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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21546_ELK1_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN" SYSTEMATIC_NAME="M7531" HISTORICAL_NAMES="" PMID="20554967" AUTHORS="Costello P,Nicolas R,Willoughby J,Wasylyk B,Nordheim A,Treisman R" GEOID="GSE21546" EXACT_SOURCE="GSE21546_3646_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in stimulated by anti-CD3 double positive thymocytes: ELK1 [GeneID=2002] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout." DESCRIPTION_FULL="Removal of the transcription factor SAP1a member of the Ternary Complex Factor (TCF) group of transcription factors which in conjunction with Serum Response Factor (SRF) has been shown to have a profound effect on positive selection in the thymus. When another TCF Elk1 is knocked out in mice there is no effect on positive selection unless it is on a Sap1a KO background where the phenotype is very severe. We have stimulated isolated double positive T cells (DPs) with anti-CD3 to mimic positive selection and compared basal and stimulated transcription across the four genotypes to discover the downstream targets of Sap1a involved in positive selection." TAGS="" MEMBERS="ABL2,ACCN3,ACOT13,ACSM1,AHSA1,ANKRD11,AREG,ARHGAP21,ARHGEF26,ARL4D,ARL5B,ARL8B,AZI2,B3GNT3,B4GALT5,BAG3,BCL6,BDP1,BEND3,BMP5,BNC1,BRE,C16orf72,C19orf56,C1orf9,C20orf165,C6orf106,C7orf60,C8orf4,CABLES2,CABS1,CBS,CCDC107,CCDC117,CCNT1,CDC25A,CDC42SE1,CDK17,CDK3,CDV3,CHKA,CHORDC1,CLEC2L,CLK3,CNGA1,CNPY3,CORO1C,CREB5,CRHR2,CSNK1G1,CSRNP1,CXCL3,DDX6,DENND1B,DENND1C,DHFR,DHX16,DHX29,DIEXF,DNAJB6,DPCD,DUSP16,DUSP2,DUSP6,DUSP8,DYRK2,DYRK3,EDN2,EFHD2,EGR1,EIF2B2,ELFN1,ETS1,EXOC5,FAM84A,FBXO30,FBXO34,FIBCD1,FLJ36031,GABPB1,GADD45B,GEM,GLE1,GRSF1,GUSB,HSD17B12,HSF2,HSPA8,HSPE1,HSPH1,IL10RA,IL3RA,INPP5F,INPPL1,IPMK,ITIH3,IZUMO1,JARID2,KCMF1,KCNJ14,KCNJ6,KCNT1,KCTD4,KIAA0232,KIAA1267,KLHL28,KRT72,LMF2,LOC283692,LPIN2,LY6D,LY6H,LZTS2,MANBAL,MAPKAPK2,MAPKAPK5,MARVELD2,MDM2,MED13,MFHAS1,MGEA5,MLF1IP,MRPL20,MTA1,NFKBID,NGEF,NIPSNAP3B,NMT2,NPM3,NR4A1,NUDT6,OPN3,OSGIN1,PAK6,PDXP,PER1,PGF,PHF17,PHLPP2,PHRF1,PIM1,PITHD1,PKN2,PLA2G5,PLCB2,PLEKHF1,PLK2,POLR1B,PPP1R13L,PTBP1,QPCT,RBM12,RCVRN,RGS16,RTCD1,RUFY3,SCGN,SEPN1,SEPT1,SERP1,SERPINB12,SH3BP2,SKIL,SKP1,SLC1A1,SLC30A1,SLCO1C1,SNPH,SPRY2,SPRY4,SQSTM1,SRP72,STIP1,TAF1A,TAGLN2,TBC1D1,TFB2M,TMCC1,TMEM200A,TMEM66,TNFAIP3,TNFRSF1B,TRAF6,TRAPPC9,TREML4,TRHR,UBAP1,UBE2B,UBE2F,UPP1,USPL1,YTHDC1,YTHDF1,ZFAND2A,ZNF367,ZNF469,ZNF623,ZNF655,ZNF703,ZNF777" MEMBERS_SYMBOLIZED="ABL2,ACOT13,ACSM1,AHSA1,ANKRD11,AREG,ARHGAP21,ARHGEF26,ARL4D,ARL5B,ARL8B,ASIC3,AZI2,B3GNT3,B4GALT5,BABAM2,BAG3,BCL6,BDP1,BEND3,BMP5,BNC1,CABLES2,CABS1,CBS,CCDC107,CCDC117,CCDC71L,CCNT1,CDC25A,CDC42SE1,CDK17,CDK3,CDV3,CENPU,CHKA,CHORDC1,CLEC2L,CLK3,CNGA1,CNPY3,CORO1C,CPEB1-AS1,CREB5,CRHR2,CSNK1G1,CSRNP1,CXCL3,DDX6,DENND1B,DENND1C,DHFR,DHX16,DHX29,DNAJB6,DPCD,DUSP16,DUSP2,DUSP6,DUSP8,DYRK2,DYRK3,EDN2,EFHD2,EGR1,EIF2B2,ELFN1,ETS1,EXOC5,FBXO30,FBXO34,FIBCD1,GABPB1,GADD45B,GEM,GLE1,GRSF1,GUSB,HAPSTR1,HSD17B12,HSF2,HSPA8,HSPE1,HSPH1,IL10RA,IL3RA,ILRUN,INPP5F,INPPL1,IPMK,ITIH3,IZUMO1,JADE1,JARID2,KANSL1,KCMF1,KCNJ14,KCNJ6,KCNT1,KCTD4,KIAA0232,KLHL28,KRT72,LMF2,LPIN2,LRATD1,LY6D,LY6H,LZTS2,MANBAL,MAPKAPK2,MAPKAPK5,MARVELD2,MDM2,MED13,MFHAS1,MRPL20,MTA1,NFKBID,NGEF,NIPSNAP3B,NMT2,NPM3,NR4A1,NUDT6,OGA,OPN3,OSGIN1,PAK6,PDXP,PER1,PGF,PHLPP2,PHRF1,PIM1,PITHD1,PKN2,PLA2G5,PLCB2,PLEKHF1,PLK2,POLR1B,PPP1R13L,PTBP1,QPCT,RBM12,RCVRN,RGS16,RTCA,RUFY3,SAMTOR,SARAF,SCGN,SELENON,SEPTIN1,SERP1,SERPINB12,SH3BP2,SKIL,SKP1,SLC1A1,SLC30A1,SLCO1C1,SNPH,SPATA25,SPRY2,SPRY4,SQSTM1,SRP72,STIP1,SUCO,TAF1A,TAGLN2,TBC1D1,TCIM,TFB2M,TMCC1,TMEM200A,TNFAIP3,TNFRSF1B,TRAF6,TRAPPC9,TREML4,TRHR,UBAP1,UBE2B,UBE2F,UPP1,USPL1,UTP25,WDR83OS,YTHDC1,YTHDF1,ZFAND2A,ZNF367,ZNF469,ZNF623,ZNF655,ZNF703,ZNF777" MEMBERS_EZID="10049,10137,1018,10208,10253,10331,10360,10590,10598,10640,10695,10724,10769,10808,10848,10963,11162,1119,114801,116285,1198,1259,128497,1395,140739,140807,150275,151354,153562,154743,154790,163486,1656,168455,1719,1731,1844,1848,1850,1907,1958,195828,203260,2113,221079,22876,22902,23023,23035,23216,23596,23603,253430,2553,25791,25797,25911,26084,2669,26973,27,27042,27153,27230,2733,283692,284058,284359,285852,29035,29123,2921,2926,2990,29948,3164,3298,3312,3336,3563,3587,3636,3699,3720,374,3763,3770,379,386618,392617,4