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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21927_BALBC_VS_C57BL6_MONOCYTE_TUMOR_DN" SYSTEMATIC_NAME="M7575" HISTORICAL_NAMES="" PMID="20605485" AUTHORS="Marigo I,Bosio E,Solito S,Mesa C,Fernandez A,Dolcetti L,Ugel S,Sonda N,Bicciato S,Falisi E,Calabrese F,Basso G,Zanovello P,Cozzi E,Mandruzzato S,Bronte V" GEOID="GSE21927" EXACT_SOURCE="GSE21927_2531_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD11b Tumor from BALBc mouse versus CD11b Tumor from C57BL6 mouse." DESCRIPTION_FULL="Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correction of the diabetic status. Cytokines inducing MDSCs acted on a common molecular pathway. Immunoregulatory activity of both tumor-induced and BM-derived MDSCs was entirely dependent on C/EBP transcription factor, a key component of the emergency myelopoiesis triggered by stress and inflammation. Adoptive transfer of tumor antigen-specific CD8+ T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBP in myeloid compartment. These data unveil another link between inflammation and cancer and identify a novel molecular target to control tumor-induced immune suppression. We used gene expression analysis to identify those factors, secreted by tumor-infiltrating MDSC, which could drive emathopoiesis. Moreover we compare gene expression profile of tumor-induced MDSC, obtained from either the spleen and the tumor infiltrate of tumor bearing mice, and in vitro bone marrow-derived MDSC." TAGS="" MEMBERS="AARSD1,ABCG5,ABHD3,ACBD5,ACTR2,ACTR6,AGAP11,AGK,AGL,AIDA,ALDOC,ALG10,AMD1,AP4S1,APOL3,ARID4B,ASNSD1,ATXN7,BBS2,BTBD10,C12orf11,C17orf108,C18orf42,C19orf73,C1D,C1orf222,C8orf38,C8orf50,C8orf59,C9orf103,C9orf40,C9orf80,CARTPT,CASP8AP2,CCDC134,CCDC159,CCNYL1,CDKL3,CDV3,CENPH,CHI3L2,CHST11,CLN5,CMPK1,COL16A1,COL21A1,CPM,CPT2,CR1,CROCCP2,CSNK1G1,CTRB2,CXCL16,CYP2C19,DBP,DENND4C,DHRS1,DKFZP434I0714,DNAJC22,DNTTIP1,DSERG1,DYNLT3,EAF1,EBF4,EEF1E1,EFHB,EIF2B3,ERLIN2,ETAA1,FAM9C,FANCI,FLJ38379,FLJ45244,FOXM1,GALNT3,GAPDHP62,GART,GBP2,GCNT3,GK5,GOLGA2B,GORAB,GPCPD1,GPR31,GRAMD1C,GUSBP1,HGSNAT,HIGD1A,HIVEP2,HLF,HSP90AA1,HSPH1,HTRA3,HUS1,IFI16,IMMP2L,ITPKB,KBTBD7,KBTBD8,KCNH6,KIAA1147,KIAA1731,LACTB2,LNX2,LOC100132884,LOC100286909,LOC100288860,LOC100290278,LOC100505761,LOC100507140,LOC170425,LOC253573,LOC283663,LOC340085,LOC440104,LOC730631,LOXL2,LSM3,MDGA2,MEGF8,MLH3,MPHOSPH9,MRPL44,MTR,MYL4,NBEA,NCRNA00201,NFU1,NHLRC3,NKD2,NUDT9P1,NUPL1,OR11A1,PATL2,PEAK1,PHF16,PIK3IP1,PINX1,PLEKHF2,POU1F1,PPP1R12A,PPP2CB,PPP3CB,RAB18,RAB3A,RBMX2,RLN2,RNF20,RSPH4A,S100A9,SCRN3,SERPINB9,SHANK1,SLC2A2,SLC30A9,SLC40A1,SLC9A9,SMC1B,SNAP25,SP3P,SPG20,SUCLG2,TAF9B,TARSL2,TCEANC2,TCTA,TM2D2,TMEM131,TMEM194B,TMEM2,TMOD4,TNFRSF10B,TNS4,TP53INP1,TRANK1,TRIM40,TRMT61B,TSPAN6,TSPYL1,TTC14,TTLL12,UBA3,USP14,VAV3,VWDE,YIPF5,YIPF6,ZBTB10,ZBTB44,ZDHHC6,ZKSCAN5,ZNF101,ZNF146,ZNF347,ZNF616,ZNF770,ZNF829,ZNF844,ZNF85,ZWILCH" MEMBERS_SYMBOLIZED="AARSD1,ABCG5,ABHD3,ACBD5,ACTR2,ACTR6,AGAP11,AGK,AGL,AIDA,AKAIN1,ALDOC,ALG10,AMD1,AP4S1,APOL3,ARID4B,ASNSD1,ATXN7,BBS2,BTBD10,C10orf95-AS1,C19orf73,C1D,C9orf40,CARTPT,CASP8AP2,CCDC134,CCDC159,CCNYL1,CDKL3,CDV3,CEMIP2,CENPH,CEP295,CFAP74,CHI3L2,CHST11,CLN5,CMPK1,COL16A1,COL21A1,CPM,CPT2,CR1,CROCCP2,CSNK1G1,CTRB2,CXCL16,CYP2C19,DBP,DENND11,DENND4C,DHRS1,DICER1-AS1,DNAJC22,DNTTIP1,DYNLT3,EAF1,EBF4,EEF1E1,EFHB,EIF2B3,ENSG00000280119,ERLIN2,ETAA1,EXTL3-AS1,FAM9C,FANCI,FOXM1,GALNT3,GAPDHP62,GART,GBP2,GCNT3,GK5,GOLGA2P5,GORAB,GPCPD1,GPR31,GRAMD1C,GUSBP1,HGSNAT,HIGD1A,HIVEP2,HLF,HNRNPU,HSP90AA1,HSPH1,HTRA3,HUS1,IDNK,IFI16,IMMP2L,INIP,INTS13,ITPKB,JADE3,KBTBD7,KBTBD8,KCNH6,LACTB2,LINC00858,LINC00926,LINC01792,LINC02052,LNX2,LOXL2,LSM3,LYRM9,MDGA2,MEGF8,MIR4453HG,MLH3,MPHOSPH9,MRPL44,MTR,MYL4,NBEA,NDUFAF6,NEMP2,NFU1,NHLRC3,NKD2,NUDT9P1,NUP58,OR11A1,PATL2,PEAK1,PIK3IP1,PINX1,PLEKHF2,POU1F1,PPP1R12A,PPP2CB,PPP3CB,RAB18,RAB3A,RBIS,RBMX2,RLN2,RNF20,RSPH4A,S100A9,SCRN3,SERPINB9,SHANK1,SLC2A2,SLC30A9,SLC40A1,SLC9A9,SMC1B,SNAP25,SP3P,SPART,SUCLG2,TAF9B,TARS3,TCEANC2,TCTA,TM2D2,TMEM131,TMEM198B,TMOD4,TNFRSF10B,TNS4,TP53INP1,TRANK1,TRIM40,TRMT61B,TSPAN6,TSPYL1,TTC14,TTLL12,UBA3,USP14,VAV3,VWDE,YIPF5,YIPF6,ZBTB10,ZBTB44,ZDHHC6,ZKSCAN5,ZNF101,ZNF146,ZNF347,ZNF616,ZNF770,ZNF829,ZNF844,ZNF85,ZWILCH" MEMBERS_EZID="100128961,100131211,100505761,100507140,10097,101929402,10198,10438,10451,10463,10808,11154,11160,1117,113791,115817,116092,119369,119385,1203,123283,126075,127428,1307,135644,1368,1376,137682,1378,138050,151195,151613,151651,1557,160824,161357,1628,170425,171484,171586,178,1954,197135,201229,221806,222484,22931,230,2305,23111,23170,23505,23660,23670,253573,256356,2591,25994,2618,262,2634,26531,26960,27030,27127,27247,27258,283663,284391,285097,285