STANDARD_NAME GSE21927_SPLEEN_VS_TUMOR_MONOCYTE_C57BL6_UP SYSTEMATIC_NAME M7582 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21927_SPLEEN_VS_TUMOR_MONOCYTE_C57BL6_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD11b Spleen from C57BL6 mouse versus CD11b Tumor from C57BL6 mouse. DESCRIPTION_FULL Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correction of the diabetic status. Cytokines inducing MDSCs acted on a common molecular pathway. Immunoregulatory activity of both tumor-induced and BM-derived MDSCs was entirely dependent on C/EBP transcription factor, a key component of the emergency myelopoiesis triggered by stress and inflammation. Adoptive transfer of tumor antigen-specific CD8+ T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBP in myeloid compartment. These data unveil another link between inflammation and cancer and identify a novel molecular target to control tumor-induced immune suppression. We used gene expression analysis to identify those factors, secreted by tumor-infiltrating MDSC, which could drive emathopoiesis. Moreover we compare gene expression profile of tumor-induced MDSC, obtained from either the spleen and the tumor infiltrate of tumor bearing mice, and in vitro bone marrow-derived MDSC. PMID 20605485 GEOID GSE21927 AUTHORS Marigo I,Bosio E,Solito S,Mesa C,Fernandez A,Dolcetti L,Ugel S,Sonda N,Bicciato S,Falisi E,Calabrese F,Basso G,Zanovello P,Cozzi E,Mandruzzato S,Bronte V CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE21927_2533_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS A4GALT,ADAD1,AK5,ALDH1L2,ANKRD42,ANUBL1,ARF5,ARHGAP24,ARL6IP1,ASF1A,BBOX1,BCKDK,BMP15,BMX,BRD7P3,C12orf28,C18orf2,C20orf203,C3orf23,C3orf24,C4orf52,C7orf34,C8orf75,CAMKV,CBX6,CCDC19,CCL2,CCT6B,CCZ1,CD163,CD300LG,CD3G,CDH4,CDK9,CELSR3,CGNL1,CLCN3,CLIC2,CLSTN2,CNDP1,CPA3,CPSF7,CR1,CTSE,CYP17A1,DGCR9,DLX6-AS1,DNAH10,DPPA5,DTWD2,DUSP15,DUSP16,DUSP18,EHD3,ELSPBP1,EMX2OS,ENC1,ENDOV,ENSA,ESPNL,ETV6,ETV7,F13B,FADD,FAM182B,FBXO39,FGF1,FLCN,FOXRED2,FZD1,FZD4,GLRA2,GSX1,GUCY1B2,GZF1,HCAR1,HOXA11,HOXC13,HR,HSPC159,HUNK,IL13RA2,IMPA2,IWS1,JAK1,KCNH4,KCNK4,KIAA1919,KIR2DL4,KISS1,KISS1R,KITLG,KLLN,KPNA5,KSR2,LAMA4,LCAT,LMOD3,LOC100128594,LOC100129380,LOC100289026,LOC100289494,LOC100506392,LOC283270,LOC283658,LOC285281,LOC389199,LOC440416,LOC440981,LOC642426,LOC642533,LOC644620,LOC645638,LOC646324,LOC646870,LOC647107,LOC80054,LRRC27,LRRC38,LRRC68,LRRN4CL,LTBR,MAB21L3,MMP2,MRAP2,MTTP,MYCBPAP,MYH10,MYOM1,NBPF3,NDUFAF3,NEU4,NEUROG3,NFATC1,NFE2L3,NLRP8,NPBWR1,OCM2,OPN5,OR51I1,OR7E24,PACRG,PAIP2B,PAX7,PCA3,PDE6G,PDGFB,PDZK1,PGC,PKD1L1,PKD1L2,POLH,PPM1M,PPM1N,PRKAR1B,PRR15,PRRT3,PTCSC,PTPN22,PURB,PURG,RAB8A,RASIP1,RCHY1,RHOD,RLTPR,RNASE3,RNF112,RNF208,RUVBL1,S1PR2,SEPT12,SIGLEC8,SLA,SLC9A3R2,SMOX,SMR3B,SMYD4,STAG3,SUGT1P1,TBC1D2,TBKBP1,TBXAS1,TCHP,THAP8,TIMM23B,TM4SF18,TMEM150B,TMEM50B,TRHDE,TRIM67,TRNP1,TSPAN4,UEVLD,UGT2B28,UPK1B,ZC3H12C,ZNF167,ZNF30,ZNF575 GENE_SYMBOLS A4GALT,ADAD1,AK5,ALDH1L2,ANKRD42,ZFAND4,ARF5,ARHGAP24,ARL6IP1,ASF1A,BBOX1,BCKDK,BMP15,BMX,BRD7P3,MYRFL,LINC00470,C20orf203,TCAIM,FANCD2OS,SMIM20,LLCFC1,LINC00589,CAMKV,CBX6,CFAP45,CCL2,CCT6B,CCZ1,CD163,CD300LG,CD3G,CDH4,CDK9,CELSR3,CGNL1,CLCN3,CLIC2,CLSTN2,CNDP1,CPA3,CPSF7,CR1,CTSE,CYP17A1,DGCR5,DLX6-AS1,DNAH10,DPPA5,DTWD2,DUSP15,DUSP16,DUSP18,EHD3,ELSPBP1,EMX2OS,ENC1,ENDOV,ENSA,ESPNL,ETV6,ETV7,F13B,FADD,FAM182B,FBXO39,FGF1,FLCN,FOXRED2,FZD1,FZD4,GLRA2,GSX1,GUCY1B2,GZF1,HCAR1,HOXA11,HOXC13,HR,LGALSL,HUNK,IL13RA2,IMPA2,IWS1,JAK1,KCNH4,KCNK4,MFSD4B,KIR2DL4,KISS1,KISS1R,KITLG,KLLN,KPNA5,KSR2,LAMA4,LCAT,LMOD3,TMSB15B-AS1,,,,SLC16A1-AS1,,PYGO1,MOBP,ENSG00000228919,CCDC144NL-AS1,,LINC02297,,,WFDC21P,LINC00607,,LINC01192,CEBPA-DT,LRRC27,LRRC38,PPP1R37,LRRN4CL,LTBR,MAB21L3,MMP2,MRAP2,MTTP,MYCBPAP,MYH10,MYOM1,NBPF3,NDUFAF3,NEU4,NEUROG3,NFATC1,NFE2L3,NLRP8,NPBWR1,OCM2,OPN5,OR51I1,OR7E24,PACRG,PAIP2B,PAX7,PCA3,PDE6G,PDGFB,PDZK1,PGC,PKD1L1,PKD1L2,POLH,PPM1M,PPM1N,PRKAR1B,PRR15,PRRT3,PTCSC1,PTPN22,PURB,PURG,RAB8A,RASIP1,RCHY1,RHOD,CARMIL2,RNASE3,RNF112,RNF208,RUVBL1,S1PR2,SEPTIN12,SIGLEC8,SLA,NHERF2,SMOX,SMR3B,SMYD4,STAG3,SUGT1P1,TBC1D2,TBKBP1,TBXAS1,TCHP,THAP8,TIMM23B,TM4SF18,TMEM150B,TMEM50B,TRHDE,TRIM67,TRNP1,TSPAN4,UEVLD,UGT2B28,UPK1B,ZC3H12C,ZKSCAN7,ZNF30,ZNF575 FOUNDER_NAMES