STANDARD_NAME	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_DN
SYSTEMATIC_NAME	M8274
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 8h.
DESCRIPTION_FULL	Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function.
PMID	21464221
GEOID	GSE21063
AUTHORS	Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE21063_3436_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABCD2,AEN,AKIP1,ALS2,ANLN,ANP32E,ANXA4,AP2B1,AP3B1,ARHGAP18,ARHGAP19,ARHGEF6,ARHGEF9,ARV1,ASF1B,ASPM,ATF3,ATIC,ATP5G1,AURKA,B3GNTL1,BARD1,BCAS4,BIRC5,BIVM,BLM,BUB1B,C11orf49,C14orf159,C17orf58,C1GALT1C1,C1orf31,C22orf40,C4orf43,C4orf52,C6orf108,C9orf40,CBR3,CCDC138,CCDC14,CCDC25,CCNA2,CCNB2,CCR2,CDC25A,CDCA2,CDK19,CDKN2C,CDRT4,CENPO,CHCHD3,CHEK2,CHID1,CKS1B,COQ3,CPPED1,CSF1,DECR1,DEPDC1B,DMC1,DONSON,DPAGT1,DUT,E2F7,EDEM1,ELP4,EPRS,ERP44,EXO1,FAM82B,FANCD2,FANCI,FIG4,FKBP15,FLOT1,FUCA2,FUT8,GANC,GATAD1,GGCT,GMDS,GMPPA,GNPAT,HDDC3,HDGFRP3,HERC4,HIRIP3,HJURP,HMGB3,HMMR,HRSP12,HSD17B8,IAH1,IARS,IDH1,ITPR1,KIAA0586,KIF15,KNTC1,LOC100049716,LOC100289211,LOC220930,LOC283588,LOC646808,LRR1,LSM4,MAD2L1,MAGOHB,MAP3K5,MAPKAPK3,MCCC1,MCM10,MCM5,MCTS1,MDM1,MGMT,MLF1IP,MNAT1,MPV17,MRPS9,MTHFD1L,MTHFD2,MYL6B,NAA35,NBAS,NCALD,NCAPG,NCAPH,NEDD4,NINJ2,NRD1,NTHL1,NUBPL,NUTF2,OBFC1,ORC3,PAAF1,PCCA,PHF14,PHF19,PHLDA1,PIBF1,PIGN,PKM2,PKP4,PLA2G16,PLCXD1,POC5,PRIM1,PRKCE,PSME2,PSRC1,PTGER2,PYCARD,RAD51,RFC3,RNASEH2A,RNF167,RNF187,RPL22L1,RPL39L,RPS6KC1,SAC3D1,SEL1L3,SERPINB6,SFXN4,SIT1,SKA1,SLC27A2,SLC35E4,SMC2,SNX5,SPAG5,SRD5A1,SRI,STMN1,STYXL1,TARS,TFDP1,TM7SF2,TMEM107,TMEM218,TMEM5,TMEM79,TOP2A,TRAP1,TRERF1,TRIM46,TTK,TTLL12,TXN,TYMS,UCHL3,VANGL1,VPS29,VRK1,WDR70,WHSC1,XRCC6BP1,ZNF512
GENE_SYMBOLS	ABCD2,AEN,AKIP1,ALS2,ANLN,ANP32E,ANXA4,AP2B1,AP3B1,ARHGAP18,ARHGAP19,ARHGEF6,ARHGEF9,ARV1,ASF1B,ASPM,ATF3,ATIC,ATP5MC1,AURKA,B3GNTL1,BARD1,BCAS4,BIRC5,BIVM,BLM,BUB1B,CSTPP1,DGLUCY,C17orf58,C1GALT1C1,COA6,CDPF1,TMA16,SMIM20,DNPH1,C9orf40,CBR3,CCDC138,CCDC14,CCDC25,CCNA2,CCNB2,CCR2,CDC25A,CDCA2,CDK19,CDKN2C,CDRT4,CENPO,CHCHD3,CHEK2,CHID1,CKS1B,COQ3,CPPED1,CSF1,DECR1,DEPDC1B,DMC1,DONSON,DPAGT1,DUT,E2F7,EDEM1,ELP4,EPRS1,ERP44,EXO1,RMDN1,FANCD2,FANCI,FIG4,FKBP15,FLOT1,FUCA2,FUT8,GANC,GATAD1,GGCT,GMDS,GMPPA,GNPAT,HDDC3,,HERC4,HIRIP3,HJURP,HMGB3,HMMR,RIDA,HSD17B8,IAH1,IARS1,IDH1,ITPR1,KIAA0586,KIF15,KNTC1,NINJ2-AS1,LINC00624,ZEB1-AS1,,LAGE3P1,LRR1,LSM4,MAD2L1,MAGOHB,MAP3K5,MAPKAPK3,MCCC1,MCM10,MCM5,MCTS1,MDM1,MGMT,CENPU,MNAT1,MPV17,MRPS9,MTHFD1L,MTHFD2,MYL6B,NAA35,NBAS,NCALD,NCAPG,NCAPH,NEDD4,NINJ2,NRDC,NTHL1,NUBPL,NUTF2,STN1,ORC3,PAAF1,PCCA,PHF14,PHF19,PHLDA1,PIBF1,PIGN,PKM,PKP4,PLAAT3,PLCXD1,POC5,PRIM1,PRKCE,PSME2,PSRC1,PTGER2,PYCARD,RAD51,RFC3,RNASEH2A,RNF167,RNF187,RPL22L1,RPL39L,RPS6KC1,SAC3D1,SEL1L3,SERPINB6,SFXN4,SIT1,SKA1,SLC27A2,SLC35E4,SMC2,SNX5,SPAG5,SRD5A1,SRI,STMN1,STYXL1,TARS1,TFDP1,TM7SF2,TMEM107,TMEM218,RXYLT1,TMEM79,TOP2A,TRAP1,TRERF1,TRIM46,TTK,TTLL12,TXN,TYMS,UCHL3,VANGL1,VPS29,VRK1,WDR70,NSD2,ATP23,ZNF512
FOUNDER_NAMES