062,4193,4616,51144,51271,5128,51398,51430,51669,5187,5228,5292,5322,5330,53919,53944,54505,54813,54915,55030,55052,55207,55335,55573,55814,55856,5586,56882,56888,56892,56924,57026,57095,57190,5725,57582,57584,57661,57673,5957,6004,604,63905,64216,64343,6452,646,64651,64771,6498,6500,6505,653,6731,7128,7133,7189,7201,7320,7378,7779,79027,79156,79180,79682,79958,79960,80139,80824,81848,81928,83696,8407,84085,84172,8444,84445,8445,8449,84627,84807,84929,85438,8550,8581,8634,875,8878,8892,89777,9015,904,90637,9112,91289,91746,9258,9261,9311,9334,9397,9531,9577,9586,9663,9751,9778,9831,993,9969" MEMBERS_MAPPING="ABL2,ABL2,27|ACCN3,ASIC3,9311|ACOT13,ACOT13,55856|ACSM1,ACSM1,116285|AHSA1,AHSA1,10598|ANKRD11,ANKRD11,29123|AREG,AREG,374|ARHGAP21,ARHGAP21,57584|ARHGEF26,ARHGEF26,26084|ARL4D,ARL4D,379|ARL5B,ARL5B,221079|ARL8B,ARL8B,55207|AZI2,AZI2,64343|B3GNT3,B3GNT3,10331|B4GALT5,B4GALT5,9334|BAG3,BAG3,9531|BCL6,BCL6,604|BDP1,BDP1,55814|BEND3,BEND3,57673|BMP5,BMP5,653|BNC1,BNC1,646|BRE,BABAM2,9577|C16orf72,HAPSTR1,29035|C19orf56,WDR83OS,51398|C1orf9,SUCO,51430|C20orf165,SPATA25,128497|C6orf106,ILRUN,64771|C7orf60,SAMTOR,154743|C8orf4,TCIM,56892|CABLES2,CABLES2,81928|CABS1,CABS1,85438|CBS,CBS,875|CCDC107,CCDC107,203260|CCDC117,CCDC117,150275|CCNT1,CCNT1,904|CDC25A,CDC25A,993|CDC42SE1,CDC42SE1,56882|CDK17,CDK17,5128|CDK3,CDK3,1018|CDV3,CDV3,55573|CHKA,CHKA,1119|CHORDC1,CHORDC1,26973|CLEC2L,CLEC2L,154790|CLK3,CLK3,1198|CNGA1,CNGA1,1259|CNPY3,CNPY3,10695|CORO1C,CORO1C,23603|CREB5,CREB5,9586|CRHR2,CRHR2,1395|CSNK1G1,CSNK1G1,53944|CSRNP1,CSRNP1,64651|CXCL3,CXCL3,2921|DDX6,DDX6,1656|DENND1B,DENND1B,163486|DENND1C,DENND1C,79958|DHFR,DHFR,1719|DHX16,DHX16,8449|DHX29,DHX29,54505|DIEXF,UTP25,27042|DNAJB6,DNAJB6,10049|DPCD,DPCD,25911|DUSP16,DUSP16,80824|DUSP2,DUSP2,1844|DUSP6,DUSP6,1848|DUSP8,DUSP8,1850|DYRK2,DYRK2,8445|DYRK3,DYRK3,8444|EDN2,EDN2,1907|EFHD2,EFHD2,79180|EGR1,EGR1,1958|EIF2B2,EIF2B2,8892|ELFN1,ELFN1,392617|ETS1,ETS1,2113|EXOC5,EXOC5,10640|FAM84A,LRATD1,151354|FBXO30,FBXO30,84085|FBXO34,FBXO34,55030|FIBCD1,FIBCD1,84929|FLJ36031,CCDC71L,168455|GABPB1,GABPB1,2553|GADD45B,GADD45B,4616|GEM,GEM,2669|GLE1,GLE1,2733|GRSF1,GRSF1,2926|GUSB,GUSB,2990|HSD17B12,HSD