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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE21927_SPLEEN_VS_C26GM_TUMOR_MONOCYTE_BALBC_DN" SYSTEMATIC_NAME="M7573" HISTORICAL_NAMES="" PMID="20605485" AUTHORS="Marigo I,Bosio E,Solito S,Mesa C,Fernandez A,Dolcetti L,Ugel S,Sonda N,Bicciato S,Falisi E,Calabrese F,Basso G,Zanovello P,Cozzi E,Mandruzzato S,Bronte V" GEOID="GSE21927" EXACT_SOURCE="GSE21927_2517_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD11b+ cells from BALB/c mice bearing C26GM colon carcinoma: spleen of BALB/c mice: spleen versus tumor infiltrating monocytes." DESCRIPTION_FULL="Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correction of the diabetic status. Cytokines inducing MDSCs acted on a common molecular pathway. Immunoregulatory activity of both tumor-induced and BM-derived MDSCs was entirely dependent on C/EBP transcription factor, a key component of the emergency myelopoiesis triggered by stress and inflammation. Adoptive transfer of tumor antigen-specific CD8+ T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBP in myeloid compartment. These data unveil another link between inflammation and cancer and identify a novel molecular target to control tumor-induced immune suppression. We used gene expression analysis to identify those factors, secreted by tumor-infiltrating MDSC, which could drive emathopoiesis. Moreover we compare gene expression profile of tumor-induced MDSC, obtained from either the spleen and the tumor infiltrate of tumor bearing mice, and in vitro bone marrow-derived MDSC." TAGS="" MEMBERS="AAK1,ABCB10,ACSM1,AKAP3,ALG2,ALOX5AP,AMOTL2,ANKRD10,ANKRD32,ANXA4,AP3M1,APIP,ARHGEF9,ASXL1,ATXN7,BLM,BTBD11,C12orf23,C12orf5,C19orf42,C1D,C1orf174,C4orf27,C4orf32,C8orf76,CAPZA2,CCDC113,CCDC127,CCDC136,CCDC14,CCDC141,CDK6,CEP44,CHCHD1,CHMP4C,CHUK,CKAP2,CLRN1-AS1,COX5A,CPD,CSGALNACT2,CUL4B,CYP2C19,DAZL,DDX21,DEFB114,DFNB59,DHRS3,DOCK7,E2F3,EMB,EPB41,ESCO1,FAM5B,FAM91A1,FAM98B,FAP,FBXO5,FLJ13224,FMO2,FNBP1L,FRYL,FSIP1,GALNT3,GALR2,GCA,GCFC1,GMFB,GNB4,GNG3,GPATCH2,GPR18,GPR31,GRHPR,GUSBP5,HAUS3,HDGFRP3,HES1,HIP1,HIST1H2AC,HIST1H2BE,HNRNPA2B1,HRK,IFT52,IL3,ITGAM,ITM2C,JKAMP,KBTBD8,KDM1A,KIAA1804,KLHL28,KPNA3,LAMP2,LAPTM4B,LARP1B,LEF1,LEMD3,LEPROT,LHFPL2,LNX2,LOC100128594,LOC100286844,LOC100286910,LOC100288282,LOC100506089,LOC220594,LOC400692,LOC654433,LSM3,LYPLA1,MAD2L1,MAEL,MAGEH1,MC5R,ME2,MGAT5B,MLF1IP,MON1B,MPP6,MRPL47,MTHFD2L,MTMR6,NAPSA,NBEAP1,NID1,NOL12,NSUN3,OGFRL1,OR1Q1,ORMDL3,PELI2,PHC1,PPP1R14A,PRDM7,PRO1483,PRRG1,PTPN11,PTPN2,RABGGTB,RALGAPA1,RBBP6,RHBDL3,RHOBTB1,RNF180,RNF39,RNFT2,RNGTT,RYK,SDCBP,SEMG1,SERPINB12,SGOL2,SLC12A6,SLC22A4,SLC2A1,SLC5A3,SMAP1,SNRNP27,SNX30,SORD,SOS1,SOX4,SRD5A1,SRPX2,SSX2IP,STS,STX10,SUSD1,SYDE2,SYF2,TAF5,TAPT1,TAS2R19,TCP10,TIFA,TLN2,TLR7,TMCO6,TNFRSF21,TNS3,TOR1AIP1,TRA2B,TSPAN6,TSTA3,TTL,TWF1,UGT2A3,UGT2B4,UHRF1,URB2,USH1G,VPREB3,VPS26A,WASF1,WDR67,ZEB2,ZFAND3,ZNF177,ZNF880" MEMBERS_SYMBOLIZED="AAK1,ABCB10,ABTB3,ACSM1,AKAP3,ALG2,ALOX5AP,AMOTL2,ANKRD10,ANXA4,AP3M1,APIP,ARHGEF9,ASXL1,ATXN7,BCDIN3D-AS1,BLM,BRINP2,C1D,C1orf174,C8orf76,CAPZA2,CCDC127,CCDC136,CCDC14,CCDC141,CDK6,CENPU,CEP44,CFAP263,CHCHD1,CHMP4C,CHUK,CKAP2,COX5A,CPD,CSGALNACT2,CUL4B,CYP2C19,DAZL,DDX21,DEFB114,DHRS3,DOCK7,E2F3,EMB,EPB41,ESCO1,FAM241A,FAM91A1,FAM98B,FAP,FBXO5,FLJ13224,FMO2,FNBP1L,FRYL,FSIP1,GALNT3,GALR2,GCA,GFUS,GMFB,GNB4,GNG3,GPATCH2,GPR18,GPR31,GRHPR,GUSBP5,H2AC6,H2BC6,HAUS3,HES1,HIP1,HNRNPA2B1,HPF1,HRK,IFT52,IL3,ITGAM,ITM2C,JKAMP,KBTBD8,KDM1A,KLHL28,KPNA3,LAMP2,LAPTM4B,LARP1B,LEF1,LEMD3,LEPROT,LHFPL2,LNX2,LSM3,LYPLA1,MAD2L1,MAEL,MAGEH1,MAP3K21,MC5R,ME2,MGAT5B,MON1B,MRPL47,MTHFD2L,MTMR6,NAPSA,NBEAP1,NID1,NOL12,NSUN3,OGFRL1,OR1Q1,ORMDL3,PALS2,PAX8-AS1,PAXBP1,PELI2,PHC1,PJVK,PPP1R14A,PRDM7,PRRG1,PTPN11,PTPN2,RABGGTB,RALGAPA1,RBBP6,RHBDL3,RHOBTB1,RNF180,RNF39,RNFT2,RNGTT,RYK,SDCBP,SEMG1,SERPINB12,SGO2,SIAH2-AS1,SLC12A6,SLC22A4,SLC2A1,SLC5A3,SLF1,SMAP1,SMIM7,SNRNP27,SNX30,SORD,SOS1,SOX4,SRD5A1,SRPX2,SSX2IP,STS,STX10,SUSD1,SYDE2,SYF2,TAF5,TAPT1,TAS2R19,TBC1D31,TCP10L3,TIFA,TIGAR,TLN2,TLR7,TMCO6,TMEM263,TMSB15B-AS1,TNFRSF21,TNS3,TOR1AIP1,TRA2B,TSPAN6,TTL,TWF1,UGT2A3,UGT2B4,UHRF1,URB2,USH1G,USP32P2,VPREB3,VPS26A,WASF1,ZEB2,ZFAND3,ZNF177,ZNF880" MEMBERS_EZID="100128594,100286844,10184,1021,10434,10438,105374155,10566,11017,11105,1147,114799,116285,117178,118487,121551,124590,132720,133418,133957,1362,146664,150465,151246,1557,157769,158131,1618,161835,162494,171023,1871,1911,202018,2035,2191,220594,222484,22848,22879,23028,23229,2327,23456,23592,241,245928,253959,25801,2591,259294,25949,26092,26271,26586,26985,27242,27258,27286,2764,2785