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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21927_SPLEEN_VS_4T1_TUMOR_MONOCYTE_BALBC_UP" SYSTEMATIC_NAME="M7574" HISTORICAL_NAMES="" PMID="20605485" AUTHORS="Marigo I,Bosio E,Solito S,Mesa C,Fernandez A,Dolcetti L,Ugel S,Sonda N,Bicciato S,Falisi E,Calabrese F,Basso G,Zanovello P,Cozzi E,Mandruzzato S,Bronte V" GEOID="GSE21927" EXACT_SOURCE="GSE21927_2518_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in CD11b+ cells from BALB/c mice bearing 4T1 mammary carcinoma: spleen of BALB/c mice: spleen versus tumor infiltrating monocytes." DESCRIPTION_FULL="Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correction of the diabetic status. Cytokines inducing MDSCs acted on a common molecular pathway. Immunoregulatory activity of both tumor-induced and BM-derived MDSCs was entirely dependent on C/EBP transcription factor, a key component of the emergency myelopoiesis triggered by stress and inflammation. Adoptive transfer of tumor antigen-specific CD8+ T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBP in myeloid compartment. These data unveil another link between inflammation and cancer and identify a novel molecular target to control tumor-induced immune suppression. We used gene expression analysis to identify those factors, secreted by tumor-infiltrating MDSC, which could drive emathopoiesis. Moreover we compare gene expression profile of tumor-induced MDSC, obtained from either the spleen and the tumor infiltrate of tumor bearing mice, and in vitro bone marrow-derived MDSC." TAGS="" MEMBERS="ACOX3,ACSM1,ACY1,ADSL,ALS2CR12,AMBP,ANAPC2,AOAH,AP3S1,ASB17,ATG4A,ATOX1,ATP1B1,ATP6V1C2,B3GNT7,BAD,BCKDHA,BPNT1,BRSK1,C11orf9,C12orf23,C16orf13,C17orf103,C17orf90,C19orf42,C1QA,C3orf37,C3orf52,C5orf48,C7orf29,C7orf62,C9orf29,CACHD1,CAMK1D,CCDC127,CCHCR1,CD300A,CD38,CD47,CD79B,CD86,CDH16,CEP152,CHAD,CHML,CHST12,CKB,CLCA2,CLN8,CMA1,CORO1C,COTL1,CREB3L2,CREG1,CRYM,CSRP1,CTBP2,CXCL2,CXXC5,CYTL1,DBN1,DDX28,DNMT3A,ENPP6,ETS2,FABP1,FAM124B,FAM133B,FBLN2,FLJ40292,FLJ41170,FOXD2,FZD10,GAB3,GBGT1,GCNT1,GHRHR,GLCE,GLRX5,GNAI2,GRHPR,GRIK1-AS1,HDHD2,HIPK3,HIST1H2BK,IFI30,INTS10,INVS,ITGAM,KCNG3,KIAA0101,KIF21A,KIN,KLRC3,LCNL1,LEF1,LOC100131510,LOC100131993,LOC100287547,LOC100287572,LOC100287584,LOC100288809,LOC100499466,LOC100506325