STANDARD_NAME GSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_TREG_UP SYSTEMATIC_NAME M4313 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_TREG_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of TregLP versus Homeo Convert (see Table 1S in the paper for details). DESCRIPTION_FULL Regulatory T (Treg) cells that express the FoxP3 transcription factor are essential for lymphoid homeostasis and immune tolerance to self. Other non-immunological functions of Treg cells, such as controlling metabolic function in adipose tissue, are also emerging. Treg cells originate primarily in the thymus, but can also be elicited from conventional T cells by in vivo exposure to low-dose antigen or homeostatic expansion, or by activation in the presence of TGFβ in vitro. Treg cells are characterized by a distinct transcriptional signature controlled in part, but not solely, by FoxP3. For a better perspective on transcriptional control in Treg cells, we compared gene expression profiles of a broad panel of Treg cells from various origins or anatomical locations. Treg cells generated by different means form different sub-phenotypes identifiable by particular combinations of transcripts, none of which fully encompass the entire Treg signature. Molecules involved in Treg effector function, chemokine receptors, and the transcription factors that control them are differentially represented in these subphenotypes. Treg cells from the gut proved dissimilar to cells elicited by exposure to TGFβ, but instead they resembled a CD103+Klrg1+ subphenotype preferentially generated in response to lymphopenia. PMID 20231436 GEOID GSE20366 AUTHORS Feuerer M,Hill JA,Kretschmer K,von Boehmer H,Mathis D,Benoist C CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE20366_1427_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACOT11,ADAMTS6,ADCK5,AGRN,AHI1,AIM2,AIP,AKAP7,AKR1E2,ALKBH1,ALS2,ANKIB1,APOBEC3B,ARHGAP36,ARL13B,ASXL2,ATP6V1E2,BAIAP3,BCKDHA,BLCAP,BRD9,C18orf54,C20orf54,C3orf38,C5orf51,CABLES1,CAMSAP1,CANT1,CARNS1,CBLB,CBX7,CCDC134,CCDC28A,CCNL2,CD164,CD72,CDA,CDKAL1,CEP350,CEP63,CEP95,CERK,CHIC2,CLK4,COQ2,CREB3L2,CRYBA2,CSTF1,CXCR6,CYB561D1,CYFIP1,CYP51A1,DDX60,DIS3L,DNAJA1,DOM3Z,DPY19L3,EPHB2,ERCC4,EXOSC10,F2R,FAM151B,FBXO32,FGD3,FKBP3,FKBP8,FSD2,GNPNAT1,GPR183,GRHL1,GSDMD,HAUS7,HDAC4,HERC1,HLA-C,HMHA1,HOMER1,HSBP1L1,HSPA4L,HTT,ICAM1,IPCEF1,IRAK2,ITPKB,KIAA0040,KIAA1958,KLHL17,KLHL35,LAG3,LCLAT1,LETM2,LOC81691,LONP2,LRRC45,MAP3K7,MAPKBP1,MARVELD2,MCM3AP,MED13L,MEPCE,MGAT5,MSI2,MUM1,NAGA,NAV2,NEB,NELF,NEMF,NEU3,NFAT5,NFATC1,NKX2-3,NOP14,NPAS4,NPEPL1,NR2F6,NUDT19,OTUD4,OTUD6B,P2RX4,PARP16,PDK1,PGM2L1,PHF6,PHKB,PHKG2,PHTF1,PIGU,PIK3IP1,PITX1,PIWIL2,PLCL2,PLIN2,PLK3,PNPLA6,PODXL,POLR1A,PRSS55,PTCD1,RASSF5,RBM33,RMND1,RPS9,RRP1,RSRC2,SC4MOL,SDAD1,SEC14L1,SEPP1,SLC26A11,SLC35A4,SLC35B3,SLC35C2,SLC41A1,SLTM,SMAP2,SMG6,SPACA1,SPATA5L1,SPG20,SPSB3,SRSF11,STAU1,STRA8,STX5,SUCLG2,TASP1,TBC1D17,TBCCD1,TBCE,TCERG1,TDP2,TEC,TELO2,THNSL2,TIAL1,TK2,TMEM135,TMEM140,TMEM154,TNFRSF9,TOP3B,TOR1B,TRAF2,TRIM17,TRIM68,TRMU,TRPM4,TRPS1,TRPT1,TUBGCP4,UCP2,UPF2,WIPF2,WIPI2,XRCC5,ZMAT1,ZNF281,ZNF740,ZRSR2 GENE_SYMBOLS ACOT11,ADAMTS6,ADCK5,AGRN,AHI1,AIM2,AIP,AKAP7,AKR1E2,ALKBH1,ALS2,ANKIB1,APOBEC3B,ARHGAP36,ARL13B,ASXL2,ATP6V1E2,BAIAP3,BCKDHA,BLCAP,BRD9,C18orf54,SLC52A3,C3orf38,RIMOC1,CABLES1,CAMSAP1,CANT1,CARNS1,CBLB,CBX7,CCDC134,CCDC28A,CCNL2,CD164,CD72,CDA,CDKAL1,CEP350,CEP63,CEP95,CERK,CHIC2,CLK4,COQ2,CREB3L2,CRYBA2,CSTF1,CXCR6,CYB561D1,CYFIP1,CYP51A1,DDX60,DIS3L,DNAJA1,DXO,DPY19L3,EPHB2,ERCC4,EXOSC10,F2R,FAM151B,FBXO32,FGD3,FKBP3,FKBP8,FSD2,GNPNAT1,GPR183,GRHL1,GSDMD,HAUS7,HDAC4,HERC1,HLA-C,ARHGAP45,HOMER1,HSBP1L1,HSPA4L,HTT,ICAM1,IPCEF1,IRAK2,ITPKB,KIAA0040,KIAA1958,KLHL17,KLHL35,LAG3,LCLAT1,LETM2,REXO5,LONP2,LRRC45,MAP3K7,MAPKBP1,MARVELD2,MCM3AP,MED13L,MEPCE,MGAT5,MSI2,IRF4,NAGA,NAV2,NEB,NSMF,NEMF,NEU3,NFAT5,NFATC1,NKX2-3,NOP14,NPAS4,NPEPL1,NR2F6,NUDT19,OTUD4,OTUD6B,P2RX4,PARP16,PDK1,PGM2L1,PHF6,PHKB,PHKG2,PHTF1,PIGU,PIK3IP1,PITX1,PIWIL2,PLCL2,PLIN2,PLK3,PNPLA6,PODXL,POLR1A,PRSS55,PTCD1,RASSF5,RBM33,RMND1,RPS9,RRP1,RSRC2,MSMO1,SDAD1,SEC14L1,SELENOP,SLC26A11,SLC35A4,SLC35B3,SLC35C2,SLC41A1,SLTM,SMAP2,SMG6,SPACA1,SPATA5L1,SPART,SPSB3,SRSF11,STAU1,STRA8,STX5,SUCLG2,TASP1,TBC1D17,TBCCD1,TBCE,TCERG1,TDP2,TEC,TELO2,THNSL2,TIAL1,TK2,TMEM135,TMEM140,TMEM154,TNFRSF9,TOP3B,TOR1B,TRAF2,TRIM17,TRIM68,TRMU,TRPM4,TRPS1,TRPT1,TUBGCP4,UCP2,UPF2,WIPF2,WIPI2,XRCC5,ZMAT1,ZNF281,ZNF740,ZRSR2 FOUNDER_NAMES