STANDARD_NAME GSE21546_ELK1_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP SYSTEMATIC_NAME M7530 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21546_ELK1_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in stimulated by anti-CD3 double positive thymocytes: ELK1 [GeneID=2002] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout. DESCRIPTION_FULL Removal of the transcription factor SAP1a member of the Ternary Complex Factor (TCF) group of transcription factors which in conjunction with Serum Response Factor (SRF) has been shown to have a profound effect on positive selection in the thymus. When another TCF Elk1 is knocked out in mice there is no effect on positive selection unless it is on a Sap1a KO background where the phenotype is very severe. We have stimulated isolated double positive T cells (DPs) with anti-CD3 to mimic positive selection and compared basal and stimulated transcription across the four genotypes to discover the downstream targets of Sap1a involved in positive selection. PMID 20554967 GEOID GSE21546 AUTHORS Costello P,Nicolas R,Willoughby J,Wasylyk B,Nordheim A,Treisman R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE21546_3646_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AACS,ADAMTS1,ALS2,AMELX,ANAPC4,ANKRD49,ANKS3,ARFGAP2,ARMC6,ASXL2,ATG16L2,AVL9,B3GALT6,BIVM,C12orf24,C12orf4,C1orf50,C1orf65,C1QTNF1,C3orf33,C8orf37,C8orf48,C9orf150,C9orf23,CBR4,CBX5,CCDC51,CCDC71,CDCA2,CFB,CHD6,CNOT3,CRKL,CST8,CYBASC3,DARS2,DDHD1,DFFA,DGCR14,DLG3,DRD1,DUSP27,EIF4A3,ENPP4,ERBB3,EVC2,EXOSC4,FAM118B,FAM173A,FAM19A1,FAM49B,FARSA,FBXO38,FEN1,FGFBP3,FKBPL,FZR1,GCM2,GLRA3,GORASP1,GPR172A,GPR85,GRHL2,GRIA3,GTF3C5,H2AFX,HCFC1,HEXIM1,HOXB4,HPS6,HSDL1,HYAL2,IK,INCENP,INHBB,INPP4A,INTU,IPW,IRF9,ITCH,KBTBD11,KIAA0319L,KIAA1430,KIAA1530,KLHDC5,LENG1,LMO2,LRRC28,MAPK12,MARCH6,MED23,MEIS2,METTL3,METTL7B,MLST8,MMAA,MOS,MRPL50,MSTO1,MTIF3,MTMR3,MUL1,MUM1,MUS81,MYO7A,NDUFA8,NETO2,NFKBIE,NKIRAS2,NOL12,NR2F1,NRF1,NUMA1,NUP88,NUP93,OR52A1,PAPOLG,PBLD,PBXIP1,PIAS1,POC1A,POLD3,POP5,POT1,PPPDE1,PRKAG1,PRR14,PRR15L,PUF60,PUM2,QRICH1,RABEPK,RBM5,RBX1,RENBP,RERE,RFX3,RNASEH1,RNF167,RNMT,RTP4,SAP130,SCAI,SCYL3,SETX,SHPRH,SIPA1L1,SIRT4,SLC12A2,SLC35D2,SLC39A9,SNTB1,SNX12,SNX33,SOX18,SRSF6,STAT3,SUV39H1,SZT2,TAB1,TAZ,TBC1D25,TFDP1,TGM4,TH1L,THUMPD2,TIAM1,TLR1,TMEM165,TMEM18,TMEM205,TMEM63A,TMEM67,TP53BP1,TRIM45,TRRAP,TTC30B,TTC9C,TUB,TXLNG,UBA3,UBA6,UBR5,USP32,VPS13B,VWA3A,WDR24,WDR60,WDR89,WRAP73,ZBTB8OS,ZC3H4,ZMYND8,ZNF414,ZNF449,ZNF569,ZNF585A,ZSCAN21,ZSWIM3,ZYG11B GENE_SYMBOLS AACS,ADAMTS1,ALS2,AMELX,ANAPC4,ANKRD49,ANKS3,ARFGAP2,ARMC6,ASXL2,ATG16L2,AVL9,B3GALT6,BIVM,FAM216A,C12orf4,C1QTNF1,C1orf50,CCDC185,C3orf33,CFAP418,C8orf48,LURAP1L,RPP25L,CBR4,CBX5,CCDC51,CCDC71,CDCA2,CFB,CHD6,CNOT3,CRKL,CST8,CYB561A3,DARS2,DDHD1,DFFA,ESS2,DLG3,DRD1,STYXL2,EIF4A3,ENPP4,ERBB3,EVC2,EXOSC4,FAM118B,ANTKMT,TAFA1,CYRIB,FARSA,FBXO38,FEN1,FGFBP3,FKBPL,FZR1,GCM2,GLRA3,GORASP1,SLC52A2,GPR85,GRHL2,GRIA3,GTF3C5,H2AX,HCFC1,HEXIM1,HOXB4,HPS6,HSDL1,HYAL2,IK,INCENP,INHBB,INPP4A,INTU,,IRF9,ITCH,KBTBD11,KIAA0319L,CFAP97,UVSSA,KLHL42,LENG1,LMO2,LRRC28,MAPK12,MARCHF6,MED23,MEIS2,METTL3,METTL7B,MLST8,MMAA,MOS,MRPL50,MSTO1,MTIF3,MTMR3,MUL1,IRF4,MUS81,MYO7A,NDUFA8,NETO2,NFKBIE,NKIRAS2,NOL12,NR2F1,NRF1,NUMA1,NUP88,NUP93,OR52A1,PAPOLG,PBLD,PBXIP1,PIAS1,POC1A,POLD3,POP5,POT1,DESI2,PRKAG1,PRR14,PRR15L,PUF60,PUM2,QRICH1,RABEPK,RBM5,RBX1,RENBP,RERE,RFX3,RNASEH1,RNF167,RNMT,RTP4,SAP130,SCAI,SCYL3,SETX,SHPRH,SIPA1L1,SIRT4,SLC12A2,SLC35D2,SLC39A9,SNTB1,SNX12,SNX33,SOX18,SRSF6,STAT3,SUV39H1,SZT2,TAB1,TAFAZZIN,TBC1D25,TFDP1,TGM4,NELFCD,THUMPD2,TIAM1,TLR1,TMEM165,TMEM18,TMEM205,TMEM63A,TMEM67,TP53BP1,TRIM45,TRRAP,TTC30B,TTC9C,TUB,TXLNG,UBA3,UBA6,UBR5,USP32,VPS13B,VWA3A,WDR24,DYNC2I1,WDR89,WRAP73,ZBTB8OS,ZC3H4,ZMYND8,ZNF414,ZNF449,ZNF569,ZNF585A,ZSCAN21,ZSWIM3,ZYG11B FOUNDER_NAMES