<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_UP" SYSTEMATIC_NAME="M8272" HISTORICAL_NAMES="" PMID="21464221" AUTHORS="Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E" GEOID="GSE21063" EXACT_SOURCE="GSE21063_3436_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 8h." DESCRIPTION_FULL="Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function." TAGS="" MEMBERS="ABCB1,ACSL1,AGFG1,AIM1,ALK,ANKRD13D,ARFGEF2,ARHGEF7,ARID5A,ARNTL,ASB6,ATG2A,ATP2B1,B7H6,BACH2,BAMBI,BCL6,BCL9L,BCOR,BRD1,C14orf43,C1orf115,C20orf108,C20orf112,C21orf2,C21orf96,C22orf37,CACNA2D2,CAMK2N1,CARNS1,CCDC93,CCNL2,CDK12,CHD1,CHD7,CHKA,CKAP4,CLCF1,CNOT6L,COG3,COL6A2,CRTC2,CRY2,CTRL,CTSO,CXorf65,CYTH3,DCTN6,DDI2,DDR2,DDX6,DHX36,DNAJC3,DNMBP,DNTTIP2,DUSP10,DUSP2,EID3,ELL,ENC1,ENTPD4,EPC1,EPHA4,ERO1LB,ETV3,FAM102A,FAM160A2,FAM177A1,FAM53B,FAM83G,FBXL20,FBXO21,FGF9,FOSB,FOXO3,GALNT11,GGA3,GNL1,GPATCH8,GPR65,GTF3C4,HCP5P10,HERC1,HOOK1,HSPA13,IBA57,IDI1,IER5L,IFNGR1,IKZF5,IL18BP,IL7R,ITGA5,ITPKB,ITPRIP,JHDM1D,KDM6B,KIAA2018,KLF3,LOC100130744,LOC100133660,LOC100190986,LOC100289246,LOC152024,LOC400590,LOC727820,LONRF3,LTBP4,LUZP1,LYPD3,LYZ,MAP2K7,MAP3K2,MAPKAPK2,MIA3,MID2,MIDN,MIR101-1,MLL4,MLNR,MLXIP,MMP9,MSL2,MXD4,MYST3,NBEAL2,NFE2L2,NIPBL,NR1D2,NRIP3,OSBPL5,OSBPL7,PDE4B,PDP1,PELI2,PER1,PHLDB3,PIAS2,PIK3CA,PIK3IP1,PIK3R1,PLK3,POFUT2,PSME4,PTP4A1,PTPRE,RAB30,RABGEF1,RAPGEF2,RB1CC1,RBM38,RBMS2,RC3H1,REL,REXO1,RINT1,RNF125,RNF38,RPS6KB1,RSC1A1,RYK,SC5DL,SERTAD1,SETD2,SFN,SGK3,SIRT1,SLC11A2,SMAD7,SMAGP,SMURF1,SMURF2,SNX30,SPEN,SPON2,STX1A,SYAP1,TBC1D23,TCF7L2,TGFB1,TMEM57,TMEM88,TNRC6A,TOPORS,TP53BP2,TRIM39,TRIM52,TSC22D2,TSPYL2,UBL3,WDR91,YPEL5,ZBTB10,ZBTB11,ZBTB2,ZC3H12A,ZFP36,ZFYVE28,ZNF276,ZRANB1" MEMBERS_SYMBOLIZED="ABCB1,ACSL1,AGFG1,ALK,ANKRD13D,ARFGEF2,ARHGEF7,ARID5A,ASB6,ATG2A,ATP2B1,BACH2,BAMBI,BCL6,BCL9L,BCOR,BMAL1,BRD1,C1orf115,CACNA2D2,CAMK2N1,CARNS1,CCDC93,CCNL2,CDK12,CFAP410,CHD1,CHD7,CHKA,CKAP4,CLCF1,CNOT6L,COG3,COL6A2,CRTC2,CRY2,CRYBG1,CTRL,CTSO,CXorf65,CYTH3,DCTN6,DDI2,DDR2,DDX6,DHX36,DNAJC3,DNMBP,DNTTIP2,DUSP10,DUSP2,EEIG1,EID3,ELL,ENC1,ENTPD4,EPC1,EPHA4,ERO1B,ETV3,FAM177A1,FAM210B,FAM53B,FAM83G,FBXL20,FBXO21,FGF9,FHIP1B,FOSB,FOXO3,GALNT11,GGA3,GNL1,GPATCH8,GPR65,GTF3C4,HCP5B,HERC1,HOOK1,HSPA13,IBA57,IDI1,IER5L,IFNGR1,IKZF5,IL18BP,IL7R,ITGA5,ITPKB,ITPRIP,KAT6A,KDM6B,KDM7A,KLF3,KMT2D,LINC00528,LINC00691,LONRF3,LTBP4,LUZP1,LYPD3,LYZ,MACO1,MAP2K7,MAP3K2,MAPKAPK2,MIA3,MID2,MIDEAS,MIDN,MIR101-1,MLNR,MLXIP,MMP9,MSL2,MXD4,NBEAL2,NFE2L2,NIPBL,NOL4L,NR1D2,NRIP3,OSBPL5,OSBPL7,PDE4B,PDP1,PELI2,PER1,PHLDB3,PIAS2,PIK3CA,PIK3IP1,PIK3R1,PLK3,POFUT2,PSME4,PTP4A1,PTPRE,RAB30,RABGEF1,RAPGEF2,RB1CC1,RBM38,RBMS2,RC3H1,REL,REXO1,RINT1,RNF125,RNF38,RPS6KB1,RSC1A1,RYK,SC5D,SERTAD1,SETD2,SFN,SGK3,SIRT1,SLC11A2,SMAD7,SMAGP,SMURF1,SMURF2,SNX30,SPEN,SPON2,STX1A,SYAP1,TBC1D23,TCF7L2,TGFB1,TMEM88,TNRC6A,TOPORS,TP53BP2,TRIM39,TRIM52,TSC22D2,TSPYL2,UBL3,USF3,WDR91,YPEL5,ZBTB10,ZBTB11,ZBTB2,ZC3H12A,ZFP36,ZFYVE28,ZNF276,ZRANB1" MEMBERS_EZID="10068,10210,10417,10564,10608,10671,10746,10865,10970,11043,1105,1119,11221,113791,114879,114881,116151,1263,1292,140459,140688,1408,149041,1506,1519,152006,152024,158830,1656,170506,1844,200186,200205,200298,202,2043,205717,2117,2180,2254,22877,23013,23014,2309,23130,23131,23135,23163,23198,23218,23268,23275,23411,23529,2354,23678,23774,238,246175,25805,25836,27076,27107,27314,27327,27342,2794,2810,283149,283635,2862,29062,29072,29950,30836,3267,338692,3422,3459,352990,3575,3678,3707,375056,389792,399665,401548,406,406893,4069,4092,4318,4780,4891,490,4921,493861,51274,51361,5142,51646,51755,5187,5243,5290,5295,5412,54520,54704,54764,54880,54941,55167,55219,55450,55544,55636,55773,5609,5611,56605,56658,56675,57154,57161,57228,57455,57571,57621,57732,5791,5939,5966,604,60468,60561,6198,6248,6259,6309,63917,64061,64376,644815,64750,653583,65986,6782,6804,6934,7040,7159,7538,755,7798,7803,79762,79836,7994,80149,80314,8085,80853,81669,8178,83548,84067,8425,84301,8477,84851,84961,8507,85450,8874,8925,90007,9063,91748,92162,9254,9261,9265,92822,9329,94056,9583,9679,9693,9819,9821,9975" MEMBERS_MAPPING="ABCB1,ABCB1,5243|ACSL1,ACSL1,2180|AGFG1,AGFG1,3267|AIM1,CRYBG1,202|ALK,ALK,238|ANKRD13D,ANKRD13D,338692|ARFGEF2,ARFGEF2,10564|ARHGEF7,ARHGEF7,8874|ARID5A,ARID5A,10865|ARNTL,BMAL1,406|ASB6,ASB6,140459|ATG2A,ATG2A,23130|ATP2B1,ATP2B1,490|B7H6,null,null|BACH2,BACH2,60468|BAMBI,BAMBI,25805|BCL6,BCL6,604|BCL9L,BCL9L,283149|BCOR,BCOR,54880|BRD1,BRD1,23774|C14orf43,MIDEAS,91748|C1orf115,C1orf115,79762|C20orf108,FAM210B,116151|C20orf112,NOL4L,140688|C21orf2,CFAP410,755|C21orf96,null,null|C22orf37,LINC00528,200298|CACNA2D2,CACNA2D2,9254|CAMK2N1,CAMK2N1,55450|CARNS1,CARNS1,57571|CCDC93,CCDC93,54520|CCNL2,CCNL2,81669|CDK12,CDK12,51755|CHD1,CHD1,1105|CHD7,CHD7,55636|CHKA,CHKA,1119|CKAP4,CKAP4,10970|CLCF1,CLCF1,23529|CNOT6L,CNOT6L,246175|COG3,COG3,83548|COL6A2,COL6A2,1292|CRTC2,CRTC2,200186|CRY2,CRY2,1408|CTRL,CTRL,1506|CTSO,CTSO,1519|CXorf65,CXorf65,158830|CYTH3,CYTH3,9265|DCTN6,DCTN6,10671|DDI2,DDI2,84301|DDR2,DDR2,4921|DDX6,DDX6,1656|DHX36,DHX36,170506|DNAJC3,DNAJC3,5611|DNMBP,DNMBP,23268|DNTTIP2,DNTTIP2,30836|DUSP10,DUSP10,11221|DUSP2,DUSP2,1844|EID3,EID3,493861|ELL,ELL,8178|ENC1,ENC1,8507|ENTPD4,ENTPD4,9583|EPC1,EPC1,80314|EPHA4,EPHA4,2043|ERO1LB,ERO1B,56605|ETV3,ETV3,2117|FAM102A,EEIG1,399665|FAM160A2,FHIP1B,84067|FAM177A1,FAM177A1,283635|FAM53B,FAM53B,9679|FAM83G,FAM83G,644815|FBXL20,FBXL20,84961|FBXO21,FBXO21,23014|FGF9,FGF9,2254|FOSB,FOSB,2354|FOXO3,FOXO3,2309|GALNT11,GALNT11,63917|GGA3,GGA3,23163|GNL1,GNL1,2794|GPATCH8,GPATCH8,23131|GPR65,GPR65,8477|GTF3C4,GTF3C4,9329|HCP5P10,HCP5B,352990|HERC1,HERC1,8925|HOOK1,HOOK1,51361|HSPA13,HSPA13,6782|IBA57,IBA57,200205|IDI1,IDI1,3422|IER5L,IER5L,389792|IFNGR1,IFNGR1,3459|IKZF5,IKZF5,64376|IL18BP,IL18BP,10068|IL7R,IL7R,3575|ITGA5,ITGA5,3678|ITPKB,ITPKB,3707|ITPRIP,ITPRIP,85450|JHDM1D,KDM7A,80853|KDM6B,KDM6B,23135|KIAA2018,USF3,205717|KLF3,KLF3,51274|LOC100130744,null,null|LOC100133660,null,null|LOC100190986,null,null|LOC100289246,null,null|LOC152024,LINC00691,152024|LOC400590,null,null|LOC727820,null,null|LONRF3,LONRF3,79836|LTBP4,LTBP4,8425|LUZP1,LUZP1,7798|LYPD3,LYPD3,27076|LYZ,LYZ,4069|MAP2K7,MAP2K7,5609|MAP3K2,MAP3K2,10746|MAPKAPK2,MAPKAPK2,9261|MIA3,MIA3,375056|MID2,MID2,11043|MIDN,MIDN,90007|MIR101-1,MIR101-1,406893|MLL4,KMT2D,8085|MLNR,MLNR,2862|MLXIP,MLXIP,22877|MMP9,MMP9,4318|MSL2,MSL2,55167|MXD4,MXD4,10608|MYST3,KAT6A,7994|NBEAL2,NBEAL2,23218|NFE2L2,NFE2L2,4780|NIPBL,NIPBL,25836|NR1D2,NR1D2,9975|NRIP3,NRIP3,56675|OSBPL5,OSBPL5,114879|OSBPL7,OSBPL7,114881|PDE4B,PDE4B,5142|PDP1,PDP1,54704|PELI2,PELI2,57161|PER1,PER1,5187|PHLDB3,PHLDB3,653583|PIAS2,PIAS2,9063|PIK3CA,PIK3CA,5290|PIK3IP1,PIK3IP1,113791|PIK3R1,PIK3R1,5295|PLK3,PLK3,1263|POFUT2,POFUT2,23275|PSME4,PSME4,23198|PTP4A1,PTP4A1,7803|PTPRE,PTPRE,5791|RAB30,RAB30,27314|RABGEF1,RABGEF1,27342|RAPGEF2,RAPGEF2,9693|RB1CC1,RB1CC1,9821|RBM38,RBM38,55544|RBMS2,RBMS2,5939|RC3H1,RC3H1,149041|REL,REL,5966|REXO1,REXO1,57455|RINT1,RINT1,60561|RNF125,RNF125,54941|RNF38,RNF38,152006|RPS6KB1,RPS6KB1,6198|RSC1A1,RSC1A1,6248|RYK,RYK,6259|SC5DL,SC5D,6309|SERTAD1,SERTAD1,29950|SETD2,SETD2,29072|SFN,SFN,2810|SGK3,SGK3,23678|SIRT1,SIRT1,23411|SLC11A2,SLC11A2,4891|SMAD7,SMAD7,4092|SMAGP,SMAGP,57228|SMURF1,SMURF1,57154|SMURF2,SMURF2,64750|SNX30,SNX30,401548|SPEN,SPEN,23013|SPON2,SPON2,10417|STX1A,STX1A,6804|SYAP1,SYAP1,94056|TBC1D23,TBC1D23,55773|TCF7L2,TCF7L2,6934|TGFB1,TGFB1,7040|TMEM57,MACO1,55219|TMEM88,TMEM88,92162|TNRC6A,TNRC6A,27327|TOPORS,TOPORS,10210|TP53BP2,TP53BP2,7159|TRIM39,TRIM39,56658|TRIM52,TRIM52,84851|TSC22D2,TSC22D2,9819|TSPYL2,TSPYL2,64061|UBL3,UBL3,5412|WDR91,WDR91,29062|YPEL5,YPEL5,51646|ZBTB10,ZBTB10,65986|ZBTB11,ZBTB11,27107|ZBTB2,ZBTB2,57621|ZC3H12A,ZC3H12A,80149|ZFP36,ZFP36,7538|ZFYVE28,ZFYVE28,57732|ZNF276,ZNF276,92822|ZRANB1,ZRANB1,54764" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
