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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP" SYSTEMATIC_NAME="M8264" HISTORICAL_NAMES="" PMID="21464221" AUTHORS="Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E" GEOID="GSE21063" EXACT_SOURCE="GSE21063_3442_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in B lymphocytes stimulated by anti-IgM: 3h versus 16h." DESCRIPTION_FULL="Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function." TAGS="" MEMBERS="ABCC1,ABHD16B,ADAM22,ADAMDEC1,ALDH6A1,AMMECR1,AMPD2,ANKRD43,ANKRD50,AQP7,ARC,ARHGAP31,ARMCX3,ARRB2,ATF3,ATG9B,ATP6V0A1,ATP8B2,AXL,B2M,B3GNT2,BCOR,BMPER,BRP44L,BVES,C11orf61,C11orf70,C12orf23,C15orf57,C9orf89,CARD14,CCDC120,CCDC63,CCDC66,CCDC79,CCDC85A,CCL7,CCR7,CD200,CD2AP,CDH17,CDH5,CDKN1B,CHRNA9,CLN8,CNDP1,CNNM2,COMMD7,CTC1,CYFIP2,DDHD1,DGCR6,DIRC2,DNMT3B,DOCK10,EBI3,EML1,EPOR,ERO1L,FAM118A,FAM129B,FUCA2,GABRP,GALNT10,GANAB,GAP43,GJA4,GNAL,GNG8,GOSR1,GPATCH8,GPR110,GPR98,GUCY1B3,HBZ,HIF1A,HIF1AN,HNF4G,HSPA4L,HYI,ICOSLG,IGSF9,IL17A,IL2,INO80,IPO8,ITGA5,KIAA1737,KIF11,KPNA7,KTN1,LALBA,LCA5L,LRRC42,LRRTM4,LY75,MAB21L3,MAP4,MAPKAPK2,MBNL2,MED10,MED24,MEIR5,MERTK,METTL9,MIOX,MLL,MPHOSPH6,MRPL45,MTX2,MXD3,MYC,MYO1F,NARS,NDUFA12,NEB,NEK4,NHLH2,NIPAL3,OPTN,PARP4,PATL1,PAX3,PBX2,PCDH10,PDE1C,PDGFB,PDIA2,PDP1,PELI1,PLA2R1,POLK,PPARG,PPT1,PRCP,PTPLB,PUS10,PXK,RAB12,RAB40B,RAD52,RAMP1,RASD1,RCOR3,REG3G,RGS13,RINT1,RPL27A,RPL36A,S1PR4,SATB1,SCAF11,SCAF4,SDCBP2,SIRT1,SIT1,SLC37A1,SLC9A9,SMAD3,SMN1,SMNDC1,SNRNP48,SON,SP1,SPATA6,SPATS2L,SPINT1,SRP72,SRSF11,STK33,SULT1B1,TAF11,TARDBP,TERF1,TFPI,TGIF1,THEM4,TMEM35,TMPO,TNFAIP3,TNFRSF14,TNFSF4,TNP2,TRAF5,TRAT1,TSC22D3,USP16,UTP3,WISP1,XRN2,ZBTB7A,ZC3H13,ZC3H7B,ZCCHC11,ZCCHC9,ZFP14,ZNF212,ZNF471,ZNF524,ZNF655" MEMBERS_SYMBOLIZED="ABCC1,ABHD16B,ADAM22,ADAMDEC1,ADGRF1,ADGRV1,ALDH6A1,AMMECR1,AMPD2,ANKRD50,AQP7,ARC,ARHGAP31,ARMCX3,ARRB2,ATF3,ATG9B,ATP6V0A1,ATP8B2,AXL,B2M,B3GNT2,BCOR,BMPER,CARD14,CARD19,CCDC120,CCDC32,CCDC63,CCDC66,CCDC85A,CCL7,CCN4,CCR7,CD200,CD2AP,CDH17,CDH5,CDKN1B,CFAP300,CHRNA9,CIPC,CLN8,CNDP1,CNNM2,COMMD7,CTC1,CYFIP2,DDHD1,DGCR6,DNMT3B,DOCK10,EBI3,EML1,EPOR,ERO1A,FAM118A,FUCA2,GABRP,GALNT10,GANAB,GAP43,GJA4,GNAL,GNG8,GOSR1,GPATCH8,GUCY1B1,HACD2,HBZ,HIF1A,HIF1AN,HNF4G,HSPA4L,HYI,ICOSLG,IGSF9,IL17A,IL2,INO80,IPO8,ITGA5,KIF11,KMT2A,KPNA7,KTN1,LALBA,LCA5L,LRRC42,LRRTM4,LY75,MAB21L3,MAP4,MAPKAPK2,MBNL2,MED10,MED24,MERTK,METTL9,MIOX,MPC1,MPHOSPH6,MRPL45,MSANTD2,MTX2,MXD3,MYC,MYO1F,NARS1,NDUFA12,NEB,NEK4,NHLH2,NIBAN2,NIPAL3,OPTN,PARP4,PATL1,PAX3,PBX2,PCDH10,PDE1C,PDGFB,PDIA2,PDP1,PELI1,PLA2R1,POLK,POPDC1,PPARG,PPT1,PRCP,PUS10,PXK,RAB12,RAB40B,RAD52,RAMP1,RASD1,RCOR3,REG3G,RGS13,RINT1,RPL27A,RPL36A,S1PR4,SATB1,SCAF11,SCAF4,SDCBP2,SFR1,SIRT1,SIT1,SLC37A1,SLC49A4,SLC9A9,SMAD3,SMN1,SMNDC1,SNRNP48,SON,SOWAHA,SP1,SPATA6,SPATS2L,SPINT1,SRP72,SRSF11,STK33,SULT1B1,TAF11,TARDBP,TERB1,TERF1,TFPI,TGIF1,THEM4,TMEM263,TMEM35A,TMPO,TNFAIP3,TNFRSF14,TNFSF4,TNP2,TRAF5,TRAT1,TSC22D3,TUT4,USP16,UTP3,XRN2,ZBTB7A,ZC3H13,ZC3H7B,ZCCHC9,ZFP14,ZNF212,ZNF471,ZNF524,ZNF655" MEMBERS_EZID="1003,10133,10148,1015,10150,10200,10267,1027,10285,10461,10526,10600,10651,10678,10966,11149,114800,115353,117145,119392,1236,126868,130120,134548,140701,143,147807,149951,150082,150962,154007,160762,168667,1789,1831,2009,201475,201562,2055,2057,219988,22803,22824,22925,23091,23131,23193,23237,23264,23308,23318,23411,23435,23607,2519,2568,2596,26010,266977,26999,2701,271,27111,27240,27284,27299,2774,283847,285195,285331,285973,2983,30001,3050,3091,3174,3558,3605,364,3678,3832,3895,3906,402569,4065,4088,409,4134,4297,4329,4345,4363,4542,4609,467,4677,4703,4808,5077,50852,5089,51108,51341,5137,51426,5155,51566,51655,51660,535,53616,54020,54558,54617,5468,54704,54805,54880,54899,55007,5538,5547,55568,55584,55586,55619,55662,55758,558,55967,567,57050,57162,57182,57185,57198,57466,57514,57549,57573,57575,57677,5893,59353,6003,60561,6157,6173,6304,6354,64714,64855,65975,6606,6651,6667,6692,6731,6787,6882,7013,7035,7050,7112,7128,7142,7188,7292,79027,79092,79684,7988,80059,80169,80821,81888,8214,83463,84059,84240,84246,84270,84311,84735,84925,85016,85457,8698,8764,8840,90060,90416,90488,9169,9261,9295,94235,9527,9862,9949" MEMBERS_MAPPING="ABCC1,ABCC1,4363|ABHD16B,ABHD16B,140701|ADAM22,ADAM22,53616|ADAMDEC1,ADAMDEC1,27299|ALDH6A1,ALDH6A1,4329|AMMECR1,AMMECR1,9949|AMPD2,AMPD2,271|ANKRD43,SOWAHA,134548|ANKRD50,ANKRD50,57182|AQP7,AQP7,364|ARC,ARC,23237|ARHGAP31,ARHGAP31,57514|ARMCX3,ARMCX3,51566|ARRB2,ARRB2,409|ATF3,ATF3,467|ATG9B,ATG9B,285973|ATP6V0A1,ATP6V0A1,535|ATP8B2,ATP8B2,57198|AXL,AXL,558|B2M,B2M,567|B3GNT2,B3GNT2,10678|BCOR,BCOR,54880|BMPER,BMPER,168667|BRP44L,MPC1,51660|BVES,POPDC1,11149|C11orf61,MSANTD2,79684|C11orf70,CFAP300,85016|C12orf23,TMEM263,90488|C15orf57,CCDC32,90416|C9orf89,CARD19,84270|CARD14,CARD14,79092|CCDC120,CCDC120,90060|CCDC63,CCDC63,160762|CCDC66,CCDC66,285331|CCDC79,TERB1,283847|CCDC85A,CCDC85A,114800|CCL7,CCL7,6354|CCR7,CCR7,1236|CD200,CD200,4345|CD2AP,CD2AP,23607|CDH17,CDH17,1015|CDH5,CDH5,1003|CDKN1B,CDKN1B,1027|CHRNA9,CHRNA9,55584|CLN8,CLN8,2055|CNDP1,CNDP1,84735|CNNM2,CNNM2,54805|COMMD7,COMMD7,149951|CTC1,CTC1,80169|CYFIP2,CYFIP2,26999|DDHD1,DDHD1,80821|DGCR6,DGCR6,8214|DIRC2,SLC49A4,84925|DNMT3B,DNMT3B,1789|DOCK10,DOCK10,55619|EBI3,EBI3,10148|EML1,EML1,2009