STANDARD_NAME	GSE21670_UNTREATED_VS_TGFB_IL6_TREATED_STAT3_KO_CD4_TCELL_DN
SYSTEMATIC_NAME	M7444
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21670_UNTREATED_VS_TGFB_IL6_TREATED_STAT3_KO_CD4_TCELL_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus TGF beta and IL6 [GeneID=3569].
DESCRIPTION_FULL	STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data linking STAT3 with inflammatory bowel disease, exactly how it contributes to chronic intestinal inflammation is not known. Using a T cell transfer model of colitis we found that STAT3 expression in T cells was essential for the induction of both colitis and systemic inflammation. STAT3 was critical in modulating the balance of T helper 17 (Th17) and regulatory T (Treg) cells, as well as in promoting CD4+ T cell proliferation. We used chromatin immunoprecipitation and massive parallel sequencing (ChIP-Seq) to define the genome-wide targets of STAT3 in CD4+ T cells. We found that STAT3 bound to multiple genes involved in Th17 cell differentiation, cell activation, proliferation and survival, regulating both expression and epigenetic modifications. Thus, STAT3 orchestrates multiple critical aspects of T cell function in inflammation and homeostasis.
PMID	20493732
GEOID	GSE21670
AUTHORS	Durant L,Watford WT,Ramos HL,Laurence A,Vahedi G,Wei L,Takahashi H,Sun HW,Kanno Y,Powrie F,O'Shea JJ
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE21670_2386_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AAK1,AAMP,ABCG1,ACSS2,ACTR3,ADD3,AHNAK,AIM1,AKIRIN1,ALDH3A2,ALKBH6,ANXA6,ARFGEF1,ARHGAP18,ARHGAP4,ASCC1,ATP1B3,BBS4,BTF3,C19orf70,C22orf32,C7orf59,C7orf60,C8orf37,C9orf78,CARD11,CAST,CBL,CCND3,CD2,CD3G,CD53,CD7,CD8B,CHFR,CNPPD1,CNTRL,COMMD8,CYTIP,DAPK3,DGKZ,DNAJA4,DNAJB13,DNPEP,DOK2,DONSON,DPP4,EAF1,EIF3K,FAM108B1,FAM36A,FAM54B,FBXO17,FBXO38,FLI1,FLT3LG,FYB,GPD1L,HEATR2,HERPUD2,HEXB,HLA-C,HN1,HNRNPL,HSP90B1,HUWE1,IFNAR2,IFT80,IKZF1,IL2RG,INO80D,INPP5D,ITGAE,ITGAL,ITGB2,KDM3B,KIAA0182,KIAA1109,KIAA1967,KLF2,KLHL28,KRCC1,LBR,LCK,LMBRD1,LMO4,LRRC8C,MAP4K2,MBNL1,MED13,MEX3D,MLLT6,MLX,MSN,MST4,MTA2,MTHFS,MTSS1,MYLIP,MYST1,N4BP2L2,NADSYN1,NCK1,NDUFA6,NFKBIE,NPC2,NPRL2,NR2C2AP,NSA2,NSF,P4HTM,PARP4,PFDN2,PHF1,PI4KB,PITPNA,PLEKHG2,PNPLA7,PPP2R5A,PRPF39,PSAP,PSD4,PSENEN,PTPRCAP,RAB6A,RABGGTA,RAP1A,RB1CC1,RBM25,RBM3,RCBTB2,RCSD1,RFWD2,RMND1,RMND5A,RNF220,ROCK1,ROD1,RPL11,RPL23,RPS27,RPS29,RSF1,RUNX3,S100A10,S1PR1,SAT1,SATB1,SDCBP2,SDHC,SEC22B,SEC61G,SGPL1,SH2D1A,SIPA1,SKIV2L,SLC12A7,SLC37A1,SMAP2,SMC4,SMPD5,SMURF1,SNAPC1,SPG21,SPSB3,SPTBN1,SSU72,STAG2,STAT3,STAT4,SUSD3,SYNE1,TACC1,TAPT1,TECR,TK2,TMEM134,TMEM184C,TMEM66,TMEM71,TMOD3,TMX4,TPT1,TRIM23,TRRAP,TSPYL2,TTC14,UBE2B,UBE2D1,UBE2G1,UBE2S,UBL7,UNC13D,VPRBP,YIPF4,YME1L1,YWHAZ,ZDHHC20,ZHX2,ZNF23
GENE_SYMBOLS	AAK1,AAMP,ABCG1,ACSS2,ACTR3,ADD3,AHNAK,CRYBG1,AKIRIN1,ALDH3A2,ALKBH6,ANXA6,ARFGEF1,ARHGAP18,ARHGAP4,ASCC1,ATP1B3,BBS4,BTF3,MICOS13,SMDT1,LAMTOR4,SAMTOR,CFAP418,C9orf78,CARD11,CAST,CBL,CCND3,CD2,CD3G,CD53,CD7,CD8B,CHFR,CNPPD1,CNTRL,COMMD8,CYTIP,DAPK3,DGKZ,DNAJA4,DNAJB13,DNPEP,DOK2,DONSON,DPP4,EAF1,EIF3K,ABHD17B,COX20,MTFR1L,FBXO17,FBXO38,FLI1,FLT3LG,FYB1,GPD1L,DNAAF5,HERPUD2,HEXB,HLA-C,JPT1,HNRNPL,HSP90B1,HUWE1,IFNAR2,IFT80,IKZF1,IL2RG,INO80D,INPP5D,ITGAE,ITGAL,ITGB2,KDM3B,GSE1,BLTP1,CCAR2,KLF2,KLHL28,KRCC1,LBR,LCK,LMBRD1,LMO4,LRRC8C,MAP4K2,MBNL1,MED13,MEX3D,MLLT6,MLX,MSN,STK26,MTA2,MTHFS,MTSS1,MYLIP,KAT8,N4BP2L2,NADSYN1,NCK1,NDUFA6,NFKBIE,NPC2,NPRL2,NR2C2AP,NSA2,NSF,P4HTM,PARP4,PFDN2,PHF1,PI4KB,PITPNA,PLEKHG2,PNPLA7,PPP2R5A,PRPF39,PSAP,PSD4,PSENEN,PTPRCAP,RAB6A,RABGGTA,RAP1A,RB1CC1,RBM25,RBM3,RCBTB2,RCSD1,COP1,RMND1,RMND5A,RNF220,ROCK1,PTBP3,RPL11,RPL23,RPS27,RPS29,RSF1,RUNX3,S100A10,S1PR1,SAT1,SATB1,SDCBP2,SDHC,SEC22B,SEC61G,SGPL1,SH2D1A,SIPA1,SKIC2,SLC12A7,SLC37A1,SMAP2,SMC4,SMPD5,SMURF1,SNAPC1,SPG21,SPSB3,SPTBN1,SSU72,STAG2,STAT3,STAT4,SUSD3,SYNE1,TACC1,TAPT1,TECR,TK2,TMEM134,TMEM184C,SARAF,TMEM71,TMOD3,TMX4,TPT1,TRIM23,TRRAP,TSPYL2,TTC14,UBE2B,UBE2D1,UBE2G1,UBE2S,UBL7,UNC13D,DCAF1,YIPF4,YME1L1,YWHAZ,ZDHHC20,ZHX2,ZNF23
FOUNDER_NAMES