,283742,2841,285025,2853,285527,285671,28986,29070,29128,29802,307,3092,3181,3280,339448,3562,3684,3839,3920,400713,401548,4085,412,4161,4200,441024,441046,4811,494513,51074,51098,51176,51284,51421,51528,51678,54741,54813,54874,54969,55105,55132,55353,55374,55454,55608,5638,57103,57129,57161,5756,5771,57795,5781,5876,5930,59345,606,60682,60685,6259,6314,6386,63899,6406,641,6434,64420,64753,64759,64770,6513,6526,654433,6583,6652,6654,6659,6715,6877,6953,7105,7264,7363,7730,79086,79159,79441,79627,79682,79799,79857,80352,80817,81618,830,8334,8344,83660,84144,84250,84451,8450,84541,84900,84933,84944,85365,85440,8677,8732,8739,8811,8936,89777,90488,9107,9188,92421,9249,92610,93594,9377,9380,94103,94104,94274,9476,9559,9816,9839,9886,9990" MEMBERS_MAPPING="AAK1,AAK1,22848|ABCB10,ABCB10,23456|ACSM1,ACSM1,116285|AKAP3,AKAP3,10566|ALG2,ALG2,85365|ALOX5AP,ALOX5AP,241|AMOTL2,AMOTL2,51421|ANKRD10,ANKRD10,55608|ANKRD32,SLF1,84250|ANXA4,ANXA4,307|AP3M1,AP3M1,26985|APIP,APIP,51074|ARHGEF9,ARHGEF9,23229|ASXL1,ASXL1,171023|ATXN7,ATXN7,6314|BLM,BLM,641|BTBD11,ABTB3,121551|C12orf23,TMEM263,90488|C12orf5,TIGAR,57103|C19orf42,SMIM7,79086|C1D,C1D,10438|C1orf174,C1orf174,339448|C4orf27,HPF1,54969|C4orf32,FAM241A,132720|C8orf76,C8orf76,84933|CAPZA2,CAPZA2,830|CCDC113,CFAP263,29070|CCDC127,CCDC127,133957|CCDC136,CCDC136,64753|CCDC14,CCDC14,64770|CCDC141,CCDC141,285025|CDK6,CDK6,1021|CEP44,CEP44,80817|CHCHD1,CHCHD1,118487|CHMP4C,CHMP4C,92421|CHUK,CHUK,1147|CKAP2,CKAP2,26586|CLRN1-AS1,SIAH2-AS1,105374155|COX5A,COX5A,9377|CPD,CPD,1362|CSGALNACT2,CSGALNACT2,55454|CUL4B,CUL4B,8450|CYP2C19,CYP2C19,1557|DAZL,DAZL,1618|DDX21,DDX21,9188|DEFB114,DEFB114,245928|DFNB59,PJVK,494513|DHRS3,DHRS3,9249|DOCK7,DOCK7,85440|E2F3,E2F3,1871|EMB,EMB,133418|EPB41,EPB41,2035|ESCO1,ESCO1,114799|FAM5B,BRINP2,57795|FAM91A1,FAM91A1,157769|FAM98B,FAM98B,283742|FAP,FAP,2191|FBXO5,FBXO5,26271|FLJ13224,FLJ13224,79857|FMO2,FMO2,2327|FNBP1L,FNBP1L,54874|FRYL,FRYL,285527|FSIP1,FSIP1,161835|GALNT3,GALNT3,2591|GALR2,GALR2,8811|GCA,GCA,25801|GCFC1,PAXBP1,94104|GMFB,GMFB,2764|GNB4,GNB4,59345|GNG3,GNG3,2785|GPATCH2,GPATCH2,55105|GPR18,GPR18,2841|GPR31,GPR31,2853|GRHPR,GRHPR,9380|GUSBP5,GUSBP5,441046|HAUS3,HAUS3,79441|HDGFRP3,null,null|HES1,HES1,3280|HIP1,HIP1,3092|HIST1H2AC,H2AC6,8334|HIST1H2BE,H2BC6,8344|HNRNPA2B1