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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21063_WT_VS_NFATC1_KO_BCELL_DN" SYSTEMATIC_NAME="M8261" HISTORICAL_NAMES="" PMID="21464221" AUTHORS="Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E" GEOID="GSE21063" EXACT_SOURCE="GSE21063_3438_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in B lymphocytes: wildtype versus NFATC1 [GeneID=4772] knockout." DESCRIPTION_FULL="Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function." TAGS="" MEMBERS="ABHD15,AIMP1,AKR1B1,ANGPTL4,ANLN,ANP32B,AP3D1,ARHGAP11A,ARMCX6,ARNT,ARNTL,ASF1A,ASPM,AURKA,BRIP1,C13orf27,C13orf34,C4orf22,C5orf46,C6orf48,C7orf55,CBX2,CCDC90B,CCR6,CCT5,CDC16,CDC20,CDC25C,CDC45,CDCA3,CDK1,CEP76,CHKB,CKAP2L,CKS1B,CLIC4,CLNS1A,CNIH,CNTROB,COX16,CPD,CRBN,CYTH1,DBP,DDHD1,DNAJC21,DNER,DNMT3B,DNTTIP2,E2F2,ECHDC1,ECSCR,EEF1B2,EIF3A,ENPP1,EPC2,EPRS,ERCC6L,ERI2,ETAA1,FAM110A,FBXO45,FLNB,FMR1,FOXN2,GALNT3,GFM1,GJA4,GLCE,GOLGA3,GOT2,GPANK1,GPSM2,GTF2IRD1,HDGF,HIPK3,HIVEP2,HP1BP3,HPS4,HS6ST1,HSF1,HSPA4L,HUS1,IARS,IFRD1,IK,JAK2,KCNT2,KDM6A,KIF20A,KIF20B,KIF2A,KNTC1,KTN1,LIX1L,LRRC40,LYAR,LYL1,MAPK14,MARCH3,MARCKSL1,MED17,METTL1,MFN1,MIB2,MLF1IP,MLLT3,MLST8,MMS22L,MYCN,NAP1L1,NBEAL1,NEURL1B,NFKB2,NNT,NRBF2,NSUN6,NUDCD2,NUP37,NUPR1,NUSAP1,OLA1,ORC5,OSBPL3,PALB2,PAPD7,PCBP2,PHF20,PI4K2B,PIBF1,PPM1F,PPP2R3C,PRKCI,PRPF8,PSMA6,PSMD8,PTPRA,PWWP2A,RAB10,RALA,RBBP5,RCOR2,RCOR3,REXO4,RPS6KA5,RSPRY1,SELS,SENP6,SIRT1,SLA,SLC35C2,SLC38A2,SLC3A2,SLC9A5,SMC2,SMC4,SMNDC1,SNRPF,SNX13,SOCS7,SP1,SP4,SPATA5L1,SSRP1,SYPL1,SZT2,TACC3,TATDN1,TBC1D12,TCERG1,TEX10,TMED3,TMEM126A,TMEM188,TMEM218,TMPO,TOPBP1,TOX2,TRAIP,TRIM68,TTC37,TULP3,UBE2C,UBE4B,UTP11L,UTP3,WDR62,XRCC6,YAF2,YAP1,ZFP36L1,ZNF25,ZNF318,ZNF48,ZNF490,ZNF652,ZNF7,ZNF799,ZNRF1,ZWILCH" MEMBERS_SYMBOLIZED="ABHD15,AFG2B,AIMP1,AKR1B1,ANGPTL4,ANLN,ANP32B,AP3D1,ARHGAP11A,ARMCX6,ARNT,ASF1A,ASPM,AURKA,BMAL1,BORA,BRIP1,C5orf46,CBX2,CCDC90B,CCR6,CCT5,CDC16,CDC20,CDC25C,CDC45,CDCA3,CDK1,CENPU,CEP76,CFAP299,CHKB,CKAP2L,CKS1B,CLIC4,CLNS1A,CNEP1R1,CNIH1,CNTROB,COX16,CPD,CRBN,CYTH1,DBP,DDHD1,DNAJC21,DNER,DNMT3B,DNTTIP2,E2F2,ECHDC1,ECSCR,EEF1B2,EIF3A,ENPP1,EPC2,EPRS1,ERCC6L,ERI2,ETAA1,FAM110A,FBXO45,FLNB,FMC1,FMR1,FOXN2,GALNT3,GFM1,GJA4,GLCE,GOLGA3,GOT2,GPANK1,GPSM2,GTF2IRD1,HDGF,HIPK3,HIVEP2,HP1BP3,HPS4,HS6ST1,HSF1,HSPA4L,HUS1,IARS1,IFRD1,IK,JAK2,KCNT2,KDM6A,KIF20A,KIF20B,KIF2A,KNTC1,KTN1,LIX1L,LRRC40,LYAR,LYL1,MAPK14,MARCHF3,MARCKSL1,MED17,METTL1,MFN1,MIB2,MLLT3,MLST8,MMS22L,MYCN,NAP1L1,NBEAL1,NEURL1B,NFKB2,NNT,NRBF2,NSUN6,NUDCD2,NUP37,NUPR1,NUSAP1,OLA1,ORC5,OSBPL3,PALB2,PCBP2,PHF20,PI4K2B,PIBF1,PPM1F,PPP2R3C,PRKCI,PRPF8,PSMA6,PSMD8,PTPRA,PWWP2A,RAB10,RALA,RBBP5,RCOR2,RCOR3,REXO4,RPS6KA5,RSPRY1,SELENOS,SENP6,SIRT1,SKIC3,SLA,SLC35C2,SLC38A2,SLC3A2,SLC9A5,SMC2,SMC4,SMNDC1,SNHG32,SNRPF,SNX13,SOCS7,SP1,SP4,SSRP1,SYPL1,SZT2,TACC3,TATDN1,TBC1D12,TCERG1,TENT4A,TEX10,TEX30,TMED3,TMEM126A,TMEM218,TMPO,TOPBP1,TOX2,TRAIP,TRIM68,TULP3,UBE2C,UBE4B,UTP11,UTP3,WDR62,XRCC6,YAF2,YAP1,ZFP36L1,ZNF25,ZNF318,ZNF48,ZNF490,ZNF652,ZNF7,ZNF799,ZNRF1,ZWILCH" MEMBERS_EZID="10051,10112,10114,10138,10175,10277,10285,10293,10413,10460,10464,10541,10592,10594,10890,10915,11044,11065,11073,1120,112479,114825,115123,116236,1163,116840,1207,1235,128077,134218,134492,1362,142678,1432,150468,154791,1628,1789,1870,1933,197407,200933,2058,219749,219854,221078,22824,22834,22948,231,23161,2317,23232,2332,23334,23411,23423,23530,24149,253714,2547,255119,255919,25842,2591,259266,25932,26031,26035,26054,26122,26471,2701,2802,2806,283248,284403,29789,29899,29982,3068,30836,30837,3097,3297,3344,3364,3376,343450,3475,3550,3717,3796,389336,3895,405,406,4066,4234,4300,4613,4673,4791,5001,50809,50854,5094,51006,51118,51129,51185,51203,51230,51241,5167,54407,54443,54465,54470,54492,54821,54881,55012,55055,55128,55300,55631,55646,55669,55758,55829,5584,55862,5687,57050,57109,5714,57474,5786,5898,5929,60492,641700,64223,6503,65065,65108,6520,6553,6636,6667,6671,6749,677,6790,6856,7112,7289,7403,7553,79023,79029,7918,79682,79728,79866,79959,80821,8318,83461,83541,83940,83990,84233,84733,84937,84969,85476,8661,8881,8943,89781,89970,90576,9252,9255,9267,92737,93081,9394,9440,9569,9585,9647,9652,9735,9824,983,991,995" MEMBERS_MAPPING="ABHD15,ABHD15,116236|AIMP1,AIMP1,9255|AKR1B1,AKR1B1,231|ANGPTL4,ANGPTL4,51129|ANLN,ANLN,54443|ANP32B,ANP32B,10541|AP3D1,AP3D1,8943|ARHGAP11A,ARHGAP11A,9824|ARMCX6,ARMCX6,54470|ARNT,ARNT,405|ARNTL,BMAL1,406|ASF1A,ASF1A,25842|ASPM,ASPM,259266|AURKA,AURKA,6790|BRIP1,BRIP1,83990|C13orf27,TEX30,93081|C13orf34,BORA,79866|C4orf22,CFAP299,255119|C5orf46,C5orf46,389336|C6orf48,SNHG32,50854|C7orf55,FMC1,154791|CBX2,CBX2,84733|CCDC90B,CCDC90B,60492|CCR6,CCR6,1235|CCT5,CCT5,22948|CDC16,CDC16,8881|CDC20,CDC20,991|CDC25C,CDC25C,995|CDC45,CDC45,8318|CDCA3,CDCA3,83461|CDK1,CDK1,983|CEP76,CEP76,79959|CHKB,CHKB,1120|CKAP2L,CKAP2L,150468|CKS1B,CKS1B,1163|CLIC4,CLIC4,25932|CLNS1A,CLNS1A,1207|CNIH,CNIH1,10175|CNTROB,CNTROB,116840|COX16,COX16,51241|CPD,CPD,1362|CRBN,CRBN,51185|CYTH1,CYTH1,9267|DBP,DBP,1628|DDHD1,DDHD1,80821|DNAJC21,DNAJC21,134218|DNER,DNER,92737|DNMT3B,DNMT3B,1789|DNTTIP2,DNTTIP2,30836|E2F2,E2F2,1870|ECHDC1,ECHDC1,55862|ECSCR,ECSCR,641700|EEF1B2,EEF1B2,1933|EIF3A,EIF3A,8661|ENPP1,ENPP1,5167|EPC2,EPC2,26122|EPRS,EPRS1,2058|ERCC6L,ERCC6L,54821