,LOC100507043,LOC152586,LOC283454,LOC284861,LOC285441,LOC338620,LOC339442,LOC441025,LPHN1,LRRC14,MAML3,MAPK7,MGC12916,MORC2-AS1,MRPS6,NAA10,NCRNA00263,NDUFS7,NOD2,NOLC1,NPTX1,NTN1,NUDT11,NUMB,NUP62CL,O3FAR1,ORMDL3,PAG1,PAR5,PCDH9,PDCD2L,PDZRN3,PELI2,PGAM1,PHACTR1,PIK3R1,PKD2L2,PPP1CC,PRKAG3,PRR5,PTPRM,QTRTD1,RAG1,RCL1,RILPL2,RIMS3,RING1,RNASEH2C,RNF130,RPIA,RPS6KA3,RRBP1,S1PR5,SAMD13,SCGB2A2,SCIN,SEC22A,SFTA3,SGK223,SGSM2,SLC27A4,SLC31A2,SLCO2B1,SNRNP25,SNX30,SORT1,SPHKAP,SPP1,TAAR3,TAF4,TAPT1,TCEB3,TEAD3,TIMD4,TMEM144,TMEM147,TMEM161A,TMEM170B,TMEM176A,TMEM70,TMEM9,TMPRSS12,TNFSF15,TRIT1,TRMT61A,TSEN54,UBAP2,UCMA,UPK2,URB2,VPREB3,WDFY3,ZMIZ1,ZNF232,ZNF503,ZNF718" MEMBERS_SYMBOLIZED="ACOX3,ACSM1,ACY1,ADGRL1,ADSL,AMBP,ANAPC2,AOAH,AP3S1,ASB17,ATG4A,ATOX1,ATP1B1,ATP6V1C2,B3GNT7,BAD,BCKDHA,BPNT1,BRSK1,C1QA,C3orf52,CACHD1,CAMK1D,CCDC127,CCHCR1,CD300A,CD38,CD47,CD79B,CD86,CDH16,CEP152,CHAD,CHML,CHST12,CKB,CLCA2,CLN8,CMA1,CORO1C,COTL1,CREB3L2,CREG1,CRYM,CSRP1,CTBP2,CXCL2,CXXC5,CYTL1,DBN1,DDX28,DNMT3A,EHMT1,ELOA,ENPP6,ETS2,F11-AS1,FABP1,FAM124B,FAM133B,FAM230B,FBLN2,FFAR4,FLACC1,FOXD2,FZD10,GAB3,GBGT1,GCNT1,GHRHR,GLCE,GLRX5,GNAI2,GRHPR,GRIK1-AS1,H2BC12,HDHD2,HIPK3,HMCES,HRK,IFI30,INTS10,INVS,ITGAM,KCNG3,KIF21A,KIN,KLRC3,LCNL1,LEF1,LINC00674,LINC01343,LINC02483,LRRC14,LRRC37A5P,MAML3,MAPK7,METTL26,MGAT4D,MORC2-AS1,MRPS6,MYRF,NAA10,NATD1,NDUFS7,NOD2,NOLC1,NPTX1,NTN1,NUDT11,NUMB,NUP62CL,OLMALINC,ORMDL3,OXLD1,PAG1,PCDH9,PCLAF,PDCD2L,PDZRN3,PELI2,PGAM1,PHACTR1,PIK3R1,PKD2L2,PPP1CC,PRKAG3,PRR5,PTPRM,PWAR5,QTRT2,RAG1,RCL1,RILPL2,RIMS3,RING1,RNASEH2C,RNF130,RPIA,RPS6KA3,RRBP1,S1PR5,SAMD13,SCGB2A2,SCIN,SEC22A,SFTA3,SGSM2,SLC27A4,SLC31A2,SLCO2B1,SMIM7,SNRNP25,SNX30,SORT1,SP2-AS1,SPHKAP,SPMIP10,SPP1,TAAR3P,TAF4,TAPT1,TEAD3,TEX47,TIMD4,TMEM144,TMEM147,TMEM161A,TMEM170B,TMEM176A,TMEM263,TMEM70,TMEM9,TMPRSS12,TNFSF15,TRIT1,TRMT61A,TSEN54,TUNAR,UBAP2,UCMA,UPK2,URB2,VPREB3,WDFY3,ZBED10P,ZMIZ1,ZNF232,ZNF503,ZNF718" MEMBERS_EZID="100113407,100499466,100506325,100507043,10114,1014,10171,10380,10430,10437,10999,1101,11211,1122,11309,11314,113763,1152,115201,115708,116285,1176,1215,127247,130540,1318,133121,133957,139716,1428,1465,148418,1488,150291,152586,158,1627,170850,1788,196383,202018,2055,2114,2168,219557,2199,221044,221692,22859,22934,22944,22995,23001,23024,2306,23406,23603,245973,252839,253970,255