17B12,51144|HSF2,HSF2,3298|HSPA8,HSPA8,3312|HSPE1,HSPE1,3336|HSPH1,HSPH1,10808|IL10RA,IL10RA,3587|IL3RA,IL3RA,3563|INPP5F,INPP5F,22876|INPPL1,INPPL1,3636|IPMK,IPMK,253430|ITIH3,ITIH3,3699|IZUMO1,IZUMO1,284359|JARID2,JARID2,3720|KCMF1,KCMF1,56888|KCNJ14,KCNJ14,3770|KCNJ6,KCNJ6,3763|KCNT1,KCNT1,57582|KCTD4,KCTD4,386618|KIAA0232,KIAA0232,9778|KIAA1267,KANSL1,284058|KLHL28,KLHL28,54813|KRT72,KRT72,140807|LMF2,LMF2,91289|LOC283692,CPEB1-AS1,283692|LPIN2,LPIN2,9663|LY6D,LY6D,8581|LY6H,LY6H,4062|LZTS2,LZTS2,84445|MANBAL,MANBAL,63905|MAPKAPK2,MAPKAPK2,9261|MAPKAPK5,MAPKAPK5,8550|MARVELD2,MARVELD2,153562|MDM2,MDM2,4193|MED13,MED13,9969|MFHAS1,MFHAS1,9258|MGEA5,OGA,10724|MLF1IP,CENPU,79682|MRPL20,MRPL20,55052|MTA1,MTA1,9112|NFKBID,NFKBID,84807|NGEF,NGEF,25791|NIPSNAP3B,NIPSNAP3B,55335|NMT2,NMT2,9397|NPM3,NPM3,10360|NR4A1,NR4A1,3164|NUDT6,NUDT6,11162|OPN3,OPN3,23596|OSGIN1,OSGIN1,29948|PAK6,PAK6,56924|PDXP,PDXP,57026|PER1,PER1,5187|PGF,PGF,5228|PHF17,JADE1,79960|PHLPP2,PHLPP2,23035|PHRF1,PHRF1,57661|PIM1,PIM1,5292|PITHD1,PITHD1,57095|PKN2,PKN2,5586|PLA2G5,PLA2G5,5322|PLCB2,PLCB2,5330|PLEKHF1,PLEKHF1,79156|PLK2,PLK2,10769|POLR1B,POLR1B,84172|PPP1R13L,PPP1R13L,10848|PTBP1,PTBP1,5725|QPCT,QPCT,25797|RBM12,RBM12,10137|RCVRN,RCVRN,5957|RGS16,RGS16,6004|RTCD1,RTCA,8634|RUFY3,RUFY3,22902|SCGN,SCGN,10590|SEPN1,SELENON,57190|SEPT1,SEPTIN1,1731|SERP1,SERP1,27230|SERPINB12,SERPINB12,89777|SH3BP2,SH3BP2,6452|SKIL,SKIL,6498|SKP1,SKP1,6500|SLC1A1,SLC1A1,6505|SLC30A1,SLC30A1,7779|SLCO1C1,SLCO1C1,53919|SNPH,SNPH,9751|SPRY2,SPRY2,10253|SPRY4,SPRY4,81848|SQSTM1,SQSTM1,8878|SRP72,SRP72,6731|STIP1,STIP1,10963|TAF1A,TAF1A,9015|TAGLN2,TAGLN2,8407|TBC1D1,TBC1D1,23216|TFB2M,TFB2M,64216|TMCC1,TMCC1,23023|TMEM200A,TMEM200A,114801|TMEM66,SARAF,51669|TNFAIP3,TNFAIP3,7128|TNFRSF1B,TNFRSF1B,7133|TRAF6,TRAF6,7189|TRAPPC9,TRAPPC9,83696|TREML4,TREML4,285852|TRHR,TRHR,7201|UBAP1,UBAP1,51271|UBE2B,UBE2B,7320|UBE2F,UBE2F,140739|UPP1,UPP1,7378|USPL1,USPL1,10208|YTHDC1,YTHDC1,91746|YTHDF1,YTHDF1,54915|ZFAND2A,ZFAND2A,90637|ZNF367,ZNF367,195828|ZNF469,ZNF469,84627|ZNF623,ZNF623,9831|ZNF655,ZNF655,79027|ZNF703,ZNF703,80139|ZNF777,ZNF777,27153" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