195,2853,286451,29068,29765,30061,3097,3131,3192,3320,3364,3428,345895,3707,374899,387921,400242,401466,4017,414328,440104,440387,4548,4635,4659,50515,50944,51110,51265,51616,51634,51727,51742,5272,53944,54465,5449,54529,54553,54762,54984,54989,55006,55055,55071,55150,5516,55215,5532,55573,55592,55667,55726,55750,56254,56261,57189,57593,58191,583,58493,5864,6019,6280,6314,64240,642597,64429,64431,64853,64946,65080,6514,65986,6616,6988,6990,7105,7259,728411,7639,7705,79634,79666,79834,79879,79962,80755,80833,81033,81555,81578,83877,83943,84078,84280,84541,84671,84809,84920,84951,85403,85409,85452,85459,8795,8801,8891,90317,9039,9097,91452,92344,9245,94031,94039,94241,9521,9607,9767,9818,9881,9994" MEMBERS_MAPPING="AARSD1,AARSD1,80755|ABCG5,ABCG5,64240|ABHD3,ABHD3,171586|ACBD5,ACBD5,91452|ACTR2,ACTR2,10097|ACTR6,ACTR6,64431|AGAP11,AGAP11,119385|AGK,AGK,55750|AGL,AGL,178|AIDA,AIDA,64853|ALDOC,ALDOC,230|ALG10,ALG10,84920|AMD1,AMD1,262|AP4S1,AP4S1,11154|APOL3,APOL3,80833|ARID4B,ARID4B,51742|ASNSD1,ASNSD1,54529|ATXN7,ATXN7,6314|BBS2,BBS2,583|BTBD10,BTBD10,84280|C12orf11,INTS13,55726|C17orf108,LYRM9,201229|C18orf42,AKAIN1,642597|C19orf73,C19orf73,55150|C1D,C1D,10438|C1orf222,CFAP74,85452|C8orf38,NDUFAF6,137682|C8orf50,EXTL3-AS1,101929402|C8orf59,RBIS,401466|C9orf103,IDNK,414328|C9orf40,C9orf40,55071|C9orf80,INIP,58493|CARTPT,CARTPT,9607|CASP8AP2,CASP8AP2,9994|CCDC134,CCDC134,79879|CCDC159,CCDC159,126075|CCNYL1,CCNYL1,151195|CDKL3,CDKL3,51265|CDV3,CDV3,55573|CENPH,CENPH,64946|CHI3L2,CHI3L2,1117|CHST11,CHST11,50515|CLN5,CLN5,1203|CMPK1,CMPK1,51727|COL16A1,COL16A1,1307|COL21A1,COL21A1,81578|CPM,CPM,1368|CPT2,CPT2,1376|CR1,CR1,1378|CROCCP2,CROCCP2,84809|CSNK1G1,CSNK1G1,53944|CTRB2,CTRB2,440387|CXCL16,CXCL16,58191|CYP2C19,CYP2C19,1557|DBP,DBP,1628|DENND4C,DENND4C,55667|DHRS1,DHRS1,115817|DKFZP434I0714,MIR4453HG,54553|DNAJC22,DNAJC22,79962|DNTTIP1,DNTTIP1,116092|DSERG1,null,null|DYNLT3,DYNLT3,6990|EAF1,EAF1,85403|EBF4,EBF4,57593|EEF1E1,EEF1E1,9521|EFHB,EFHB,151651|EIF2B3,EIF2B3,8891|ERLIN2,ERLIN2,11160|ETAA1,ETAA1,54465|FAM9C,FAM9C,171484|FANCI,FANCI,55215|FLJ38379,ENSG00000280119,285097|FLJ45244,DICER1-AS1,400242|FOXM1,FOXM1,2305|GALNT3,GALNT3,2591|GAPDHP62,GAPDHP62,100128961|GART,GART,2618|GBP2,GBP2,2634|GCNT3,GCNT3,9245|GK5,GK5,256356|GOLGA2B,GOLGA2P5,55592|GORAB,GORAB,92344|GPCPD1,GPCPD1,56261|GPR31,GPR31,2853|GRAMD1