STANDARD_NAME	GSE21063_WT_VS_NFATC1_KO_BCELL_DN
SYSTEMATIC_NAME	M8261
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21063_WT_VS_NFATC1_KO_BCELL_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in B lymphocytes: wildtype versus NFATC1 [GeneID=4772] knockout.
DESCRIPTION_FULL	Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function.
PMID	21464221
GEOID	GSE21063
AUTHORS	Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE21063_3438_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABHD15,AIMP1,AKR1B1,ANGPTL4,ANLN,ANP32B,AP3D1,ARHGAP11A,ARMCX6,ARNT,ARNTL,ASF1A,ASPM,AURKA,BRIP1,C13orf27,C13orf34,C4orf22,C5orf46,C6orf48,C7orf55,CBX2,CCDC90B,CCR6,CCT5,CDC16,CDC20,CDC25C,CDC45,CDCA3,CDK1,CEP76,CHKB,CKAP2L,CKS1B,CLIC4,CLNS1A,CNIH,CNTROB,COX16,CPD,CRBN,CYTH1,DBP,DDHD1,DNAJC21,DNER,DNMT3B,DNTTIP2,E2F2,ECHDC1,ECSCR,EEF1B2,EIF3A,ENPP1,EPC2,EPRS,ERCC6L,ERI2,ETAA1,FAM110A,FBXO45,FLNB,FMR1,FOXN2,GALNT3,GFM1,GJA4,GLCE,GOLGA3,GOT2,GPANK1,GPSM2,GTF2IRD1,HDGF,HIPK3,HIVEP2,HP1BP3,HPS4,HS6ST1,HSF1,HSPA4L,HUS1,IARS,IFRD1,IK,JAK2,KCNT2,KDM6A,KIF20A,KIF20B,KIF2A,KNTC1,KTN1,LIX1L,LRRC40,LYAR,LYL1,MAPK14,MARCH3,MARCKSL1,MED17,METTL1,MFN1,MIB2,MLF1IP,MLLT3,MLST8,MMS22L,MYCN,NAP1L1,NBEAL1,NEURL1B,NFKB2,NNT,NRBF2,NSUN6,NUDCD2,NUP37,NUPR1,NUSAP1,OLA1,ORC5,OSBPL3,PALB2,PAPD7,PCBP2,PHF20,PI4K2B,PIBF1,PPM1F,PPP2R3C,PRKCI,PRPF8,PSMA6,PSMD8,PTPRA,PWWP2A,RAB10,RALA,RBBP5,RCOR2,RCOR3,REXO4,RPS6KA5,RSPRY1,SELS,SENP6,SIRT1,SLA,SLC35C2,SLC38A2,SLC3A2,SLC9A5,SMC2,SMC4,SMNDC1,SNRPF,SNX13,SOCS7,SP1,SP4,SPATA5L1,SSRP1,SYPL1,SZT2,TACC3,TATDN1,TBC1D12,TCERG1,TEX10,TMED3,TMEM126A,TMEM188,TMEM218,TMPO,TOPBP1,TOX2,TRAIP,TRIM68,TTC37,TULP3,UBE2C,UBE4B,UTP11L,UTP3,WDR62,XRCC6,YAF2,YAP1,ZFP36L1,ZNF25,ZNF318,ZNF48,ZNF490,ZNF652,ZNF7,ZNF799,ZNRF1,ZWILCH
GENE_SYMBOLS	ABHD15,AIMP1,AKR1B1,ANGPTL4,ANLN,ANP32B,AP3D1,ARHGAP11A,ARMCX6,ARNT,BMAL1,ASF1A,ASPM,AURKA,BRIP1,TEX30,BORA,CFAP299,C5orf46,SNHG32,FMC1,CBX2,CCDC90B,CCR6,CCT5,CDC16,CDC20,CDC25C,CDC45,CDCA3,CDK1,CEP76,CHKB,CKAP2L,CKS1B,CLIC4,CLNS1A,CNIH1,CNTROB,COX16,CPD,CRBN,CYTH1,DBP,DDHD1,DNAJC21,DNER,DNMT3B,DNTTIP2,E2F2,ECHDC1,ECSCR,EEF1B2,EIF3A,ENPP1,EPC2,EPRS1,ERCC6L,ERI2,ETAA1,FAM110A,FBXO45,FLNB,FMR1,FOXN2,GALNT3,GFM1,GJA4,GLCE,GOLGA3,GOT2,GPANK1,GPSM2,GTF2IRD1,HDGF,HIPK3,HIVEP2,HP1BP3,HPS4,HS6ST1,HSF1,HSPA4L,HUS1,IARS1,IFRD1,IK,JAK2,KCNT2,KDM6A,KIF20A,KIF20B,KIF2A,KNTC1,KTN1,LIX1L,LRRC40,LYAR,LYL1,MAPK14,MARCHF3,MARCKSL1,MED17,METTL1,MFN1,MIB2,CENPU,MLLT3,MLST8,MMS22L,MYCN,NAP1L1,NBEAL1,NEURL1B,NFKB2,NNT,NRBF2,NSUN6,NUDCD2,NUP37,NUPR1,NUSAP1,OLA1,ORC5,OSBPL3,PALB2,TENT4A,PCBP2,PHF20,PI4K2B,PIBF1,PPM1F,PPP2R3C,PRKCI,PRPF8,PSMA6,PSMD8,PTPRA,PWWP2A,RAB10,RALA,RBBP5,RCOR2,RCOR3,REXO4,RPS6KA5,RSPRY1,SELENOS,SENP6,SIRT1,SLA,SLC35C2,SLC38A2,SLC3A2,SLC9A5,SMC2,SMC4,SMNDC1,SNRPF,SNX13,SOCS7,SP1,SP4,AFG2B,SSRP1,SYPL1,SZT2,TACC3,TATDN1,TBC1D12,TCERG1,TEX10,TMED3,TMEM126A,CNEP1R1,TMEM218,TMPO,TOPBP1,TOX2,TRAIP,TRIM68,SKIC3,TULP3,UBE2C,UBE4B,UTP11,UTP3,WDR62,XRCC6,YAF2,YAP1,ZFP36L1,ZNF25,ZNF318,ZNF48,ZNF490,ZNF652,ZNF7,ZNF799,ZNRF1,ZWILCH
FOUNDER_NAMES