STANDARD_NAME	GSE21927_SPLEEN_VS_4T1_TUMOR_MONOCYTE_BALBC_UP
SYSTEMATIC_NAME	M7574
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21927_SPLEEN_VS_4T1_TUMOR_MONOCYTE_BALBC_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in CD11b+ cells from BALB/c mice bearing 4T1 mammary carcinoma: spleen of BALB/c mice: spleen versus tumor infiltrating monocytes.
DESCRIPTION_FULL	Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correction of the diabetic status. Cytokines inducing MDSCs acted on a common molecular pathway. Immunoregulatory activity of both tumor-induced and BM-derived MDSCs was entirely dependent on C/EBP transcription factor, a key component of the emergency myelopoiesis triggered by stress and inflammation. Adoptive transfer of tumor antigen-specific CD8+ T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBP in myeloid compartment. These data unveil another link between inflammation and cancer and identify a novel molecular target to control tumor-induced immune suppression. We used gene expression analysis to identify those factors, secreted by tumor-infiltrating MDSC, which could drive emathopoiesis. Moreover we compare gene expression profile of tumor-induced MDSC, obtained from either the spleen and the tumor infiltrate of tumor bearing mice, and in vitro bone marrow-derived MDSC.
PMID	20605485
GEOID	GSE21927
AUTHORS	Marigo I,Bosio E,Solito S,Mesa C,Fernandez A,Dolcetti L,Ugel S,Sonda N,Bicciato S,Falisi E,Calabrese F,Basso G,Zanovello P,Cozzi E,Mandruzzato S,Bronte V
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE21927_2518_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACOX3,ACSM1,ACY1,ADSL,ALS2CR12,AMBP,ANAPC2,AOAH,AP3S1,ASB17,ATG4A,ATOX1,ATP1B1,ATP6V1C2,B3GNT7,BAD,BCKDHA,BPNT1,BRSK1,C11orf9,C12orf23,C16orf13,C17orf103,C17orf90,C19orf42,C1QA,C3orf37,C3orf52,C5orf48,C7orf29,C7orf62,C9orf29,CACHD1,CAMK1D,CCDC127,CCHCR1,CD300A,CD38,CD47,CD79B,CD86,CDH16,CEP152,CHAD,CHML,CHST12,CKB,CLCA2,CLN8,CMA1,CORO1C,COTL1,CREB3L2,CREG1,CRYM,CSRP1,CTBP2,CXCL2,CXXC5,CYTL1,DBN1,DDX28,DNMT3A,ENPP6,ETS2,FABP1,FAM124B,FAM133B,FBLN2,FLJ40292,FLJ41170,FOXD2,FZD10,GAB3,GBGT1,GCNT1,GHRHR,GLCE,GLRX5,GNAI2,GRHPR,GRIK1-AS1,HDHD2,HIPK3,HIST1H2BK,IFI30,INTS10,INVS,ITGAM,KCNG3,KIAA0101,KIF21A,KIN,KLRC3,LCNL1,LEF1,LOC100131510,LOC100131993,LOC100287547,LOC100287572,LOC100287584,LOC100288809,LOC100499466,LOC100506325,LOC100507043,LOC152586,LOC283454,LOC284861,LOC285441,LOC338620,LOC339442,LOC441025,LPHN1,LRRC14,MAML3,MAPK7,MGC12916,MORC2-AS1,MRPS6,NAA10,NCRNA00263,NDUFS7,NOD2,NOLC1,NPTX1,NTN1,NUDT11,NUMB,NUP62CL,O3FAR1,ORMDL3,PAG1,PAR5,PCDH9,PDCD2L,PDZRN3,PELI2,PGAM1,PHACTR1,PIK3R1,PKD2L2,PPP1CC,PRKAG3,PRR5,PTPRM,QTRTD1,RAG1,RCL1,RILPL2,RIMS3,RING1,RNASEH2C,RNF130,RPIA,RPS6KA3,RRBP1,S1PR5,SAMD13,SCGB2A2,SCIN,SEC22A,SFTA3,SGK223,SGSM2,SLC27A4,SLC31A2,SLCO2B1,SNRNP25,SNX30,SORT1,SPHKAP,SPP1,TAAR3,TAF4,TAPT1,TCEB3,TEAD3,TIMD4,TMEM144,TMEM147,TMEM161A,TMEM170B,TMEM176A,TMEM70,TMEM9,TMPRSS12,TNFSF15,TRIT1,TRMT61A,TSEN54,UBAP2,UCMA,UPK2,URB2,VPREB3,WDFY3,ZMIZ1,ZNF232,ZNF503,ZNF718
GENE_SYMBOLS	ACOX3,ACSM1,ACY1,ADSL,FLACC1,AMBP,ANAPC2,AOAH,AP3S1,ASB17,ATG4A,ATOX1,ATP1B1,ATP6V1C2,B3GNT7,BAD,BCKDHA,BPNT1,BRSK1,MYRF,TMEM263,METTL26,NATD1,OXLD1,SMIM7,C1QA,HMCES,C3orf52,SPMIP10,ZBED10P,TEX47,LRRC37A5P,CACHD1,CAMK1D,CCDC127,CCHCR1,CD300A,CD38,CD47,CD79B,CD86,CDH16,CEP152,CHAD,CHML,CHST12,CKB,CLCA2,CLN8,CMA1,CORO1C,COTL1,CREB3L2,CREG1,CRYM,CSRP1,CTBP2,CXCL2,CXXC5,CYTL1,DBN1,DDX28,DNMT3A,ENPP6,ETS2,FABP1,FAM124B,FAM133B,FBLN2,EHMT1,,FOXD2,FZD10,GAB3,GBGT1,GCNT1,GHRHR,GLCE,GLRX5,GNAI2,GRHPR,GRIK1-AS1,HDHD2,HIPK3,H2BC12,IFI30,INTS10,INVS,ITGAM,KCNG3,PCLAF,KIF21A,KIN,KLRC3,LCNL1,LEF1,,,,,,,LINC00674,SP2-AS1,TUNAR,MGAT4D,HRK,FAM230B,F11-AS1,,LINC01343,LINC02483,ADGRL1,LRRC14,MAML3,MAPK7,,MORC2-AS1,MRPS6,NAA10,OLMALINC,NDUFS7,NOD2,NOLC1,NPTX1,NTN1,NUDT11,NUMB,NUP62CL,FFAR4,ORMDL3,PAG1,PWAR5,PCDH9,PDCD2L,PDZRN3,PELI2,PGAM1,PHACTR1,PIK3R1,PKD2L2,PPP1CC,PRKAG3,PRR5,PTPRM,QTRT2,RAG1,RCL1,RILPL2,RIMS3,RING1,RNASEH2C,RNF130,RPIA,RPS6KA3,RRBP1,S1PR5,SAMD13,SCGB2A2,SCIN,SEC22A,SFTA3,,SGSM2,SLC27A4,SLC31A2,SLCO2B1,SNRNP25,SNX30,SORT1,SPHKAP,SPP1,TAAR3P,TAF4,TAPT1,ELOA,TEAD3,TIMD4,TMEM144,TMEM147,TMEM161A,TMEM170B,TMEM176A,TMEM70,TMEM9,TMPRSS12,TNFSF15,TRIT1,TRMT61A,TSEN54,UBAP2,UCMA,UPK2,URB2,VPREB3,WDFY3,ZMIZ1,ZNF232,ZNF503,ZNF718
FOUNDER_NAMES