STANDARD_NAME GSE21927_UNTREATED_VS_GMCSF_IL6_TREATED_BONE_MARROW_DN SYSTEMATIC_NAME M7567 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21927_UNTREATED_VS_GMCSF_IL6_TREATED_BONE_MARROW_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD11b BoneMarrow from BALBc mouse versus CD11b BoneMarrow from BALBc mouse incubated with GMCSF and IL-6. DESCRIPTION_FULL Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correction of the diabetic status. Cytokines inducing MDSCs acted on a common molecular pathway. Immunoregulatory activity of both tumor-induced and BM-derived MDSCs was entirely dependent on C/EBP transcription factor, a key component of the emergency myelopoiesis triggered by stress and inflammation. Adoptive transfer of tumor antigen-specific CD8+ T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBP in myeloid compartment. These data unveil another link between inflammation and cancer and identify a novel molecular target to control tumor-induced immune suppression. We used gene expression analysis to identify those factors, secreted by tumor-infiltrating MDSC, which could drive emathopoiesis. Moreover we compare gene expression profile of tumor-induced MDSC, obtained from either the spleen and the tumor infiltrate of tumor bearing mice, and in vitro bone marrow-derived MDSC. PMID 20605485 GEOID GSE21927 AUTHORS Marigo I,Bosio E,Solito S,Mesa C,Fernandez A,Dolcetti L,Ugel S,Sonda N,Bicciato S,Falisi E,Calabrese F,Basso G,Zanovello P,Cozzi E,Mandruzzato S,Bronte V CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE21927_2528_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AAK1,ABCB4,ACSM3,ADAMTS3,ADARB1,ADM,AFF1,AFM,AGPAT4,ALG10B,ALG2,AMN1,ANKRD10,ARHGAP32,ATP6V1C2,ATXN3L,BAIAP2L1,BCAR4,BIRC2,C10orf140,C10orf46,C12orf23,C13orf18,C14orf118,C17orf48,C1QA,C3orf52,C5orf13,C9orf107,CALR,CASC5,CCDC155,CD47,CD79B,CD8B,CLCA2,CLDN12,CLEC2B,CLEC2D,CLGN,CMTM3,CMTM7,CORO1C,CPD,CRNDE,CRYM,CTBP2,CTCF,CYB5A,CYP2R1,CYTH3,DACT1,DCAF16,DKC1,DPYD,DTHD1,DZIP3,FAM184B,FAM91A2,FBXO15,FBXO30,FBXO42,FCRL1,FEN1,FOXP1-IT1,GABRB1,GALNT3,GNB4,GNG8,GRHPR,GRRP1,GUCY1A3,GULP1,H2BFS,HDGFRP3,HDHD2,HIP1,HIST1H2AC,HIST1H2AK,HIST1H2BF,HIST1H3H,HNRNPA2B1,HOXB2,IGKV1D-13,IGLJ3,IL5,IQGAP2,IRS2,JAKMIP2,KANK2,KCNQ5,KIAA0125,KIAA1704,KLB,KLHDC8A,KLHL20,KMO,LASS6,LATS2,LCNL1,LOC100130815,LOC100130987,LOC100131993,LOC100133109,LOC100287547,LOC100289436,LOC100505716,LOC100507524,LOC284263,LOC440983,LOC441025,LOC728606,MAGED1,MAPK14,MC3R,MFAP1,MGC10814,MGC12916,MORC2-AS1,MRAS,MST4,MTMR1,MXI1,NCRNA00115,NEGR1,NPC2,NPTX1,NUBP1,NUDT12,OR51B2,ORMDL3,PCDH9,PDGFC,PELI2,PGM3,PIK3CG,PRO1596,PSMB4,PSME2,PSME4,PTPRE,RAB30,RAE1,RAI2,RAPGEF5,RASAL2,RBBP9,RGS11,RGS5,RING1,RMND5A,RPP30,SBF2,SFMBT2,SGK494,SGPL1,SIAH1,SLC1A4,SLC2A4,SLC2A5,SLC38A9,SLC39A7,SLC43A1,SPRY2,SRSF8,SSBP2,STAM,STMN1,STX7,TAF4,TCL1A,TMEM176A,TNFRSF18,TNPO2,TOP1,TRIM38,TSPAN15,TTYH2,TUBB6,TXNDC3,UBE2E1,UBE2H,UNKL,UPF3B,UTP11L,UTRN,UXS1,WRNIP1,WT1,ZCCHC7,ZEB1,ZNF134,ZNF232,ZNF260,ZNF28,ZNF285,ZNF354A,ZNF512,ZNF618,ZNF815 GENE_SYMBOLS AAK1,ABCB4,ACSM3,ADAMTS3,ADARB1,ADM,AFF1,AFM,AGPAT4,ALG10B,ALG2,AMN1,ANKRD10,ARHGAP32,ATP6V1C2,ATXN3L,BAIAP2L1,BCAR4,BIRC2,SKIDA1,CACUL1,TMEM263,RUBCNL,GPATCH2L,ADPRM,C1QA,C3orf52,NREP,LINC00587,CALR,KNL1,KASH5,CD47,CD79B,CD8B,CLCA2,CLDN12,CLEC2B,CLEC2D,CLGN,CMTM3,CMTM7,CORO1C,CPD,CRNDE,CRYM,CTBP2,CTCF,CYB5A,CYP2R1,CYTH3,DACT1,DCAF16,DKC1,DPYD,DTHD1,DZIP3,FAM184B,,FBXO15,FBXO30,FBXO42,FCRL1,FEN1,FOXP1-IT1,GABRB1,GALNT3,GNB4,GNG8,GRHPR,FAM110D,GUCY1A1,GULP1,H2BC12L,,HDHD2,HIP1,H2AC6,H2AC15,H2BC7,H3C10,HNRNPA2B1,HOXB2,IGKV1D-13,IGLJ3,IL5,IQGAP2,IRS2,JAKMIP2,KANK2,KCNQ5,FAM30A,GPALPP1,KLB,KLHDC8A,KLHL20,KMO,CERS6,LATS2,LCNL1,,,,,,,,ARHGEF26-AS1,,,LINC02483,PCAT18,MAGED1,MAPK14,MC3R,MFAP1,,,MORC2-AS1,MRAS,STK26,MTMR1,MXI1,LINC00115,NEGR1,NPC2,NPTX1,NUBP1,NUDT12,OR51B2,ORMDL3,PCDH9,PDGFC,PELI2,PGM3,PIK3CG,,PSMB4,PSME2,PSME4,PTPRE,RAB30,RAE1,RAI2,RAPGEF5,RASAL2,RBBP9,RGS11,RGS5,RING1,RMND5A,RPP30,SBF2,SFMBT2,,SGPL1,SIAH1,SLC1A4,SLC2A4,SLC2A5,SLC38A9,SLC39A7,SLC43A1,SPRY2,SRSF8,SSBP2,STAM,STMN1,STX7,TAF4,TCL1A,TMEM176A,TNFRSF18,TNPO2,TOP1,TRIM38,TSPAN15,TTYH2,TUBB6,NME8,UBE2E1,UBE2H,UNKL,UPF3B,UTP11,UTRN,UXS1,WRNIP1,WT1,ZCCHC7,ZEB1,ZNF134,ZNF232,ZNF260,ZNF28,ZNF285,ZNF354A,ZNF512,ZNF618,ZNF815P FOUNDER_NAMES