403,256302,257415,259,26035,26301,2650,2692,26984,27039,27130,2771,283471,283989,285441,2920,29802,29882,313,338557,339229,339442,3684,374291,3823,389320,401548,401562,4250,441025,475,481,4884,5101,51176,51218,51523,5223,5295,53632,53637,54360,54535,54802,54830,54929,54968,5501,55174,55190,55314,55365,55501,55534,55605,55615,55794,55819,55824,55833,5598,56941,57118,57161,57178,572,57685,5797,5896,593,6015,6197,6238,6272,64127,642633,642976,64764,64968,652972,6696,6874,6924,7005,712,7379,745,7775,79086,79622,79669,79691,79813,79843,80309,8123,8260,8310,84064,84153,84306,84326,84446,84858,85236,85477,8650,8739,8804,90271,90488,91937,9221,9288,93010,9380,94103,942,9423,95,952,961,9635,9684,974,9768,9783,9816,9905,9966" MEMBERS_MAPPING="ACOX3,ACOX3,8310|ACSM1,ACSM1,116285|ACY1,ACY1,95|ADSL,ADSL,158|ALS2CR12,FLACC1,130540|AMBP,AMBP,259|ANAPC2,ANAPC2,29882|AOAH,AOAH,313|AP3S1,AP3S1,1176|ASB17,ASB17,127247|ATG4A,ATG4A,115201|ATOX1,ATOX1,475|ATP1B1,ATP1B1,481|ATP6V1C2,ATP6V1C2,245973|B3GNT7,B3GNT7,93010|BAD,BAD,572|BCKDHA,BCKDHA,593|BPNT1,BPNT1,10380|BRSK1,BRSK1,84446|C11orf9,MYRF,745|C12orf23,TMEM263,90488|C16orf13,METTL26,84326|C17orf103,NATD1,256302|C17orf90,OXLD1,339229|C19orf42,SMIM7,79086|C1QA,C1QA,712|C3orf37,HMCES,56941|C3orf52,C3orf52,79669|C5orf48,SPMIP10,389320|C7orf29,ZBED10P,113763|C7orf62,TEX47,219557|C9orf29,LRRC37A5P,652972|CACHD1,CACHD1,57685|CAMK1D,CAMK1D,57118|CCDC127,CCDC127,133957|CCHCR1,CCHCR1,54535|CD300A,CD300A,11314|CD38,CD38,952|CD47,CD47,961|CD79B,CD79B,974|CD86,CD86,942|CDH16,CDH16,1014|CEP152,CEP152,22995|CHAD,CHAD,1101|CHML,CHML,1122|CHST12,CHST12,55501|CKB,CKB,1152|CLCA2,CLCA2,9635|CLN8,CLN8,2055|CMA1,CMA1,1215|CORO1C,CORO1C,23603|COTL1,COTL1,23406|CREB3L2,CREB3L2,64764|CREG1,CREG1,8804|CRYM,CRYM,1428|CSRP1,CSRP1,1465|CTBP2,CTBP2,1488|CXCL2,CXCL2,2920|CXXC5,CXXC5,51523|CYTL1,CYTL1,54360|DBN1,DBN1,1627|DDX28,DDX28,55794|DNMT3A,DNMT3A,1788|ENPP6,ENPP6,133121|ETS2,ETS2,2114|FABP1,FABP1,2168|FAM124B,FAM124B,79843|FAM133B,FAM133B,257415|FBLN2,FBLN2,2199|FLJ40292,EHMT1,79813|FLJ41170,null,null|FOXD2,FOXD2,2306|FZD10,FZD10,11211|GAB3,GAB3,139716|GBGT1,GBGT1,26301|GCNT1,GCNT1,2650|GHRHR,GHRHR,2692|GLCE,GLCE,26035|GLRX5,GLRX5,51218|GNAI2,GNAI2,2771|GRHPR,GRHPR,9380|GRIK1-AS1,GRIK1-AS1,642976|HDHD2,HDHD2,84064|HIPK3,HIPK3,10114|HIST1H2BK,H2BC12,85236|IFI30,IFI30,