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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21546_WT_VS_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP" SYSTEMATIC_NAME="M7535" HISTORICAL_NAMES="" PMID="20554967" AUTHORS="Costello P,Nicolas R,Willoughby J,Wasylyk B,Nordheim A,Treisman R" GEOID="GSE21546" EXACT_SOURCE="GSE21546_3641_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in double positive thymocytes stimulated by anti-CD3: wildtype versus ELK1 [GeneID=2002] knockout." DESCRIPTION_FULL="Removal of the transcription factor SAP1a member of the Ternary Complex Factor (TCF) group of transcription factors which in conjunction with Serum Response Factor (SRF) has been shown to have a profound effect on positive selection in the thymus. When another TCF Elk1 is knocked out in mice there is no effect on positive selection unless it is on a Sap1a KO background where the phenotype is very severe. We have stimulated isolated double positive T cells (DPs) with anti-CD3 to mimic positive selection and compared basal and stimulated transcription across the four genotypes to discover the downstream targets of Sap1a involved in positive selection." TAGS="" MEMBERS="ABCB9,ABL2,ADI1,ALS2CR12,ARAP2,AREG,ARHGAP21,ARL3,ARL4D,ARL5B,ASB15,AZI2,BAI2,BCL6,C11orf51,C11orf67,C11orf73,C12orf56,C13orf23,C19orf56,C2orf61,CALR3,CCDC11,CCDC124,CD207,CELA3B,CELF6,CHEK1,CHKA,CHORDC1,CHRD,CISD3,CISH,CLK3,COPG,CRHR2,CSRNP1,CSTA,CTSW,CYB5RL,CYP11B2,CYP24A1,DARS,DCTD,DDX6,DIO1,DNASE2B,DOC2B,DOK3,DPH3,DTNB,DUOXA1,DUSP16,DUSP2,DUSP8,EGR1,EIF2B2,ERAS,ERF,ERG,EVC,EXOC5,FGD6,FGF21,FGF3,FIBCD1,FLJ36031,FNTA,FOSB,FOXN1,GADD45B,GALNS,GAS8,GATA2,GCDH,GEM,GKAP1,GLIS1,GNAZ,GPNMB,GPR26,GTSF1,H2AFJ,HBG2,HBS1L,HERPUD2,HPS1,HSCB,HSPA2,HSPC159,HSPD1,HSPE1,HSPH1,HTATIP2,IL17RA,IRX3,IRX5,ITGB1BP1,JAM2,JARID2,JSRP1,JUNB,KCMF1,KIAA0564,KIAA1267,KIF9,KLHL28,KRT32,LAMA3,LEF1,LOC100129269,LPPR1,LSAMP,MANBAL,MAP1LC3A,MAP1LC3B,MARCH4,MARCKSL1,MARVELD3,MCTS1,MGEA5,MLLT11,MRPL20,MRPL42,MTMR1,NDUFAB1,NFKBID,NPAS1,NR4A1,NRAS,NUDT5,PCNP,PDLIM2,PGF,PHF16,PHOSPHO1,PIGO,PIM1,PINK1,PITHD1,PLEKHH2,POU5F1,PQLC1,PRDM4,PSMD2,PTPN1,PWWP2B,QPCT,RAB2B,RALYL,RBBP5,RBM12,RBM33,RDH10,RTCD1,RYR2,SATB1,SDHA,SERF1A,SETD1B,SH3BP2,SLC13A4,SLC5A11,SLC5A2,SLCO1B3,SNAPC5,SRD5A2,SRF,SRXN1,SVIP,TAGLN3,TAT,TBCK,TCFL5,TDP1,TLR9,TMEM132D,TMEM200A,TMEM223,TMEM66,TNFRSF25,TOB2,TOX2,TP53BP2,TRPV6,TSTA3,TUBB2A,UBE2F,UBE2G2,UBL3,UBP1,UBXN8,USP15,VKORC1,VLDLR,XRCC5,ZFAND2A,ZNF469,ZNF623,ZNF703" MEMBERS_SYMBOLIZED="AAMDC,ABCB9,ABL2,ADGRB2,ADI1,ANAPC15,ARAP2,AREG,ARHGAP21,ARL3,ARL4D,ARL5B,ASB15,AZI2,BCL6,C12orf56,CALR3,CCDC124,CCDC71L,CD207,CELA3B,CELF6,CFAP53,CHEK1,CHKA,CHORDC1,CHRD,CISD3,CISH,CLK3,COPG1,CRHR2,CSRNP1,CSTA,CTSW,CYB5RL,CYP11B2,CYP24A1,DARS1,DCTD,DDX6,DIO1,DNASE2B,DOC2B,DOK3,DPH3,DTNB,DUOXA1,DUSP16,DUSP2,DUSP8,EGR1,EIF2B2,ERAS,ERF,ERG,EVC,EXOC5,FGD6,FGF21,FGF3,FIBCD1,FLACC1,FNTA,FOSB,FOXN1,GADD45B,GALNS,GAS8,GATA2,GCDH,GEM,GFUS,GKAP1,GLIS1,GNAZ,GPNMB,GPR26,GTSF1,H2AJ,HBG2,HBS1L,HERPUD2,HIKESHI,HPS1,HSCB,HSPA2,HSPD1,HSPE1,HSPH1,HTATIP2,IL17RA,IRX3,IRX5,ITGB1BP1,JADE3,JAM2,JARID2,JSRP1,JUNB,KANSL1,KCMF1,KIF9,KLHL28,KRT32,LAMA3,LEF1,LGALSL,LINC01160,LSAMP,MANBAL,MAP1LC3A,MAP1LC3B,MARCHF4,MARCKSL1,MARVELD3,MCTS1,MLLT11,MRPL20,MRPL42,MTMR1,NDUFAB1,NFKBID,NPAS1,NR4A1,NRAS,NUDT5,OGA,PCNP,PDLIM2,PGF,PHOSPHO1,PIGO,PIM1,PINK1,PITHD1,PLEKHH2,PLPPR1,POU5F1,PRDM4,PROSER1,PSMD2,PTPN1,PWWP2B,QPCT,RAB2B,RALYL,RBBP5,RBM12,RBM33,RDH10,RTCA,RYR2,SARAF,SATB1,SDHA,SERF1A,SETD1B,SH3BP2,SLC13A4,SLC5A11,SLC5A2,SLC66A2,SLCO1B3,SNAPC5,SRD5A2,SRF,SRXN1,STPG4,SVIP,TAGLN3,TAT,TBCK,TCFL5,TDP1,TLR9,TMEM132D,TMEM200A,TMEM223,TNFRSF25,TOB2,TOX2,TP53BP2,TRPV6,TUBB2A,UBE2F,UBE2G2,UBL3,UBP1,UBXN8,USP15,VKORC1,VLDLR,VWA8,WDR83OS,XRCC5,ZFAND2A,ZNF469,ZNF623,ZNF703" MEMBERS_EZID="100129269,10137,10265,10302,10457,10553,10640,10724,10732,10766,10767,10808,10962,11108,1111,11164,1119,114801,115098,1154,115584,115749,116984,1198,121256,121355,125972,126306,130271,130540,138046,1395,140739,140809,142685,1475,148979,150274,1521,155435,157506,1585,1591,1615,162466,1635,1656,168455,170394,1733,1838,1844,1850,1958,2077,2078,2121,220136,221079,2248,22820,23067,23078,2339,23436,23457,2354,23765,25797,258010,2588,25906,2622,2624,26266,26291,2639,2669,26973,27,2781,28234,284058,284106,2849,285051,285381,28971,28977,28985,29094,29114,3048,