,HNRNPA2B1,3181|HRK,HRK,8739|IFT52,IFT52,51098|IL3,IL3,3562|ITGAM,ITGAM,3684|ITM2C,ITM2C,81618|JKAMP,JKAMP,51528|KBTBD8,KBTBD8,84541|KDM1A,KDM1A,23028|KIAA1804,MAP3K21,84451|KLHL28,KLHL28,54813|KPNA3,KPNA3,3839|LAMP2,LAMP2,3920|LAPTM4B,LAPTM4B,55353|LARP1B,LARP1B,55132|LEF1,LEF1,51176|LEMD3,LEMD3,23592|LEPROT,LEPROT,54741|LHFPL2,LHFPL2,10184|LNX2,LNX2,222484|LOC100128594,TMSB15B-AS1,100128594|LOC100286844,BCDIN3D-AS1,100286844|LOC100286910,null,null|LOC100288282,null,null|LOC100506089,null,null|LOC220594,USP32P2,220594|LOC400692,null,null|LOC654433,PAX8-AS1,654433|LSM3,LSM3,27258|LYPLA1,LYPLA1,10434|MAD2L1,MAD2L1,4085|MAEL,MAEL,84944|MAGEH1,MAGEH1,28986|MC5R,MC5R,4161|ME2,ME2,4200|MGAT5B,MGAT5B,146664|MLF1IP,CENPU,79682|MON1B,MON1B,22879|MPP6,PALS2,51678|MRPL47,MRPL47,57129|MTHFD2L,MTHFD2L,441024|MTMR6,MTMR6,9107|NAPSA,NAPSA,9476|NBEAP1,NBEAP1,606|NID1,NID1,4811|NOL12,NOL12,79159|NSUN3,NSUN3,63899|OGFRL1,OGFRL1,79627|OR1Q1,OR1Q1,158131|ORMDL3,ORMDL3,94103|PELI2,PELI2,57161|PHC1,PHC1,1911|PPP1R14A,PPP1R14A,94274|PRDM7,PRDM7,11105|PRO1483,null,null|PRRG1,PRRG1,5638|PTPN11,PTPN11,5781|PTPN2,PTPN2,5771|RABGGTB,RABGGTB,5876|RALGAPA1,RALGAPA1,253959|RBBP6,RBBP6,5930|RHBDL3,RHBDL3,162494|RHOBTB1,RHOBTB1,9886|RNF180,RNF180,285671|RNF39,RNF39,80352|RNFT2,RNFT2,84900|RNGTT,RNGTT,8732|RYK,RYK,6259|SDCBP,SDCBP,6386|SEMG1,SEMG1,6406|SERPINB12,SERPINB12,89777|SGOL2,SGO2,151246|SLC12A6,SLC12A6,9990|SLC22A4,SLC22A4,6583|SLC2A1,SLC2A1,6513|SLC5A3,SLC5A3,6526|SMAP1,SMAP1,60682|SNRNP27,SNRNP27,11017|SNX30,SNX30,401548|SORD,SORD,6652|SOS1,SOS1,6654|SOX4,SOX4,6659|SRD5A1,SRD5A1,6715|SRPX2,SRPX2,27286|SSX2IP,SSX2IP,117178|STS,STS,412|STX10,STX10,8677|SUSD1,SUSD1,64420|SYDE2,SYDE2,84144|SYF2,SYF2,25949|TAF5,TAF5,6877|TAPT1,TAPT1,202018|TAS2R19,TAS2R19,259294|TCP10,TCP10L3,6953|TIFA,TIFA,92610|TLN2,TLN2,83660|TLR7,TLR7,51284|TMCO6,TMCO6,55374|TNFRSF21,TNFRSF21,27242|TNS3,TNS3,64759|TOR1AIP1,TOR1AIP1,26092|TRA2B,TRA2B,6434|TSPAN6,TSPAN6,7105|TSTA3,GFUS,7264|TTL,TTL,150465|TWF1,TWF1,5756|UGT2A3,UGT2A3,79799|UGT2B4,UGT2B4,7363|UHRF1,UHRF1,29128|URB2,URB2,9816|USH1G,USH1G,124590|VPREB3,VPREB3,29802|VPS26A,VPS26A,9559|WASF1,WASF1,8936|WDR67,TBC1D31,93594|ZEB2,ZEB2,9839|ZFAND3,ZFAND3,60685|ZNF177,ZNF177,7730|ZNF880,ZNF880,400713" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