|ERI2,ERI2,112479|ETAA1,ETAA1,54465|FAM110A,FAM110A,83541|FBXO45,FBXO45,200933|FLNB,FLNB,2317|FMR1,FMR1,2332|FOXN2,FOXN2,3344|GALNT3,GALNT3,2591|GFM1,GFM1,85476|GJA4,GJA4,2701|GLCE,GLCE,26035|GOLGA3,GOLGA3,2802|GOT2,GOT2,2806|GPANK1,GPANK1,7918|GPSM2,GPSM2,29899|GTF2IRD1,GTF2IRD1,9569|HDGF,HDGF,3068|HIPK3,HIPK3,10114|HIVEP2,HIVEP2,3097|HP1BP3,HP1BP3,50809|HPS4,HPS4,89781|HS6ST1,HS6ST1,9394|HSF1,HSF1,3297|HSPA4L,HSPA4L,22824|HUS1,HUS1,3364|IARS,IARS1,3376|IFRD1,IFRD1,3475|IK,IK,3550|JAK2,JAK2,3717|KCNT2,KCNT2,343450|KDM6A,KDM6A,7403|KIF20A,KIF20A,10112|KIF20B,KIF20B,9585|KIF2A,KIF2A,3796|KNTC1,KNTC1,9735|KTN1,KTN1,3895|LIX1L,LIX1L,128077|LRRC40,LRRC40,55631|LYAR,LYAR,55646|LYL1,LYL1,4066|MAPK14,MAPK14,1432|MARCH3,MARCHF3,115123|MARCKSL1,MARCKSL1,65108|MED17,MED17,9440|METTL1,METTL1,4234|MFN1,MFN1,55669|MIB2,MIB2,142678|MLF1IP,CENPU,79682|MLLT3,MLLT3,4300|MLST8,MLST8,64223|MMS22L,MMS22L,253714|MYCN,MYCN,4613|NAP1L1,NAP1L1,4673|NBEAL1,NBEAL1,65065|NEURL1B,NEURL1B,54492|NFKB2,NFKB2,4791|NNT,NNT,23530|NRBF2,NRBF2,29982|NSUN6,NSUN6,221078|NUDCD2,NUDCD2,134492|NUP37,NUP37,79023|NUPR1,NUPR1,26471|NUSAP1,NUSAP1,51203|OLA1,OLA1,29789|ORC5,ORC5,5001|OSBPL3,OSBPL3,26031|PALB2,PALB2,79728|PAPD7,TENT4A,11044|PCBP2,PCBP2,5094|PHF20,PHF20,51230|PI4K2B,PI4K2B,55300|PIBF1,PIBF1,10464|PPM1F,PPM1F,9647|PPP2R3C,PPP2R3C,55012|PRKCI,PRKCI,5584|PRPF8,PRPF8,10594|PSMA6,PSMA6,5687|PSMD8,PSMD8,5714|PTPRA,PTPRA,5786|PWWP2A,PWWP2A,114825|RAB10,RAB10,10890|RALA,RALA,5898|RBBP5,RBBP5,5929|RCOR2,RCOR2,283248|RCOR3,RCOR3,55758|REXO4,REXO4,57109|RPS6KA5,RPS6KA5,9252|RSPRY1,RSPRY1,89970|SELS,SELENOS,55829|SENP6,SENP6,26054|SIRT1,SIRT1,23411|SLA,SLA,6503|SLC35C2,SLC35C2,51006|SLC38A2,SLC38A2,54407|SLC3A2,SLC3A2,6520|SLC9A5,SLC9A5,6553|SMC2,SMC2,10592|SMC4,SMC4,10051|SMNDC1,SMNDC1,10285|SNRPF,SNRPF,6636|SNX13,SNX13,23161|SOCS7,SOCS7,30837|SP1,SP1,6667|SP4,SP4,6671|SPATA5L1,AFG2B,79029|SSRP1,SSRP1,6749|SYPL1,SYPL1,6856|SZT2,SZT2,23334|TACC3,TACC3,10460|TATDN1,TATDN1,83940|TBC1D12,TBC1D12,23232|TCERG1,TCERG1,10915|TEX10,TEX10,54881|TMED3,TMED3,23423|TMEM126A,TMEM126A,84233|TMEM188,CNEP1R1,255919|TMEM218,TMEM218,219854|TMPO,TMPO,7112|TOPBP1,TOPBP1,11073|TOX2,TOX2,84969|TRAIP,TRAIP,10293|TRIM68,TRIM68,55128|TTC37,SKIC3,9652|TULP3,TULP3,7289|UBE2C,UBE2C,11065|UBE4B,UBE4B,10277|UTP11L,UTP11,51118|UTP3,UTP3,57050|WDR62,WDR62,284403|XRCC6,XRCC6,2547|YAF2,YAF2,10138|YAP1,YAP1,10413|ZFP36L1,ZFP36L1,677|ZNF25,ZNF25,219749|ZNF318,ZNF318,24149|ZNF48,ZNF48,197407|ZNF490,ZNF490,57474|ZNF652,ZNF652,22834|ZNF7,ZNF7,7553|ZNF799,ZNF799,90576|ZNRF1,ZNRF1,84937|ZWILCH,ZWILCH,55055" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
