STANDARD_NAME	GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP
SYSTEMATIC_NAME	M8264
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in B lymphocytes stimulated by anti-IgM: 3h versus 16h.
DESCRIPTION_FULL	Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function.
PMID	21464221
GEOID	GSE21063
AUTHORS	Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE21063_3442_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABCC1,ABHD16B,ADAM22,ADAMDEC1,ALDH6A1,AMMECR1,AMPD2,ANKRD43,ANKRD50,AQP7,ARC,ARHGAP31,ARMCX3,ARRB2,ATF3,ATG9B,ATP6V0A1,ATP8B2,AXL,B2M,B3GNT2,BCOR,BMPER,BRP44L,BVES,C11orf61,C11orf70,C12orf23,C15orf57,C9orf89,CARD14,CCDC120,CCDC63,CCDC66,CCDC79,CCDC85A,CCL7,CCR7,CD200,CD2AP,CDH17,CDH5,CDKN1B,CHRNA9,CLN8,CNDP1,CNNM2,COMMD7,CTC1,CYFIP2,DDHD1,DGCR6,DIRC2,DNMT3B,DOCK10,EBI3,EML1,EPOR,ERO1L,FAM118A,FAM129B,FUCA2,GABRP,GALNT10,GANAB,GAP43,GJA4,GNAL,GNG8,GOSR1,GPATCH8,GPR110,GPR98,GUCY1B3,HBZ,HIF1A,HIF1AN,HNF4G,HSPA4L,HYI,ICOSLG,IGSF9,IL17A,IL2,INO80,IPO8,ITGA5,KIAA1737,KIF11,KPNA7,KTN1,LALBA,LCA5L,LRRC42,LRRTM4,LY75,MAB21L3,MAP4,MAPKAPK2,MBNL2,MED10,MED24,MEIR5,MERTK,METTL9,MIOX,MLL,MPHOSPH6,MRPL45,MTX2,MXD3,MYC,MYO1F,NARS,NDUFA12,NEB,NEK4,NHLH2,NIPAL3,OPTN,PARP4,PATL1,PAX3,PBX2,PCDH10,PDE1C,PDGFB,PDIA2,PDP1,PELI1,PLA2R1,POLK,PPARG,PPT1,PRCP,PTPLB,PUS10,PXK,RAB12,RAB40B,RAD52,RAMP1,RASD1,RCOR3,REG3G,RGS13,RINT1,RPL27A,RPL36A,S1PR4,SATB1,SCAF11,SCAF4,SDCBP2,SIRT1,SIT1,SLC37A1,SLC9A9,SMAD3,SMN1,SMNDC1,SNRNP48,SON,SP1,SPATA6,SPATS2L,SPINT1,SRP72,SRSF11,STK33,SULT1B1,TAF11,TARDBP,TERF1,TFPI,TGIF1,THEM4,TMEM35,TMPO,TNFAIP3,TNFRSF14,TNFSF4,TNP2,TRAF5,TRAT1,TSC22D3,USP16,UTP3,WISP1,XRN2,ZBTB7A,ZC3H13,ZC3H7B,ZCCHC11,ZCCHC9,ZFP14,ZNF212,ZNF471,ZNF524,ZNF655
GENE_SYMBOLS	ABCC1,ABHD16B,ADAM22,ADAMDEC1,ALDH6A1,AMMECR1,AMPD2,SOWAHA,ANKRD50,AQP7,ARC,ARHGAP31,ARMCX3,ARRB2,ATF3,ATG9B,ATP6V0A1,ATP8B2,AXL,B2M,B3GNT2,BCOR,BMPER,MPC1,POPDC1,MSANTD2,CFAP300,TMEM263,CCDC32,CARD19,CARD14,CCDC120,CCDC63,CCDC66,TERB1,CCDC85A,CCL7,CCR7,CD200,CD2AP,CDH17,CDH5,CDKN1B,CHRNA9,CLN8,CNDP1,CNNM2,COMMD7,CTC1,CYFIP2,DDHD1,DGCR6,SLC49A4,DNMT3B,DOCK10,EBI3,EML1,EPOR,ERO1A,FAM118A,NIBAN2,FUCA2,GABRP,GALNT10,GANAB,GAP43,GJA4,GNAL,GNG8,GOSR1,GPATCH8,ADGRF1,ADGRV1,GUCY1B1,HBZ,HIF1A,HIF1AN,HNF4G,HSPA4L,HYI,ICOSLG,IGSF9,IL17A,IL2,INO80,IPO8,ITGA5,CIPC,KIF11,KPNA7,KTN1,LALBA,LCA5L,LRRC42,LRRTM4,LY75,MAB21L3,MAP4,MAPKAPK2,MBNL2,MED10,MED24,SFR1,MERTK,METTL9,MIOX,KMT2A,MPHOSPH6,MRPL45,MTX2,MXD3,MYC,MYO1F,NARS1,NDUFA12,NEB,NEK4,NHLH2,NIPAL3,OPTN,PARP4,PATL1,PAX3,PBX2,PCDH10,PDE1C,PDGFB,PDIA2,PDP1,PELI1,PLA2R1,POLK,PPARG,PPT1,PRCP,HACD2,PUS10,PXK,RAB12,RAB40B,RAD52,RAMP1,RASD1,RCOR3,REG3G,RGS13,RINT1,RPL27A,RPL36A,S1PR4,SATB1,SCAF11,SCAF4,SDCBP2,SIRT1,SIT1,SLC37A1,SLC9A9,SMAD3,SMN1,SMNDC1,SNRNP48,SON,SP1,SPATA6,SPATS2L,SPINT1,SRP72,SRSF11,STK33,SULT1B1,TAF11,TARDBP,TERF1,TFPI,TGIF1,THEM4,TMEM35A,TMPO,TNFAIP3,TNFRSF14,TNFSF4,TNP2,TRAF5,TRAT1,TSC22D3,USP16,UTP3,CCN4,XRN2,ZBTB7A,ZC3H13,ZC3H7B,TUT4,ZCCHC9,ZFP14,ZNF212,ZNF471,ZNF524,ZNF655
FOUNDER_NAMES