STANDARD_NAME	GSE21927_BALBC_VS_C57BL6_MONOCYTE_TUMOR_DN
SYSTEMATIC_NAME	M7575
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21927_BALBC_VS_C57BL6_MONOCYTE_TUMOR_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in CD11b Tumor from BALBc mouse versus CD11b Tumor from C57BL6 mouse.
DESCRIPTION_FULL	Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correction of the diabetic status. Cytokines inducing MDSCs acted on a common molecular pathway. Immunoregulatory activity of both tumor-induced and BM-derived MDSCs was entirely dependent on C/EBP transcription factor, a key component of the emergency myelopoiesis triggered by stress and inflammation. Adoptive transfer of tumor antigen-specific CD8+ T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBP in myeloid compartment. These data unveil another link between inflammation and cancer and identify a novel molecular target to control tumor-induced immune suppression. We used gene expression analysis to identify those factors, secreted by tumor-infiltrating MDSC, which could drive emathopoiesis. Moreover we compare gene expression profile of tumor-induced MDSC, obtained from either the spleen and the tumor infiltrate of tumor bearing mice, and in vitro bone marrow-derived MDSC.
PMID	20605485
GEOID	GSE21927
AUTHORS	Marigo I,Bosio E,Solito S,Mesa C,Fernandez A,Dolcetti L,Ugel S,Sonda N,Bicciato S,Falisi E,Calabrese F,Basso G,Zanovello P,Cozzi E,Mandruzzato S,Bronte V
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE21927_2531_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AARSD1,ABCG5,ABHD3,ACBD5,ACTR2,ACTR6,AGAP11,AGK,AGL,AIDA,ALDOC,ALG10,AMD1,AP4S1,APOL3,ARID4B,ASNSD1,ATXN7,BBS2,BTBD10,C12orf11,C17orf108,C18orf42,C19orf73,C1D,C1orf222,C8orf38,C8orf50,C8orf59,C9orf103,C9orf40,C9orf80,CARTPT,CASP8AP2,CCDC134,CCDC159,CCNYL1,CDKL3,CDV3,CENPH,CHI3L2,CHST11,CLN5,CMPK1,COL16A1,COL21A1,CPM,CPT2,CR1,CROCCP2,CSNK1G1,CTRB2,CXCL16,CYP2C19,DBP,DENND4C,DHRS1,DKFZP434I0714,DNAJC22,DNTTIP1,DSERG1,DYNLT3,EAF1,EBF4,EEF1E1,EFHB,EIF2B3,ERLIN2,ETAA1,FAM9C,FANCI,FLJ38379,FLJ45244,FOXM1,GALNT3,GAPDHP62,GART,GBP2,GCNT3,GK5,GOLGA2B,GORAB,GPCPD1,GPR31,GRAMD1C,GUSBP1,HGSNAT,HIGD1A,HIVEP2,HLF,HSP90AA1,HSPH1,HTRA3,HUS1,IFI16,IMMP2L,ITPKB,KBTBD7,KBTBD8,KCNH6,KIAA1147,KIAA1731,LACTB2,LNX2,LOC100132884,LOC100286909,LOC100288860,LOC100290278,LOC100505761,LOC100507140,LOC170425,LOC253573,LOC283663,LOC340085,LOC440104,LOC730631,LOXL2,LSM3,MDGA2,MEGF8,MLH3,MPHOSPH9,MRPL44,MTR,MYL4,NBEA,NCRNA00201,NFU1,NHLRC3,NKD2,NUDT9P1,NUPL1,OR11A1,PATL2,PEAK1,PHF16,PIK3IP1,PINX1,PLEKHF2,POU1F1,PPP1R12A,PPP2CB,PPP3CB,RAB18,RAB3A,RBMX2,RLN2,RNF20,RSPH4A,S100A9,SCRN3,SERPINB9,SHANK1,SLC2A2,SLC30A9,SLC40A1,SLC9A9,SMC1B,SNAP25,SP3P,SPG20,SUCLG2,TAF9B,TARSL2,TCEANC2,TCTA,TM2D2,TMEM131,TMEM194B,TMEM2,TMOD4,TNFRSF10B,TNS4,TP53INP1,TRANK1,TRIM40,TRMT61B,TSPAN6,TSPYL1,TTC14,TTLL12,UBA3,USP14,VAV3,VWDE,YIPF5,YIPF6,ZBTB10,ZBTB44,ZDHHC6,ZKSCAN5,ZNF101,ZNF146,ZNF347,ZNF616,ZNF770,ZNF829,ZNF844,ZNF85,ZWILCH
GENE_SYMBOLS	AARSD1,ABCG5,ABHD3,ACBD5,ACTR2,ACTR6,AGAP11,AGK,AGL,AIDA,ALDOC,ALG10,AMD1,AP4S1,APOL3,ARID4B,ASNSD1,ATXN7,BBS2,BTBD10,INTS13,LYRM9,AKAIN1,C19orf73,C1D,CFAP74,NDUFAF6,EXTL3-AS1,RBIS,IDNK,C9orf40,INIP,CARTPT,CASP8AP2,CCDC134,CCDC159,CCNYL1,CDKL3,CDV3,CENPH,CHI3L2,CHST11,CLN5,CMPK1,COL16A1,COL21A1,CPM,CPT2,CR1,CROCCP2,CSNK1G1,CTRB2,CXCL16,CYP2C19,DBP,DENND4C,DHRS1,MIR4453HG,DNAJC22,DNTTIP1,,DYNLT3,EAF1,EBF4,EEF1E1,EFHB,EIF2B3,ERLIN2,ETAA1,FAM9C,FANCI,ENSG00000280119,DICER1-AS1,FOXM1,GALNT3,GAPDHP62,GART,GBP2,GCNT3,GK5,GOLGA2P5,GORAB,GPCPD1,GPR31,GRAMD1C,GUSBP1,HGSNAT,HIGD1A,HIVEP2,HLF,HSP90AA1,HSPH1,HTRA3,HUS1,IFI16,IMMP2L,ITPKB,KBTBD7,KBTBD8,KCNH6,DENND11,CEP295,LACTB2,LNX2,,,,,C10orf95-AS1,LINC01792,LINC00858,LINC02052,LINC00926,,TMEM198B,,LOXL2,LSM3,MDGA2,MEGF8,MLH3,MPHOSPH9,MRPL44,MTR,MYL4,NBEA,HNRNPU,NFU1,NHLRC3,NKD2,NUDT9P1,NUP58,OR11A1,PATL2,PEAK1,JADE3,PIK3IP1,PINX1,PLEKHF2,POU1F1,PPP1R12A,PPP2CB,PPP3CB,RAB18,RAB3A,RBMX2,RLN2,RNF20,RSPH4A,S100A9,SCRN3,SERPINB9,SHANK1,SLC2A2,SLC30A9,SLC40A1,SLC9A9,SMC1B,SNAP25,SP3P,SPART,SUCLG2,TAF9B,TARS3,TCEANC2,TCTA,TM2D2,TMEM131,NEMP2,CEMIP2,TMOD4,TNFRSF10B,TNS4,TP53INP1,TRANK1,TRIM40,TRMT61B,TSPAN6,TSPYL1,TTC14,TTLL12,UBA3,USP14,VAV3,VWDE,YIPF5,YIPF6,ZBTB10,ZBTB44,ZDHHC6,ZKSCAN5,ZNF101,ZNF146,ZNF347,ZNF616,ZNF770,ZNF829,ZNF844,ZNF85,ZWILCH
FOUNDER_NAMES