C,GRAMD1C,54762|GUSBP1,GUSBP1,728411|HGSNAT,HGSNAT,138050|HIGD1A,HIGD1A,25994|HIVEP2,HIVEP2,3097|HLF,HLF,3131|HSP90AA1,HSP90AA1,3320|HSPH1,HSPH1,10808|HTRA3,HTRA3,94031|HUS1,HUS1,3364|IFI16,IFI16,3428|IMMP2L,IMMP2L,83943|ITPKB,ITPKB,3707|KBTBD7,KBTBD7,84078|KBTBD8,KBTBD8,84541|KCNH6,KCNH6,81033|KIAA1147,DENND11,57189|KIAA1731,CEP295,85459|LACTB2,LACTB2,51110|LNX2,LNX2,222484|LOC100132884,null,null|LOC100286909,null,null|LOC100288860,null,null|LOC100290278,null,null|LOC100505761,C10orf95-AS1,100505761|LOC100507140,LINC01792,100507140|LOC170425,LINC00858,170425|LOC253573,LINC02052,253573|LOC283663,LINC00926,283663|LOC340085,null,null|LOC440104,TMEM198B,440104|LOC730631,null,null|LOXL2,LOXL2,4017|LSM3,LSM3,27258|MDGA2,MDGA2,161357|MEGF8,MEGF8,1954|MLH3,MLH3,27030|MPHOSPH9,MPHOSPH9,10198|MRPL44,MRPL44,65080|MTR,MTR,4548|MYL4,MYL4,4635|NBEA,NBEA,26960|NCRNA00201,HNRNPU,3192|NFU1,NFU1,27247|NHLRC3,NHLRC3,387921|NKD2,NKD2,85409|NUDT9P1,NUDT9P1,119369|NUPL1,NUP58,9818|OR11A1,OR11A1,26531|PATL2,PATL2,197135|PEAK1,PEAK1,79834|PHF16,JADE3,9767|PIK3IP1,PIK3IP1,113791|PINX1,PINX1,54984|PLEKHF2,PLEKHF2,79666|POU1F1,POU1F1,5449|PPP1R12A,PPP1R12A,4659|PPP2CB,PPP2CB,5516|PPP3CB,PPP3CB,5532|RAB18,RAB18,22931|RAB3A,RAB3A,5864|RBMX2,RBMX2,51634|RLN2,RLN2,6019|RNF20,RNF20,56254|RSPH4A,RSPH4A,345895|S100A9,S100A9,6280|SCRN3,SCRN3,79634|SERPINB9,SERPINB9,5272|SHANK1,SHANK1,50944|SLC2A2,SLC2A2,6514|SLC30A9,SLC30A9,10463|SLC40A1,SLC40A1,30061|SLC9A9,SLC9A9,285195|SMC1B,SMC1B,27127|SNAP25,SNAP25,6616|SP3P,SP3P,160824|SPG20,SPART,23111|SUCLG2,SUCLG2,8801|TAF9B,TAF9B,51616|TARSL2,TARS3,123283|TCEANC2,TCEANC2,127428|TCTA,TCTA,6988|TM2D2,TM2D2,83877|TMEM131,TMEM131,23505|TMEM194B,NEMP2,100131211|TMEM2,CEMIP2,23670|TMOD4,TMOD4,29765|TNFRSF10B,TNFRSF10B,8795|TNS4,TNS4,84951|TP53INP1,TP53INP1,94241|TRANK1,TRANK1,9881|TRIM40,TRIM40,135644|TRMT61B,TRMT61B,55006|TSPAN6,TSPAN6,7105|TSPYL1,TSPYL1,7259|TTC14,TTC14,151613|TTLL12,TTLL12,23170|UBA3,UBA3,9039|USP14,USP14,9097|VAV3,VAV3,10451|VWDE,VWDE,221806|YIPF5,YIPF5,81555|YIPF6,YIPF6,286451|ZBTB10,ZBTB10,65986|ZBTB44,ZBTB44,29068|ZDHHC6,ZDHHC6,64429|ZKSCAN5,ZKSCAN5,23660|ZNF101,ZNF101,94039|ZNF146,ZNF146,7705|ZNF347,ZNF347,84671|ZNF616,ZNF616,90317|ZNF770,ZNF770,54989|ZNF829,ZNF829,374899|ZNF844,ZNF844,284391|ZNF85,ZNF85,7639|ZWILCH,ZWILCH,55055" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
