STANDARD_NAME GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_DN SYSTEMATIC_NAME M7541 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in double positive thymocytes with ELK1 and ELK4 [GeneID=2002;2005] knockout: untreated versus stimulated by anti-CD3. DESCRIPTION_FULL Removal of the transcription factor SAP1a member of the Ternary Complex Factor (TCF) group of transcription factors which in conjunction with Serum Response Factor (SRF) has been shown to have a profound effect on positive selection in the thymus. When another TCF Elk1 is knocked out in mice there is no effect on positive selection unless it is on a Sap1a KO background where the phenotype is very severe. We have stimulated isolated double positive T cells (DPs) with anti-CD3 to mimic positive selection and compared basal and stimulated transcription across the four genotypes to discover the downstream targets of Sap1a involved in positive selection. PMID 20554967 GEOID GSE21546 AUTHORS Costello P,Nicolas R,Willoughby J,Wasylyk B,Nordheim A,Treisman R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE21546_3636_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC12,ACSL6,ADRA2C,AKAP7,AMELX,APOA1,ASPRV1,BMPER,BPIL3,C10orf96,C11orf20,C11orf63,C13orf26,C1orf172,C1QA,C1RL,C20orf166,C20orf187,C22orf26,C2orf16,C2orf51,C3orf45,C3orf71,C9orf11,CABS1,CALCR,CAPN12,CBX7,CCDC75,CCL24,CCT2,CD3D,CD4,CFLAR-AS1,CITED1,CKMT2,CLEC4D,CLVS2,CNNM4,COL11A1,CRYAA,CSN2,CTC1,CTDSP1,CTNNA3,CXorf27,CXorf30,CYP19A1,CYP3A43,DAOA,DCAF13,DCDC2,DEC1,DHRS13,DKFZp667F0711,DKKL1,DNAJB9,EFCAB4A,FAM172A,FAM55D,FAM69C,FCRL1,FGF6,FLJ20518,FLJ39639,FLJ41649,FLJ44054,FMO9P,FNDC9,FRMPD4,FRY-AS1,GHSR,GK2,GKN1,GNG13,GOLGA8IP,GPR125,GRHL3,HLA-DOA,HNRNPA0,HRH3,HSPB3,HTR1A,IDI2-AS1,IGLV1-44,IGSF21,IL2RG,IQCF1,ITGB7,JPH1,KCP,KIR3DS1,KRTAP11-1,KRTDAP,LGR6,LILRA2,LOC100128108,LOC100128590,LOC100128653,LOC100131496,LOC100288249,LOC100289436,LOC100291860,LOC100506699,LOC145678,LOC284912,LOC285224,LOC285326,LOC285957,LOC400590,LOC440894,LOC441178,LOC644192,LOC646576,LOC728437,LOC728789,LRFN2,MAFB,MARCH10,METTL19,MGC15705,MGC27382,MPPED2,MYL2,NANP,NCRNA00204,NCRNA00269,NCRNA00319,NCRNA00335,NEURL1B,NOMO3,NPAS2,NTSR2,ODC1,ODF3L1,OOEP,OR10J1,OR1A2,OR1E1,OR2M4,PADI4,PAMR1,PCDHA10,PCDHA6,PEX11G,PIK3C2B,PNLIP,PNPLA7,POLR2C,PRL,PRO2949,PRR19,PRSS47,PSEN2,PSG1,PSORS1C3,PTH,RBM46,RNASE3,RNF180,S1PR1,SCN7A,SDPR,SEMA6B,SFTPC,SLC19A3,SLC22A16,SLC24A4,SLC43A1,SLC43A3,SLC5A7,SLC9A9,SLFN11,SLPI,SNX22,SOCS4,SP140,SPAG11A,SPIB,SSTR1,ST8SIA1,TLR9,TMC1,TSEN54,TSPAN11,TSPAN16,TSPAN9,TSSK3,TTTY13,UBE4B,UGT2B28,UMODL1,USP29,VIPR1,WNT5B,ZFP64,ZNF174,ZNF296,ZNF507,ZNF771 GENE_SYMBOLS ABCC12,ACSL6,ADRA2C,AKAP7,AMELX,APOA1,ASPRV1,BMPER,BPIFB6,CCDC172,CATSPERZ,JHY,TEX26,C1QA,C1RL,KDF1,MIR1-1HG,LINC02871,PRR34,C2orf16,TEX37,LSMEM2,ARIH2OS,EQTN,CABS1,CALCR,CAPN12,CBX7,GPATCH11,CCL24,CCT2,CD3D,CD4,CFLAR-AS1,CITED1,CKMT2,CLEC4D,CLVS2,CNNM4,COL11A1,CRYAA,CSN2,CTC1,CTDSP1,CTNNA3,H2AP,CFAP47,CYP19A1,CYP3A43,DAOA,DCAF13,DCDC2,DELEC1,DHRS13,,DKKL1,DNAJB9,CRACR2B,FAM172A,NXPE4,DIPK1C,FCRL1,FGF6,FRG2EP,LINC00921,LINC00951,GAS6-DT,FMO9P,FNDC9,FRMPD4,FRY-AS1,GHSR,GK2,GKN1,GNG13,GOLGA8IP,ADGRA3,GRHL3,HLA-DOA,HNRNPA0,HRH3,HSPB3,HTR1A,IDI2-AS1,IGLV1-44,IGSF21,IL2RG,IQCF1,ITGB7,JPH1,KCP,KIR3DS1,KRTAP11-1,KRTDAP,LGR6,LILRA2,UBE2Q2P13,SLC8A1-AS1,,ENSG00000267882,,,,,,,DNAJB8-AS1,LINC00692,,,LINC01123,LINC02487,NR2F2-AS1,HHIP-AS1,MTUS2-AS1,,LRFN2,MAFB,MARCHF10,TRMT44,,MGC27382,MPPED2,MYL2,NANP,FAM223A,LINC00269,LINC00319,CRMA,NEURL1B,NOMO3,NPAS2,NTSR2,ODC1,ODF3L1,OOEP,OR10J1,OR1A2,OR1E1,OR2M4,PADI4,PAMR1,PCDHA10,PCDHA6,PEX11G,PIK3C2B,PNLIP,PNPLA7,POLR2C,PRL,,PRR19,PRSS47P,PSEN2,PSG1,PSORS1C3,PTH,RBM46,RNASE3,RNF180,S1PR1,SCN7A,CAVIN2,SEMA6B,SFTPC,SLC19A3,SLC22A16,SLC24A4,SLC43A1,SLC43A3,SLC5A7,SLC9A9,SLFN11,SLPI,SNX22,SOCS4,SP140,SPAG11A,SPIB,SSTR1,ST8SIA1,TLR9,TMC1,TSEN54,TSPAN11,TSPAN16,TSPAN9,TSSK3,TTTY13,UBE4B,UGT2B28,UMODL1,USP29,VIPR1,WNT5B,ZFP64,ZNF174,ZNF296,ZNF507,ZNF771 FOUNDER_NAMES