STANDARD_NAME GSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP SYSTEMATIC_NAME M4299 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] high T cells at. DESCRIPTION_FULL CD25, the high affinity interleukin-2 (IL-2) receptor alpha-chain, is rapidly upregulated by antigen-specific CD8+ T cells after T cell receptor stimulation. We demonstrated that during an acute viral infection, CD25 expression was dynamic, and a subset of virus-specific CD8+ T cells sustained CD25 expression longer than the rest. Examination of the in vivo fate of effector CD8+ T cells exhibiting differential responsiveness to IL-2 revealed that CD25lo cells, which were relatively less sensitive to IL-2, preferentially upregulated CD127 and CD62L and gave rise to the functional long-lived memory pool. In contrast, CD25hi cells that accumulate enhanced IL-2 signals, proliferated more rapidly, were prone to apoptosis, exhibited a more pronounced effector phenotype, and appeared to be terminally differentiated. Sustained IL-2 receptor signaling resulted in increased CD8+ T cell proliferation, higher granzyme B expression and exaggerated contraction after antigen clearance. These data support the hypothesis that prolonged IL-2 signals during priming promote terminal effector differentiation of CD8+ T cells. PMID 20096608 GEOID GSE19825 AUTHORS Kalia V,Sarkar S,Subramaniam S,Haining WN,Smith KA,Ahmed R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE19825_1388_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACTN1,ACVR1,ADAM12,ADAM28,AGXT,AKAP6,ALDH5A1,ANGPTL1,AR,ARHGEF25,ATP7B,AZGP1,BCL2L11,BHLHE41,BIRC3,BMPR1A,BTG1,C10orf96,C14orf50,C15orf27,C16orf86,C17orf100,C18orf1,C1orf105,C1orf190,C20orf165,C20orf185,C2orf88,C4orf34,C5orf13,C5orf25,CABP5,CARD6,CASQ1,CD69,CD96,CELF3,CFI,CHD5,CHST1,CLDN4,CLRN3,CLSTN2,COL5A2,COL6A1,CORO2B,CSF3,CTSK,CYFIP1,DENND5B,DEPTOR,DIRAS1,DLX4,DNAJC17,DNAJC28,DUOX1,DUOXA2,EDAR,EGFLAM,EGFR,EHD2,EPHB1,FAM123B,FAM171A2,FAM19A5,FCGR3A,FEV,FIBIN,FLYWCH2,FMO4,FOXA2,GABRB1,GLB1L,GPC5,GPR12,GPR97,GPX6,HAO2,HIST2H3C,HLA-DOB,HOXB3,HRC,IDS,IFT88,IL36A,IL7R,INTU,ISM1,ITGBL1,KCNA2,KCND2,KCNH1,KERA,KIFC2,KRT35,KRT73,KRTAP17-1,LAMA5,LARP6,LBP,LCE2B,LEP,LOC283174,LOC728637,LPAR6,LPPR1,LYPD4,LYPLAL1,MAP6,MC3R,MMP8,MS4A10,MS4A15,MYO7B,MYO9A,MYOZ1,NAPSA,NAT8,NCCRP1,NIPAL2,NPY,NRIP2,ODZ1,OR2C1,OR51B4,OR5P3,OXT,PARP8,PCDH1,PCDHB7,PEG3,PGBD5,PLCL1,PPAPDC1A,PPARGC1B,PRKAA2,PRKCG,PRMT8,PTCH2,PTPRM,RARB,RASGRP3,RBFOX1,RHBDL3,RHO,RPL18,RPL30,RPL35,RPL37A,RRH,SATB1,SCML2,SERPINA3,SERPINF1,SESN3,SH3BP5,SLC10A1,SLC14A1,SLC22A7,SLC24A3,SLC29A4,SLC2A4,SLC35F1,SNED1,SPARCL1,SPINLW1,ST6GALNAC1,STAT1,SV2A,SYP,TACR2,TBC1D8,TBX19,TCEA2,TET3,THBS2,THRSP,TIMP3,TM4SF4,TMEM108,TRH,TRIM2,TRIO,TRPM5,TSPAN7,TUBB4,UNC5C,UPP2,UTRN,WBSCR27,WNT1,XPNPEP2,ZBTB5,ZC3H11A,ZEB2,ZFPM2,ZFX,ZNF420,ZNF536,ZP2 GENE_SYMBOLS ACTN1,ACVR1,ADAM12,ADAM28,AGXT,AKAP6,ALDH5A1,ANGPTL1,AR,ARHGEF25,ATP7B,AZGP1,BCL2L11,BHLHE41,BIRC3,BMPR1A,BTG1,CCDC172,PPP1R36,TMEM266,C16orf86,C17orf100,LDLRAD4,C1orf105,LURAP1,SPATA25,BPIFB3,C2orf88,SMIM14,NREP,SIMC1,CABP5,CARD6,CASQ1,CD69,CD96,CELF3,CFI,CHD5,CHST1,CLDN4,CLRN3,CLSTN2,COL5A2,COL6A1,CORO2B,CSF3,CTSK,CYFIP1,DENND5B,DEPTOR,DIRAS1,DLX4,DNAJC17,DNAJC28,DUOX1,DUOXA2,EDAR,EGFLAM,EGFR,EHD2,EPHB1,AMER1,FAM171A2,TAFA5,FCGR3A,FEV,FIBIN,FLYWCH2,FMO4,FOXA2,GABRB1,GLB1L,GPC5,GPR12,ADGRG3,GPX6,HAO2,H3C14,HLA-DOB,HOXB3,HRC,IDS,IFT88,IL36A,IL7R,INTU,ISM1,ITGBL1,KCNA2,KCND2,KCNH1,KERA,KIFC2,KRT35,KRT73,KRTAP17-1,LAMA5,LARP6,LBP,LCE2B,LEP,IGSF9B,MEIKIN,LPAR6,PLPPR1,LYPD4,LYPLAL1,MAP6,MC3R,MMP8,MS4A10,MS4A15,MYO7B,MYO9A,MYOZ1,NAPSA,NAT8,NCCRP1,NIPAL2,NPY,NRIP2,TENM1,OR2C1,OR51B4,OR5P3,OXT,PARP8,PCDH1,PCDHB7,PEG3,PGBD5,PLCL1,PLPP4,PPARGC1B,PRKAA2,PRKCG,PRMT8,PTCH2,PTPRM,RARB,RASGRP3,RBFOX1,RHBDL3,RHO,RPL18,RPL30,RPL35,RPL37A,RRH,SATB1,SCML2,SERPINA3,SERPINF1,SESN3,SH3BP5,SLC10A1,SLC14A1,SLC22A7,SLC24A3,SLC29A4,SLC2A4,SLC35F1,SNED1,SPARCL1,EPPIN,ST6GALNAC1,STAT1,SV2A,SYP,TACR2,TBC1D8,TBX19,TCEA2,TET3,THBS2,THRSP,TIMP3,TM4SF4,TMEM108,TRH,TRIM2,TRIO,TRPM5,TSPAN7,TUBB4A,UNC5C,UPP2,UTRN,METTL27,WNT1,XPNPEP2,ZBTB5,ZC3H11A,ZEB2,ZFPM2,ZFX,ZNF420,ZNF536,ZP2 FOUNDER_NAMES