STANDARD_NAME GSE19772_HCMV_INFL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_UP SYSTEMATIC_NAME M7283 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE19772_HCMV_INFL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in monocytes after HCMV infection: untreated versus pre-treated with Ly294002 [PubChem=3973]. DESCRIPTION_FULL Human cytomegalovirus (HCMV) induces pro-inflammatory monocytes following infection and we have evidence that phosphatidylinositol 3-kinase [PI(3)K] is a key mediator in this activation. To begin to address how this signalling pathway is responsible for the functional changes in infected monocytes, we examined the role this pathway played in the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number of genes were regulated in a PI(3)K-dependent manner, identifying this pathway as a key cellular control point in the conversion of monocytes to an activated pro-inflammatory state following HCMV infection. PMID 20173022 GEOID GSE19772 AUTHORS Chan G,Nogalski MT,Bentz GL,Smith MS,Parmater A,Yurochko AD CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE19772_3043_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACTA1,ACTL6B,ACY1,ADA,ADCY6,ADCYAP1R1,AFP,ANGPTL2,ANKRD11,ANXA3,ARID3B,ARL4C,ATP5G1,BARX1,BCL7B,BMP1,BZW2,C11orf16,C1orf52,C20orf29,C3AR1,C7orf70,C8G,CAMK2A,CCDC164,CCDC93,CCR7,CD151,CD5L,CD79A,CD8B,CD97,CDH16,CDS2,CDSN,CEBPA,CELA1,CELSR1,CFP,CIC,CLCN7,CLDN7,CLEC11A,CLEC4F,CMTM4,CNTROB,DAB2IP,DCX,DDR2,DHODH,DLG3,DNAJB5,DNTT,DPYSL4,DSC1,EFNA2,EIF3F,EIF4EBP2,ELK4,EMID2,EPAS1,EPX,ERF,EXO1,EXOSC8,F10,F2RL3,F5,FAM101B,FAM195B,FASTKD5,FBLN2,FGF5,FGFR4,FLT1,FMNL3,GADD45B,GAMT,GDNF,GGT1,GJA8,GJB5,GPR27,GRB10,GRK6,GSTM3,HCN3,HEMGN,HS3ST3A1,HTR3A,IDS,IGFBPL1,IL6R,IMMT,INA,ISLR,JUP,KCNJ11,KHDC1L,KIF5A,KLF1,KLF13,KLF5,KLKB1,KRT17,KRT81,LAMB1,LCOR,LDB2,LMO2,LY6D,MAFF,MCM6,MED27,MEF2B,MIA,MMP11,MST1,MYBL2,MYL4,NAP1L4,NCAPH,NHSL2,NOTCH1,NPPA,NR1H2,OAZ3,OC90,ORC1,PAPOLA,PARM1,PAX2,PAX8,PDGFRB,PDYN,PIP5K1C,PKDCC,PKNOX1,PLP1,PLXNB2,PMEL,PNKD,POLR2L,POU3F1,PRKCZ,PRR15,PRRC2A,PTCRA,PTPRK,RAB3A,RAD54L,RAMP2,RBP1,RFWD2,RGS11,RPS25,RSPO2,RXRA,SCMH1,SEMA6B,SEMA6D,SERPINA10,SERPIND1,SFRP2,SIM2,SIT1,SLC16A2,SLC22A4,SLC22A6,SLC2A2,SLC4A1,SLC4A4,SLC5A11,SLC6A3,SMPD2,SOCS3,SORD,SRCIN1,SYT11,TARBP2,TCF7L1,TCP10L,TECTA,TGFBR1,TMUB2,TNNC2,TPO,TRAIP,TRPC4,TSN,TSPYL1,TUBB6,TULP3,USP3,VDR,WNT5B,WWTR1,XCR1,ZNF385A,ZNF703 GENE_SYMBOLS ACTA1,ACTL6B,ACY1,ADA,ADCY6,ADCYAP1R1,AFP,ANGPTL2,ANKRD11,ANXA3,ARID3B,ARL4C,ATP5MC1,BARX1,BCL7B,BMP1,BZW2,C11orf16,C1orf52,AP5S1,C3AR1,FAM220A,C8G,CAMK2A,DRC1,CCDC93,CCR7,CD151,CD5L,CD79A,CD8B,ADGRE5,CDH16,CDS2,CDSN,CEBPA,CELA1,CELSR1,CFP,CIC,CLCN7,CLDN7,CLEC11A,CLEC4F,CMTM4,CNTROB,DAB2IP,DCX,DDR2,DHODH,DLG3,DNAJB5,DNTT,DPYSL4,DSC1,EFNA2,EIF3F,EIF4EBP2,ELK4,COL26A1,EPAS1,EPX,ERF,EXO1,EXOSC8,F10,F2RL3,F5,RFLNB,MCRIP1,FASTKD5,FBLN2,FGF5,FGFR4,FLT1,FMNL3,GADD45B,GAMT,GDNF,GGT1,GJA8,GJB5,GPR27,GRB10,GRK6,GSTM3,HCN3,HEMGN,HS3ST3A1,HTR3A,IDS,IGFBPL1,IL6R,IMMT,INA,ISLR,JUP,KCNJ11,KHDC1L,KIF5A,KLF1,KLF13,KLF5,KLKB1,KRT17,KRT81,LAMB1,LCOR,LDB2,LMO2,LY6D,MAFF,MCM6,MED27,MEF2B,MIA,MMP11,MST1,MYBL2,MYL4,NAP1L4,NCAPH,NHSL2,NOTCH1,NPPA,NR1H2,OAZ3,OC90,ORC1,PAPOLA,PARM1,PAX2,PAX8,PDGFRB,PDYN,PIP5K1C,PKDCC,PKNOX1,PLP1,PLXNB2,PMEL,PNKD,POLR2L,POU3F1,PRKCZ,PRR15,PRRC2A,PTCRA,PTPRK,RAB3A,RAD54L,RAMP2,RBP1,COP1,RGS11,RPS25,RSPO2,RXRA,SCMH1,SEMA6B,SEMA6D,SERPINA10,SERPIND1,SFRP2,SIM2,SIT1,SLC16A2,SLC22A4,SLC22A6,SLC2A2,SLC4A1,SLC4A4,SLC5A11,SLC6A3,SMPD2,SOCS3,SORD,SRCIN1,SYT11,TARBP2,TCF7L1,TCP10L,TECTA,TGFBR1,TMUB2,TNNC2,TPO,TRAIP,TRPC4,TSN,TSPYL1,TUBB6,TULP3,USP3,VDR,WNT5B,WWTR1,XCR1,ZNF385A,ZNF703 FOUNDER_NAMES