STANDARD_NAME GSE21670_TGFB_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN SYSTEMATIC_NAME M7432 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21670_TGFB_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: TGF beta versus IL6 [GeneID=3569]. DESCRIPTION_FULL STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data linking STAT3 with inflammatory bowel disease, exactly how it contributes to chronic intestinal inflammation is not known. Using a T cell transfer model of colitis we found that STAT3 expression in T cells was essential for the induction of both colitis and systemic inflammation. STAT3 was critical in modulating the balance of T helper 17 (Th17) and regulatory T (Treg) cells, as well as in promoting CD4+ T cell proliferation. We used chromatin immunoprecipitation and massive parallel sequencing (ChIP-Seq) to define the genome-wide targets of STAT3 in CD4+ T cells. We found that STAT3 bound to multiple genes involved in Th17 cell differentiation, cell activation, proliferation and survival, regulating both expression and epigenetic modifications. Thus, STAT3 orchestrates multiple critical aspects of T cell function in inflammation and homeostasis. PMID 20493732 GEOID GSE21670 AUTHORS Durant L,Watford WT,Ramos HL,Laurence A,Vahedi G,Wei L,Takahashi H,Sun HW,Kanno Y,Powrie F,O'Shea JJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE21670_2375_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACAP1,ACTN1,ACVR1B,ADAR,AKNA,AMIGO2,AMPD1,AMPD3,ANXA1,APPL2,ARHGAP26,ARHGAP4,ARHGAP9,ARHGEF10,ARMC3,ASAP1,ATF7IP,ATP10D,ATP8B4,AXIN2,BAZ2B,BTLA,C19orf38,C22orf36,C3orf70,C5orf34,C5orf51,C8orf42,C9orf142,CAMKMT,CARNS1,CCL5,CCR9,CD1D,CD200R1L,CD7,CD84,CD8B,CD96,CD97,CHD2,CHDH,CHST10,CNGA1,CRBN,CREB1,CTSE,CYP2D6,CYP2S1,CYTH1,D2HGDH,DAXX,DENND1C,DMTF1,DNAH8,DNAJC6,DSE,DTX1,DUSP7,DZIP1,EHD3,EPSTI1,ESM1,EVI2A,EVI2B,FAM102A,FAM117A,FAM49A,FICD,GABRR2,GGT1,GLCCI1,GLTSCR1,GPR97,GRAMD1A,GSN,HAL,HCST,HEBP1,HLA-DQA1,HLA-DRB1,HMBOX1,HMP19,IDUA,IFIT1,IFIT1B,IL27RA,ITM2C,KBTBD2,KCTD12,KIAA0040,KIAA1109,KIF21B,KLHDC1,KLHDC5,KLRD1,KREMEN1,L1CAM,LASS6,LGALS8,LHFPL3,LIPA,LNPEP,LOC339929,LYPD6B,MAGEF1,MAP2K6,MAP3K3,MATK,MEF2D,MEX3B,MLL5,MOBKL1B,MSRA,MSRB2,MXRA8,MYCBP2,MYLIP,NBEAL1,NIPAL3,NLK,NMB,NQO2,NT5DC1,NUDT16,P2RX7,PAQR7,PARP12,PDE2A,PDE5A,PELI1,PGAP1,PGLYRP1,PITPNC1,PITPNM1,PLEKHG2,PNPLA7,POLR3GL,PPM1K,PRDM1,PRF1,PRKAB1,PRR14,PTPRE,RALGAPA2,RAMP3,RAP1GAP2,RAPGEF4,RASGRF2,RASGRP1,RASGRP2,RNF32,RSBN1,RUFY2,SCG5,SCML4,SCP2,SERPINI1,SGK3,SH3PXD2A,SLC14A1,SLC16A5,SLFN13,SMAD4,SMC6,SMPD5,SORL1,SP4,SPO11,SPPL2A,SRPK2,SRSF12,STK4,STXBP3,SYNE2,TBC1D1,TBCEL,TCF20,TET1,TMEM146,TMEM229B,TMEM31,TMEM63A,TNFRSF1A,TPCN1,TSPAN13,USP32,USP53,VEZF1,VIPR1,VRK3,XKRX,ZBTB44,ZBTB7B,ZFP36,ZMYND11,ZNF292,ZNF354C,ZNF418,ZNF571 GENE_SYMBOLS ACAP1,ACTN1,ACVR1B,ADAR,AKNA,AMIGO2,AMPD1,AMPD3,ANXA1,APPL2,ARHGAP26,ARHGAP4,ARHGAP9,ARHGEF10,ARMC3,ASAP1,ATF7IP,ATP10D,ATP8B4,AXIN2,BAZ2B,BTLA,C19orf38,LRRC75B,C3orf70,C5orf34,RIMOC1,TDRP,PAXX,CAMKMT,CARNS1,CCL5,CCR9,CD1D,CD200R1L,CD7,CD84,CD8B,CD96,ADGRE5,CHD2,CHDH,CHST10,CNGA1,CRBN,CREB1,CTSE,CYP2D6,CYP2S1,CYTH1,D2HGDH,DAXX,DENND1C,DMTF1,DNAH8,DNAJC6,DSE,DTX1,DUSP7,DZIP1,EHD3,EPSTI1,ESM1,EVI2A,EVI2B,EEIG1,FAM117A,CYRIA,FICD,GABRR2,GGT1,GLCCI1,BICRA,ADGRG3,GRAMD1A,GSN,HAL,HCST,HEBP1,HLA-DQA1,HLA-DRB1,HMBOX1,NSG2,IDUA,IFIT1,IFIT1B,IL27RA,ITM2C,KBTBD2,KCTD12,KIAA0040,BLTP1,KIF21B,KLHDC1,KLHL42,KLRD1,KREMEN1,L1CAM,CERS6,LGALS8,LHFPL3,LIPA,LNPEP,LPP-AS2,LYPD6B,MAGEF1,MAP2K6,MAP3K3,MATK,MEF2D,MEX3B,KMT2E,MOB1A,MSRA,MSRB2,MXRA8,MYCBP2,MYLIP,NBEAL1,NIPAL3,NLK,NMB,NQO2,NT5DC1,NUDT16,P2RX7,PAQR7,PARP12,PDE2A,PDE5A,PELI1,PGAP1,PGLYRP1,PITPNC1,PITPNM1,PLEKHG2,PNPLA7,POLR3GL,PPM1K,PRDM1,PRF1,PRKAB1,PRR14,PTPRE,RALGAPA2,RAMP3,RAP1GAP2,RAPGEF4,RASGRF2,RASGRP1,RASGRP2,RNF32,RSBN1,RUFY2,SCG5,SCML4,SCP2,SERPINI1,SGK3,SH3PXD2A,SLC14A1,SLC16A5,SLFN13,SMAD4,SMC6,SMPD5,SORL1,SP4,SPO11,SPPL2A,SRPK2,SRSF12,STK4,STXBP3,SYNE2,TBC1D1,TBCEL,TCF20,TET1,CATSPERD,TMEM229B,TMEM31,TMEM63A,TNFRSF1A,TPCN1,TSPAN13,USP32,USP53,VEZF1,VIPR1,VRK3,XKRX,ZBTB44,ZBTB7B,ZFP36,ZMYND11,ZNF292,ZNF354C,ZNF418,ZNF571 FOUNDER_NAMES