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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_DN" SYSTEMATIC_NAME="M8274" HISTORICAL_NAMES="" PMID="21464221" AUTHORS="Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E" GEOID="GSE21063" EXACT_SOURCE="GSE21063_3436_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 8h." DESCRIPTION_FULL="Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function." TAGS="" MEMBERS="ABCD2,AEN,AKIP1,ALS2,ANLN,ANP32E,ANXA4,AP2B1,AP3B1,ARHGAP18,ARHGAP19,ARHGEF6,ARHGEF9,ARV1,ASF1B,ASPM,ATF3,ATIC,ATP5G1,AURKA,B3GNTL1,BARD1,BCAS4,BIRC5,BIVM,BLM,BUB1B,C11orf49,C14orf159,C17orf58,C1GALT1C1,C1orf31,C22orf40,C4orf43,C4orf52,C6orf108,C9orf40,CBR3,CCDC138,CCDC14,CCDC25,CCNA2,CCNB2,CCR2,CDC25A,CDCA2,CDK19,CDKN2C,CDRT4,CENPO,CHCHD3,CHEK2,CHID1,CKS1B,COQ3,CPPED1,CSF1,DECR1,DEPDC1B,DMC1,DONSON,DPAGT1,DUT,E2F7,EDEM1,ELP4,EPRS,ERP44,EXO1,FAM82B,FANCD2,FANCI,FIG4,FKBP15,FLOT1,FUCA2,FUT8,GANC,GATAD1,GGCT,GMDS,GMPPA,GNPAT,HDDC3,HDGFRP3,HERC4,HIRIP3,HJURP,HMGB3,HMMR,HRSP12,HSD17B8,IAH1,IARS,IDH1,ITPR1,KIAA0586,KIF15,KNTC1,LOC100049716,LOC100289211,LOC220930,LOC283588,LOC646808,LRR1,LSM4,MAD2L1,MAGOHB,MAP3K5,MAPKAPK3,MCCC1,MCM10,MCM5,MCTS1,MDM1,MGMT,MLF1IP,MNAT1,MPV17,MRPS9,MTHFD1L,MTHFD2,MYL6B,NAA35,NBAS,NCALD,NCAPG,NCAPH,NEDD4,NINJ2,NRD1,NTHL1,NUBPL,NUTF2,OBFC1,ORC3,PAAF1,PCCA,PHF14,PHF19,PHLDA1,PIBF1,PIGN,PKM2,PKP4,PLA2G16,PLCXD1,POC5,PRIM1,PRKCE,PSME2,PSRC1,PTGER2,PYCARD,RAD51,RFC3,RNASEH2A,RNF167,RNF187,RPL22L1,RPL39L,RPS6KC1,SAC3D1,SEL1L3,SERPINB6,SFXN4,SIT1,SKA1,SLC27A2,SLC35E4,SMC2,SNX5,SPAG5,SRD5A1,SRI,STMN1,STYXL1,TARS,TFDP1,TM7SF2,TMEM107,TMEM218,TMEM5,TMEM79,TOP2A,TRAP1,TRERF1,TRIM46,TTK,TTLL12,TXN,TYMS,UCHL3,VANGL1,VPS29,VRK1,WDR70,WHSC1,XRCC6BP1,ZNF512" MEMBERS_SYMBOLIZED="ABCD2,AEN,AKIP1,ALS2,ANLN,ANP32E,ANXA4,AP2B1,AP3B1,ARHGAP18,ARHGAP19,ARHGEF6,ARHGEF9,ARV1,ASF1B,ASPM,ATF3,ATIC,ATP23,ATP5MC1,AURKA,B3GNTL1,BARD1,BCAS4,BIRC5,BIVM,BLM,BUB1B,C17orf58,C1GALT1C1,C9orf40,CBR3,CCDC138,CCDC14,CCDC25,CCNA2,CCNB2,CCR2,CDC25A,CDCA2,CDK19,CDKN2C,CDPF1,CDRT4,CENPO,CENPU,CHCHD3,CHEK2,CHID1,CKS1B,COA6,COQ3,CPPED1,CSF1,CSTPP1,DECR1,DEPDC1B,DGLUCY,DMC1,DNPH1,DONSON,DPAGT1,DUT,E2F7,EDEM1,ELP4,EPRS1,ERP44,EXO1,FANCD2,FANCI,FIG4,FKBP15,FLOT1,FUCA2,FUT8,GANC,GATAD1,GGCT,GMDS,GMPPA,GNPAT,HDDC3,HERC4,HIRIP3,HJURP,HMGB3,HMMR,HSD17B8,IAH1,IARS1,IDH1,ITPR1,KIAA0586,KIF15,KNTC1,LAGE3P1,LINC00624,LRR1,LSM4,MAD2L1,MAGOHB,MAP3K5,MAPKAPK3,MCCC1,MCM10,MCM5,MCTS1,MDM1,MGMT,MNAT1,MPV17,MRPS9,MTHFD1L,MTHFD2,MYL6B,NAA35,NBAS,NCALD,NCAPG,NCAPH,NEDD4,NINJ2,NINJ2-AS1,NRDC,NSD2,NTHL1,NUBPL,NUTF2,ORC3,PAAF1,PCCA,PHF14,PHF19,PHLDA1,PIBF1,PIGN,PKM,PKP4,PLAAT3,PLCXD1,POC5,PRIM1,PRKCE,PSME2,PSRC1,PTGER2,PYCARD,RAD51,RFC3,RIDA,RMDN1,RNASEH2A,RNF167,RNF187,RPL22L1,RPL39L,RPS6KC1,RXYLT1,SAC3D1,SEL1L3,SERPINB6,SFXN4,SIT1,SKA1,SLC27A2,SLC35E4,SMC2,SMIM20,SNX5,SPAG5,SRD5A1,SRI,STMN1,STN1,STYXL1,TARS1,TFDP1,TM7SF2,TMA16,TMEM107,TMEM218,TMEM79,TOP2A,TRAP1,TRERF1,TRIM46,TTK,TTLL12,TXN,TYMS,UCHL3,VANGL1,VPS29,VRK1,WDR70,ZEB1-AS1,ZNF512" MEMBERS_EZID="100049716,100289211,10131,10204,10211,10247,1031,10329,10464,10535,10591,10592,10615,10797,11001,11144,11145,11200,1163,116832,119559,122769,134359,140465,1435,144455,146712,149603,150383,157313,163,165055,1666,1798,1854,200916,2058,2177,219854,220134,220930,225,22822,23071,23097,23170,23229,23231,23307,23397,23556,23595,2519,2530,25804,25902,259266,2595,26001,26091,26147,26610,26750,27131,27240,2762,284018,284040,285148,28985,29071,29108,29901,29926,29980,307,3149,3161,332,3376,339665,3417,3708,374659,388753,389203,3925,4085,4174,4217,4255,4331,4358,467,471,4734,4815,4898,4913,5095,51115,51594,516,51657,51699,51805,5269,5315,54443,54841,54927,55071,55100,55110,55215,55246,55313,55319,55344,55355,55388,5557,55653,55723,55789,55809,5581,56672,56890,56922,56992,5721,5732,57679,57798,580,5888,5983,60560,641,64151,646808,64770,64782,64801,64965,66005,6715,6717,6790,6897,701,7027,7108,7153,7272,729230,7295,7298,7347,7443,7468,7867,79017,79096,79172,7923,79682,79991,80017,80128,80224,80227,81611,81839,83988,84283,84314,8443,84450,84722,8479,84986,8502,8546,874,890,9133,91419,9156,93663,9459,9678,9695,9735,9786,9896,993" MEMBERS_MAPPING="ABCD2,ABCD2,225|AEN,AEN,64782|AKIP1,AKIP1,56672|ALS2,ALS2,57679|ANLN,ANLN,54443|ANP32E,ANP32E,81611|ANXA4,ANXA4,307|AP2B1,AP2B1,163|AP3B1,AP3B1,8546|ARHGAP18,ARHGAP18,93663|ARHGAP19,ARHGAP19,84986|ARHGEF6,ARHGEF6,9459|ARHGEF9,ARHGEF9,23229|ARV1,ARV1,64801|ASF1B,ASF1B,55723|ASPM,ASPM,259266|ATF3,ATF3,467|ATIC,ATIC,471|ATP5G1,ATP5MC1,516|AURKA,AURKA,6790|B3GNTL1,B3GNTL1,146712|BARD1,BARD1,580|BCAS4,BCAS4,55653|BIRC5,BIRC5,332|BIVM,BIVM,54841|BLM,BLM,641|BUB1B,BUB1B,701|C11orf49,CSTPP1,79096|C14orf159,DGLUCY,80017|C17orf58,C17orf58,284018|C1GALT1C1,C1GALT1C1,29071|C1orf31,COA6,388753|C22orf40,CDPF1,150383|C4orf43,TMA16,55319|C4orf52,SMIM20,389203|C6orf108,DNPH1,10591|C9orf40,C9orf40,55071|CBR3,CBR3,874|CCDC138,CCDC138,165055|CCDC14,CCDC14,64770|CCDC25,CCDC25,55246|CCNA2,CCNA2,890|CCNB2,CCNB2,9133|CCR2,CCR2,729230|CDC25A,CDC25A,993|CDCA2,CDCA2,157313|CDK19,CDK19,23097|CDKN2C,CDKN2C,1031|CDRT4,CDRT4,284040|CENPO,CENPO,79172|CHCHD3,CHCHD3,54927|CHEK2,CHEK2,11200|CHID1,CHID1,66005|CKS1B,CKS1B,1163|COQ3,COQ3,51805|CPPED1,CPPED1,55313|CSF1,CSF1,1435|DECR1,DECR1,1666|DEPDC1B,DEPDC1B,55789|DMC1,DMC1,11144|DONSON,DONSON,29980|DPAGT1,DPAGT1,1798|DUT,DUT,1854|E2F7,E2F7,144455|EDEM1,EDEM1,9695|ELP4,ELP4,26610|EPRS,EPRS1,2058|ERP44,ERP44,23071|EXO1,EXO1,9156|FAM82B,RMDN1,51115|FANCD2,FANCD2,2177|FANCI,FANCI,55215|FIG4,FIG4,9896|FKBP15,FKBP15,23307|FLOT1,FLOT1,10211|FUCA2,FUCA2,2519|FUT8,FUT8,2530|GANC,GANC,2595|GATAD1,GATAD1,57798|GGCT,GGCT,79017|GMDS,GMDS,2762|GMPPA,GMPPA,29926|GNPAT,GNPAT,8443|HDDC3,HDDC3,374659|HDGFRP3,null,null|HERC4,HERC4,26091|HIRIP3,HIRIP3,8479|HJURP,HJURP,55355|HMGB3,HMGB3,3149|HMMR,HMMR,3161|HRSP12,RIDA,10247|HSD17B8,HSD17B8,7923|IAH1,IAH1,285148|IARS,IARS1,3376|IDH1,IDH1,3417|ITPR1,ITPR1,3708|KIAA0586,KIAA0586,9786|KIF15,KIF15,56992|KNTC1,KNTC1,9735|LOC100049716,NINJ2-AS1,100049716|LOC100289211,LINC00624,100289211|LOC220930,ZEB1-AS1,220930|LOC283588,null,null|LOC646808,LAGE3P1,646808|LRR1,LRR1,122769|LSM4,LSM4,25804|MAD2L1,MAD2L1,4085|MAGOHB,MAGOHB,55110|MAP3K5,MAP3K5,4217|MAPKAPK3,MAPKAPK3,7867|MCCC1,MCCC1,56922|MCM10,MCM10,55388|MCM5,MCM5,4174|MCTS1,MCTS1,28985|MDM1,MDM1,56890|MGMT,MGMT,4255|MLF1IP,CENPU,79682|MNAT1,MNAT1,4331|MPV17,MPV17,4358|MRPS9,MRPS9,64965|MTHFD1L,MTHFD1L,25902|MTHFD2,MTHFD2,10797|MYL6B,MYL6B,140465|NAA35,NAA35,60560|NBAS,NBAS,51594|NCALD,NCALD,83988|NCAPG,NCAPG,64151|NCAPH,NCAPH,23397|NEDD4,NEDD4,4734|NINJ2,NINJ2,4815|NRD1,NRDC,4898|NTHL1,NTHL1,4913|NUBPL,NUBPL,80224|NUTF2,NUTF2,10204|OBFC1,STN1,79991|ORC3,ORC3,23595|PAAF1,PAAF1,80227|PCCA,PCCA,5095|PHF14,PHF14,9678|PHF19,PHF19,26147|PHLDA1,PHLDA1,22822|PIBF1,PIBF1,10464|PIGN,PIGN,23556|PKM2,PKM,5315|PKP4,PKP4,8502|PLA2G16,PLAAT3,11145|PLCXD1,PLCXD1,55344|POC5,POC5,134359|PRIM1,PRIM1,5557|PRKCE,PRKCE,5581|PSME2,PSME2,5721|PSRC1,PSRC1,84722|PTGER2,PTGER2,5732|PYCARD,PYCARD,29108|RAD51,RAD51,5888|RFC3,RFC3,5983|RNASEH2A,RNASEH2A,10535|RNF167,RNF167,26001|RNF187,RNF187,149603|RPL22L1,RPL22L1,200916|RPL39L,RPL39L,116832|RPS6KC1,RPS6KC1,26750|SAC3D1,SAC3D1,29901|SEL1L3,SEL1L3,23231|SERPINB6,SERPINB6,5269|SFXN4,SFXN4,119559|SIT1,SIT1,27240|SKA1,SKA1,220134|SLC27A2,SLC27A2,11001|SLC35E4,SLC35E4,339665|SMC2,SMC2,10592|SNX5,SNX5,27131|SPAG5,SPAG5,10615|SRD5A1,SRD5A1,6715|SRI,SRI,6717|STMN1,STMN1,3925|STYXL1,STYXL1,51657|TARS,TARS1,6897|TFDP1,TFDP1,7027|TM7SF2,TM7SF2,7108|TMEM107,TMEM107,84314|TMEM218,TMEM218,219854|TMEM5,RXYLT1,10329|TMEM79,TMEM79,84283|TOP2A,TOP2A,7153|TRAP1,TRAP1,10131|TRERF1,TRERF1,55809|TRIM46,TRIM46,80128|TTK,TTK,7272|TTLL12,TTLL12,23170|TXN,TXN,7295|TYMS,TYMS,7298|UCHL3,UCHL3,7347|VANGL1,VANGL1,81839|VPS29,VPS29,51699|VRK1,VRK1,7443|WDR70,WDR70,55100|WHSC1,NSD2,7468|XRCC6BP1,ATP23,91419|ZNF512,ZNF512,84450" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