3164,3257,3266,3306,3329,3336,3720,3726,374,379,3882,3909,403,4045,4616,4706,4861,4893,50489,51176,51398,51501,51669,5228,5292,54106,5412,5460,54813,54886,55052,55256,55503,55766,55775,55785,56888,5708,57092,57095,57574,57584,576,5770,58494,58511,5929,604,606495,60677,6262,6304,6389,63905,64147,64224,64236,64343,6452,64651,65018,65108,6524,6716,6722,6898,7159,7264,7280,7327,7342,7436,7520,79001,79064,79191,7993,79930,80139,80148,80209,80318,80824,81631,8293,8447,84557,8456,84627,84720,84807,84929,84932,84969,8634,8646,8718,8776,8892,90527,90637,91862,9270,93627,9767,9831,9958" MEMBERS_MAPPING="ABCB9,ABCB9,23457|ABL2,ABL2,27|ADI1,ADI1,55256|ALS2CR12,FLACC1,130540|ARAP2,ARAP2,116984|AREG,AREG,374|ARHGAP21,ARHGAP21,57584|ARL3,ARL3,403|ARL4D,ARL4D,379|ARL5B,ARL5B,221079|ASB15,ASB15,142685|AZI2,AZI2,64343|BAI2,ADGRB2,576|BCL6,BCL6,604|C11orf51,ANAPC15,25906|C11orf67,AAMDC,28971|C11orf73,HIKESHI,51501|C12orf56,C12orf56,115749|C13orf23,PROSER1,80209|C19orf56,WDR83OS,51398|C2orf61,STPG4,285051|CALR3,CALR3,125972|CCDC11,CFAP53,220136|CCDC124,CCDC124,115098|CD207,CD207,50489|CELA3B,CELA3B,23436|CELF6,CELF6,60677|CHEK1,CHEK1,1111|CHKA,CHKA,1119|CHORDC1,CHORDC1,26973|CHRD,CHRD,8646|CISD3,CISD3,284106|CISH,CISH,1154|CLK3,CLK3,1198|COPG,COPG1,22820|CRHR2,CRHR2,1395|CSRNP1,CSRNP1,64651|CSTA,CSTA,1475|CTSW,CTSW,1521|CYB5RL,CYB5RL,606495|CYP11B2,CYP11B2,1585|CYP24A1,CYP24A1,1591|DARS,DARS1,1615|DCTD,DCTD,1635|DDX6,DDX6,1656|DIO1,DIO1,1733|DNASE2B,DNASE2B,58511|DOC2B,DOC2B,8447|DOK3,DOK3,79930|DPH3,DPH3,285381|DTNB,DTNB,1838|DUOXA1,DUOXA1,90527|DUSP16,DUSP16,80824|DUSP2,DUSP2,1844|DUSP8,DUSP8,1850|EGR1,EGR1,1958|EIF2B2,EIF2B2,8892|ERAS,ERAS,3266|ERF,ERF,2077|ERG,ERG,2078|EVC,EVC,2121|EXOC5,EXOC5,10640|FGD6,FGD6,55785|FGF21,FGF21,26291|FGF3,FGF3,2248|FIBCD1,FIBCD1,84929|FLJ36031,CCDC71L,168455|FNTA,FNTA,2339|FOSB,FOSB,2354|FOXN1,FOXN1,8456|GADD45B,GADD45B,4616|GALNS,GALNS,2588|GAS8,GAS8,2622|GATA2,GATA2,2624|GCDH,GCDH,2639|GEM,GEM,2669|GKAP1,GKAP1,80318|GLIS1,GLIS1,148979|GNAZ,GNAZ,2781|GPNMB,GPNMB,10457|GPR26,GPR26,2849|GTSF1,GTSF1,121355|H2AFJ,H2AJ,55766|HBG2,HBG2,3048|HBS1L,HBS1L,10767|HERPUD2,HERPUD2,64224|HPS1,HPS1,3257|HSCB,HSCB,150