10437|INTS10,INTS10,55174|INVS,INVS,27130|ITGAM,ITGAM,3684|KCNG3,KCNG3,170850|KIAA0101,PCLAF,9768|KIF21A,KIF21A,55605|KIN,KIN,22944|KLRC3,KLRC3,3823|LCNL1,LCNL1,401562|LEF1,LEF1,51176|LOC100131510,null,null|LOC100131993,null,null|LOC100287547,null,null|LOC100287572,null,null|LOC100287584,null,null|LOC100288809,null,null|LOC100499466,LINC00674,100499466|LOC100506325,SP2-AS1,100506325|LOC100507043,TUNAR,100507043|LOC152586,MGAT4D,152586|LOC283454,HRK,8739|LOC284861,FAM230B,642633|LOC285441,F11-AS1,285441|LOC338620,null,null|LOC339442,LINC01343,339442|LOC441025,LINC02483,441025|LPHN1,ADGRL1,22859|LRRC14,LRRC14,9684|MAML3,MAML3,55534|MAPK7,MAPK7,5598|MGC12916,null,null|MORC2-AS1,MORC2-AS1,150291|MRPS6,MRPS6,64968|NAA10,NAA10,8260|NCRNA00263,OLMALINC,90271|NDUFS7,NDUFS7,374291|NOD2,NOD2,64127|NOLC1,NOLC1,9221|NPTX1,NPTX1,4884|NTN1,NTN1,9423|NUDT11,NUDT11,55190|NUMB,NUMB,8650|NUP62CL,NUP62CL,54830|O3FAR1,FFAR4,338557|ORMDL3,ORMDL3,94103|PAG1,PAG1,55824|PAR5,PWAR5,8123|PCDH9,PCDH9,5101|PDCD2L,PDCD2L,84306|PDZRN3,PDZRN3,23024|PELI2,PELI2,57161|PGAM1,PGAM1,5223|PHACTR1,PHACTR1,221692|PIK3R1,PIK3R1,5295|PKD2L2,PKD2L2,27039|PPP1CC,PPP1CC,5501|PRKAG3,PRKAG3,53632|PRR5,PRR5,55615|PTPRM,PTPRM,5797|QTRTD1,QTRT2,79691|RAG1,RAG1,5896|RCL1,RCL1,10171|RILPL2,RILPL2,196383|RIMS3,RIMS3,9783|RING1,RING1,6015|RNASEH2C,RNASEH2C,84153|RNF130,RNF130,55819|RPIA,RPIA,22934|RPS6KA3,RPS6KA3,6197|RRBP1,RRBP1,6238|S1PR5,S1PR5,53637|SAMD13,SAMD13,148418|SCGB2A2,SCGB2A2,4250|SCIN,SCIN,85477|SEC22A,SEC22A,26984|SFTA3,SFTA3,253970|SGK223,null,null|SGSM2,SGSM2,9905|SLC27A4,SLC27A4,10999|SLC31A2,SLC31A2,1318|SLCO2B1,SLCO2B1,11309|SNRNP25,SNRNP25,79622|SNX30,SNX30,401548|SORT1,SORT1,6272|SPHKAP,SPHKAP,80309|SPP1,SPP1,6696|TAAR3,TAAR3P,9288|TAF4,TAF4,6874|TAPT1,TAPT1,202018|TCEB3,ELOA,6924|TEAD3,TEAD3,7005|TIMD4,TIMD4,91937|TMEM144,TMEM144,55314|TMEM147,TMEM147,10430|TMEM161A,TMEM161A,54929|TMEM170B,TMEM170B,100113407|TMEM176A,TMEM176A,55365|TMEM70,TMEM70,54968|TMEM9,TMEM9,252839|TMPRSS12,TMPRSS12,283471|TNFSF15,TNFSF15,9966|TRIT1,TRIT1,54802|TRMT61A,TRMT61A,115708|TSEN54,TSEN54,283989|UBAP2,UBAP2,55833|UCMA,UCMA,221044|UPK2,UPK2,7379|URB2,URB2,9816|VPREB3,VPREB3,29802|WDFY3,WDFY3,23001|ZMIZ1,ZMIZ1,57178|ZNF232,ZNF232,7775|ZNF503,ZNF503,84858|ZNF718,ZNF718,255403" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
