL2,ASIC1,ACSM2A,AKAP8,ALG13,APOA5,ARL2BP,ATG4D,ATP1A2,ATP2A2,BET1L,BIRC2,BIRC3,BMS1,BTLA,C12orf29,TEX30,TSR3,C1orf100,C1orf162,RAB5IF,C2CD2L,SSMEM1,C9orf152,CBFB,CBR1,CCDC12,CCIN,CCNJ,CDH12,CHPF2,CHRNA1,CHRND,CLIP2,CLSTN2,COQ10B,EMC8,CREB5,CTCF,CTTNBP2NL,CYCS,DAZAP1,DBNL,DCP1A,DCUN1D5,DDI2,DDX27,DEXI,DHRS2,DTHD1,EBNA1BP2,ENTPD7,SELENOI,OTULIN,HGH1,FASN,FBXO28,GAN,GLRX2,GLYATL1,GOLGA2,GOLPH3,GOPC,SLC52A2,GPR50,GSK3A,H2AX,PUDP,HES6,H2AC14,H4C9,IL17RA,INSC,IPPK,JAGN1,KCNJ16,KIAA0319,KLHL42,LAMC2,LANCL2,LEMD3,LIN37,LMNB2,LMO1,,,RPH3AL-AS1,CACNA1G-AS1,LINC01226,LINC01096,CFAP95-DT,LINC02297,,,,LPP,PLPPR2,LRRC2,LRRC8E,LSG1,MAGEB6,LINC01711,MICALL1,MIER2,MLF2,MPHOSPH6,MRPS18C,MRPS22,MTMR9,MYBBP1A,MYO10,MYO9B,NFKBIZ,NKX3-1,NOL6,NUDC,NUP54,NABP1,ODF3L1,OPA3,OR3A3,PATE2,PDE4B,PIGA,PIK3CD,PNPLA1,POLE3,POLR3A,POLR3G,POU4F2,PPP1R8,PPP2CA,PPP2R2D,PREB,PRF1,PRPF3,PRPF40A,PRPF6,PRRC1,RCSD1,REEP2,RIC8A,RPP40,RRN3P3,RTKN,S1PR5,SAMD4B,SCN3B,SDHC,SEC23IP,SGPL1,SGSM3,SH3RF3,SHROOM1,SLC25A44,SLC2A6,SLC35A2,MIEF1,SMTN,SOCS4,,TRIM51,SPZ1,SRM,SRP54,SRP68,SSTR4,ST20,STAR,STARD13,STARD8,SYNCRIP,ELOA,TCF24,CNEP1R1,TMEM33,TMEM41B,TOE1,TP53INP2,TPCN2,TRIB1,TRIM61,TRIM62,TSTD2,TUBA1B,TUBA1C,UBE2S,UPB1,USP36,USP7,VENTX,WDR26,ZBTB11,ZNF322,ZNF398,ZNF407,ZNF417,ZNF777,ZNF791,ZZEF1 FOUNDER_NAMES