STANDARD_NAME GSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_A3R_INH_AND_TCELL_MEMBRANES_ACT_MAST_CELL_UP SYSTEMATIC_NAME M7313 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_A3R_INH_AND_TCELL_MEMBRANES_ACT_MAST_CELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in HMC-1 (mast leukemia) cells incubated with the peptide ALL1 followed by treatment with: Cl-IB-MECA [PubChem=3035850] versus T cell membranes. DESCRIPTION_FULL We demonstrate that the G protein Gi3 is the cellular target of the adenosine A3 receptor (A3R). By using a cell permeable peptide comprising the C-terminal end of Gαi3 fused to an importation sequence (ALL1) as a selective inhibitor of Gi3 signaling, we show that by coupling to Gi3, the A3R stimulates multiple signaling pathways in human mast cells, leading to upregulation of cytokines, chemokines and growth factors.Following contact with activated T cell membranes, endogenous adenosine binds to and activates the A3R, resulting in Gi3-mediated signaling. Specifically, the majority of ERK1/2 signaling initiated by contact with activated T cell membranes, is mediated by Gi3, giving rise to ALL1-inhibitable cellular responses. These results unveil the physiological GPCR that couples to Gi3 and establish the important role played by this G-protein in inflammatory conditions that involve adenosine-activated mast cells. We used microarrays to detail the effect of ALL1 on gene expression of HMC-1 cells activated directly by the A3 receptor, or by contact with activated T cell membranes. PMID 20190146 GEOID GSE19888 AUTHORS Baram D,Dekel O,Mekori YA,Sagi-Eisenberg R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE19888_3605_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ADM,AKT3,AMN1,AOAH,APC,APLP2,APPBP2,ARAP1,ARID5B,ARRDC2,ASAP1,ATM,ATP2B1,ATRX,ATXN7L1,BACH1,BAZ2B,BBS1,BCL6,BOD1L,BTG1,BTN3A3,C12orf35,C13orf15,C14orf101,C1orf38,C22orf37,CAMK1D,CANX,CBX7,CD44,CFLAR,CIR1,CLK4,CSNK2A2,CSTA,CTDSP2,CXCR4,DAB2,DDX5,DIP2B,DKFZp547G183,DSERG1,DUSP1,DUSP2,DUSP22,EAPP,EFHC1,EIF4B,EPHA4,ERBB2IP,FBXL20,FCHO2,FHL3,FLJ31306,FLJ37453,FLJ39653,FOXO3,FRAT1,FTH1,FTH1P5,FTX,GKAP1,GNS,HBP1,HERPUD2,HEXIM1,HOMER1,HSPBAP1,IFNGR1,IL7R,IL8,IRF2BP2,JHDM1D,JMY,KCNMB4,KIAA0430,KPNA1,KYNU,LITAF,LOC100129550,LOC100287572,LOC100288410,LOC148189,LOC151657,LOC153577,LOC338758,LOC375190,LOC647979,LYZ,MAP3K2,MARCKS,MAT2B,MBTD1,MED13,MED13L,MED28,MGAM,MIR101-1,MKRN1,MTSS1,N4BP2L2,NAA50,NAMPT,NBR1,NCF2,NGFRAP1,NLRP3,NR4A3,NRIP1,NSD1,OGFRL1,OTUD1,PAIP2,PAN3-AS1,PCMTD2,PDE3B,PFKFB3,PI4K2A,PICALM,PIK3CA,PIK3IP1,PLAUR,PLXND1,PNISR,PNPLA8,PNRC1,PPBP,PRDM2,RAB11FIP2,RAB21,RABGAP1,RALA,RB1CC1,RGS2,RNF11,RNF19A,RNPC3,RPL27A,RPL30,RPL31,RSBN1,SAT1,SCAF4,SERINC1,SGMS1,SH3KBP1,SIPA1L3,SIRT1,SKIL,SLC26A11,SMAP2,SNRPN,SNX16,SOCS5,SORL1,SOX4,SQSTM1,SRGN,SUV420H1,TCF7L2,TCP11L2,TECPR2,TET2,TGIF1,THBS1,TMEM43,TNFAIP3,TRIM23,TSPYL1,TULP4,UBE2B,UBL3,UBN2,UBXN6,UBXN7,UNKL,VEZF1,WASL,WDR19,WDR45,YPEL4,YPEL5,ZBTB10,ZC3H10,ZEB2,ZFP106,ZFP36,ZFP36L2,ZFYVE1,ZFYVE16,ZHX2,ZMYM2,ZNF217,ZNF238,ZNF350,ZNF354A,ZNF565,ZNF644,ZSWIM6 GENE_SYMBOLS ADM,AKT3,AMN1,AOAH,APC,APLP2,APPBP2,ARAP1,ARID5B,ARRDC2,ASAP1,ATM,ATP2B1,ATRX,ATXN7L1,BACH1,BAZ2B,BBS1,BCL6,BOD1L1,BTG1,BTN3A3,RESF1,RGCC,TMEM260,THEMIS2,LINC00528,CAMK1D,CANX,CBX7,CD44,CFLAR,CIR1,CLK4,CSNK2A2,CSTA,CTDSP2,CXCR4,DAB2,DDX5,DIP2B,,,DUSP1,DUSP2,DUSP22,EAPP,EFHC1,EIF4B,EPHA4,ERBIN,FBXL20,FCHO2,FHL3,PSMA3-AS1,SPEN-AS1,TAPT1-AS1,FOXO3,FRAT1,FTH1,FTH1P5,FTX,GKAP1,GNS,HBP1,HERPUD2,HEXIM1,HOMER1,HSPBAP1,IFNGR1,IL7R,CXCL8,IRF2BP2,KDM7A,JMY,KCNMB4,MARF1,KPNA1,KYNU,LITAF,LINC02035,,,LINC00662,,,ATP2B1-AS1,FAM228B,NORAD,LYZ,MAP3K2,MARCKS,MAT2B,MBTD1,MED13,MED13L,MED28,MGAM,MIR101-1,MKRN1,MTSS1,N4BP2L2,NAA50,NAMPT,NBR1,NCF2,BEX3,NLRP3,NR4A3,NRIP1,NSD1,OGFRL1,OTUD1,PAIP2,PAN3-AS1,PCMTD2,PDE3B,PFKFB3,PI4K2A,PICALM,PIK3CA,PIK3IP1,PLAUR,PLXND1,PNISR,PNPLA8,PNRC1,PPBP,PRDM2,RAB11FIP2,RAB21,RABGAP1,RALA,RB1CC1,RGS2,RNF11,RNF19A,RNPC3,RPL27A,RPL30,RPL31,RSBN1,SAT1,SCAF4,SERINC1,SGMS1,SH3KBP1,SIPA1L3,SIRT1,SKIL,SLC26A11,SMAP2,SNRPN,SNX16,SOCS5,SORL1,SOX4,SQSTM1,SRGN,KMT5B,TCF7L2,TCP11L2,TECPR2,TET2,TGIF1,THBS1,TMEM43,TNFAIP3,TRIM23,TSPYL1,TULP4,UBE2B,UBL3,UBN2,UBXN6,UBXN7,UNKL,VEZF1,WASL,WDR19,WDR45,YPEL4,YPEL5,ZBTB10,ZC3H10,ZEB2,ZNF106,ZFP36,ZFP36L2,ZFYVE1,ZFYVE16,ZHX2,ZMYM2,ZNF217,ZBTB18,ZNF350,ZNF354A,ZNF565,ZNF644,ZSWIM6 FOUNDER_NAMES