STANDARD_NAME	GSE21546_ELK1_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN
SYSTEMATIC_NAME	M7531
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21546_ELK1_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in stimulated by anti-CD3 double positive thymocytes: ELK1 [GeneID=2002] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout.
DESCRIPTION_FULL	Removal of the transcription factor SAP1a member of the Ternary Complex Factor (TCF) group of transcription factors which in conjunction with Serum Response Factor (SRF) has been shown to have a profound effect on positive selection in the thymus. When another TCF Elk1 is knocked out in mice there is no effect on positive selection unless it is on a Sap1a KO background where the phenotype is very severe. We have stimulated isolated double positive T cells (DPs) with anti-CD3 to mimic positive selection and compared basal and stimulated transcription across the four genotypes to discover the downstream targets of Sap1a involved in positive selection.
PMID	20554967
GEOID	GSE21546
AUTHORS	Costello P,Nicolas R,Willoughby J,Wasylyk B,Nordheim A,Treisman R
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE21546_3646_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABL2,ACCN3,ACOT13,ACSM1,AHSA1,ANKRD11,AREG,ARHGAP21,ARHGEF26,ARL4D,ARL5B,ARL8B,AZI2,B3GNT3,B4GALT5,BAG3,BCL6,BDP1,BEND3,BMP5,BNC1,BRE,C16orf72,C19orf56,C1orf9,C20orf165,C6orf106,C7orf60,C8orf4,CABLES2,CABS1,CBS,CCDC107,CCDC117,CCNT1,CDC25A,CDC42SE1,CDK17,CDK3,CDV3,CHKA,CHORDC1,CLEC2L,CLK3,CNGA1,CNPY3,CORO1C,CREB5,CRHR2,CSNK1G1,CSRNP1,CXCL3,DDX6,DENND1B,DENND1C,DHFR,DHX16,DHX29,DIEXF,DNAJB6,DPCD,DUSP16,DUSP2,DUSP6,DUSP8,DYRK2,DYRK3,EDN2,EFHD2,EGR1,EIF2B2,ELFN1,ETS1,EXOC5,FAM84A,FBXO30,FBXO34,FIBCD1,FLJ36031,GABPB1,GADD45B,GEM,GLE1,GRSF1,GUSB,HSD17B12,HSF2,HSPA8,HSPE1,HSPH1,IL10RA,IL3RA,INPP5F,INPPL1,IPMK,ITIH3,IZUMO1,JARID2,KCMF1,KCNJ14,KCNJ6,KCNT1,KCTD4,KIAA0232,KIAA1267,KLHL28,KRT72,LMF2,LOC283692,LPIN2,LY6D,LY6H,LZTS2,MANBAL,MAPKAPK2,MAPKAPK5,MARVELD2,MDM2,MED13,MFHAS1,MGEA5,MLF1IP,MRPL20,MTA1,NFKBID,NGEF,NIPSNAP3B,NMT2,NPM3,NR4A1,NUDT6,OPN3,OSGIN1,PAK6,PDXP,PER1,PGF,PHF17,PHLPP2,PHRF1,PIM1,PITHD1,PKN2,PLA2G5,PLCB2,PLEKHF1,PLK2,POLR1B,PPP1R13L,PTBP1,QPCT,RBM12,RCVRN,RGS16,RTCD1,RUFY3,SCGN,SEPN1,SEPT1,SERP1,SERPINB12,SH3BP2,SKIL,SKP1,SLC1A1,SLC30A1,SLCO1C1,SNPH,SPRY2,SPRY4,SQSTM1,SRP72,STIP1,TAF1A,TAGLN2,TBC1D1,TFB2M,TMCC1,TMEM200A,TMEM66,TNFAIP3,TNFRSF1B,TRAF6,TRAPPC9,TREML4,TRHR,UBAP1,UBE2B,UBE2F,UPP1,USPL1,YTHDC1,YTHDF1,ZFAND2A,ZNF367,ZNF469,ZNF623,ZNF655,ZNF703,ZNF777
GENE_SYMBOLS	ABL2,ASIC3,ACOT13,ACSM1,AHSA1,ANKRD11,AREG,ARHGAP21,ARHGEF26,ARL4D,ARL5B,ARL8B,AZI2,B3GNT3,B4GALT5,BAG3,BCL6,BDP1,BEND3,BMP5,BNC1,BABAM2,HAPSTR1,WDR83OS,SUCO,SPATA25,ILRUN,SAMTOR,TCIM,CABLES2,CABS1,CBS,CCDC107,CCDC117,CCNT1,CDC25A,CDC42SE1,CDK17,CDK3,CDV3,CHKA,CHORDC1,CLEC2L,CLK3,CNGA1,CNPY3,CORO1C,CREB5,CRHR2,CSNK1G1,CSRNP1,CXCL3,DDX6,DENND1B,DENND1C,DHFR,DHX16,DHX29,UTP25,DNAJB6,DPCD,DUSP16,DUSP2,DUSP6,DUSP8,DYRK2,DYRK3,EDN2,EFHD2,EGR1,EIF2B2,ELFN1,ETS1,EXOC5,LRATD1,FBXO30,FBXO34,FIBCD1,CCDC71L,GABPB1,GADD45B,GEM,GLE1,GRSF1,GUSB,HSD17B12,HSF2,HSPA8,HSPE1,HSPH1,IL10RA,IL3RA,INPP5F,INPPL1,IPMK,ITIH3,IZUMO1,JARID2,KCMF1,KCNJ14,KCNJ6,KCNT1,KCTD4,KIAA0232,KANSL1,KLHL28,KRT72,LMF2,CPEB1-AS1,LPIN2,LY6D,LY6H,LZTS2,MANBAL,MAPKAPK2,MAPKAPK5,MARVELD2,MDM2,MED13,MFHAS1,OGA,CENPU,MRPL20,MTA1,NFKBID,NGEF,NIPSNAP3B,NMT2,NPM3,NR4A1,NUDT6,OPN3,OSGIN1,PAK6,PDXP,PER1,PGF,JADE1,PHLPP2,PHRF1,PIM1,PITHD1,PKN2,PLA2G5,PLCB2,PLEKHF1,PLK2,POLR1B,PPP1R13L,PTBP1,QPCT,RBM12,RCVRN,RGS16,RTCA,RUFY3,SCGN,SELENON,SEPTIN1,SERP1,SERPINB12,SH3BP2,SKIL,SKP1,SLC1A1,SLC30A1,SLCO1C1,SNPH,SPRY2,SPRY4,SQSTM1,SRP72,STIP1,TAF1A,TAGLN2,TBC1D1,TFB2M,TMCC1,TMEM200A,SARAF,TNFAIP3,TNFRSF1B,TRAF6,TRAPPC9,TREML4,TRHR,UBAP1,UBE2B,UBE2F,UPP1,USPL1,YTHDC1,YTHDF1,ZFAND2A,ZNF367,ZNF469,ZNF623,ZNF655,ZNF703,ZNF777
FOUNDER_NAMES