274|HSPA2,HSPA2,3306|HSPC159,LGALSL,29094|HSPD1,HSPD1,3329|HSPE1,HSPE1,3336|HSPH1,HSPH1,10808|HTATIP2,HTATIP2,10553|IL17RA,IL17RA,23765|IRX3,IRX3,79191|IRX5,IRX5,10265|ITGB1BP1,ITGB1BP1,9270|JAM2,JAM2,58494|JARID2,JARID2,3720|JSRP1,JSRP1,126306|JUNB,JUNB,3726|KCMF1,KCMF1,56888|KIAA0564,VWA8,23078|KIAA1267,KANSL1,284058|KIF9,KIF9,64147|KLHL28,KLHL28,54813|KRT32,KRT32,3882|LAMA3,LAMA3,3909|LEF1,LEF1,51176|LOC100129269,LINC01160,100129269|LPPR1,PLPPR1,54886|LSAMP,LSAMP,4045|MANBAL,MANBAL,63905|MAP1LC3A,MAP1LC3A,84557|MAP1LC3B,MAP1LC3B,81631|MARCH4,MARCHF4,57574|MARCKSL1,MARCKSL1,65108|MARVELD3,MARVELD3,91862|MCTS1,MCTS1,28985|MGEA5,OGA,10724|MLLT11,MLLT11,10962|MRPL20,MRPL20,55052|MRPL42,MRPL42,28977|MTMR1,MTMR1,8776|NDUFAB1,NDUFAB1,4706|NFKBID,NFKBID,84807|NPAS1,NPAS1,4861|NR4A1,NR4A1,3164|NRAS,NRAS,4893|NUDT5,NUDT5,11164|PCNP,PCNP,57092|PDLIM2,PDLIM2,64236|PGF,PGF,5228|PHF16,JADE3,9767|PHOSPHO1,PHOSPHO1,162466|PIGO,PIGO,84720|PIM1,PIM1,5292|PINK1,PINK1,65018|PITHD1,PITHD1,57095|PLEKHH2,PLEKHH2,130271|POU5F1,POU5F1,5460|PQLC1,SLC66A2,80148|PRDM4,PRDM4,11108|PSMD2,PSMD2,5708|PTPN1,PTPN1,5770|PWWP2B,PWWP2B,170394|QPCT,QPCT,25797|RAB2B,RAB2B,84932|RALYL,RALYL,138046|RBBP5,RBBP5,5929|RBM12,RBM12,10137|RBM33,RBM33,155435|RDH10,RDH10,157506|RTCD1,RTCA,8634|RYR2,RYR2,6262|SATB1,SATB1,6304|SDHA,SDHA,6389|SERF1A,SERF1A,8293|SETD1B,SETD1B,23067|SH3BP2,SH3BP2,6452|SLC13A4,SLC13A4,26266|SLC5A11,SLC5A11,115584|SLC5A2,SLC5A2,6524|SLCO1B3,SLCO1B3,28234|SNAPC5,SNAPC5,10302|SRD5A2,SRD5A2,6716|SRF,SRF,6722|SRXN1,SRXN1,140809|SVIP,SVIP,258010|TAGLN3,TAGLN3,29114|TAT,TAT,6898|TBCK,TBCK,93627|TCFL5,TCFL5,10732|TDP1,TDP1,55775|TLR9,TLR9,54106|TMEM132D,TMEM132D,121256|TMEM200A,TMEM200A,114801|TMEM223,TMEM223,79064|TMEM66,SARAF,51669|TNFRSF25,TNFRSF25,8718|TOB2,TOB2,10766|TOX2,TOX2,84969|TP53BP2,TP53BP2,7159|TRPV6,TRPV6,55503|TSTA3,GFUS,7264|TUBB2A,TUBB2A,7280|UBE2F,UBE2F,140739|UBE2G2,UBE2G2,7327|UBL3,UBL3,5412|UBP1,UBP1,7342|UBXN8,UBXN8,7993|USP15,USP15,9958|VKORC1,VKORC1,79001|VLDLR,VLDLR,7436|XRCC5,XRCC5,7520|ZFAND2A,ZFAND2A,90637|ZNF469,ZNF469,84627|ZNF623,ZNF623,9831|ZNF703,ZNF703,80139" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