|EPOR,EPOR,2057|ERO1L,ERO1A,30001|FAM118A,FAM118A,55007|FAM129B,NIBAN2,64855|FUCA2,FUCA2,2519|GABRP,GABRP,2568|GALNT10,GALNT10,55568|GANAB,GANAB,23193|GAP43,GAP43,2596|GJA4,GJA4,2701|GNAL,GNAL,2774|GNG8,GNG8,94235|GOSR1,GOSR1,9527|GPATCH8,GPATCH8,23131|GPR110,ADGRF1,266977|GPR98,ADGRV1,84059|GUCY1B3,GUCY1B1,2983|HBZ,HBZ,3050|HIF1A,HIF1A,3091|HIF1AN,HIF1AN,55662|HNF4G,HNF4G,3174|HSPA4L,HSPA4L,22824|HYI,HYI,81888|ICOSLG,ICOSLG,23308|IGSF9,IGSF9,57549|IL17A,IL17A,3605|IL2,IL2,3558|INO80,INO80,54617|IPO8,IPO8,10526|ITGA5,ITGA5,3678|KIAA1737,CIPC,85457|KIF11,KIF11,3832|KPNA7,KPNA7,402569|KTN1,KTN1,3895|LALBA,LALBA,3906|LCA5L,LCA5L,150082|LRRC42,LRRC42,115353|LRRTM4,LRRTM4,80059|LY75,LY75,4065|MAB21L3,MAB21L3,126868|MAP4,MAP4,4134|MAPKAPK2,MAPKAPK2,9261|MBNL2,MBNL2,10150|MED10,MED10,84246|MED24,MED24,9862|MEIR5,SFR1,119392|MERTK,MERTK,10461|METTL9,METTL9,51108|MIOX,MIOX,55586|MLL,KMT2A,4297|MPHOSPH6,MPHOSPH6,10200|MRPL45,MRPL45,84311|MTX2,MTX2,10651|MXD3,MXD3,83463|MYC,MYC,4609|MYO1F,MYO1F,4542|NARS,NARS1,4677|NDUFA12,NDUFA12,55967|NEB,NEB,4703|NEK4,NEK4,6787|NHLH2,NHLH2,4808|NIPAL3,NIPAL3,57185|OPTN,OPTN,10133|PARP4,PARP4,143|PATL1,PATL1,219988|PAX3,PAX3,5077|PBX2,PBX2,5089|PCDH10,PCDH10,57575|PDE1C,PDE1C,5137|PDGFB,PDGFB,5155|PDIA2,PDIA2,64714|PDP1,PDP1,54704|PELI1,PELI1,57162|PLA2R1,PLA2R1,22925|POLK,POLK,51426|PPARG,PPARG,5468|PPT1,PPT1,5538|PRCP,PRCP,5547|PTPLB,HACD2,201562|PUS10,PUS10,150962|PXK,PXK,54899|RAB12,RAB12,201475|RAB40B,RAB40B,10966|RAD52,RAD52,5893|RAMP1,RAMP1,10267|RASD1,RASD1,51655|RCOR3,RCOR3,55758|REG3G,REG3G,130120|RGS13,RGS13,6003|RINT1,RINT1,60561|RPL27A,RPL27A,6157|RPL36A,RPL36A,6173|S1PR4,S1PR4,8698|SATB1,SATB1,6304|SCAF11,SCAF11,9169|SCAF4,SCAF4,57466|SDCBP2,SDCBP2,27111|SIRT1,SIRT1,23411|SIT1,SIT1,27240|SLC37A1,SLC37A1,54020|SLC9A9,SLC9A9,285195|SMAD3,SMAD3,4088|SMN1,SMN1,6606|SMNDC1,SMNDC1,10285|SNRNP48,SNRNP48,154007|SON,SON,6651|SP1,SP1,6667|SPATA6,SPATA6,54558|SPATS2L,SPATS2L,26010|SPINT1,SPINT1,6692|SRP72,SRP72,6731|SRSF11,SRSF11,9295|STK33,STK33,65975|SULT1B1,SULT1B1,27284|TAF11,TAF11,6882|TARDBP,TARDBP,23435|TERF1,TERF1,7013|TFPI,TFPI,7035|TGIF1,TGIF1,7050|THEM4,THEM4,117145|TMEM35,TMEM35A,59353|TMPO,TMPO,7112|TNFAIP3,TNFAIP3,7128|TNFRSF14,TNFRSF14,8764|TNFSF4,TNFSF4,7292|TNP2,TNP2,7142|TRAF5,TRAF5,7188|TRAT1,TRAT1,50852|TSC22D3,TSC22D3,1831|USP16,USP16,10600|UTP3,UTP3,57050|WISP1,CCN4,8840|XRN2,XRN2,22803|ZBTB7A,ZBTB7A,51341|ZC3H13,ZC3H13,23091|ZC3H7B,ZC3H7B,23264|ZCCHC11,TUT4,23318|ZCCHC9,ZCCHC9,84240|ZFP14,ZFP14,57677|ZNF212,ZNF212,7988|ZNF471,ZNF471,57573|ZNF524,ZNF524,147807|ZNF655,ZNF655,79027" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
