STANDARD_NAME GSE22432_MULTIPOTENT_VS_COMMON_DC_PROGENITOR_UNTREATED_DN SYSTEMATIC_NAME M7829 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE22432_MULTIPOTENT_VS_COMMON_DC_PROGENITOR_UNTREATED_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in amplified multipotent progenitors versus cultured untreated common dendritic cell progenitors. DESCRIPTION_FULL Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3+c-kitintM-CSFR+ and reside in bone marrow. Here we describe a two-step culture system that recapitulates DC development from c-kithiFlt3-/lo multipotent progenitors (MPPs) into CDPs and further into cDC and pDC subsets. MPPs and CDPs are amplified in vitro with Flt3 ligand, stem cell factor, hyper-IL-6 and insulin- like growth factor-1. The four-factor cocktail readily induces self-renewal of MPPs and their progression into CDPs and has no self-renewal activity on CDPs. The amplified CDPs respond to all known DC poietins and generate all lymphoid tissue DCs in vivo and in vitro. Additionally, in vitro CDPs recapitulate the cell surface marker and gene expression profile of in vivo CDPs and possess a DC-primed transcription profile. Transforming growth factor-β1 (TGF-β1) impacts on CDPs and directs their differentiation towards cDCs. Genome-wide gene expression profiling of TGF-β1-induced genes identified transcription factors, such as interferon regulatory factor-4 (IRF-4) and RelB, that are implicated as instructive factors for cDC subset specification. TGF-β1 also induced the transcription factor inhibitor of differentiation/DNA binding 2 (Id2) that suppresses pDC development. Thus, TGF-β1 directs CDP differentiation into cDC by inducing both cDC instructive factors and pDC inhibitory factors. PMID 20881193 GEOID GSE22432 AUTHORS Felker P,Seré K,Lin Q,Becker C,Hristov M,Hieronymus T,Zenke M CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE22432_3616_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AARS,ABHD11,ACER3,AFG3L2,ALG8,APRT,ATL3,ATP13A1,ATP5G1,ATXN7L3,AZIN1,BACH1,BAG5,BFAR,BOP1,BTBD19,BZW2,C12orf66,C15orf44,C19orf25,C19orf48,C20orf20,C5orf15,C7orf25,C7orf26,C8orf59,CALU,CAMSAP1,CBFB,CC2D1B,CCDC41,CCT4,CDC16,CDV3,CENPC1,CHAC2,CHD4,CINP,CSTF1,CTNNA1,CTSZ,CTU1,CXCL10,DARS,DBF4,DDX10,DDX49,DDX51,DDX56,DIEXF,DNAJA2,DNAJC16,DNMT3B,DOHH,DPH2,DPM2,DUSP4,ECE2,EEA1,EIF2B5,EIF4E,ERH,EXOC2,FAM126A,FAM162A,FAM195A,FAM50A,FAM54A,FBL,FDFT1,FNBP1,FPGS,FTSJD1,FXYD5,GEMIN5,GFER,GLRX5,GPN1,GSTT2,GUK1,HARS,HIRIP3,HIVEP3,HMGB3,HNRPDL,IDI1,IL10,IL1R2,ILDR1,INO80,IPPK,ISYNA1,JAGN1,KDSR,KRAS,LETM1,LSM6,MAGOH,MAP2K3,MARCKSL1,METAP2,MFSD2B,MINA,MNT,MORF4L2,MRPL15,MRPL46,MRPL55,MYB,MYBBP1A,NAA20,NDUFB4,NFX1,NIP7,NOC4L,NOL11,NOP16,NSMCE2,NUDC,NUP107,ORC2,OSGIN2,OTUD4,OVCA2,PCNA,PDIK1L,PEX11A,PFDN4,PGAM5,PHB2,PHF16,PIAS2,PIGM,PIGY,PIN1,PNPO,POGLUT1,POLR1E,POLR3G,POP1,PPAT,PPFIA1,PRDM1,PRKX,PRMT7,PRPF19,PSMG2,PTCD3,PTDSS1,PTGES2,PURA,PWP2,RASGEF1B,RBM15B,RBM19,RCE1,REV1,RIPK2,RNF126,RRN3,RSL1D1,RSL24D1,RTN4RL1,RUVBL2,RWDD4,SC4MOL,SEH1L,SF3A3,SHMT2,SLC19A2,SLC25A6,SMCR8,SNHG7,SNRPB2,SRSF3,STX11,SUB1,TBL3,TELO2,TFE3,TLCD1,TMBIM1,TMEM170B,TMEM177,TNIP2,TPD52L2,TRAF4,TRIM37,TSEN54,TSR1,TUSC2,UBE2G1,UBXN2A,USP22,UTP11L,UTP15,YES1,ZC3H15,ZFP106,ZZZ3 GENE_SYMBOLS AARS1,ABHD11,ACER3,AFG3L2,ALG8,APRT,ATL3,ATP13A1,ATP5MC1,ATXN7L3,AZIN1,BACH1,BAG5,BFAR,BOP1,BTBD19,BZW2,KICS2,INTS14,C19orf25,C19orf48P,MRGBP,C5orf15,C7orf25,INTS15,RBIS,CALU,CAMSAP1,CBFB,CC2D1B,CEP83,CCT4,CDC16,CDV3,CENPC,CHAC2,CHD4,CINP,CSTF1,CTNNA1,CTSZ,CTU1,CXCL10,DARS1,DBF4,DDX10,DDX49,DDX51,DDX56,UTP25,DNAJA2,DNAJC16,DNMT3B,DOHH,DPH2,DPM2,DUSP4,ECE2,EEA1,EIF2B5,EIF4E,ERH,EXOC2,HYCC1,FAM162A,MCRIP2,FAM50A,MTFR2,FBL,FDFT1,FNBP1,FPGS,CMTR2,FXYD5,GEMIN5,GFER,GLRX5,GPN1,GSTT2,GUK1,HARS1,HIRIP3,HIVEP3,HMGB3,HNRNPDL,IDI1,IL10,IL1R2,ILDR1,INO80,IPPK,ISYNA1,JAGN1,KDSR,KRAS,LETM1,LSM6,MAGOH,MAP2K3,MARCKSL1,METAP2,MFSD2B,RIOX2,MNT,MORF4L2,MRPL15,MRPL46,MRPL55,MYB,MYBBP1A,NAA20,NDUFB4,NFX1,NIP7,NOC4L,NOL11,NOP16,NSMCE2,NUDC,NUP107,ORC2,OSGIN2,OTUD4,OVCA2,PCNA,PDIK1L,PEX11A,PFDN4,PGAM5,PHB2,JADE3,PIAS2,PIGM,PIGY,PIN1,PNPO,POGLUT1,POLR1E,POLR3G,POP1,PPAT,PPFIA1,PRDM1,PRKX,PRMT7,PRPF19,PSMG2,PTCD3,PTDSS1,PTGES2,PURA,PWP2,RASGEF1B,RBM15B,RBM19,RCE1,REV1,RIPK2,RNF126,RRN3,RSL1D1,RSL24D1,RTN4RL1,RUVBL2,RWDD4,MSMO1,SEH1L,SF3A3,SHMT2,SLC19A2,SLC25A6,SMCR8,SNHG7,SNRPB2,SRSF3,STX11,SUB1,TBL3,TELO2,TFE3,TLCD1,TMBIM1,TMEM170B,TMEM177,TNIP2,TPD52L2,TRAF4,TRIM37,TSEN54,TSR1,TUSC2,UBE2G1,UBXN2A,USP22,UTP11,UTP15,YES1,ZC3H15,ZNF106,ZZZ3 FOUNDER_NAMES