STANDARD_NAME GSE21063_WT_VS_NFATC1_KO_BCELL_UP SYSTEMATIC_NAME M8260 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21063_WT_VS_NFATC1_KO_BCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in B lymphocytes: wildtype versus NFATC1 [GeneID=4772] knockout. DESCRIPTION_FULL Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function. PMID 21464221 GEOID GSE21063 AUTHORS Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE21063_3438_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCD2,ABLIM1,ACOT7,AFF3,AGTR1,AK1,ALDOAP2,ANGEL1,ANKRD46,ANXA1,ANXA6,AQP7,ARL4C,ARRDC4,ASB2,AUH,B4GALNT2,BASP1,BBS9,BCL2L11,C12orf57,C14orf135,C14orf180,C16orf57,C16orf90,C1orf114,C20orf177,C3orf70,CACNB2,CADM2,CASP6,CBFB,CCBL2,CCDC79,CCR5,CCS,CD200R1,CD3E,CD5L,CD86,CHCHD8,CITED1,CLPTM1L,CNGB3,CTNNA1,CTRC,CTSF,CTSW,CXCR3,CXCR6,CYP2F1,DBH,DNAJB12,DUSP2,EAF2,ECM1,EFEMP2,EFNA3,EHD3,ENPP2,ENTPD1,ERN2,EXTL2,FAH,FBXO34,FBXO6,FCRL1,FKBP14,FOLR4,FOXO1,GABARAPL1,GALNT4,GATSL3,GBA,GFRA1,GIMAP6,GJA1,GPNMB,GPR161,GPR85,GPX2,GTF2H5,GUCY2C,HECW1,HIC1,HNF1A,HOXA4,HSD17B14,HTR1D,IBA57,IQGAP2,KLHDC3,KRT78,KRTAP13-2,LARGE,LGI1,LMO7,LOC641515,LOX,LOXL1,LRRTM2,MAP1S,MAP6,MFI2,MPP4,MRPS21,MXD1,MYO6,MYOZ1,NAALADL1,NEB,NGF,NLRC3,NLRP12,NOVA1,NOXO1,NPHP3,NRIP2,NT5E,NTF4,OAZ2,OR7C1,OXNAD1,OXSR1,PARP9,PCDH8,PCSK1,PCYOX1L,PDZK1IP1,PER3,PEX11A,PGLYRP2,PHF23,PIK3CG,PKHD1L1,PLAC8,PLBD2,POGLUT1,PPA1,PPP1R3G,PRR5,PTPRCAP,PYROXD1,RABL2A,RASSF2,RBMXL2,RHOH,RIPK3,RNASE4,RPE65,SAMD9L,SCN3A,SEMA7A,SEPP1,SH3BGRL3,SH3PXD2B,SH3TC2,SIGIRR,SLAMF6,SLC16A11,SLC38A3,SLC44A3,SLC7A4,SNX32,SOX6,SPACA1,SPHKAP,SPRR2F,SSBP4,ST6GALNAC1,STAT2,STK32C,STOML1,STX17,TAS1R3,TBCD,TBXA2R,TCF15,TCL1A,TEX12,THY1,TIMP1,TM9SF4,TMC7,TNS1,TPST1,TRAP1,TRAPPC2L,TRIM66,TRIP6,TSPAN4,UCP2,USP31,USP49,VASH2,VPS37A,VPS53,WNT10B,XDH,ZNF239 GENE_SYMBOLS ABCD2,ABLIM1,ACOT7,AFF3,AGTR1,AK1,ALDOAP2,ANGEL1,ANKRD46,ANXA1,ANXA6,AQP7,ARL4C,ARRDC4,ASB2,AUH,B4GALNT2,BASP1,BBS9,BCL2L11,C12orf57,PCNX4,C14orf180,USB1,C16orf90,CCDC181,FAM217B,C3orf70,CACNB2,CADM2,CASP6,CBFB,KYAT3,TERB1,CCR5,CCS,CD200R1,CD3E,CD5L,CD86,COA4,CITED1,CLPTM1L,CNGB3,CTNNA1,CTRC,CTSF,CTSW,CXCR3,CXCR6,CYP2F1,DBH,DNAJB12,DUSP2,EAF2,ECM1,EFEMP2,EFNA3,EHD3,ENPP2,ENTPD1,ERN2,EXTL2,FAH,FBXO34,FBXO6,FCRL1,FKBP14,IZUMO1R,FOXO1,GABARAPL1,GALNT4,CASTOR1,GBA1,GFRA1,GIMAP6,GJA1,GPNMB,GPR161,GPR85,GPX2,GTF2H5,GUCY2C,HECW1,HIC1,HNF1A,HOXA4,HSD17B14,HTR1D,IBA57,IQGAP2,KLHDC3,KRT78,KRTAP13-2,LARGE1,LGI1,LMO7,MGAT4EP,LOX,LOXL1,LRRTM2,MAP1S,MAP6,MELTF,MPP4,MRPS21,MXD1,MYO6,MYOZ1,NAALADL1,NEB,NGF,NLRC3,NLRP12,NOVA1,NOXO1,NPHP3,NRIP2,NT5E,NTF4,OAZ2,OR7C1,OXNAD1,OXSR1,PARP9,PCDH8,PCSK1,PCYOX1L,PDZK1IP1,PER3,PEX11A,PGLYRP2,PHF23,PIK3CG,PKHD1L1,PLAC8,PLBD2,POGLUT1,PPA1,PPP1R3G,PRR5,PTPRCAP,PYROXD1,RABL2A,RASSF2,RBMXL2,RHOH,RIPK3,RNASE4,RPE65,SAMD9L,SCN3A,SEMA7A,SELENOP,SH3BGRL3,SH3PXD2B,SH3TC2,SIGIRR,SLAMF6,SLC16A11,SLC38A3,SLC44A3,SLC7A4,SNX32,SOX6,SPACA1,SPHKAP,SPRR2F,SSBP4,ST6GALNAC1,STAT2,STK32C,STOML1,STX17,TAS1R3,TBCD,TBXA2R,TCF15,TCL1A,TEX12,THY1,TIMP1,TM9SF4,TMC7,TNS1,TPST1,TRAP1,TRAPPC2L,TRIM66,TRIP6,TSPAN4,UCP2,USP31,USP49,VASH2,VPS37A,VPS53,WNT10B,XDH,ZNF239 FOUNDER_NAMES